{"id":"https://openalex.org/W4233934934","doi":"https://doi.org/10.1038/nature07785","title":"Singh et al. reply","display_name":"Singh et al. reply","publication_year":2009,"publication_date":"2009-02-25","ids":{"openalex":"https://openalex.org/W4233934934","doi":"https://doi.org/10.1038/nature07785"},"language":"en","primary_location":{"id":"doi:10.1038/nature07785","doi":"https://doi.org/10.1038/nature07785","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature07785","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091055038","display_name":"Sanjay Kumar Singh","orcid":"https://orcid.org/0000-0003-0042-4658","observed_orcids":["https://orcid.org/0000-0003-0042-4658"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay K. Singh","raw_affiliation_strings":["Center for Stem Cell and Developmental Biology, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA","Department of Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Stem Cell and Developmental Biology, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057499302","display_name":"Mohamedi N. Kagalwala","orcid":"https://orcid.org/0000-0003-4649-0300","observed_orcids":["https://orcid.org/0000-0003-4649-0300"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamedi N. Kagalwala","raw_affiliation_strings":["Center for Stem Cell and Developmental Biology, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA","Department of Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Stem Cell and Developmental Biology, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010644764","display_name":"Jan Parker\u2010Thornburg","orcid":"https://orcid.org/0000-0002-4464-8744","observed_orcids":["https://orcid.org/0000-0002-4464-8744"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Parker-Thornburg","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110175432","display_name":"Henry P. Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry Adams","raw_affiliation_strings":["Department of Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063649774","display_name":"Sadhan Majumder","orcid":"https://orcid.org/0000-0002-1379-6699","observed_orcids":["https://orcid.org/0000-0002-1379-6699"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I16452829","display_name":"The University of Texas System","ror":"https://ror.org/01gek1696","country_code":"US","type":"education","lineage":["https://openalex.org/I16452829"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sadhan Majumder","raw_affiliation_strings":["Center for Stem Cell and Developmental Biology, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA","Department of Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA","Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA","Program in Genes and Development, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, 77030, Texas, USA","The Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Stem Cell and Developmental Biology, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Program in Genes and Development, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, 77030, Texas, USA","institution_ids":["https://openalex.org/I16452829"]},{"raw_affiliation_string":"The Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":0.25,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.55262398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"457","issue":"7233","first_page":"E7","last_page":"E7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rest","display_name":"rest","score":0.9750000238418579},{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.9430000185966492},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":1.0},{"id":"https://openalex.org/keywords/microrna-repression","display_name":"microRNA repression","score":0.7080000042915344},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.8629999756813049},{"id":"https://openalex.org/keywords/nanog","display_name":"Nanog","score":0.9990000128746033},{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.7049999833106995},{"id":"https://openalex.org/keywords/feeder-cells","display_name":"feeder cells","score":0.42899999022483826},{"id":"https://openalex.org/keywords/passage-number","display_name":"passage number","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.9391258955001831},{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.7949272394180298},{"id":"https://openalex.org/C77265313","wikidata":"https://www.wikidata.org/wiki/Q879844","display_name":"Rest (music)","level":2,"score":0.7283810973167419},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5970107913017273},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.44862914085388184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44725683331489563},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40128999948501587},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38322216272354126},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3001452684402466},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2656104564666748},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.1495685875415802},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12860646843910217},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0768451988697052}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/nature07785","doi":"https://doi.org/10.1038/nature07785","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature07785","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmh:oai:RePEc:nat:nature:v:457:y:2009:i:7233:d:10.1038_nature07785","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/nature07785","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1483685331","https://openalex.org/W1652680663","https://openalex.org/W1965428318","https://openalex.org/W1967101351","https://openalex.org/W1973876456","https://openalex.org/W1974950833","https://openalex.org/W1975489321","https://openalex.org/W1993579134","https://openalex.org/W1996457750","https://openalex.org/W2076726613","https://openalex.org/W2110015307","https://openalex.org/W2112197800","https://openalex.org/W2135341744","https://openalex.org/W2143297890"],"related_works":["https://openalex.org/W1993579134","https://openalex.org/W1782264743","https://openalex.org/W7096920582","https://openalex.org/W2005619892","https://openalex.org/W1967101351","https://openalex.org/W2076726613","https://openalex.org/W2328787249","https://openalex.org/W206658348","https://openalex.org/W2011086121","https://openalex.org/W1592611561"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}