{"id":"https://openalex.org/W4233920918","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2395","title":"Abstract 2395: A bispecific T- cell engager antibody (BiTE) against TAG-72/ CD3 for targeted cancer immunotherapy","display_name":"Abstract 2395: A bispecific T- cell engager antibody (BiTE) against TAG-72/ CD3 for targeted cancer immunotherapy","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4233920918","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2395"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-2395","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2395","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-2395","pdf_url":null,"source":{"id":"https://openalex.org/S89865888","display_name":"Immunology","issn_l":"0019-2805","issn":["0019-2805","1365-2567"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049115957","display_name":"Fatema Abbas Khambati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fatema Khambati","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090789911","display_name":"Hatem Hussein Soliman","orcid":"https://orcid.org/0000-0001-6644-2264","observed_orcids":["https://orcid.org/0000-0001-6644-2264"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hatem Soliman","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2395","last_page":"2395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.033799998462200165,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tag-72","display_name":"TAG-72","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cd3","display_name":"CD3","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7760000228881836},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7149999737739563},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.968999981880188},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9459999799728394},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.6919999718666077},{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.7080000042915344},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.5329999923706055},{"id":"https://openalex.org/keywords/nsg-mice","display_name":"NSG mice","score":0.45899999141693115},{"id":"https://openalex.org/keywords/mcf-7-xenografts","display_name":"MCF-7 xenografts","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5592098832130432},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.556532084941864},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5310894250869751},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.488944411277771},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4628407955169678},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46192213892936707},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4403780698776245},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2966562509536743},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1561163365840912},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.13050654530525208}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-2395","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2395","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-2395","pdf_url":null,"source":{"id":"https://openalex.org/S89865888","display_name":"Immunology","issn_l":"0019-2805","issn":["0019-2805","1365-2567"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W201357455","https://openalex.org/W2391101096","https://openalex.org/W2419841739","https://openalex.org/W4313383327","https://openalex.org/W4401811321","https://openalex.org/W1608022629","https://openalex.org/W2403028852","https://openalex.org/W3165570177","https://openalex.org/W2559821310","https://openalex.org/W2127132803"],"abstract_inverted_index":{"Background:":[0],"Immunotherapies":[1],"involving":[2],"cytotoxic":[3,28,424],"T":[4,14,29,190,228,425],"lymphocytes":[5],"(CTL\u2019s)":[6],"have":[7],"been":[8],"central":[9],"to":[10,91,107,279,292,401],"cancer":[11,59,104,110,127,147,222,429,465],"immunotherapy.":[12],"Bi-specific":[13],"cell":[15,32,105,111,178,304,456],"engager":[16,373,457],"antibody":[17,40,87,124,144,195,240,273,291,398,420,458],"(BiTE)":[18,459],"therapy":[19,82],"has":[20],"emerged":[21],"as":[22,306,399],"an":[23,79],"effective":[24,437],"immunotherapy":[25,466],"by":[26,169,253,308,363],"redirecting":[27],"cells":[30,128,183,191,223,229,245,426,430],"against":[31,427,460],"surface":[33,101],"protein":[34],"on":[35,54,99,125,145],"tumor":[36,43,244,303,383],"cells.":[37,281],"Our":[38,85,407],"BiTE":[39,86,123,143,194,239,272,290,397,419],"targets":[41],"human":[42,188,226],"associated":[44],"glycoprotein":[45,433],"72":[46],"(TAG-72).":[47],"TAG-72":[48,98,250,432],"is":[49,71],"a":[50,233,357],"pan-carcinoma":[51],"marker":[52],"expressed":[53,73],"the":[55,93,100,103,289,309,370,416,439,471],"surfaces":[56],"of":[57,102,120,140,235,238,249,288,360,441,470],"many":[58],"tissues":[60,76],"including":[61],"breast,":[62,442],"prostate,":[63],"ovary,":[64],"endometrium,":[65],"stomach,":[66],"esophagus,":[67],"and":[68,116,136,160,172,200,207,230,296,347,410,434,445],"pancreas.":[69],"It":[70],"not":[72],"in":[74,114,117,134,137,215,369,393,408,411,438],"normal":[75],"making":[77],"it":[78],"ideal":[80],"target":[81],"for":[83,203,298,463,474],"cancer.":[84],"can":[88,421],"bind":[89],"CD3":[90,122,142,418,462],"activate":[92],"T-cell\u2019s":[94],"while":[95],"simultaneously":[96],"binding":[97,278],"leading":[106],"perforin":[108],"induced":[109],"death.":[112],"The":[113,182,271],"vitro":[115,135,164,409],"vivo":[118,138,210,379,412],"effects":[119,139],"TAG-72/":[121,141,417,461],"different":[126,146,204,428],"are":[129],"presented":[130],"here.Methods:":[131],"We":[132],"studied":[133],"cells;":[148],"breast":[149,221],"(DOX":[150],"resistant":[151],"MCF-7,":[152],"SKBR3,":[153],"MDA-MB-175":[154],"VII),":[155],"ovarian":[156],"(OVCAR-3),":[157],"endometrium":[158,444],"(KLE)":[159],"colon":[161,446],"(Ls174T).":[162],"In":[163,209,378],"cytotoxicity":[165],"assay":[166],"was":[167,212,366],"performed":[168],"flow":[170,254],"cytometry":[171,283],"immunofluorescence":[173],"staining":[174],"using":[175],"live/":[176],"dead":[177],"labelling":[179],"fluorescent":[180],"dyes.":[181],"were":[184],"co-cultured":[185],"with":[186,219,232,388,396],"na\u00efve":[187,225,293],"CD8":[189,227,294,319,325,333,339,345,352,376],"with/":[192],"without":[193],"(1":[196],"\u00b5g,":[197],"5":[198],"\u00b5g":[199],"10":[201],"\u00b5g)":[202],"time":[205],"intervals":[206],"assayed.":[208],"study":[211],"carried":[213],"out":[214],"NSG":[216],"mice":[217],"implanted":[218],"MCF-7":[220],"+":[224,375],"treated":[231,395],"total":[234],"4":[236,299],"doses":[237],"(200\u00b5g/":[241],"dose).Results:":[242],"Different":[243],"showed":[246,275,285,381],"varying":[247],"(%)":[248],"expression":[251],"determined":[252],"cytometry,":[255],"viz;":[256],"DOX":[257,315],"(55%),":[258],"SKBR3":[259],"(16%),":[260],"MDA":[261,327],"175":[262,328],"VII":[263,329],"(8%),":[264],"OVCAR-3":[265,335],"(27%),":[266,268],"KLE":[267,341],"Ls174T":[269,348],"(30%).":[270],"also":[274],"dose":[276],"dependent":[277],"these":[280],"Flow":[282],"analysis":[284],"that":[286,415],"addition":[287],"T-cells":[295,365],"incubation":[297],"days":[300],"significantly":[301],"increases":[302],"death":[305],"indicated":[307],"Annexin":[310],"V/":[311],"PI+ve":[312],"signal":[313],"from":[314],"(52.4%":[316],"vs.":[317,323,337],"41.4%":[318],"alone),":[320,326,334,340],"SKBR-3":[321],"(47.9%":[322],"30%":[324],"(23%":[330],"vs":[331,343,350],"11%":[332],"(31.1%":[336],"23.8%":[338],"(27%":[342],"13%":[344],"alone)":[346,353],"(54%":[349],"29%":[351],"respectively":[354],"(p<0.05).":[355],"Further,":[356],"significant":[358],"level":[359],"IFN-\u03b3":[361],"secreted":[362],"activated":[364],"only":[367],"detected":[368],"bispecific":[371,454],"T-cell":[372],"Ab":[374],"conditions.":[377],"data":[380,413],"good":[382],"regression":[384],"at":[385],"day":[386],"45":[387],"tumors":[389],"measuring":[390],"(8":[391],"mm2)":[392,405],"group":[394,403],"compared":[400],"untreated":[402],"(31":[404],"(p<0.01).Conclusion:":[406],"indicates":[414],"effectively":[422],"redirect":[423],"expressing":[431],"may":[435],"be":[436],"treatment":[440],"ovarian,":[443],"cancers.Citation":[447],"Format:":[448],"Fatema":[449],"Khambati,":[450],"Hatem":[451],"Soliman.":[452],"A":[453],"T-":[455],"targeted":[464],"[abstract].":[467],"In:":[468],"Proceedings":[469],"American":[472],"Association":[473],"Cancer":[475,489],"Research":[476],"Annual":[477],"Meeting":[478],"2019;":[479],"2019":[480],"Mar":[481],"29-Apr":[482],"3;":[483],"Atlanta,":[484],"GA.":[485],"Philadelphia":[486],"(PA):":[487],"AACR;":[488],"Res":[490],"2019;79(13":[491],"Suppl):Abstract":[492],"nr":[493],"2395.":[494]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2022-05-12T00:00:00"}