{"id":"https://openalex.org/W4233780004","doi":"https://doi.org/10.2139/ssrn.3414420","title":"Pseudostellaria heterophylla Extract Polysaccharide H-1-2 Suppresses Pancreatic Cancer by Inhibiting Hypoxia-Induced Anterior Gradient 2","display_name":"Pseudostellaria heterophylla Extract Polysaccharide H-1-2 Suppresses Pancreatic Cancer by Inhibiting Hypoxia-Induced Anterior Gradient 2","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W4233780004","doi":"https://doi.org/10.2139/ssrn.3414420"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.3414420","doi":"https://doi.org/10.2139/ssrn.3414420","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.3414420","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.3414420","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032974329","display_name":"Hongwei Sun","orcid":"https://orcid.org/0000-0001-5700-8247","observed_orcids":["https://orcid.org/0000-0001-5700-8247"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongwei Sun","raw_affiliation_strings":["Wenzhou Medical University - Department of Hepatobiliary Surgery, Wenzhou, China","Wenzhou Medical University - Department of Hepatobiliary Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenzhou Medical University - Department of Hepatobiliary Surgery, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Wenzhou Medical University - Department of Hepatobiliary Surgery","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079375772","display_name":"Keqing Shi","orcid":"https://orcid.org/0000-0002-5070-3834","observed_orcids":["https://orcid.org/0000-0002-5070-3834"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Keqing Shi","raw_affiliation_strings":["Wenzhou Medical University - Department of Hepatobiliary Surgery, Wenzhou, China","Wenzhou Medical University - Department of Hepatobiliary Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenzhou Medical University - Department of Hepatobiliary Surgery, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Wenzhou Medical University - Department of Hepatobiliary Surgery","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kai Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Qi","raw_affiliation_strings":["Chinese Academy of Sciences (CAS) - Shanghai Institute of Nutrition and Health, China","Chinese Academy of Sciences (CAS) - Shanghai Institute of Nutrition and Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences (CAS) - Shanghai Institute of Nutrition and Health, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"raw_affiliation_string":"Chinese Academy of Sciences (CAS) - Shanghai Institute of Nutrition and Health","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101756789","display_name":"Hongyu Kong","orcid":"https://orcid.org/0000-0002-8133-5990","observed_orcids":["https://orcid.org/0000-0002-8133-5990"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyu Kong","raw_affiliation_strings":["Wenzhou Medical University - Department of Hepatobiliary Surgery, Wenzhou, China","Wenzhou Medical University - Department of Hepatobiliary Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenzhou Medical University - Department of Hepatobiliary Surgery, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Wenzhou Medical University - Department of Hepatobiliary Surgery","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100985519","display_name":"Qiye He","orcid":"https://orcid.org/0000-0002-7990-8606","observed_orcids":["https://orcid.org/0000-0002-7990-8606"]},"institutions":[{"id":"https://openalex.org/I4405259827","display_name":"Singlera Genomics Inc. (United States)","ror":"https://ror.org/02t5s2617","country_code":"US","type":"company","lineage":["https://openalex.org/I4405259827"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiye He","raw_affiliation_strings":["Singlera Genomics, Inc., San Diego, CA, United States","Singlera Genomics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singlera Genomics, Inc., San Diego, CA, United States","institution_ids":["https://openalex.org/I4405259827"]},{"raw_affiliation_string":"Singlera Genomics, Inc","institution_ids":["https://openalex.org/I4405259827"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051884745","display_name":"Mengtao Zhou","orcid":"https://orcid.org/0000-0002-3498-5034","observed_orcids":["https://orcid.org/0000-0002-3498-5034"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mengtao Zhou","raw_affiliation_strings":["Wenzhou Medical University - Department of Hepatobiliary Surgery, Wenzhou, China","Wenzhou Medical University - Precision Medical Center Laboratory, Wenzhou, China","Wenzhou Medical University - Department of Hepatobiliary Surgery","Wenzhou Medical University - Precision Medical Center Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenzhou Medical University - Department of Hepatobiliary Surgery, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Wenzhou Medical University - Precision Medical Center Laboratory, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Wenzhou Medical University - Department of Hepatobiliary Surgery","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Wenzhou Medical University - Precision Medical Center Laboratory","institution_ids":["https://openalex.org/I27781120"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051884745"],"corresponding_institution_ids":["https://openalex.org/I27781120"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudostellaria-heterophylla","display_name":"Pseudostellaria heterophylla","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/agr2","display_name":"AGR2","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hypoxia-response-element","display_name":"hypoxia response element","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tumor-cell-migration-and-invasion","display_name":"tumor cell migration and invasion","score":0.7680000066757202},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.8840000033378601},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6781021356582642},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5554409027099609},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.5392862558364868},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4980754852294922},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.381851464509964},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3762604892253876},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3631557822227478},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34242701530456543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.324521541595459},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32269272208213806},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20773690938949585},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.11770683526992798},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.3414420","doi":"https://doi.org/10.2139/ssrn.3414420","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.3414420","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.3414420","doi":"https://doi.org/10.2139/ssrn.3414420","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.3414420","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3015034743","https://openalex.org/W1969700645","https://openalex.org/W4308714766","https://openalex.org/W3030261656","https://openalex.org/W3163540021","https://openalex.org/W4411160879","https://openalex.org/W2903841314","https://openalex.org/W2007078464","https://openalex.org/W1563431612","https://openalex.org/W2023245815"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-05-12T00:00:00"}
