{"id":"https://openalex.org/W4233759874","doi":"https://doi.org/10.1093/toxsci/34.1.141","title":"Suppressive Effects of Bay K 8644 on Toxicity of Calcium Channel Blockers in Cultured Rat Embryos","display_name":"Suppressive Effects of Bay K 8644 on Toxicity of Calcium Channel Blockers in Cultured Rat Embryos","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W4233759874","doi":"https://doi.org/10.1093/toxsci/34.1.141"},"language":"en","primary_location":{"id":"doi:10.1093/toxsci/34.1.141","doi":"https://doi.org/10.1093/toxsci/34.1.141","is_oa":false,"landing_page_url":"https://doi.org/10.1093/toxsci/34.1.141","pdf_url":null,"source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063872632","display_name":"Yoshiki Ban","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YOSHIKI BAN","raw_affiliation_strings":["Development Research Laboratories, Banyu Pharmaceutical Co., Ltd. 810 Nishijo, Menuma-machi, Osato-gun, Saitama 360-02, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Research Laboratories, Banyu Pharmaceutical Co., Ltd. 810 Nishijo, Menuma-machi, Osato-gun, Saitama 360-02, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056142533","display_name":"Toshio Nakatsuka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"TOSHIO NAKATSUKA","raw_affiliation_strings":["Development Research Laboratories, Banyu Pharmaceutical Co., Ltd. 810 Nishijo, Menuma-machi, Osato-gun, Saitama 360-02, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Research Laboratories, Banyu Pharmaceutical Co., Ltd. 810 Nishijo, Menuma-machi, Osato-gun, Saitama 360-02, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113440257","display_name":"Hiroyoshi Matsumoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HIROYOSHI MATSUMOTO","raw_affiliation_strings":["Development Research Laboratories, Banyu Pharmaceutical Co., Ltd. 810 Nishijo, Menuma-machi, Osato-gun, Saitama 360-02, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Research Laboratories, Banyu Pharmaceutical Co., Ltd. 810 Nishijo, Menuma-machi, Osato-gun, Saitama 360-02, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020319663","display_name":"Fumihiko Ikemoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"FUMIHIKO IKEMOTO","raw_affiliation_strings":["Development Research Laboratories, Banyu Pharmaceutical Co., Ltd. 810 Nishijo, Menuma-machi, Osato-gun, Saitama 360-02, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Research Laboratories, Banyu Pharmaceutical Co., Ltd. 810 Nishijo, Menuma-machi, Osato-gun, Saitama 360-02, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065731100","display_name":"Takashi Makita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKASHI MAKITA","raw_affiliation_strings":["Department of Veterinary Anatomy, Yamaguchi University 1677-1 Yoshida, Yamaguchi-shi, Yamaguchi 753, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Anatomy, Yamaguchi University 1677-1 Yoshida, Yamaguchi-shi, Yamaguchi 753, Japan","institution_ids":["https://openalex.org/I173915773"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4671,"currency":"USD","value_usd":4671},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"1","first_page":"141","last_page":"147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.5609999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.5609999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.38179999589920044,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bay-k-8644","display_name":"Bay K 8644","score":0.996999979019165},{"id":"https://openalex.org/keywords/calcium-channel-agonists","display_name":"calcium channel agonists","score":0.7770000100135803},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.9879999756813049},{"id":"https://openalex.org/keywords/embryotoxicity","display_name":"embryotoxicity","score":0.9639999866485596},{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":0.9369999766349792},{"id":"https://openalex.org/keywords/diltiazem","display_name":"diltiazem","score":0.9990000128746033},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":1.0},{"id":"https://openalex.org/keywords/embryonic-heart-rate","display_name":"embryonic heart rate","score":0.968999981880188},{"id":"https://openalex.org/keywords/negative-chronotropic-effect","display_name":"negative chronotropic effect","score":0.8299999833106995},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.5889999866485596},{"id":"https://openalex.org/keywords/rat-embryo","display_name":"rat embryo","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7946748733520508},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6410441398620605},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5711488723754883},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.546297550201416},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47231054306030273},{"id":"https://openalex.org/C115880899","wikidata":"https://www.wikidata.org/wiki/Q1124247","display_name":"Bay","level":2,"score":0.46961766481399536},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.4385022222995758},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3821178078651428},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3239297866821289},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.301279753446579},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2899395823478699},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1334025263786316},{"id":"https://openalex.org/C147176958","wikidata":"https://www.wikidata.org/wiki/Q77590","display_name":"Civil engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/toxsci/34.1.141","doi":"https://doi.org/10.1093/toxsci/34.1.141","is_oa":false,"landing_page_url":"https://doi.org/10.1093/toxsci/34.1.141","pdf_url":null,"source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2080231887","https://openalex.org/W432127965","https://openalex.org/W2002979778","https://openalex.org/W404486910","https://openalex.org/W2049812116","https://openalex.org/W597691413","https://openalex.org/W2159450856","https://openalex.org/W1978610287","https://openalex.org/W2029339673","https://openalex.org/W1495449192"],"abstract_inverted_index":{"Previous":[0],"study":[1,31],"revealed":[2],"that":[3,208],"calcium":[4,37,220],"channel":[5,38,221],"blockers":[6],"(CCBs)":[7],"reduced":[8,135],"embryonic":[9,183],"heart":[10],"rates":[11],"(HRs)":[12],"and":[13,59,72,102,110,115,119,139,148,196],"produced":[14],"morphological":[15,130,203],"abnormalities":[16],"when":[17],"Gestational":[18],"Day":[19],"(GD)":[20],"11.5":[21,50],"rat":[22],"embryos":[23,51,169],"were":[24,52,88,96,112,120,134,158,174,185,213],"cultured":[25],"for":[26],"20":[27],"hr.":[28],"The":[29,105,152],"present":[30],"was":[32],"to":[33,54,124,136,171,187,216],"investigate":[34],"whether":[35],"a":[36,126],"agonist,":[39],"Bay":[40],"K":[41],"8644":[42],"(BAY),":[43],"prevented":[44],"CCB-induced":[45],"embryotoxicity":[46,212],"in":[47,65,144,223],"vitro.":[48],"GD":[49],"exposed":[53,170],"nifedipine":[55],"(NIF),":[56],"diltiazem":[57],"(DIL),":[58],"verapamil":[60],"(VER)":[61],"either":[62],"alone":[63,79],"or":[64,180],"combination":[66],"with":[67,162,176],"BAY":[68,78,177,198],"at":[69,90,100,178],"0.1,":[70],"1.0,":[71],"10":[73,91,181],"\u03bcg/ml.":[74,104],"These":[75,205],"doses":[76,106],"of":[77,93,107,156,189,193,210,219],"had":[80],"no":[81],"effect":[82,128],"on":[83,129,165],"gross":[84],"morphology.":[85],"Embryonic":[86,132],"HRs":[87,133,184],"increased":[89],"\u03bcg/ml":[92],"BAY,":[94,163],"but":[95],"within":[97],"control":[98,142],"levels":[99,143],"0.1":[101],"1.0":[103,179],"NIF,":[108,146],"DIL,":[109,147],"VER":[111,149],"40,":[113],"6.0,":[114],"2.0":[116],"\u03bcg/ml,":[117,182],"respectively,":[118],"the":[121,145],"minimum":[122],"concentrations":[123],"produce":[125],"100%":[127],"abnormalities.":[131,204],"22,":[137],"31,":[138],"34%":[140],"below":[141],"groups,":[150],"respectively.":[151],"negative":[153],"chronotropic":[154],"effects":[155],"CCBs":[157],"inhibited":[159],"by":[160],"coadministration":[161],"depending":[164],"its":[166],"concentration.":[167],"When":[168],"each":[172,194],"CCB":[173,195,211],"supplemented":[175],"comparable":[186],"those":[188],"controls.":[190],"Combined":[191],"exposures":[192],"10\u03bcg/ml":[197],"did":[199],"not":[200],"cause":[201],"any":[202],"results":[206],"suggested":[207],"mechanisms":[209],"directly":[214],"related":[215],"pharmacological":[217],"consequences":[218],"blockage":[222],"developing":[224],"rats.":[225]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}
