{"id":"https://openalex.org/W4233608800","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2136","title":"Abstract 2136: Doublecortin-like Kinase 1 (DCLK1) correlates with the cell proliferation in malignant pleural mesothelioma","display_name":"Abstract 2136: Doublecortin-like Kinase 1 (DCLK1) correlates with the cell proliferation in malignant pleural mesothelioma","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4233608800","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2136"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-2136","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2136","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-2136","pdf_url":null,"source":{"id":"https://openalex.org/S4306510252","display_name":"Experimental and Molecular Therapeutics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Molecular Therapeutics","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034292501","display_name":"Akihiro Miura","orcid":"https://orcid.org/0000-0002-1217-7220","observed_orcids":["https://orcid.org/0000-0002-1217-7220"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiro Miura","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021333939","display_name":"Hiromasa Yamamoto","orcid":"https://orcid.org/0000-0002-5330-5460","observed_orcids":["https://orcid.org/0000-0002-5330-5460"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromasa Yamamoto","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000310822","display_name":"Hiroyuki Tao","orcid":"https://orcid.org/0000-0002-7457-044X","observed_orcids":["https://orcid.org/0000-0002-7457-044X"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Tao","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045785731","display_name":"Ken Suzawa","orcid":"https://orcid.org/0000-0003-2463-9696","observed_orcids":["https://orcid.org/0000-0003-2463-9696"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Suzawa","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070022416","display_name":"Syunsaku Miyauchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Syunsaku Miyauchi","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062982378","display_name":"Kota Araki","orcid":"https://orcid.org/0009-0000-7050-2792","observed_orcids":["https://orcid.org/0009-0000-7050-2792"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kota Araki","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuta Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Takahashi","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000982164","display_name":"Eisuke Kurihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eisuke Kurihara","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091845509","display_name":"Yusuke Ogoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Ogoshi","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003352142","display_name":"Kazuhiko Shien","orcid":"https://orcid.org/0000-0002-4959-4220","observed_orcids":["https://orcid.org/0000-0002-4959-4220"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Shien","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009944548","display_name":"Junichi Soh","orcid":"https://orcid.org/0000-0001-8532-7915","observed_orcids":["https://orcid.org/0000-0001-8532-7915"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junichi Soh","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001765159","display_name":"Kazunori Okabe","orcid":"https://orcid.org/0000-0001-5024-0764","observed_orcids":["https://orcid.org/0000-0001-5024-0764"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunori Okabe","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052265261","display_name":"Shuta Tomida","orcid":"https://orcid.org/0000-0003-3786-936X","observed_orcids":["https://orcid.org/0000-0003-3786-936X"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuta Tomida","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021973822","display_name":"Masakiyo Sakaguchi","orcid":"https://orcid.org/0000-0002-0566-4872","observed_orcids":["https://orcid.org/0000-0002-0566-4872"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masakiyo Sakaguchi","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019215192","display_name":"Shinichi Toyooka","orcid":"https://orcid.org/0000-0002-7588-6745","observed_orcids":["https://orcid.org/0000-0002-7588-6745"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichi Toyooka","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2136","last_page":"2136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-pleural-mesothelioma","display_name":"malignant pleural mesothelioma","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dclk1","display_name":"DCLK1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8519999980926514},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cancer-stem-cell-markers","display_name":"cancer stem cell markers","score":0.6380000114440918},{"id":"https://openalex.org/keywords/microtubule-associated-proteins","display_name":"microtubule-associated proteins","score":0.871999979019165},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.649550199508667},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.5864659547805786},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.56565260887146},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.565081000328064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5367497205734253},{"id":"https://openalex.org/C2781461022","wikidata":"https://www.wikidata.org/wiki/Q14912973","display_name":"Doublecortin","level":4,"score":0.47906121611595154},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47587981820106506},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.4604412317276001},{"id":"https://openalex.org/C2777407522","wikidata":"https://www.wikidata.org/wiki/Q1077603","display_name":"Mesothelioma","level":2,"score":0.41958385705947876},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.392741858959198},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33947300910949707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26009589433670044},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11311277747154236},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10632222890853882},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.09120780229568481},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.060642242431640625},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-2136","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2136","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-2136","pdf_url":null,"source":{"id":"https://openalex.org/S4306510252","display_name":"Experimental and Molecular Therapeutics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Molecular Therapeutics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2619969047","https://openalex.org/W4388934152","https://openalex.org/W4296538634","https://openalex.org/W3210937792","https://openalex.org/W2612126035","https://openalex.org/W2516723545","https://openalex.org/W4297359830","https://openalex.org/W3178397585","https://openalex.org/W2483248188","https://openalex.org/W2035203537"],"abstract_inverted_index":{"Background:":[0],"Malignant":[1],"pleural":[2,350],"mesothelioma":[3,351],"(MPM)":[4],"is":[5,18,21,41,50,56,68],"a":[6,25,38,94,303],"refractory":[7],"disease":[8],"with":[9,344],"poor":[10],"prognosis":[11],"despite":[12],"multimodality":[13],"therapy.":[14],"Because":[15],"standard":[16],"therapy":[17,31],"unsatisfactory,":[19],"it":[20],"expected":[22],"to":[23,70,113,125,264],"establish":[24],"novel":[26],"strategy":[27],"such":[28],"as":[29,75,302],"molecular-targeting":[30],"for":[32,98,359],"MPM.":[33],"Doublecortin-like":[34,339],"kinase":[35],"1":[36,341],"(DCLK1),":[37],"microtubule-associated":[39],"protein,":[40],"one":[42],"of":[43,81,111,117,132,141,171,181,197,204,213,235,254,272,284,295,355],"the":[44,53,79,115,127,169,293,345,356],"tumor-specific":[45],"stem":[46],"cell":[47,54,121,154,162,200,232,247,261,296,346],"marker":[48],"and":[49,64,129,137,153,161,187,210,225,246,258,270,288,298],"revealed":[51,189,206,250],"that":[52,91,168,190,207,251,281],"survival":[55],"reduced":[57],"by":[58,134,148,158,241,266],"inhibiting":[59],"this":[60],"protein":[61,128],"in":[62,83,173,178,194,217,223,230,292,306,348],"pancreatic":[63],"colorectal":[65],"cancers.":[66],"DCLK1":[67,92,133,142,172,191,214,236,290],"known":[69],"have":[71],"several":[72],"isoforms":[73,143,237,256,286],"named":[74],"isoform":[76,208,211,219,226,274],"#1-#4,":[77],"although":[78],"significance":[80],"them":[82],"MPM":[84,112,120,174,199],"has":[85],"not":[86],"been":[87],"clarified.":[88],"We":[89],"hypothesized":[90],"was":[93,103,156,176,192,221,228],"potential":[95,301],"therapeutic":[96,304],"target":[97,305],"MPM.<Materials":[99],"andMethods:":[100],"Immunohistochemical":[101,165],"staining":[102,166],"performed":[104],"using":[105],"surgically":[106],"resected":[107],"formalin-fixed":[108],"paraffin-embedded":[109],"tissue":[110],"evaluate":[114],"expression":[116,131,140,170],"DCLK1.":[118],"Additionally,":[119],"lines":[122],"were":[123,144,215,238],"analyzed":[124,157],"characterize":[126],"mRNA":[130],"western":[135],"blotting":[136,186],"RT-PCR.":[138],"The":[139,202],"selectively":[145,239],"knocked":[146],"down":[147],"small":[149],"interfering":[150],"RNA":[151],"(siRNA)":[152],"viability":[155],"colony":[159],"formation":[160,245],"count":[163,248],"assays.Results:":[164],"demonstrated":[167],"specimens":[175],"positive":[177],"24":[179],"out":[180,196],"27":[182],"samples":[183],"(89%).":[184],"Western":[185],"RT-PCR":[188,205],"expressed":[193,216,222,229],"seven":[195],"nine":[198],"lines.":[201,233],"results":[203,279,291],"#2":[209,227,257,275,287],"#4":[212,220,259],"H2052,":[218],"H28,":[224],"YUMC44":[231],"Expressions":[234],"suppressed":[240,260],"isoform-specific":[242],"siRNAs.":[243],"Colony":[244],"assays":[249],"siRNA-mediated":[252],"knockdown":[253,265,271,283],"both":[255,285],"growth":[262,297],"compared":[263],"negative":[267],"control":[268],"siRNA":[269],"only":[273],"or":[276],"#4.Conclusion:":[277],"Our":[278],"demonstrate":[280],"simultaneous":[282],"#4of":[289],"inhibition":[294],"suggest":[299],"its":[300],"MPM.Citation":[307],"Format:":[308],"Akihiro":[309],"Miura,":[310],"Hiromasa":[311],"Yamamoto,":[312],"Hiroyuki":[313],"Tao,":[314],"Ken":[315],"Suzawa,":[316],"Syunsaku":[317],"Miyauchi,":[318],"Kota":[319],"Araki,":[320],"Yuta":[321],"Takahashi,":[322],"Eisuke":[323],"Kurihara,":[324],"Yusuke":[325],"Ogoshi,":[326],"Kazuhiko":[327],"Shien,":[328],"Junichi":[329],"Soh,":[330],"Kazunori":[331],"Okabe,":[332],"Shuta":[333],"Tomida,":[334],"Masakiyo":[335],"Sakaguchi,":[336],"Shinichi":[337],"Toyooka.":[338],"Kinase":[340],"(DCLK1)":[342],"correlates":[343],"proliferation":[347],"malignant":[349],"[abstract].":[352],"In:":[353],"Proceedings":[354],"American":[357],"Association":[358],"Cancer":[360,374],"Research":[361],"Annual":[362],"Meeting":[363],"2019;":[364],"2019":[365],"Mar":[366],"29-Apr":[367],"3;":[368],"Atlanta,":[369],"GA.":[370],"Philadelphia":[371],"(PA):":[372],"AACR;":[373],"Res":[375],"2019;79(13":[376],"Suppl):Abstract":[377],"nr":[378],"2136.":[379]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}