{"id":"https://openalex.org/W4233564083","doi":"https://doi.org/10.1227/00006123-200108000-00052","title":"Convulsive Seizures Following Subdural Application of Fibrin Sealant Containing Tranexamic Acid in a Rat Model","display_name":"Convulsive Seizures Following Subdural Application of Fibrin Sealant Containing Tranexamic Acid in a Rat Model","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W4233564083","doi":"https://doi.org/10.1227/00006123-200108000-00052"},"language":"en","primary_location":{"id":"doi:10.1227/00006123-200108000-00052","doi":"https://doi.org/10.1227/00006123-200108000-00052","is_oa":false,"landing_page_url":"https://doi.org/10.1227/00006123-200108000-00052","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111692586","display_name":"Michael Schlag","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael Schlag","raw_affiliation_strings":["Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vienna, Austria","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111692586"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"49","issue":"2","first_page":"480","last_page":"480"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.5160999894142151,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.5160999894142151,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12622","display_name":"Neurosurgical Procedures and Complications","score":0.2833999991416931,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tranexamic-acid","display_name":"tranexamic acid","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fibrin-glue","display_name":"fibrin glue","score":0.8370000123977661},{"id":"https://openalex.org/keywords/convulsions","display_name":"convulsions","score":0.8790000081062317},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9039999842643738},{"id":"https://openalex.org/keywords/subarachnoid-hemorrhage","display_name":"subarachnoid hemorrhage","score":0.9639999866485596},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.8270000219345093},{"id":"https://openalex.org/keywords/antifibrinolytic-agents","display_name":"antifibrinolytic agents","score":0.8370000123977661},{"id":"https://openalex.org/keywords/kainic-acid","display_name":"kainic acid","score":0.7799999713897705},{"id":"https://openalex.org/keywords/strychnine","display_name":"strychnine","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C2779637338","wikidata":"https://www.wikidata.org/wiki/Q418666","display_name":"Tranexamic acid","level":3,"score":0.9519259929656982},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9474128484725952},{"id":"https://openalex.org/C2775883587","wikidata":"https://www.wikidata.org/wiki/Q1427914","display_name":"Sealant","level":2,"score":0.7704930901527405},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.6383578777313232},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5746204257011414},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38410529494285583},{"id":"https://openalex.org/C2991743468","wikidata":"https://www.wikidata.org/wiki/Q166019","display_name":"Blood loss","level":2,"score":0.054720550775527954},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.04951581358909607},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1227/00006123-200108000-00052","doi":"https://doi.org/10.1227/00006123-200108000-00052","is_oa":false,"landing_page_url":"https://doi.org/10.1227/00006123-200108000-00052","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"doi:10.1097/00006123-200108000-00052","doi":"https://doi.org/10.1097/00006123-200108000-00052","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006123-200108000-00052","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2008802497","https://openalex.org/W2027879572","https://openalex.org/W2036468563","https://openalex.org/W2141813576"],"related_works":["https://openalex.org/W2063115832","https://openalex.org/W4240096728","https://openalex.org/W2052594545","https://openalex.org/W3127468993","https://openalex.org/W4239865350","https://openalex.org/W2264468828","https://openalex.org/W166133130","https://openalex.org/W2014278179","https://openalex.org/W1985450025","https://openalex.org/W4406361359"],"abstract_inverted_index":{"In":[0],"Reply:":[1],"We":[2],"are":[3,200],"well":[4],"aware":[5],"of":[6,13,19,55,72,142,173,222],"the":[7,11,17,32,65,70,137,140,169,210,225],"extensive":[8],"research":[9],"regarding":[10],"use":[12,57,71],"t-AMCA":[14,49,73,89,203,223],"acid":[15,182],"for":[16,97,190],"treatment":[18,96,148],"subarachnoid":[20,59,98,127],"hemorrhage":[21,128],"that":[22,88,112],"was":[23,133,145],"carried":[24],"out":[25,87],"by":[26,78,136,157],"Dr.":[27],"Fodstad":[28],"and":[29,34,51,149],"others":[30,158],"in":[31,58,74,116,124,147,197],"1970s":[33],"1980s.":[35],"However,":[36,175],"with":[37,118,126,187],"our":[38,198],"article":[39],"(3),":[40],"we":[41,62,83],"were":[42,104],"targeting":[43],"a":[44,53,80,95,107],"rapid":[45],"communication":[46],"on":[47,69],"topical":[48,220],"neurotoxicity":[50],"not":[52,134,215],"review":[54,68],"its":[56],"hemorrhage.":[60,99],"Thus,":[61,160],"only":[63],"quoted":[64],"latest":[66],"state-of-the-art":[67],"surgery":[75],"(1).":[76],"Moreover,":[77],"choosing":[79],"recent":[81],"article,":[82],"wanted":[84],"to":[85,164,167,224],"point":[86],"is":[90,209],"still":[91],"being":[92],"considered":[93],"as":[94,180],"Just":[100],"last":[101],"year,":[102],"results":[103,153],"reported":[105,156],"from":[106],"prospective":[108],"multicenter":[109],"clinical":[110],"trial":[111],"investigated":[113],"whether":[114,202],"antifibrinolytics":[115],"combination":[117],"calcium":[119,161,212],"blockers":[120,162,213],"would":[121,214],"improve":[122],"outcome":[123,132],"patients":[125],"(2).":[129],"Although":[130],"overall":[131],"improved":[135],"combined":[138],"treatment,":[139],"incidence":[141],"ischemic":[143,170],"complications":[144],"equal":[146],"control":[150],"groups.":[151],"Similar":[152],"have":[154],"been":[155],"(4).":[159],"seem":[163],"be":[165],"able":[166],"counteract":[168],"side":[171],"effects":[172],"t-AMCA.":[174],"other":[176],"convulsive":[177],"agents,":[178],"such":[179],"kainic":[181],"or":[183,192],"strychnine,":[184],"typically":[185],"interfere":[186],"neuronal":[188],"receptors":[189],"excitatory":[191],"inhibitory":[193],"neurotransmitters.":[194],"Ongoing":[195],"studies":[196],"laboratory":[199],"investigating":[201],"has":[204],"similar":[205],"properties.":[206],"If":[207],"this":[208],"case,":[211],"protect":[216],"against":[217],"convulsions":[218],"after":[219],"application":[221],"central":[226],"nervous":[227],"system.":[228]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}