{"id":"https://openalex.org/W4233353968","doi":"https://doi.org/10.1128/mcb.14.8.5466-5473.1994","title":"A Protein That Is Highly Related to GTPase-Activating Protein-Associated p62 Complexes with Phospholipase C\u03b3","display_name":"A Protein That Is Highly Related to GTPase-Activating Protein-Associated p62 Complexes with Phospholipase C\u03b3","publication_year":1994,"publication_date":"1994-08-01","ids":{"openalex":"https://openalex.org/W4233353968","doi":"https://doi.org/10.1128/mcb.14.8.5466-5473.1994"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.14.8.5466-5473.1994","doi":"https://doi.org/10.1128/mcb.14.8.5466-5473.1994","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.14.8.5466-5473.1994","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114045857","display_name":"Ming\u2010Chei Maa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming-Chei Maa","raw_affiliation_strings":["Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center","Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052686446","display_name":"Tzeng\u2010Horng Leu","orcid":"https://orcid.org/0000-0002-3212-6578","observed_orcids":["https://orcid.org/0000-0002-3212-6578"]},"institutions":[{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tzeng-Horng Leu","raw_affiliation_strings":["Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center","Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045947766","display_name":"Barbara J. Trandel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara J. Trandel","raw_affiliation_strings":["Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center","Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023737081","display_name":"Jinhong Chang","orcid":"https://orcid.org/0000-0002-6723-494X","observed_orcids":["https://orcid.org/0000-0002-6723-494X"]},"institutions":[{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin-Hong Chang","raw_affiliation_strings":["Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center","Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002041109","display_name":"Sarah J. Parsons","orcid":"https://orcid.org/0000-0002-0815-5272","observed_orcids":["https://orcid.org/0000-0002-0815-5272"]},"institutions":[{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah J. Parsons","raw_affiliation_strings":["Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center","Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Microbiology, Cancer Center and Molecular Biology Institute, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5015,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.61614979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"14","issue":"8","first_page":"5466","last_page":"5473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.9789999723434448},{"id":"https://openalex.org/keywords/phospholipase-c-gamma","display_name":"phospholipase C-gamma","score":0.9259999990463257},{"id":"https://openalex.org/keywords/gtpase-activating-protein","display_name":"GTPase-activating protein","score":0.9580000042915344},{"id":"https://openalex.org/keywords/ras-p21","display_name":"p21ras","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/sh2-domain","display_name":"SH2 domain","score":0.871999979019165},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8140000104904175},{"id":"https://openalex.org/keywords/egf-signaling","display_name":"EGF signaling","score":0.7760000228881836},{"id":"https://openalex.org/keywords/signaling-crosstalk","display_name":"signaling crosstalk","score":0.8610000014305115},{"id":"https://openalex.org/keywords/c3h10t1-2-cells","display_name":"C3H10T1/2 cells","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7387758493423462},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.5951244831085205},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.509657621383667},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.492847204208374},{"id":"https://openalex.org/C163181125","wikidata":"https://www.wikidata.org/wiki/Q408592","display_name":"GTPase-activating protein","level":4,"score":0.4879536032676697},{"id":"https://openalex.org/C196347352","wikidata":"https://www.wikidata.org/wiki/Q24771787","display_name":"SH3 domain","level":4,"score":0.4838896691799164},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.47917047142982483},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4601614475250244},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.4487178325653076},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42496001720428467},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.4142373502254486},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.41370776295661926},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.357685387134552},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33806413412094116},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.27144646644592285}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1128/mcb.14.8.5466-5473.1994","doi":"https://doi.org/10.1128/mcb.14.8.5466-5473.1994","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.14.8.5466-5473.1994","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4305482547","display_name":null,"funder_award_id":"CA 39438","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W50259775","https://openalex.org/W240647565","https://openalex.org/W1501666754","https://openalex.org/W1515371688","https://openalex.org/W1528493806","https://openalex.org/W1553563097","https://openalex.org/W1572009433","https://openalex.org/W1598998194","https://openalex.org/W1704017123","https://openalex.org/W1720535299","https://openalex.org/W1966831459","https://openalex.org/W1968610357","https://openalex.org/W1974027176","https://openalex.org/W1975978851","https://openalex.org/W1994305152","https://openalex.org/W1998645764","https://openalex.org/W2006038022","https://openalex.org/W2007660746","https://openalex.org/W2008559677","https://openalex.org/W2010403667","https://openalex.org/W2017100096","https://openalex.org/W2020403539","https://openalex.org/W2022129165","https://openalex.org/W2022821869","https://openalex.org/W2030655955","https://openalex.org/W2035439001","https://openalex.org/W2073052622","https://openalex.org/W2077317888","https://openalex.org/W2089375674","https://openalex.org/W2091848990","https://openalex.org/W2093226717","https://openalex.org/W2137433289","https://openalex.org/W2150228169","https://openalex.org/W2192438735"],"related_works":["https://openalex.org/W2099817755","https://openalex.org/W7099556716","https://openalex.org/W4236896535","https://openalex.org/W1531633240","https://openalex.org/W1983205973","https://openalex.org/W2157943836","https://openalex.org/W4249724161","https://openalex.org/W2127840964","https://openalex.org/W1522355351","https://openalex.org/W1966831459"],"abstract_inverted_index":{"p62":[0,85,105,157,180,223,238],"is":[1],"a":[2,51,182,229,244],"highly":[3,52,234],"tyrosyl":[4,58],"phosphorylated":[5,59],"protein":[6,16,55,186,230],"that":[7,56,228],"was":[8,109,134,211],"first":[9],"identified":[10],"in":[11,68,87,143,150,161,164,172],"immunoprecipitates":[12],"of":[13,18,104,116,128,156,167,179,194],"the":[14,102,123,129,138,154,165,188,203],"GTPase-activating":[15],"(GAP)":[17],"p21ras":[19],"from":[20],"cells":[21,70,163],"transformed":[22,78],"by":[23,79,136,246],"oncogenic":[24],"nonreceptor":[25],"tyrosine":[26,31],"kinases":[27],"or":[28,77,121,147,233],"stimulated":[29,71],"through":[30,114],"kinase":[32],"receptors":[33],"(C.":[34],"Ellis,":[35],"M.":[36],"Moran,":[37],"F.":[38],"McCormick,":[39],"and":[40,60,82,94,111,170,176,207,218,242,252],"T.":[41],"Pawson,":[42],"Nature":[43],"343:377-381,":[44],"1991).":[45],"In":[46],"this":[47],"article":[48],"we":[49],"describe":[50],"related":[53,235],"62-kDa":[54],"becomes":[57],"associated":[61],"with":[62,72,106,131,158,181],"phospholipase":[63],"C":[64],"gamma":[65,108,120,145,149,160,210,241],"(PLC":[66],"gamma)":[67,133],"C3H10T1/2":[69],"epidermal":[73],"growth":[74],"factor":[75],"(EGF)":[76],"v-src.":[80],"GAP-associated":[81,237],"PLC":[83,107,119,132,144,148,159,195,209,240,250],"gamma-associated":[84],"comigrated":[86],"one-dimensional":[88],"sodium":[89],"dodecyl":[90],"sulfate-polyacrylamide":[91],"gel":[92],"electrophoresis":[93],"exhibited":[95],"nearly":[96],"identical":[97,231],"phosphotryptic":[98],"peptide":[99],"patterns.":[100],"That":[101],"association":[103,155],"direct":[110,177],"not":[112],"mediated":[113],"binding":[115,175],"GAP-p62":[117],"to":[118,122,140,213,232,236],"EGF":[124,168],"receptor":[125,130],"(and":[126],"coprecipitation":[127],"demonstrated":[135],"(i)":[137],"inability":[139],"detect":[141],"GAP":[142,151,206],"immunocomplexes":[146],"immunocomplexes,":[152],"(ii)":[153],"v-src-transformed":[162],"absence":[166],"stimulation,":[169],"(iii)":[171],"vitro":[173],"solution":[174],"blotting":[178],"glutathione":[183],"S-transferase":[184],"fusion":[185],"containing":[187],"Src":[189],"homology":[190],"2":[191],"(SH2)":[192],"domains":[193],"gamma.":[196],"Unlike":[197],"GAP,":[198],"whose":[199],"N-terminal":[200],"SH2":[201,220],"mediates":[202],"interaction":[204],"between":[205,249],"p62,":[208],"found":[212],"require":[214],"both":[215],"its":[216],"N-":[217],"C-terminal":[219],"regions":[221],"for":[222],"binding.":[224],"These":[225],"studies":[226],"demonstrate":[227],"binds":[239],"suggest":[243],"means":[245],"which":[247],"\"cross-talk\"":[248],"gamma-":[251],"GAP-mediated":[253],"signalling":[254],"may":[255],"occur.":[256]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-05-12T00:00:00"}
