{"id":"https://openalex.org/W4233205667","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.e14632","title":"Decrease in CA-19-9 after neoadjuvant chemoradiation therapy to predict survival in locally advanced pancreatic cancer.","display_name":"Decrease in CA-19-9 after neoadjuvant chemoradiation therapy to predict survival in locally advanced pancreatic cancer.","publication_year":2012,"publication_date":"2012-05-20","ids":{"openalex":"https://openalex.org/W4233205667","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.e14632"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2012.30.15_suppl.e14632","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.e14632","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2012.30.15_suppl.e14632","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101500818","display_name":"Jaswinder Singh","orcid":"https://orcid.org/0000-0002-3586-770X","observed_orcids":["https://orcid.org/0000-0002-3586-770X"]},"institutions":[{"id":"https://openalex.org/I2802637454","display_name":"Research Medical Center","ror":"https://ror.org/01zp13r18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802637454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaswinder Singh","raw_affiliation_strings":["Research Medical Center, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Medical Center, Kansas City, MO","institution_ids":["https://openalex.org/I2802637454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111755425","display_name":"Syed Faisal Jafri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802637454","display_name":"Research Medical Center","ror":"https://ror.org/01zp13r18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802637454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syed Faisal Jafri","raw_affiliation_strings":["Research Medical Center, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Medical Center, Kansas City, MO","institution_ids":["https://openalex.org/I2802637454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044786239","display_name":"Maninder Pabla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802637454","display_name":"Research Medical Center","ror":"https://ror.org/01zp13r18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802637454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maninder Pabla","raw_affiliation_strings":["Research Medical Center, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Medical Center, Kansas City, MO","institution_ids":["https://openalex.org/I2802637454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058771850","display_name":"Bradley L. Freilich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802637454","display_name":"Research Medical Center","ror":"https://ror.org/01zp13r18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802637454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley L Freilich","raw_affiliation_strings":["Research Medical Center, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Medical Center, Kansas City, MO","institution_ids":["https://openalex.org/I2802637454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086277642","display_name":"Joe A. Cates","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802637454","display_name":"Research Medical Center","ror":"https://ror.org/01zp13r18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802637454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joe Cates","raw_affiliation_strings":["Research Medical Center, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Medical Center, Kansas City, MO","institution_ids":["https://openalex.org/I2802637454"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John M. Sheldon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802637454","display_name":"Research Medical Center","ror":"https://ror.org/01zp13r18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802637454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Sheldon","raw_affiliation_strings":["Research Medical Center, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Medical Center, Kansas City, MO","institution_ids":["https://openalex.org/I2802637454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019829856","display_name":"David Shaeffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802637454","display_name":"Research Medical Center","ror":"https://ror.org/01zp13r18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802637454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Shaeffer","raw_affiliation_strings":["Research Medical Center, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Medical Center, Kansas City, MO","institution_ids":["https://openalex.org/I2802637454"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Connor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802637454","display_name":"Research Medical Center","ror":"https://ror.org/01zp13r18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802637454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Connor","raw_affiliation_strings":["Research Medical Center, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Medical Center, Kansas City, MO","institution_ids":["https://openalex.org/I2802637454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052119250","display_name":"Raj J. Shah","orcid":"https://orcid.org/0000-0002-9736-4139","observed_orcids":["https://orcid.org/0000-0002-9736-4139"]},"institutions":[{"id":"https://openalex.org/I2802637454","display_name":"Research Medical Center","ror":"https://ror.org/01zp13r18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802637454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raj Shah","raw_affiliation_strings":["Research Medical Center, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Medical Center, Kansas City, MO","institution_ids":["https://openalex.org/I2802637454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002376229","display_name":"Niharika Rath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802637454","display_name":"Research Medical Center","ror":"https://ror.org/01zp13r18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802637454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niharika Rath","raw_affiliation_strings":["Research Medical Center, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Medical Center, Kansas City, MO","institution_ids":["https://openalex.org/I2802637454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026899445","display_name":"Reed Cope","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802637454","display_name":"Research Medical Center","ror":"https://ror.org/01zp13r18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802637454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reed Cope","raw_affiliation_strings":["Research Medical Center, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Medical Center, Kansas City, MO","institution_ids":["https://openalex.org/I2802637454"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Burt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802637454","display_name":"Research Medical Center","ror":"https://ror.org/01zp13r18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802637454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Burt","raw_affiliation_strings":["Research Medical Center, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Medical Center, Kansas City, MO","institution_ids":["https://openalex.org/I2802637454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030254502","display_name":"Srijita Mukherjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802637454","display_name":"Research Medical Center","ror":"https://ror.org/01zp13r18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802637454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srijita Mukherjee","raw_affiliation_strings":["Research Medical Center, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Medical Center, Kansas City, MO","institution_ids":["https://openalex.org/I2802637454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033365324","display_name":"Unnati Parikh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802637454","display_name":"Research Medical Center","ror":"https://ror.org/01zp13r18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802637454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Unnati Parikh","raw_affiliation_strings":["Research Medical Center, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Medical Center, Kansas City, MO","institution_ids":["https://openalex.org/I2802637454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068326475","display_name":"Jennifer Wanpen Feeback","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802637454","display_name":"Research Medical Center","ror":"https://ror.org/01zp13r18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802637454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Wanpen Feeback","raw_affiliation_strings":["Research Medical Center, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Medical Center, Kansas City, MO","institution_ids":["https://openalex.org/I2802637454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802637454"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"15_suppl","first_page":"e14632","last_page":"e14632"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ca19-9","display_name":"CA19-9","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.656000018119812},{"id":"https://openalex.org/keywords/neoadjuvant-chemoradiotherapy","display_name":"neoadjuvant chemoradiotherapy","score":0.9279999732971191},{"id":"https://openalex.org/keywords/locally-advanced-unresectable-pancreatic-cancer","display_name":"locally advanced unresectable pancreatic cancer","score":0.7360000014305115},{"id":"https://openalex.org/keywords/borderline-resectable-pancreatic-cancer","display_name":"borderline resectable pancreatic cancer","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tumor-marker-response","display_name":"tumor marker response","score":0.6359999775886536},{"id":"https://openalex.org/keywords/overall-survival-prediction","display_name":"overall survival prediction","score":0.7879999876022339},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9139999747276306},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.9190000295639038},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8360000252723694},{"id":"https://openalex.org/keywords/endoscopic-ultrasound-staging","display_name":"endoscopic ultrasound staging","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9731055498123169},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.6412049531936646},{"id":"https://openalex.org/C2780390042","wikidata":"https://www.wikidata.org/wiki/Q1340838","display_name":"Endoscopic ultrasound","level":2,"score":0.5728235840797424},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5543389916419983},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5181878209114075},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.49986958503723145},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45655080676078796},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3995162546634674},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3327799439430237},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29950442910194397}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2012.30.15_suppl.e14632","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.e14632","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2012.30.15_suppl.e14632","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4384118646","https://openalex.org/W2596931520","https://openalex.org/W3092291343","https://openalex.org/W1555976827","https://openalex.org/W2149700376","https://openalex.org/W7122426551","https://openalex.org/W2603131417","https://openalex.org/W2940299410","https://openalex.org/W2128454729","https://openalex.org/W2590813042"],"abstract_inverted_index":{"e14632":[0],"Background:":[1],"Carcinoma":[2],"of":[3,11,20,32,50,74,82,128,138,162,202,227,257],"the":[4,8,16,24,30,46,57,83,106,159],"pancreas":[5],"is":[6],"among":[7],"most":[9],"lethal":[10],"human":[12],"cancers.":[13],"Data":[14,173],"on":[15,158,176],"overall":[17,58,305],"survival":[18,59,306],"rates":[19],"patients":[21,55,178,203,217,242,269,291,308,310],"treated":[22,117],"in":[23,105,253,274,283,290,294,307,321,326,330],"community":[25,64],"hospital":[26,65],"setting":[27],"are":[28],"limited;":[29],"purpose":[31],"this":[33,284],"retrospective":[34],"data":[35],"collection":[36],"study":[37],"was":[38,93,103,191,243,280],"to":[39,287,332],"assess":[40],"\u2013":[41],"Does":[42],"CA-19-9":[43],"change":[44],"during":[45,170],"neo":[47,333],"adjuvant":[48,334],"treatment":[49],"locally":[51,75,219,312],"advanced":[52,76,220,313],"pancreatic":[53,314],"cancer":[54,315],"predicts":[56],"(OS)":[60],"at":[61],"high":[62],"volume":[63],"setting.":[66],"Methods:":[67],"Eligibility":[68],"included":[69],"cytological":[70],"or":[71,223,262],"histological":[72],"evidence":[73],"unresectable":[77],"and":[78,97,102,186,196,232,336],"borderline":[79,224],"resectable":[80],"adenocarcinoma":[81],"pancreas,":[84],"not":[85],"amenable":[86],"for":[87,123,134,239,309],"complete":[88],"surgical":[89],"resection.":[90],"Their":[91],"respectability":[92],"determined":[94],"with":[95,118,126,211,249,292,311],"EUS":[96],"CT":[98],"scan":[99],"/":[100],"MRI":[101],"discussed":[104],"multi":[107],"disciplinary":[108],"conference.":[109],"Patients":[110,144],"diagnosed":[111,145,183,206],"before":[112],"July":[113,147],"2009":[114,148],"were":[115,174,198,205,218,234],"essentially":[116],"continuous":[119],"5-FU":[120],"200":[121],"mg/m2":[122,152],"5":[124],"weeks":[125,245,282,289],"radiation":[127,163],"1.8":[129],"Gy":[130,140],"per":[131],"daily":[132],"fraction,":[133],"a":[135],"total":[136],"dose":[137],"50.4":[139],"over":[141],"5.5":[142],"weeks.":[143],"after":[146],"received":[149],"gemcitabine":[150],"400":[151],"intravenously":[153],"(over":[154],"60":[155],"minutes)":[156],"beginning":[157],"first":[160],"day":[161],"therapy":[164],"(before":[165],"radiation),":[166],"then":[167],"weekly":[168],"thereafter":[169],"radiation.":[171,337],"Results:":[172],"abstracted":[175],"64":[177,241],"(40":[179],"deceased;":[180],"24":[181],"alive)":[182],"between":[184],"6/2005":[185],"4/2011.":[187],"The":[188,200],"median":[189,278],"age":[190],"68":[192],"years":[193],"(range:":[194],"41-87),":[195],"52%":[197],"male.":[199],"majority":[201],"(97%)":[204],"by":[207,255],"endoscopic":[208],"ultrasound":[209],"(EUS)":[210],"biopsy.":[212],"At":[213],"diagnosis,":[214],"56":[215],"(88%)":[216],"unresectable(without":[221],"metastasis)":[222],"unresectable;":[225],"49":[226],"these":[228],"had":[229,271,318],"neoadjuvant":[230],"treatment,":[231],"13":[233],"later":[235],"resected.":[236],"Median":[237],"OS":[238,254,279],"all":[240],"45.4":[244],"(95%":[246],"CI:":[247],"29.6-61.3),":[248],"no":[250],"significant":[251,319],"differences":[252],"sex":[256],"patient":[258],"(p":[259,265,297],"=":[260,266,298],"0.210)":[261],"smoking":[263],"history":[264],"0.625).":[267],"Twenty-two":[268],"(34%)":[270],">75%":[272],"decreases":[273,325],"CA19-9":[275,295,327],"from":[276,328],"baseline;":[277],"89.4":[281],"group":[285],"compared":[286],"41.3":[288],"changes":[293],"<75%":[296],"0.025).":[299],"Conclusions:":[300],"This":[301],"trial":[302],"demonstrates":[303],"improved":[304],",":[316],"who":[317],"decrease":[320],"CA":[322],"-19-9":[323],"(>75%":[324],"baseline)":[329],"response":[331],"chemotherapy":[335]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2022-05-12T00:00:00"}