{"id":"https://openalex.org/W4232995499","doi":"https://doi.org/10.3109/9780849375965-1","title":"Introduction","display_name":"Introduction","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W4232995499","doi":"https://doi.org/10.3109/9780849375965-1"},"language":"en","primary_location":{"id":"doi:10.3109/9780849375965-1","doi":"https://doi.org/10.3109/9780849375965-1","is_oa":false,"landing_page_url":"https://doi.org/10.3109/9780849375965-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4251941377","display_name":"Drug Metabolism"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039008828","display_name":"Jack Uetrecht","orcid":"https://orcid.org/0000-0003-1024-1302","observed_orcids":["https://orcid.org/0000-0003-1024-1302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jack P. Uetrecht","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111461042","display_name":"William F. Trager","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Trager","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.40540541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.9399999976158142},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.7379999756813049},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6909999847412109},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.5600000023841858},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8579999804496765},{"id":"https://openalex.org/keywords/glucuronidation","display_name":"glucuronidation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/amino-acid-conjugation","display_name":"amino acid conjugation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bilirubin","display_name":"bilirubin","score":0.7369999885559082},{"id":"https://openalex.org/keywords/neonatal-jaundice","display_name":"neonatal jaundice","score":0.8199999928474426},{"id":"https://openalex.org/keywords/drug-elimination","display_name":"drug elimination","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3732549548149109}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3109/9780849375965-1","doi":"https://doi.org/10.3109/9780849375965-1","is_oa":false,"landing_page_url":"https://doi.org/10.3109/9780849375965-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2082335023"],"related_works":["https://openalex.org/W4237829702","https://openalex.org/W2107613102","https://openalex.org/W2614806950","https://openalex.org/W50873332","https://openalex.org/W2524109414","https://openalex.org/W2148929632","https://openalex.org/W2015670477","https://openalex.org/W1565963242","https://openalex.org/W2469110247","https://openalex.org/W2520066685"],"abstract_inverted_index":{"Metabolism":[0],"is":[1,31,112,117],"often":[2],"required":[3],"in":[4,134],"order":[5],"for":[6,121],"the":[7,32,36,51,101,105,118,122,126,132,135],"body":[8],"to":[9,43,56,73,95,140],"eliminate":[10],"a":[11,44,63,74],"drug.":[12,37,75],"Most":[13],"drugs":[14,20,96],"are":[15,86,98],"given":[16],"orally":[17],"and":[18,23,82,109,131],"some":[19],"have":[21,62,69],"variable":[22],"incomplete":[24],"absorption.":[25],"The":[26,38],"major":[27],"determinant":[28],"of":[29,35,40,58,107,124,129,137],"absorption":[30],"physical":[33],"properties":[34],"response":[39],"different":[41],"patients":[42,59,67],"drug":[45,52],"varies":[46],"widely":[47],"and,":[48],"depending":[49],"on":[50],"category,":[53],"from":[54],"20%":[55],"75%":[57],"do":[60],"not":[61],"therapeutic":[64],"response.":[65],"Many":[66],"will":[68],"an":[70],"adverse":[71],"reaction":[72],"Some":[76],"metabolic":[77],"pathways,":[78],"such":[79],"as":[80],"glucuronidation":[81,108,116],"amino":[83],"acid":[84],"conjugation,":[85],"deficient":[87],"at":[88],"birth":[89],"thereby":[90],"making":[91],"newborns":[92],"more":[93],"sensitive":[94],"that":[97],"cleared":[99],"by":[100],"enzymes":[102],"involved.":[103],"In":[104],"case":[106],"newborns,":[110],"this":[111],"particularly":[113],"important":[114],"because":[115],"primary":[119],"mechanism":[120],"elimination":[123],"bilirubin,":[125],"breakdown":[127],"product":[128],"hemoglobin,":[130],"increase":[133],"levels":[136],"bilirubin":[138],"leads":[139],"jaundice.":[141]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2022-05-12T00:00:00"}
