{"id":"https://openalex.org/W4232936722","doi":"https://doi.org/10.2139/ssrn.3771098","title":"Abnormal Flow Conditions Promote Endocardial Fibroelastosis Via Endothelial-to-Mesenchymal Transition, Which is Responsive to Losartan Treatment","display_name":"Abnormal Flow Conditions Promote Endocardial Fibroelastosis Via Endothelial-to-Mesenchymal Transition, Which is Responsive to Losartan Treatment","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W4232936722","doi":"https://doi.org/10.2139/ssrn.3771098"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.3771098","doi":"https://doi.org/10.2139/ssrn.3771098","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.3771098","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.3771098","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112766264","display_name":"Nicholas A Oh","orcid":"https://orcid.org/0000-0001-7967-7089","observed_orcids":["https://orcid.org/0000-0001-7967-7089"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicholas Oh","raw_affiliation_strings":["Cleveland Clinic Foundation - Department of Cardiovascular Surgery, 9500 Euclid Ave., J4-133, Cleveland, OH 44195, United States","Cleveland Clinic Foundation - Department of Cardiovascular Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation - Department of Cardiovascular Surgery, 9500 Euclid Ave., J4-133, Cleveland, OH 44195, United States","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Cleveland Clinic Foundation - Department of Cardiovascular Surgery","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053549326","display_name":"Xuechong Hong","orcid":"https://orcid.org/0000-0002-0804-672X","observed_orcids":["https://orcid.org/0000-0002-0804-672X"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuechong Hong","raw_affiliation_strings":["Department of Cardiac Surgery, Boston Children\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, Boston Children\u2019s Hospital","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003046613","display_name":"Ilias P. Doulamis","orcid":"https://orcid.org/0000-0002-4128-7111","observed_orcids":["https://orcid.org/0000-0002-4128-7111"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilias P. Doulamis","raw_affiliation_strings":["Department of Cardiac Surgery, Boston Children\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, Boston Children\u2019s Hospital","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009077380","display_name":"Elamaran Meibalah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elamaran Meibalah","raw_affiliation_strings":["Center for Excellence in Vascular Biology, Brigham and Women\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Excellence in Vascular Biology, Brigham and Women\u2019s Hospital","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032879075","display_name":"Teresa Peiseler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teresa Peiseler","raw_affiliation_strings":["Department of Cardiac Surgery, Boston Children\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, Boston Children\u2019s Hospital","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073019524","display_name":"Juan M. Melero\u2010Martin","orcid":"https://orcid.org/0000-0002-4689-8149","observed_orcids":["https://orcid.org/0000-0002-4689-8149"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan M. Melero-Martin","raw_affiliation_strings":["Department of Cardiac Surgery, Boston Children\u2019s Hospital"],"raw_orcid":"https://orcid.org/0000-0002-4689-8149","affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, Boston Children\u2019s Hospital","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015474261","display_name":"Guillermo Garc\u00eda\u2010Carde\u00f1a","orcid":"https://orcid.org/0000-0003-2663-3706","observed_orcids":["https://orcid.org/0000-0003-2663-3706"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guillermo Garcia-Cardena","raw_affiliation_strings":["Center for Excellence in Vascular Biology, Brigham and Women\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Excellence in Vascular Biology, Brigham and Women\u2019s Hospital","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001927963","display_name":"Pedro J. del Nido","orcid":"https://orcid.org/0000-0003-4252-8789","observed_orcids":["https://orcid.org/0000-0003-4252-8789"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedro J. del Nido","raw_affiliation_strings":["Department of Cardiac Surgery, Boston Children\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, Boston Children\u2019s Hospital","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022775023","display_name":"Ingeborg Friehs","orcid":"https://orcid.org/0000-0002-2631-2972","observed_orcids":["https://orcid.org/0000-0002-2631-2972"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ingeborg Friehs","raw_affiliation_strings":["Department of Cardiac Surgery, Boston Children\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, Boston Children\u2019s Hospital","institution_ids":["https://openalex.org/I1288882113"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112766264"],"corresponding_institution_ids":["https://openalex.org/I1316902750"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.5806000232696533,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.5806000232696533,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.298799991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.038600001484155655,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocardial-fibroelastosis","display_name":"endocardial fibroelastosis","score":1.0},{"id":"https://openalex.org/keywords/endothelial-mesenchymal-transition","display_name":"endothelial-to-mesenchymal transition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/regurgitant-flow","display_name":"regurgitant flow","score":0.890999972820282},{"id":"https://openalex.org/keywords/laminar-shear-stress","display_name":"laminar shear stress","score":0.7630000114440918},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.925000011920929},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8889999985694885},{"id":"https://openalex.org/keywords/notch1-signaling","display_name":"Notch1 signaling","score":0.8880000114440918},{"id":"https://openalex.org/keywords/endocardial-endothelial-cells","display_name":"endocardial endothelial cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.6399999856948853},{"id":"https://openalex.org/keywords/neonatal-heart-development","display_name":"neonatal heart development","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.770266056060791},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5688735842704773},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5522112250328064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5435407757759094},{"id":"https://openalex.org/C2781278803","wikidata":"https://www.wikidata.org/wiki/Q5376225","display_name":"Endocardial fibroelastosis","level":2,"score":0.4801730215549469},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42083480954170227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37919068336486816},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.1441076695919037},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12382230162620544},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10737055540084839}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.3771098","doi":"https://doi.org/10.2139/ssrn.3771098","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.3771098","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.3771098","doi":"https://doi.org/10.2139/ssrn.3771098","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.3771098","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3103177437","https://openalex.org/W4328026537","https://openalex.org/W2976542671","https://openalex.org/W2131977410","https://openalex.org/W4391990057","https://openalex.org/W2922054427","https://openalex.org/W4384942643","https://openalex.org/W2043807237","https://openalex.org/W2080761855","https://openalex.org/W3216300722"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2022-05-12T00:00:00"}
