{"id":"https://openalex.org/W4232904485","doi":"https://doi.org/10.1002/1521-3773(20000818)39:16<2795::aid-anie2795>3.0.co;2-8","title":"Cover Picture","display_name":"Cover Picture","publication_year":2000,"publication_date":"2000-08-18","ids":{"openalex":"https://openalex.org/W4232904485","doi":"https://doi.org/10.1002/1521-3773(20000818)39:16<2795::aid-anie2795>3.0.co;2-8"},"language":"en","primary_location":{"id":"doi:10.1002/1521-3773(20000818)39:16<2795::aid-anie2795>3.0.co;2-8","doi":"https://doi.org/10.1002/1521-3773(20000818)39:16<2795::aid-anie2795>3.0.co;2-8","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1521-3773(20000818)39:16<2795::aid-anie2795>3.0.co;2-8","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111651335","display_name":"K. Ulrich Wendt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K.\u2005Ulrich Wendt","raw_affiliation_strings":["Institut fu\u0308r Organische Chemie und Biochemie Albertstrasse 21, 79104 Freiburg (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Organische Chemie und Biochemie Albertstrasse 21, 79104 Freiburg (Germany)","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104130781","display_name":"Georg E. Schulz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Georg\u2005E. Schulz","raw_affiliation_strings":["Institut fu\u0308r Organische Chemie und Biochemie Albertstrasse 21, 79104 Freiburg (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Organische Chemie und Biochemie Albertstrasse 21, 79104 Freiburg (Germany)","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062182194","display_name":"Elias James Corey","orcid":"https://orcid.org/0000-0002-1196-7896","observed_orcids":["https://orcid.org/0000-0002-1196-7896"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elias\u2005J. Corey","raw_affiliation_strings":["Department of Chemistry and Chemical Biology Harvard University 12 Oxford Street, Cambridge, MA 02138 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology Harvard University 12 Oxford Street, Cambridge, MA 02138 (USA)","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065535610","display_name":"David R. Liu","orcid":"https://orcid.org/0000-0002-9943-7557","observed_orcids":["https://orcid.org/0000-0002-9943-7557","https://orcid.org/0000-0003-0346-5033","https://orcid.org/0000-0002-6078-6506"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David\u2005R. Liu","raw_affiliation_strings":["Department of Chemistry and Chemical Biology Harvard University 12 Oxford Street, Cambridge, MA 02138 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology Harvard University 12 Oxford Street, Cambridge, MA 02138 (USA)","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29115008,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"16","first_page":"2795","last_page":"2795"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/squalene-hopene-cyclase","display_name":"squalene-hopene cyclase","score":0.9490000009536743},{"id":"https://openalex.org/keywords/squalene-cyclase","display_name":"squalene cyclase","score":0.9079999923706055},{"id":"https://openalex.org/keywords/2-3-oxidosqualene-cyclase","display_name":"2,3-oxidosqualene cyclase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/triterpene-biosynthesis","display_name":"triterpene biosynthesis","score":0.828000009059906},{"id":"https://openalex.org/keywords/x-ray-crystal-structure","display_name":"X-ray crystal structure","score":0.6790000200271606},{"id":"https://openalex.org/keywords/chiral-centers","display_name":"stereogenic centers","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C2776703722","wikidata":"https://www.wikidata.org/wiki/Q407560","display_name":"Squalene","level":2,"score":0.9301779270172119},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.7031729817390442},{"id":"https://openalex.org/C2780428219","wikidata":"https://www.wikidata.org/wiki/Q16952335","display_name":"Cover (algebra)","level":2,"score":0.6218230724334717},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.594770073890686},{"id":"https://openalex.org/C44937612","wikidata":"https://www.wikidata.org/wiki/Q212364","display_name":"Terpene","level":2,"score":0.5237277150154114},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.468228280544281},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4547242224216461},{"id":"https://openalex.org/C134195300","wikidata":"https://www.wikidata.org/wiki/Q902071","display_name":"Stereocenter","level":4,"score":0.4156702160835266},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3226975202560425},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2854022979736328},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1540946066379547},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12889781594276428},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.11532655358314514},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/1521-3773(20000818)39:16<2795::aid-anie2795>3.0.co;2-8","doi":"https://doi.org/10.1002/1521-3773(20000818)39:16<2795::aid-anie2795>3.0.co;2-8","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1521-3773(20000818)39:16<2795::aid-anie2795>3.0.co;2-8","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4233193469","https://openalex.org/W1970440469","https://openalex.org/W2070456262","https://openalex.org/W2021944478","https://openalex.org/W2050293242","https://openalex.org/W60308525","https://openalex.org/W2165218676","https://openalex.org/W2057199171","https://openalex.org/W2951903526","https://openalex.org/W2891042982"],"abstract_inverted_index":{"The":[0,39],"cover":[1],"picture":[2],"shows":[3],"the":[4,14,21,45,48,53],"X-ray":[5],"structure":[6,46],"of":[7,23,56],"a":[8],"squalene\u2013hopene":[9],"cyclase":[10],"(ribbon":[11],"diagram)":[12],"in":[13,31],"center.":[15],"Squalene":[16],"and":[17,28,37,60],"2,3-oxidosqualene":[18],"cyclases":[19],"catalyze":[20],"formation":[22],"up":[24],"to":[25],"five":[26],"rings":[27],"nine":[29],"stereocenters":[30],"transformations":[32],"that":[33],"are":[34,42,70],"both":[35],"complex":[36],"elegant.":[38],"triterpenes":[40],"which":[41],"arranged":[43],"around":[44],"outline":[47],"principal":[49],"reaction":[50],"pathways":[51],"for":[52],"enzymatic":[54],"conversion":[55],"oxidosqualene":[57],"(upper":[58],"semicircle)":[59],"squalene":[61],"(lower":[62],"semicircle).":[63],"Further":[64],"details":[65],"about":[66],"these":[67],"fascinating":[68],"reactions":[69],"discussed":[71],"by":[72],"Schulz,":[73],"Liu":[74],"et":[75],"al.":[76],"on":[77],"p.":[78],"2812":[79],"ff.":[80]},"counts_by_year":[],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2022-05-12T00:00:00"}
