{"id":"https://openalex.org/W4232795384","doi":"https://doi.org/10.1001/archderm.129.4.448","title":"Immune-mediated subepithelial blistering diseases of mucous membranes. Pure ocular cicatricial pemphigoid is a unique clinical and immunopathological entity distinct from bullous pemphigoid and other subsets identified by antigenic specificity of autoantibodies","display_name":"Immune-mediated subepithelial blistering diseases of mucous membranes. Pure ocular cicatricial pemphigoid is a unique clinical and immunopathological entity distinct from bullous pemphigoid and other subsets identified by antigenic specificity of autoantibodies","publication_year":1993,"publication_date":"1993-04-01","ids":{"openalex":"https://openalex.org/W4232795384","doi":"https://doi.org/10.1001/archderm.129.4.448"},"language":"en","primary_location":{"id":"doi:10.1001/archderm.129.4.448","doi":"https://doi.org/10.1001/archderm.129.4.448","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archderm.129.4.448","pdf_url":null,"source":{"id":"https://openalex.org/S115046667","display_name":"Archives of Dermatology","issn_l":"0003-987X","issn":["0003-987X","1538-3652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030763743","display_name":"Lawrence S. Chan","orcid":"https://orcid.org/0009-0007-0640-980X","observed_orcids":["https://orcid.org/0009-0007-0640-980X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L. S. Chan","raw_affiliation_strings":["Department of Dermatology, University of Michigan School of Medicine, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Michigan School of Medicine, Ann Arbor","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030763743"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.45971707,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"129","issue":"4","first_page":"448","last_page":"455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11730","display_name":"Autoimmune Bullous Skin Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11730","display_name":"Autoimmune Bullous Skin Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ocular-cicatricial-pemphigoid","display_name":"ocular cicatricial pemphigoid","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bullous-pemphigoid","display_name":"bullous pemphigoid","score":0.9660000205039978},{"id":"https://openalex.org/keywords/mucous-membrane-pemphigoid","display_name":"mucous membrane pemphigoid","score":0.8989999890327454},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.8529999852180481},{"id":"https://openalex.org/keywords/basement-membrane-antigens","display_name":"basement membrane antigens","score":0.8690000176429749},{"id":"https://openalex.org/keywords/anti-bp180-antibodies","display_name":"anti-BP180 antibodies","score":0.7369999885559082},{"id":"https://openalex.org/keywords/disease-classification","display_name":"disease classification","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8002700805664062},{"id":"https://openalex.org/C2779252107","wikidata":"https://www.wikidata.org/wiki/Q1004647","display_name":"Bullous pemphigoid","level":3,"score":0.7877480387687683},{"id":"https://openalex.org/C2778075117","wikidata":"https://www.wikidata.org/wiki/Q881811","display_name":"Pemphigoid","level":4,"score":0.7196584343910217},{"id":"https://openalex.org/C2776536667","wikidata":"https://www.wikidata.org/wiki/Q627291","display_name":"Cicatricial pemphigoid","level":5,"score":0.7055914998054504},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6760063171386719},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.6569697260856628},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.6240867972373962},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.5205034613609314},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5094442963600159},{"id":"https://openalex.org/C98246554","wikidata":"https://www.wikidata.org/wiki/Q5280334","display_name":"Direct fluorescent antibody","level":3,"score":0.4943711757659912},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.48404043912887573},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.38825398683547974},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3834834694862366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1001/archderm.129.4.448","doi":"https://doi.org/10.1001/archderm.129.4.448","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archderm.129.4.448","pdf_url":null,"source":{"id":"https://openalex.org/S115046667","display_name":"Archives of Dermatology","issn_l":"0003-987X","issn":["0003-987X","1538-3652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Dermatology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3598794514","display_name":null,"funder_award_id":"T32 AR07197-11","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4622154332","display_name":null,"funder_award_id":"AR37446","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2044603809","https://openalex.org/W2336588544","https://openalex.org/W2060268864","https://openalex.org/W1991802541","https://openalex.org/W1992884814","https://openalex.org/W2130430247","https://openalex.org/W2100125091","https://openalex.org/W40646205","https://openalex.org/W1994997529","https://openalex.org/W2081733768"],"abstract_inverted_index":{"\u2022":[0],"Background":[1],"and":[2,59,70,115,123,127,153,164,198,211],"Design.\u2014":[3],"There":[4],"is":[5],"much":[6],"confusion":[7],"in":[8,121,128,148,180],"the":[9,67,75,93,103,214,249,264],"clinical":[10,68,83,197,267],"classification":[11],"of":[12,17,74,82,92,109,139,151,157,161,216,251,266],"immune-mediated":[13],"subepithelial":[14],"blistering":[15],"diseases":[16],"mucous":[18,203,239],"membranes.":[19],"We":[20],"conducted":[21],"a":[22,38,107,137,195],"6-year":[23],"comprehensive":[24],"study":[25],"to":[26,41,131,168,213,253],"better":[27],"classify":[28],"this":[29],"heterogeneous":[30],"disease":[31],"group.":[32],"Indirect":[33],"immunofluorescence":[34,72,125],"was":[35,54],"performed":[36],"on":[37,248,263],"salt-split-skin":[39,217],"substrate":[40,218],"detect":[42],"circulating":[43,162],"antibasement":[44],"membrane":[45,204,240,256],"antibodies":[46,212],"(n=47).":[47],"Serologic":[48],"reactivity":[49,130,167],"against":[50],"cultured":[51],"keratinocyte":[52],"antigens":[53],"examined":[55],"by":[56],"immunoblots":[57],"(n=38)":[58],"immunoprecipitation":[60],"(n=15).":[61],"The":[62,237],"results":[63,89],"were":[64],"correlated":[65],"with":[66,90,102,111,141,183,202],"features":[69,268],"direct":[71,122],"data":[73],"entire":[76],"patient":[77],"group":[78,97],"(n=87)":[79],"without":[80,175],"preassignment":[81],"diagnoses.":[84],"\u03c72Statistical":[85],"analyses":[86],"compared":[87,101],"these":[88],"those":[91,182],"classic":[94],"bullous":[95,104,132,169],"pemphigoid":[96,105,133,170,273],"(n=36).":[98],"Results.\u2014":[99],"When":[100],"patients,":[106],"subset":[108,138],"patients":[110,140,174,241],"combined":[112],"oral":[113,233,271],"mucosal":[114,225,272,276],"skin":[116,176,209],"lesions":[117,144,210],"demonstrated":[118],"marked":[119],"similarity":[120],"indirect":[124,185],"findings":[126],"serologic":[129,166],"antigens.":[134,171],"By":[135],"contrast,":[136],"only":[142],"ocular":[143,192,235],"exhibited":[145],"significantly":[146],"lower":[147],"vivo":[149],"deposits":[150,156],"IgG":[152],"C3,":[154],"higher":[155],"fibrin,":[158],"virtual":[159],"absence":[160],"antibodies,":[163],"negative":[165,184],"Conclusions.\u2014":[172],"Ocular":[173],"or":[177,258,274],"mouth":[178],"lesions,":[179],"particular":[181],"immunofluorescence,":[186],"should":[187,219],"be":[188,220,246],"distinctively":[189],"classified":[190,221,247],"as":[191,222],"cicatricial":[193],"pemphigoid,":[194,226],"unique":[196],"immunopathologic":[199],"entity.":[200],"Patients":[201],"involvement":[205],"who":[206],"also":[207],"demonstrate":[208],"roof":[215],"anti-BP":[223],"Ag":[224],"even":[227],"though":[228],"they":[229],"may":[230],"exhibit":[231],"severe":[232],"and/or":[234],"diseases.":[236],"remaining":[238],"are":[242],"heterogeneous.":[243],"Some":[244],"can":[245],"basis":[250,265],"autoantibodies":[252],"other":[254],"basement":[255],"determinants,":[257],"if":[259],"serum":[260],"autoantibody":[261],"negative,":[262],"(ie,":[269],"pure":[270],"overlapping":[275],"involvement).":[277],"(Arch":[278],"Dermatol.1993;129:448-455)":[279]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2022-05-12T00:00:00"}