{"id":"https://openalex.org/W4232664470","doi":"https://doi.org/10.1158/1538-7445.am2019-368a","title":"Abstract 368A: Functional assessment of DNA damage repair defects and the anti-tumor immune response in high grade serous ovarian cancers using patient-derived organoids","display_name":"Abstract 368A: Functional assessment of DNA damage repair defects and the anti-tumor immune response in high grade serous ovarian cancers using patient-derived organoids","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4232664470","doi":"https://doi.org/10.1158/1538-7445.am2019-368a"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2019-368a","doi":"https://doi.org/10.1158/1538-7445.am2019-368a","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-368a","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052565225","display_name":"Sarah J. Hill","orcid":"https://orcid.org/0000-0002-9199-9459","observed_orcids":["https://orcid.org/0000-0002-9199-9459"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah J. Hill","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072719557","display_name":"Patrick Hall Lizotte","orcid":"https://orcid.org/0000-0001-9510-0036","observed_orcids":["https://orcid.org/0000-0001-9510-0036"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Lizotte","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089158382","display_name":"Neil Stuart Horowitz","orcid":"https://orcid.org/0000-0002-4854-0642","observed_orcids":["https://orcid.org/0000-0002-4854-0642"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil S. Horowitz","raw_affiliation_strings":["2Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014639724","display_name":"Michael George Muto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. Muto","raw_affiliation_strings":["2Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008611385","display_name":"Michael J. Worley","orcid":"https://orcid.org/0000-0002-5076-838X","observed_orcids":["https://orcid.org/0000-0002-5076-838X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Worley","raw_affiliation_strings":["2Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025921511","display_name":"Colleen M. Feltmate","orcid":"https://orcid.org/0000-0002-7700-8575","observed_orcids":["https://orcid.org/0000-0002-7700-8575"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen M. Feltmate","raw_affiliation_strings":["2Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088192892","display_name":"Bose S. Kochupurakkal","orcid":"https://orcid.org/0000-0001-8929-3070","observed_orcids":["https://orcid.org/0000-0001-8929-3070"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bose Kochupurakkal","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027987889","display_name":"Khanh T. Do","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khanh T. Do","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076246054","display_name":"Panagiotis A. Konstantinopoulos","orcid":"https://orcid.org/0000-0002-1032-1479","observed_orcids":["https://orcid.org/0000-0002-1032-1479"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Panagiotis Konstantinopoulos","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103618488","display_name":"Marisa R. Nucci","orcid":"https://orcid.org/0009-0008-7371-5695","observed_orcids":["https://orcid.org/0009-0008-7371-5695"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marisa R. Nucci","raw_affiliation_strings":["2Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060953135","display_name":"Joyce F. Liu","orcid":"https://orcid.org/0000-0003-3888-3972","observed_orcids":["https://orcid.org/0000-0003-3888-3972"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce F. Liu","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058249824","display_name":"Ursula A. Matulonis","orcid":"https://orcid.org/0000-0002-3103-6992","observed_orcids":["https://orcid.org/0000-0002-3103-6992"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ursula A. Matulonis","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045419282","display_name":"Geoffrey Ira Shapiro","orcid":"https://orcid.org/0000-0002-3331-4095","observed_orcids":["https://orcid.org/0000-0002-3331-4095"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey I. Shapiro","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086662756","display_name":"Ross Stuart Berkowitz","orcid":"https://orcid.org/0000-0002-7569-898X","observed_orcids":["https://orcid.org/0000-0002-7569-898X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ross S. Berkowitz","raw_affiliation_strings":["2Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055130061","display_name":"Christopher P. Crum","orcid":"https://orcid.org/0000-0001-7746-1436","observed_orcids":["https://orcid.org/0000-0001-7746-1436"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher P. Crum","raw_affiliation_strings":["2Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044648110","display_name":"Alan D. D\u2019Andrea","orcid":"https://orcid.org/0000-0001-6168-6294","observed_orcids":["https://orcid.org/0000-0001-6168-6294","https://orcid.org/0000-0002-3672-8760"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan D. D'Andrea","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"13_Supplement","first_page":"368A","last_page":"368A"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.17190000414848328,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-grade-serous-ovarian-carcinoma","display_name":"high-grade serous ovarian cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/dna-repair-deficiency","display_name":"DNA repair deficiency","score":0.9269999861717224},{"id":"https://openalex.org/keywords/patient-derived-organoids","display_name":"patient-derived organoids","score":0.9470000267028809},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.9700000286102295},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.8669999837875366},{"id":"https://openalex.org/keywords/atr-inhibitors","display_name":"ATR inhibitors","score":0.6840000152587891},{"id":"https://openalex.org/keywords/chk1-inhibitor","display_name":"CHK1 inhibitor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.8040000200271606},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.6320000290870667},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.6129999756813049},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.3179999887943268},{"id":"https://openalex.org/keywords/cytokine-expression","display_name":"cytokine expression","score":0.5400000214576721},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.4099999964237213},{"id":"https://openalex.org/keywords/functional-assays","display_name":"functional assays","score":0.41200000047683716},{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6334171295166016},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6210333108901978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5904204249382019},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5382063388824463},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5344222187995911},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5338662266731262},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4402673840522766},{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.41973134875297546},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3058159649372101},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.19280844926834106},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12586230039596558},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1032242476940155}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2019-368a","doi":"https://doi.org/10.1158/1538-7445.am2019-368a","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-368a","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2992258588","https://openalex.org/W2891058330","https://openalex.org/W2989813630","https://openalex.org/W2604905280","https://openalex.org/W2887798690","https://openalex.org/W4393088125","https://openalex.org/W4362543292","https://openalex.org/W2991136705","https://openalex.org/W3040414646","https://openalex.org/W4245386350"],"abstract_inverted_index":{"Abstract":[0],"Patients":[1],"with":[2,197,209,216,300,313],"high":[3,484],"grade":[4,485],"serous":[5,486],"ovarian":[6,487],"cancer":[7],"(HGSC)":[8],"have":[9,22,34,44,72,163,220,259,415],"limited":[10,24],"additional":[11],"therapeutic":[12,87,133,138,396],"options":[13],"beyond":[14],"traditional":[15,143],"carboplatin":[16],"and":[17,26,57,86,108,116,135,142,146,161,166,184,243,309,350,358,388,391,478],"paclitaxel.":[18],"Immuno-oncologic":[19],"(IO)":[20],"agents":[21,145,148,211,383],"had":[23],"effect,":[25],"despite":[27],"the":[28,78,98,119,123,126,159,181,204,250,276,282,329,338,348,479,496],"fact":[29],"that":[30,191,222,237,244,261,410],"50%":[31],"of":[32,47,50,89,118,158,180,234,275,281,290,321,331,347,352,363,379,400,404,473,495],"HGSCs":[33],"genomic":[35,165],"alterations":[36,172],"in":[37,97,122,152,214,262,356,386,419,483],"DNA":[38,79,101,254,474],"damage":[39,80,102,255,475],"repair":[40,55,81,103,256,277,339,353,476],"genes,":[41],"we":[42,71,219,406],"still":[43],"no":[45],"means":[46],"predicting":[48,421],"which":[49,66,323],"these":[51,61,295,411],"tumors":[52,160,183,357],"actually":[53,384],"harbor":[54],"defects":[56,96,267,354,477],"will":[58,341,372],"respond":[59],"to":[60,76,140,173,203,232,293,307,319,365,408],"agents.":[62,367],"Using":[63],"patient-derived":[64,490],"organoids":[65,162,189,192,299,491],"contain":[67,193],"patient":[68,422],"immune":[69,84,120,195,369,387,481],"cells,":[70],"developed":[73],"functional":[74,257,370,412],"assays":[75,92,258,340,371,413],"test":[77],"capacity,":[82],"anti-tumor":[83,241,480],"response,":[85,242],"vulnerability":[88],"HGSCs.":[90],"These":[91],"include":[93],"testing":[94,113,136],"for":[95,114,137,170,343,374,393,499],"two":[99],"key":[100],"pathways,":[104],"homologous":[105],"recombination":[106],"(HR)":[107],"stalled":[109,264],"replication":[110,302,325],"fork":[111,265],"protection,":[112],"activity":[115],"specificity":[117],"cells":[121,128,390],"cultures":[124],"against":[125],"tumor":[127,389],"when":[129],"exacerbated":[130],"by":[131],"specific":[132,223,382],"combinations,":[134],"sensitivity":[139,364],"targeted":[141,366],"chemotherapy":[144],"IO":[147,198,210,224],"either":[149],"alone":[150,212],"or":[151,213],"rational":[153,395],"combinations.":[154],"In":[155],"parallel,":[156],"many":[157],"undergone":[164],"RNA":[167],"sequencing,":[168],"searching":[169],"relevant":[171],"explain":[174],"detected":[175],"defects.":[176,296],"Flow":[177],"cytometry":[178],"analysis":[179],"parent":[182,205],"short":[185],"term":[186],"(7-10":[187],"day)":[188],"reveal":[190],"an":[194,240],"milieu":[196],"receptor":[199,225],"expression":[200,226,236],"levels":[201],"similar":[202],"tumors.":[206,283],"Upon":[207],"treatment":[208],"combination":[215,330],"chemotherapeutic":[217],"agents,":[218],"found":[221],"is":[227,286],"altered,":[228],"certain":[229],"combinations":[230,246,320],"lead":[231],"induction":[233],"cytokine":[235],"may":[238],"repress":[239],"some":[245],"do":[247],"not":[248],"induce":[249,385],"expected":[251],"cytotoxicity.":[252],"The":[253,368],"revealed":[260],"HGSC,":[263],"protection":[266],"are":[268,304,316],"more":[269,305,317,360],"common":[270],"than":[271],"HR":[272],"defects,":[273],"regardless":[274],"gene":[278],"mutational":[279],"status":[280],"Importantly,":[284],"there":[285],"a":[287,332,344,359,375,401,416],"wider":[288],"array":[289],"therapies":[291],"available":[292],"target":[294],"For":[297],"instance,":[298],"unstable":[301],"forks":[303,315],"sensitive":[306,318],"ATR":[308],"CHK1":[310,333],"inhibitors.":[311],"Organoids":[312],"stable":[314],"drugs":[322],"confer":[324],"stress,":[326],"such":[327],"as":[328],"inhibitor":[334],"plus":[335],"gemcitabine.":[336],"Overall,":[337],"allow":[342,373,392],"better":[345,376,394],"understanding":[346,378],"types":[349],"mechanisms":[351],"present":[355],"accurate":[361],"prediction":[362],"mechanistic":[377],"what":[380],"response":[381,482],"pairings.":[397],"Through":[398],"assessment":[399,472],"larger":[402],"number":[403],"patients,":[405],"hope":[407],"demonstrate":[409],"can":[414],"clinical":[417],"impact":[418],"rapidly":[420],"response.":[423],"Citation":[424],"Format:":[425],"Sarah":[426],"J.":[427,438],"Hill,":[428],"Patrick":[429],"Lizotte,":[430],"Neil":[431],"S.":[432,463],"Horowitz,":[433],"Michael":[434,437],"G.":[435],"Muto,":[436],"Worley,":[439],"Colleen":[440],"M.":[441],"Feltmate,":[442],"Bose":[443],"Kochupurakkal,":[444],"Khanh":[445],"T.":[446],"Do,":[447],"Panagiotis":[448],"Konstantinopoulos,":[449],"Marisa":[450],"R.":[451],"Nucci,":[452],"Joyce":[453],"F.":[454],"Liu,":[455],"Ursula":[456],"A.":[457],"Matulonis,":[458],"Geoffrey":[459],"I.":[460],"Shapiro,":[461],"Ross":[462],"Berkowitz,":[464],"Christopher":[465],"P.":[466],"Crum,":[467],"Alan":[468],"D.":[469],"D'Andrea.":[470],"Functional":[471],"cancers":[488],"using":[489],"[abstract].":[492],"In:":[493],"Proceedings":[494],"American":[497],"Association":[498],"Cancer":[500,514],"Research":[501],"Annual":[502],"Meeting":[503],"2019;":[504],"2019":[505],"Mar":[506],"29-Apr":[507],"3;":[508],"Atlanta,":[509],"GA.":[510],"Philadelphia":[511],"(PA):":[512],"AACR;":[513],"Res":[515],"2019;79(13":[516],"Suppl):Abstract":[517],"nr":[518],"368A.":[519]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-05-12T00:00:00"}
