{"id":"https://openalex.org/W4232610776","doi":"https://doi.org/10.1201/9781482298215-10","title":"THE DEATH RECEPTORS","display_name":"THE DEATH RECEPTORS","publication_year":1999,"publication_date":"1999-05-24","ids":{"openalex":"https://openalex.org/W4232610776","doi":"https://doi.org/10.1201/9781482298215-10"},"language":"en","primary_location":{"id":"doi:10.1201/9781482298215-10","doi":"https://doi.org/10.1201/9781482298215-10","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781482298215-10","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signalling Pathways in Apoptosis","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W563569470","display_name":"Signalling Pathways in Apoptosis"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5099902787","display_name":"Klaus Schuhe-Osthoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Klaus Schuhe-Osthoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056606410","display_name":"Marcus E. Peter","orcid":"https://orcid.org/0000-0003-3216-036X","observed_orcids":["https://orcid.org/0000-0003-3216-036X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcus E. Peter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34362718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"46","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/death-receptors","display_name":"death receptors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.9459999799728394},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ligand-receptor-signaling","display_name":"ligand-receptor signaling","score":0.7250000238418579},{"id":"https://openalex.org/keywords/prosurvival-signaling","display_name":"survival signaling","score":0.4429999887943268},{"id":"https://openalex.org/keywords/tumor-necrosis-factor-receptor","display_name":"TNF receptor","score":0.7639999985694885},{"id":"https://openalex.org/keywords/t-cell-receptor","display_name":"T cell receptor","score":0.5879999995231628},{"id":"https://openalex.org/keywords/b-cell-receptor","display_name":"B cell receptor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cd4","display_name":"CD4","score":0.753000020980835},{"id":"https://openalex.org/keywords/cd2","display_name":"CD2","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cytokine-receptors","display_name":"cytokine receptors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/costimulation","display_name":"costimulation","score":0.609000027179718},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4639434814453125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3304503262042999},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08876654505729675}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1201/9781482298215-10","doi":"https://doi.org/10.1201/9781482298215-10","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781482298215-10","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signalling Pathways in Apoptosis","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W1831418501"],"related_works":["https://openalex.org/W2087669979","https://openalex.org/W196790738","https://openalex.org/W2097319041","https://openalex.org/W7099262140","https://openalex.org/W7095270909","https://openalex.org/W2031133522","https://openalex.org/W167134486","https://openalex.org/W2018667424","https://openalex.org/W1971411560","https://openalex.org/W2038114873"],"abstract_inverted_index":{"Higher":[0],"organisms":[1],"have":[2,101],"developed":[3],"elaborate":[4],"mechanisms":[5],"to":[6,32,50,56,89,109,159],"rapidly":[7],"and":[8,59,114,120,168],"selectively":[9],"eliminate":[10],"unwanted":[11],"cells":[12],"by":[13,154],"programmed":[14],"cell":[15,30,51,63,110,116,142,160],"death.":[16,52,111],"Exposure":[17],"or":[18,36,129,146,162],"depletion":[19],"of":[20,29,39,44,61,67,105,134,148,173,185,198],"certain":[21],"steroid":[22],"hormones,":[23],"incubation":[24],"with":[25,70],"noxious":[26],"agents,":[27],"loss":[28],"adhesion":[31],"the":[33,45,65,94,151],"extracellular":[34],"matrix,":[35],"dysregulated":[37],"expression":[38],"oncogenes":[40],"are":[41,87,132],"only":[42],"some":[43],"conditions":[46],"that":[47,136],"can":[48,179,191],"lead":[49,158],"A":[53],"fine-tuned":[54],"mechanism":[55],"regulate":[57],"life":[58],"death":[60,163,193],"a":[62,78,102,155],"is":[64,164],"interaction":[66],"surface":[68],"receptors":[69,86,178],"their":[71],"cognate":[72],"ligands,":[73,131],"which":[74],"may":[75],"either":[76],"trigger":[77],"survival":[79],"or,":[80],"oppositely,":[81],"an":[82],"apoptogenic":[83],"signal.":[84],"Several":[85],"able":[88],"transmit":[90],"cytotoxic":[91],"signals":[92,139,152,182,194],"into":[93],"cytoplasm,":[95],"but":[96],"in":[97,141],"most":[98],"cases":[99],"they":[100],"wide":[103],"range":[104],"other":[106],"functions":[107],"unrelated":[108],"The":[112],"T":[113],"B":[115],"receptors,":[117,122],"CD2,":[118],"CD4":[119],"cytokine":[121],"such":[123],"as":[124,188,190],"those":[125],"for":[126,183,196],"interferons,":[127],"TGF-\u03b2":[128],"TNFrelated":[130],"examples":[133],"molecules":[135],"induce":[137,192],"diverse":[138],"resulting":[140],"activation,":[143],"differentiation,":[144],"proliferation,":[145],"induction":[147],"apoptosis.":[149],"Whether":[150],"induced":[153],"given":[156],"receptor":[157],"activation":[161],"highly":[165],"celltype":[166],"specific":[167],"tightly":[169],"regulated":[170],"during":[171],"differentiation":[172],"cells.":[174],"For":[175],"example,":[176],"TNF":[177],"exert":[180],"costimulatory":[181],"proliferation":[184],"naive":[186],"lymphocytes":[187],"well":[189],"required":[195],"deletion":[197],"activated":[199],"lymphocytes.":[200]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2022-05-12T00:00:00"}
