{"id":"https://openalex.org/W4232598086","doi":"https://doi.org/10.1158/1538-7445.am2019-1953","title":"Abstract 1953: HER2 functionalized nanoparticles are safe and specific for in vivo HER2+ breast tumor cell detection","display_name":"Abstract 1953: HER2 functionalized nanoparticles are safe and specific for in vivo HER2+ breast tumor cell detection","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4232598086","doi":"https://doi.org/10.1158/1538-7445.am2019-1953"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2019-1953","doi":"https://doi.org/10.1158/1538-7445.am2019-1953","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-1953","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003105195","display_name":"Marie Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie Zhang","raw_affiliation_strings":["1Imagion Biosystems, Inc., San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Imagion Biosystems, Inc., San Diego, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jose Vargas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jose Vargas","raw_affiliation_strings":["1Imagion Biosystems, Inc., San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Imagion Biosystems, Inc., San Diego, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038735919","display_name":"Antimone Dewing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antimone Dewing","raw_affiliation_strings":["1Imagion Biosystems, Inc., San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Imagion Biosystems, Inc., San Diego, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023084146","display_name":"Farideh Z. Bischoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farideh Bischoff","raw_affiliation_strings":["1Imagion Biosystems, Inc., San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Imagion Biosystems, Inc., San Diego, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010567388","display_name":"Kelsey B. Mathieu","orcid":"https://orcid.org/0000-0001-9180-1150","observed_orcids":["https://orcid.org/0000-0001-9180-1150"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelsey Mathieu","raw_affiliation_strings":["2MD Anderson, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2MD Anderson, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063856758","display_name":"John D. Hazle","orcid":"https://orcid.org/0000-0003-4695-5825","observed_orcids":["https://orcid.org/0000-0003-4695-5825"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Hazle","raw_affiliation_strings":["2MD Anderson, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2MD Anderson, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"13_Supplement","first_page":"1953","last_page":"1953"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superparamagnetic-iron-oxide-nanoparticles","display_name":"superparamagnetic iron oxide nanoparticles","score":0.9169999957084656},{"id":"https://openalex.org/keywords/pegylation","display_name":"PEGylation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/tumor-cell-detection","display_name":"cancer cell detection","score":0.671999990940094},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5699999928474426},{"id":"https://openalex.org/keywords/xenograft-tumor-model","display_name":"xenograft tumor model","score":0.6899999976158142},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.7570000290870667},{"id":"https://openalex.org/keywords/nanoparticle-biodistribution","display_name":"nanoparticle biodistribution","score":0.6940000057220459},{"id":"https://openalex.org/keywords/squid-magnetometry","display_name":"SQUID magnetometry","score":0.7139999866485596},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.48500001430511475},{"id":"https://openalex.org/keywords/bt474-cells","display_name":"BT474 cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/her2-expression","display_name":"HER2 expression","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7035733461380005},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.570146918296814},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5392796397209167},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5180090069770813},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5018775463104248},{"id":"https://openalex.org/C112613896","wikidata":"https://www.wikidata.org/wiki/Q898370","display_name":"Conjugated system","level":3,"score":0.46491295099258423},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4561353325843811},{"id":"https://openalex.org/C23792430","wikidata":"https://www.wikidata.org/wiki/Q1122780","display_name":"Superparamagnetism","level":4,"score":0.44671887159347534},{"id":"https://openalex.org/C2778889443","wikidata":"https://www.wikidata.org/wiki/Q6073014","display_name":"Iron oxide nanoparticles","level":3,"score":0.42027193307876587},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.348522812128067},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3383033871650696},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.27386200428009033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13408005237579346},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1118689775466919},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.09524503350257874},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C32546565","wikidata":"https://www.wikidata.org/wiki/Q856711","display_name":"Magnetization","level":3,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C115260700","wikidata":"https://www.wikidata.org/wiki/Q11408","display_name":"Magnetic field","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2019-1953","doi":"https://doi.org/10.1158/1538-7445.am2019-1953","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-1953","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2740444734","https://openalex.org/W2594047082","https://openalex.org/W4379984750","https://openalex.org/W2921448208","https://openalex.org/W2739876190","https://openalex.org/W2191371251","https://openalex.org/W2085688911","https://openalex.org/W7098580353","https://openalex.org/W2887643195","https://openalex.org/W7095393458"],"abstract_inverted_index":{"Abstract":[0],"Superparamagnetic":[1],"Relaxometry":[2],"(SPMR)":[3],"is":[4,129,354],"a":[5,107,113,264],"highly":[6],"sensitive":[7],"in":[8,48,58,98,181,183,239,279,307,344,390,439],"vivo":[9,240,391,440],"detection":[10,287,399,445],"technology":[11],"that":[12,28,80,159,223,375],"can":[13,164,191,251,381],"localize":[14],"and":[15,30,64,66,88,94,118,168,217,271,292,317,384,392,436],"quantify":[16],"superparamagnetic":[17],"iron":[18],"oxide":[19],"(Fe3O4)":[20],"nanoparticles":[21,52,84,104,163,225,250,270,299,343,378,433],"when":[22,309],"bound":[23],"to":[24,32,147,152,357,368,387],"tumor":[25,92,244,443],"cells.":[26],"Nanoparticles":[27],"reach":[29],"bind":[31],"the":[33,59,122,148,224,249,298,359,362,450],"target":[34],"cells":[35],"are":[36,61,95,282,379,434],"measureable":[37],"by":[38,112,136,195,303],"superconducting":[39],"quantum":[40],"interference":[41],"device":[42],"(SQUID)":[43],"magnetometers":[44],"(MRX":[45],"instrument":[46],"developed":[47],"house),":[49],"while":[50],"unbound":[51],"such":[53,174,206,289],"as":[54,134,175,207,263,290],"those":[55],"freely":[56],"circulating":[57],"bloodstream":[60],"not":[62,70,227,275,327],"detected":[63],"bone":[65],"normal":[67],"tissue":[68,389],"do":[69,226,274,326],"produce":[71,209,228],"any":[72],"magnetic":[73],"signal.":[74],"In":[75,201,261],"this":[76],"study":[77,351,412],"we":[78,266],"demonstrate":[79,358],"anti-HER2":[81,363],"antibody":[82,102,119,143,161,364],"conjugated":[83,103,120,162,365],"exhibit":[85],"great":[86],"specificity":[87,216],"selectivity":[89],"towards":[90],"HER2+":[91,170,441],"cells,":[93],"safe":[96,435],"(non-toxic)":[97],"preclinical":[99],"models.":[100],"Anti-HER2":[101],"consist":[105],"of":[106,127,297,342,361,449],"25nm":[108],"Fe3O4":[109],"core":[110],"covered":[111],"polymer":[114],"shell":[115],"with":[116,131,150,197,220,236],"PEG":[117,268],"on":[121,396],"surface.":[123],"The":[124,294],"overall":[125],"size":[126],"particles":[128],"70-80nm":[130],"PDI":[132],"<0.1":[133],"measured":[135],"DLS.":[137],"Each":[138],"particle":[139],"has":[140,300],"between":[141,254],"3-5":[142],"molecules":[144],"covalently":[145],"attached":[146],"surface":[149],"PEGylation":[151],"reduce":[153],"opsonization.":[154],"Our":[155],"results":[156,373],"have":[157,247],"shown":[158,248],"our":[160,376,397,408],"distinguish":[165,253],"high,":[166],"medium":[167],"low":[169],"expression":[171],"cell":[172,185,204,444],"lines,":[173,205],"BT474":[176,257],"(3+),":[177],"ZR75":[178],"(2+),":[179],"MCF7(0/1+)":[180],"an":[182,229],"vitro":[184],"based":[186],"assay.":[187],"Furthermore,":[188],"positive":[189],"signal":[190,278,331,395],"be":[192],"competed":[193],"out":[194,404],"pre-incubation":[196],"free":[198],"HER2":[199,377,431],"antibody.":[200],"additional,":[202],"negative":[203],"MCF10":[208],"undetectable":[210],"SPMR":[211,230],"signal,":[212,231],"demonstrating":[213],"good":[214],"sensitivity,":[215],"selectivity.":[218],"Incubation":[219],"PBMC":[221],"indicates":[222],"suggesting":[232],"minimum":[233],"non-specific":[234],"interaction":[235],"lymphocytes.":[237],"Extensive":[238],"studies":[241,402],"using":[242,284,352],"xenograph":[243],"mouse":[245],"models":[246],"selectively":[252],"MCF7":[255],"vs":[256],"dual":[258],"implanted":[259],"tumors.":[260],"addition,":[262],"control,":[265],"used":[267],"only":[269],"showed":[272],"they":[273],"generate":[276,328,393],"measurable":[277,329,394],"tumor.":[280],"Results":[281],"corroborated":[283],"other":[285],"orthogonal":[286],"methods,":[288],"IHC":[291],"ICP-MS.":[293],"safety":[295,360],"profile":[296],"been":[301],"demonstrated":[302],"analyzing":[304],"nanoparticle":[305,366],"accumulation":[306,341],"organs":[308,323],"injected":[310],"at":[311,332],"20mg/kg":[312],"dose":[313],"via":[314],"intravenous,":[315],"intraperitoneal":[316],"subcutaneous":[318],"delivery":[319,386],"routes.":[320],"All":[321],"major":[322,345],"except":[324],"liver":[325],"MRX":[330,398],"multiple":[333],"time":[334],"points":[335],"post":[336],"injection,":[337],"indicating":[338],"no":[339],"significant":[340],"organs.":[346],"A":[347],"full":[348],"GLP":[349],"toxicity":[350],"rats":[353],"being":[355],"conducted":[356],"prior":[367],"first-in-human":[369],"use.":[370],"Together,":[371],"these":[372],"suggest":[374],"safe;":[380],"provide":[382],"targeted":[383],"specific":[385,437],"cancerous":[388],"instrument.":[400],"These":[401],"lay":[403],"ground":[405],"work":[406],"for":[407,413,438,453],"future":[409],"human":[410],"clinical":[411],"breast":[414,442],"cancer":[415],"detection.":[416],"Citation":[417],"Format:":[418],"Marie":[419],"Zhang,":[420],"Jose":[421],"Vargas,":[422],"Antimone":[423],"Dewing,":[424],"Farideh":[425],"Bischoff,":[426],"Kelsey":[427],"Mathieu,":[428],"John":[429],"Hazle.":[430],"functionalized":[432],"[abstract].":[446],"In:":[447],"Proceedings":[448],"American":[451],"Association":[452],"Cancer":[454,468],"Research":[455],"Annual":[456],"Meeting":[457],"2019;":[458],"2019":[459],"Mar":[460],"29-Apr":[461],"3;":[462],"Atlanta,":[463],"GA.":[464],"Philadelphia":[465],"(PA):":[466],"AACR;":[467],"Res":[469],"2019;79(13":[470],"Suppl):Abstract":[471],"nr":[472],"1953.":[473]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2022-05-12T00:00:00"}