{"id":"https://openalex.org/W4232554530","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.9086","title":"Phase I/II study of resiquimod as an immunologic adjuvant for NY-ESO-1 protein vaccination in patients with melanoma.","display_name":"Phase I/II study of resiquimod as an immunologic adjuvant for NY-ESO-1 protein vaccination in patients with melanoma.","publication_year":2014,"publication_date":"2014-05-20","ids":{"openalex":"https://openalex.org/W4232554530","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.9086"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2014.32.15_suppl.9086","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.9086","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.15_suppl.9086","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022765571","display_name":"Rachel Lubong Sabado","orcid":"https://orcid.org/0009-0002-4008-263X","observed_orcids":["https://orcid.org/0009-0002-4008-263X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Lubong Sabado","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056507476","display_name":"Anna C. Pavlick","orcid":"https://orcid.org/0000-0001-7088-0742","observed_orcids":["https://orcid.org/0000-0001-7088-0742"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna C. Pavlick","raw_affiliation_strings":["Department of Medicine, NYU Langone Medical Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, NYU Langone Medical Center, New York, NY","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078046623","display_name":"Sacha Gnjatic","orcid":"https://orcid.org/0000-0001-5643-9520","observed_orcids":["https://orcid.org/0000-0001-5643-9520"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sacha Gnjatic","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002885229","display_name":"Crystal M. Cruz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal M Cruz","raw_affiliation_strings":["New York University School of Medicine Cancer Institite, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University School of Medicine Cancer Institite, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012822100","display_name":"Isabelita Vengco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isabelita Vengco","raw_affiliation_strings":["New York University School of Medicine Cancer Institite, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University School of Medicine Cancer Institite, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076979802","display_name":"Farah Hasan","orcid":"https://orcid.org/0000-0001-6941-7822","observed_orcids":["https://orcid.org/0000-0001-6941-7822"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farah Hasan","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073591942","display_name":"Farbod Darvishian","orcid":"https://orcid.org/0000-0002-9883-1982","observed_orcids":["https://orcid.org/0000-0002-9883-1982"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farbod Darvishian","raw_affiliation_strings":["Department of Pathology, New York University School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University School of Medicine, New York, NY","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050859964","display_name":"Luis A. Chiriboga","orcid":"https://orcid.org/0000-0002-2028-6873","observed_orcids":["https://orcid.org/0000-0002-2028-6873"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis Chiriboga","raw_affiliation_strings":["NYU Langone Medical Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Langone Medical Center, New York, NY","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076789267","display_name":"Rose Marie Holman","orcid":"https://orcid.org/0000-0001-5687-0724","observed_orcids":["https://orcid.org/0000-0001-5687-0724"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rose Marie Holman","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112130549","display_name":"Juliet Escalon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juliet Escalon","raw_affiliation_strings":["New York University Cancer Institute, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Cancer Institute, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056286265","display_name":"Caroline Muren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Muren","raw_affiliation_strings":["New York University Cancer Institute, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Cancer Institute, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018696817","display_name":"Crystal Escano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal Escano","raw_affiliation_strings":["New York University Cancer Institute, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Cancer Institute, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000768057","display_name":"Ethel Yepes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethel Yepes","raw_affiliation_strings":["New York University Cancer Institute, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Cancer Institute, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038991295","display_name":"Dunbar Sharpe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dunbar Sharpe","raw_affiliation_strings":["New York University Cancer Institute, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Cancer Institute, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035762260","display_name":"Sylvia Adams","orcid":"https://orcid.org/0000-0003-4737-1952","observed_orcids":["https://orcid.org/0000-0003-4737-1952"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sylvia Adams","raw_affiliation_strings":["New York University Langone Medical Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Langone Medical Center, New York, NY","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041066193","display_name":"Patrick Alexander Ott","orcid":"https://orcid.org/0000-0002-4253-943X","observed_orcids":["https://orcid.org/0000-0002-4253-943X"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Alexander Ott","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009105564","display_name":"Achim A. Jungbluth","orcid":"https://orcid.org/0000-0002-8949-2333","observed_orcids":["https://orcid.org/0000-0002-8949-2333"]},"institutions":[{"id":"https://openalex.org/I4210150094","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05qdwtz81","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Achim A Jungbluth","raw_affiliation_strings":["Ludwig Institute for Cancer Research, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, New York, NY","institution_ids":["https://openalex.org/I4210150094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112263249","display_name":"Linda S. Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150094","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05qdwtz81","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda S. Pan","raw_affiliation_strings":["Ludwig Institute for Cancer Research, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, New York, NY","institution_ids":["https://openalex.org/I4210150094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007088159","display_name":"Ralph Rudolph Venhaus","orcid":"https://orcid.org/0000-0003-1106-8943","observed_orcids":["https://orcid.org/0000-0003-1106-8943"]},"institutions":[{"id":"https://openalex.org/I4210150094","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05qdwtz81","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph Rudolph Venhaus","raw_affiliation_strings":["Ludwig Institute for Cancer Research, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, New York, NY","institution_ids":["https://openalex.org/I4210150094"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055358847","display_name":"Nina Bhardwaj","orcid":"https://orcid.org/0000-0003-1865-4187","observed_orcids":["https://orcid.org/0000-0003-1865-4187"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nina Bhardwaj","raw_affiliation_strings":["Tisch Cancer Institute, Icahn School of Medicine, Mount Sinai Medical Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tisch Cancer Institute, Icahn School of Medicine, Mount Sinai Medical Center, New York, NY","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"15_suppl","first_page":"9086","last_page":"9086"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ny-eso-1","display_name":"NY-ESO-1","score":0.8809999823570251},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cancer-vaccine-adjuvant","display_name":"cancer vaccine adjuvant","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tlr7-8-agonist","display_name":"TLR7/8 agonist","score":0.9610000252723694},{"id":"https://openalex.org/keywords/montanide-isa-51","display_name":"Montanide ISA 51","score":0.8410000205039978},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cd4-t-cell-responses","display_name":"CD4+ T cell responses","score":0.9480000138282776},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.722000002861023},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.5040000081062317},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.4690000116825104},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.47600001096725464},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.5799999833106995},{"id":"https://openalex.org/keywords/syncopal-episodes","display_name":"syncopal episodes","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8137838840484619},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.6684500575065613},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6357084512710571},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5990355610847473},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.5976220965385437},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5446135997772217},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5260022878646851},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4951418936252594},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.43036195635795593},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4268212914466858},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4134743809700012}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2014.32.15_suppl.9086","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.9086","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.15_suppl.9086","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6600000262260437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1552738310","https://openalex.org/W2470318958","https://openalex.org/W2428121789","https://openalex.org/W2018608294","https://openalex.org/W2393152609","https://openalex.org/W1992410431","https://openalex.org/W2464521541","https://openalex.org/W2978251200","https://openalex.org/W1999684327","https://openalex.org/W2432770450"],"abstract_inverted_index":{"9086":[0],"Background:":[1],"The":[2,119,203,316],"TLR":[3],"7/8":[4],"agonist,":[5],"Resiquimod":[6,55,77,100,163,321],"has":[7],"been":[8],"shown":[9],"to":[10,140,246,264,326],"induce":[11],"local":[12],"activation":[13],"of":[14,18,40,95,97,127,133,154,161,186,195,329],"immune":[15,200,330],"cells,":[16,24],"production":[17],"cytokines,":[19],"and":[20,38,105,114,188,198,250,324],"antigen-presentation":[21],"by":[22,92,151],"dendritic":[23],"features":[25],"desirable":[26],"for":[27,107,116,192],"cancer":[28],"vaccine":[29,204],"adjuvants.":[30],"In":[31],"this":[32],"study,":[33,135],"we":[34],"evaluated":[35],"the":[36,98,134,168,193,247,265,327],"safety":[37],"immunogenicity":[39],"vaccination":[41],"with":[42,52,76,82,208],"NY-ESO-1":[43,84,143,268,288,304],"protein":[44,85,144],"emulsified":[45,86,145],"in":[46,56,87,146,172,274,285,296,298,312,332],"Montanide":[47,89,148],"ISA-51":[48],"VG":[49],"when":[50],"given":[51],"or":[53,110,159,214,228],"without":[54],"surgically":[57],"resected":[58],"stage":[59],"IIB-IV":[60],"melanoma":[61],"patients.":[62,333],"Methods:":[63],"This":[64],"is":[65,322],"a":[66,238,254],"two-part":[67],"study":[68,218,248,266,276,300,318],"design.":[69],"Part":[70,173],"I":[71],"represents":[72],"an":[73],"open-label":[74],"dose-escalation":[75],"using":[78,167],"2":[79,229],"cohorts":[80],"treated":[81],"100ug":[83,142],"1.25mL":[88,147],"(day1)":[90,149],"followed":[91,150],"topical":[93,152],"application":[94,153],"1000mg":[96,160],"0.2%":[99,162],"gel":[101,156,164],"on":[102],"days":[103,111],"1":[104,227],"3":[106,124,240,256],"cohort-1":[108],"(N=3)":[109],"1,":[112],"3,":[113],"5":[115],"cohort-2":[117],"(N=3).":[118],"cycles":[120],"were":[121,137,177,272,283,294,309],"repeated":[122],"every":[123],"weeks,":[125],"total":[126],"4":[128,211],"cycles.":[129],"For":[130],"part":[131],"II":[132],"patients":[136,297],"blindly":[138],"randomized":[139],"receive":[141],"placebo":[155],"(Arm-A;":[157],"N=8)":[158],"(Arm-B;":[165],"N=12)":[166],"dosing":[169],"regimen":[170],"established":[171],"I.":[174],"Blood":[175],"samples":[176],"collected":[178],"at":[179,189],"baseline,":[180],"one":[181],"week":[182],"after":[183],"each":[184],"cycle":[185],"vaccination,":[187],"follow-up":[190],"visit":[191],"assessment":[194],"NY-ESO-1-specific":[196],"humoral":[197],"cellular":[199],"responses.":[201],"Results:":[202],"was":[205,244,261],"generally":[206],"well-tolerated,":[207],"no":[209],"grade":[210,239,255],"adverse":[212,222],"events":[213],"study-related":[215],"deaths.":[216],"Most":[217],"participants":[219],"experienced":[220,237],"mild":[221],"reactions":[223],"reported":[224],"as":[225],"Grade":[226],"per":[230],"CTCAE":[231],"criteria":[232],"v.":[233],"4.":[234],"One":[235],"patient":[236,252],"syncopal":[241],"episode":[242],"that":[243,260,320],"unrelated":[245],"drugs":[249],"another":[251],"had":[253],"injection":[257],"site":[258],"necrosis":[259],"possibly":[262],"related":[263],"drugs.":[267],"specific":[269,289],"antibody":[270,281],"responses":[271,293,308,331],"induced":[273,295],"both":[275,299],"arms":[277],"although":[278],"higher":[279],"mean":[280],"titers":[282],"observed":[284],"Arm":[286,313],"B.":[287,314],"CD4+":[290],"T":[291,306],"cell":[292,307],"arms.":[301],"However,":[302],"significant":[303],"CD8+":[305],"detected":[310],"only":[311],"Conclusions:":[315],"current":[317],"shows":[319],"safe":[323],"contributes":[325],"induction":[328],"Clinical":[334],"trial":[335],"information:":[336],"NCT00821652.":[337]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2025-10-10T00:00:00"}