{"id":"https://openalex.org/W4232508490","doi":"https://doi.org/10.1093/ibd/izaa347.040","title":"SHAPE MEMORY POLYMER HYDROGEL FOAMS FOR FISTULA CLOSURE","display_name":"SHAPE MEMORY POLYMER HYDROGEL FOAMS FOR FISTULA CLOSURE","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W4232508490","doi":"https://doi.org/10.1093/ibd/izaa347.040"},"language":"en","primary_location":{"id":"doi:10.1093/ibd/izaa347.040","doi":"https://doi.org/10.1093/ibd/izaa347.040","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ibd/izaa347.040","pdf_url":null,"source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018219022","display_name":"Mary Beth Browning Monroe","orcid":"https://orcid.org/0000-0003-4540-5303","observed_orcids":["https://orcid.org/0000-0003-4540-5303"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary Monroe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005441431","display_name":"Henry T. Beaman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry Beaman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024557348","display_name":"Anand Utpal Vakil","orcid":"https://orcid.org/0000-0002-6303-8562","observed_orcids":["https://orcid.org/0000-0002-6303-8562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anand Vakil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Changling Du","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Changling Du","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3317,"currency":"USD","value_usd":3317},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"Supplement_1","first_page":"S16","last_page":"S16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11737","display_name":"Advanced Materials and Mechanics","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shape-memory-polymers","display_name":"shape memory polymers","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6260174512863159},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.5125889182090759},{"id":"https://openalex.org/C2776341189","wikidata":"https://www.wikidata.org/wiki/Q189470","display_name":"Fistula","level":2,"score":0.4763258099555969},{"id":"https://openalex.org/C2777516009","wikidata":"https://www.wikidata.org/wiki/Q194207","display_name":"Ethylene glycol","level":2,"score":0.4124661386013031},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.3730200529098511},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3362833857536316},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3177664875984192},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2392101287841797},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.20332232117652893},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.18671292066574097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12469509243965149},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ibd/izaa347.040","doi":"https://doi.org/10.1093/ibd/izaa347.040","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ibd/izaa347.040","pdf_url":null,"source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4214625467","https://openalex.org/W2779509510","https://openalex.org/W3092172478","https://openalex.org/W3005913033","https://openalex.org/W2943057283","https://openalex.org/W3030052505","https://openalex.org/W3189880928","https://openalex.org/W2891887718","https://openalex.org/W2102957404","https://openalex.org/W2034634310"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"Crohn\u2019s":[2,36],"disease":[3],"can":[4,89,327,351],"lead":[5],"to":[6,44,68,112,121,127,131,133,190,236,335,357],"fistula":[7,39,50,79,114,157,359],"formation":[8,40],"between":[9],"portions":[10],"of":[11,35,54,183,203,232,246,315,318],"the":[12,49,117,134,181,244,316],"urinary,":[13],"reproductive,":[14],"and":[15,30,52,81,92,148,166,172,186,211,264,266,302,321],"digestive":[16],"systems.":[17],"The":[18],"abnormal":[19],"connections":[20],"caused":[21],"by":[22,227,260],"these":[23,55],"tunneling":[24],"sores":[25],"cause":[26],"severe":[27],"pain,":[28],"infections,":[29],"abscess":[31],"formation.":[32],"Currently,":[33],"83%":[34],"patients":[37,56],"with":[38,146,164,177,286,354],"undergo":[41],"surgical":[42],"intervention":[43],"either":[45],"drain":[46],"or":[47],"bypass":[48],"openings,":[51],"~23%":[53],"ultimately":[57],"require":[58],"bowel":[59],"resections.":[60],"To":[61],"address":[62],"this":[63],"clinical":[64],"need,":[65],"we":[66,139],"propose":[67],"synthesize":[69],"a":[70,95,113,141,156,192,337,345],"shape":[71,104,130,212,255],"memory":[72,256],"polymer":[73],"(SMP)":[74],"hydrogel":[75,144,251,342],"foam":[76,145,187],"system":[77,326],"for":[78,152],"closure":[80,158],"healing.":[82],"SMP":[83,143,237,250,294,341],"foams":[84,118,198,295,343],"are":[85,119,258,277],"porous":[86],"materials":[87],"that":[88,98,350],"be":[90,328,352],"heated":[91,120],"compressed":[93],"into":[94],"low-profile":[96],"geometry":[97],"is":[99,284],"retained":[100],"after":[101],"cooling.":[102],"This":[103,325],"enables":[105],"minimally":[106],"invasive":[107],"delivery":[108],"(i.e.":[109],"via":[110],"catheter)":[111],"site.":[115],"Once":[116],"body":[122],"temperature,":[123],"they":[124],"expand":[125],"back":[126],"their":[128],"original":[129],"conform":[132],"implantation":[135],"site":[136],"geometry.":[137],"Here,":[138],"present":[140,344],"degradable":[142],"antimicrobial":[147,297],"antioxidant":[149,303],"phenolic":[150,173],"acids":[151,174],"potential":[153],"use":[154],"as":[155],"scaffold.":[159],"Methods":[160],"Foams":[161],"were":[162,199,216,241],"synthesized":[163,319],"3-arm":[165],"linear":[167],"poly(ethylene":[168],"glycol)":[169],"(PEG),":[170],"amylopectin/pullulan,":[171],"in":[175,180,201,218,243,273,305,332],"combination":[176],"hexamethylene":[178],"diisocyanate":[179],"presence":[182,245],"surfactants,":[184],"catalysts,":[185],"blowing":[188],"agents":[189],"form":[191],"hydrophilic,":[193],"chemically":[194],"crosslinked":[195],"foam.":[196],"Resulting":[197],"characterized":[200,217],"terms":[202],"swelling":[204,252],"ratios,":[205],"pore":[206],"sizes,":[207],"glass":[208],"transition":[209],"temperatures,":[210],"recovery.":[213],"Degradation":[214],"profiles":[215],"glucoamylase.":[219],"Antimicrobial":[220],"efficacy":[221,298],"against":[222,299],"E.":[223,300],"coli":[224,301],"was":[225],"measured":[226],"quantifying":[228],"colony":[229],"forming":[230],"units":[231],"bacteria":[233],"following":[234],"exposure":[235],"hydrogels.":[238],"Antioxidant":[239],"properties":[240,257,304],"assessed":[242],"hydrogen":[247,306],"peroxide.":[248,307],"Results":[249],"ratio,":[253],"stiffness,":[254],"tuned":[259],"altering":[261],"monomer":[262],"ratios":[263],"lengths":[265],"foaming":[267],"conditions.":[268],"In":[269],"preliminary":[270],"degradation":[271,275,283,323],"studies":[272,310,334],"glucoamylase,":[274],"rates":[276],"dependent":[278],"upon":[279,331],"starch":[280],"content;":[281],"increased":[282],"observe":[285],"increase":[287],"pullalan":[288],"content,":[289],"Figure":[290],"1.":[291],"Phenolic":[292],"acid-containing":[293],"exhibit":[296],"Conclusions":[308],"Current":[309],"include":[311,336],"full":[312],"material":[313,349],"characterization":[314],"library":[317],"hydrogels":[320],"longer-term":[322],"analysis.":[324],"further":[329],"built":[330],"future":[333],"drug-delivery":[338],"component.":[339],"Overall,":[340],"highly":[346],"tunable":[347],"platform":[348],"modified":[353],"required":[355],"functionalities":[356],"promote":[358],"closure.":[360]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2022-05-12T00:00:00"}