{"id":"https://openalex.org/W4232300087","doi":"https://doi.org/10.1097/00007890-199806270-00737","title":"VIRAL IL-10 GENE TRANSDUCTION MARKEDLY INHIBITS THE ALLOSTIMULATORY ACTIVITY OF DENDRITIC CELLS","display_name":"VIRAL IL-10 GENE TRANSDUCTION MARKEDLY INHIBITS THE ALLOSTIMULATORY ACTIVITY OF DENDRITIC CELLS","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W4232300087","doi":"https://doi.org/10.1097/00007890-199806270-00737"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199806270-00737","doi":"https://doi.org/10.1097/00007890-199806270-00737","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199806270-00737","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Takuya Takayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Takuya Takayama","raw_affiliation_strings":["Thomas E. Starzl Transplantation Institute and Department of Surgery and\u2020Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA15217, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute and Department of Surgery and\u2020Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA15217, U.S.A","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025137523","display_name":"Yasuhiko Nishioka","orcid":"https://orcid.org/0000-0001-6311-1654","observed_orcids":["https://orcid.org/0000-0001-6311-1654"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yasuhiko Nishioka","raw_affiliation_strings":["Thomas E. Starzl Transplantation Institute and Department of Surgery and\u2020Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA15217, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute and Department of Surgery and\u2020Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA15217, U.S.A","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100563871","display_name":"Lina Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lina Lu","raw_affiliation_strings":["Thomas E. Starzl Transplantation Institute and Department of Surgery and\u2020Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA15217, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute and Department of Surgery and\u2020Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA15217, U.S.A","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082293320","display_name":"Walter J. Storkus","orcid":"https://orcid.org/0000-0001-8961-4444","observed_orcids":["https://orcid.org/0000-0001-8961-4444"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Walter J. Storkus","raw_affiliation_strings":["Thomas E. Starzl Transplantation Institute and Department of Surgery and\u2020Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA15217, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute and Department of Surgery and\u2020Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA15217, U.S.A","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024528047","display_name":"Michael T. Lotze","orcid":"https://orcid.org/0000-0003-3988-5419","observed_orcids":["https://orcid.org/0000-0003-3988-5419"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael T. Lotze","raw_affiliation_strings":["Thomas E. Starzl Transplantation Institute and Department of Surgery and\u2020Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA15217, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute and Department of Surgery and\u2020Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA15217, U.S.A","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019908789","display_name":"Hideaki Tahara","orcid":"https://orcid.org/0000-0002-1735-5372","observed_orcids":["https://orcid.org/0000-0002-1735-5372"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hideaki Tahara","raw_affiliation_strings":["Thomas E. Starzl Transplantation Institute and Department of Surgery and\u2020Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA15217, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute and Department of Surgery and\u2020Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA15217, U.S.A","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069651723","display_name":"Angus W. Thomson","orcid":"https://orcid.org/0000-0001-6731-8871","observed_orcids":["https://orcid.org/0000-0001-6731-8871"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Angus W. Thomson","raw_affiliation_strings":["Thomas E. Starzl Transplantation Institute and Department of Surgery and\u2020Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA15217, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute and Department of Surgery and\u2020Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA15217, U.S.A","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019908789","https://openalex.org/A5024528047","https://openalex.org/A5025137523","https://openalex.org/A5069651723","https://openalex.org/A5082293320","https://openalex.org/A5100563871"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34183673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":"12","first_page":"S182","last_page":"S182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viral-il-10","display_name":"viral IL-10","score":0.9789999723434448},{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9409999847412109},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/retroviral-gene-transfer","display_name":"retroviral gene transfer","score":0.8059999942779541},{"id":"https://openalex.org/keywords/allogeneic-t-cell-stimulation","display_name":"allogeneic T cell stimulation","score":0.777999997138977},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.6520000100135803},{"id":"https://openalex.org/keywords/mhc-class-ii-expression","display_name":"MHC class II expression","score":0.8619999885559082},{"id":"https://openalex.org/keywords/t-cell-anergy","display_name":"T cell anergy","score":0.5429999828338623},{"id":"https://openalex.org/keywords/transplantation-tolerance","display_name":"transplantation tolerance","score":0.515999972820282},{"id":"https://openalex.org/keywords/bone-marrow-derived-dendritic-cells","display_name":"bone marrow-derived dendritic cells","score":0.7459999918937683},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.593999981880188},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.5799999833106995},{"id":"https://openalex.org/keywords/cd80","display_name":"CD80","score":0.5400000214576721},{"id":"https://openalex.org/keywords/il-10-receptor","display_name":"IL-10 receptor","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C2778297628","wikidata":"https://www.wikidata.org/wiki/Q5009843","display_name":"CD80","level":5,"score":0.5937873125076294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5884295701980591},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.5621459484100342},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.5283963084220886},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.5200807452201843},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5147040486335754},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5004310607910156},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4816414415836334},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46430447697639465},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.45100629329681396},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.4316880702972412},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4290992319583893},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4268991947174072},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.41428664326667786},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2702907919883728},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23252740502357483},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18940365314483643},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.13865244388580322},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.08258149027824402},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00007890-199806270-00737","doi":"https://doi.org/10.1097/00007890-199806270-00737","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199806270-00737","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2145850608","https://openalex.org/W1983174956","https://openalex.org/W1968492586","https://openalex.org/W4243528886","https://openalex.org/W4232678812","https://openalex.org/W2100372484","https://openalex.org/W2011502022","https://openalex.org/W2031817202","https://openalex.org/W2042258096","https://openalex.org/W1970978600"],"abstract_inverted_index":{"718":[0],"Background:":[1],"Antigen":[2],"presenting":[3],"cells":[4,25,256,292,303],"(APC)":[5],"play":[6],"critical":[7],"roles":[8],"in":[9,47,152,263,293,329],"the":[10,29,98,133,145,159,168,195,211,225,230,249,268],"generation":[11,298],"and":[12,33,55,92,130,140,206,209,260,285,332],"regulation":[13],"of":[14,101,105,117,148,177,213,227,232,251,299,315,325],"T":[15,52,93,291,302],"cell-mediated":[16],"immune":[17,327],"responses.":[18],"Moreover,":[19],"there":[20],"is":[21,78],"evidence":[22],"that":[23,40,311],"dendritic":[24],"(DC)":[26],"may":[27,110,319],"determine":[28,194,224],"balance":[30],"between":[31],"tolerance":[32],"immunity.":[34],"It":[35],"has":[36],"been":[37],"demonstrated":[38],"previously":[39],"costimulatory":[41],"molecule-deficient":[42],"donor":[43,316],"DC":[44,64,106,126,142,235,245,276,318],"progenitors":[45],"propagated":[46,143],"vitro":[48],"can":[49],"induce":[50],"alloantigen-specific":[51],"cell":[53,94,173,279,333],"anergy":[54],"prolong":[56],"organ":[57,331],"allograft":[58],"survival.":[59],"Factors":[60],"known":[61],"to":[62,81,107,121,127,131,287],"potentiate":[63,111],"tolerogenicity":[65],"include":[66],"the'immunosuppressive'":[67],"cytokine":[68,90],"IL-10.":[69],"Viral":[70],"IL-10":[71,83],"(vIL-10),":[72],"encoded":[73],"by":[74,158,180,215,242,338],"Epstein":[75],"Barr":[76],"virus":[77],"highly":[79],"homologous":[80],"mammalian":[82],"(mIL-10).":[84],"vIL-10":[85,109,178,228,239,247,312],"impairs":[86],"APC":[87],"function,":[88],"decreases":[89],"production":[91,226],"proliferation,":[95],"but":[96],"lacks":[97],"immunostimulatory":[99],"properties":[100],"mIL-10.":[102],"Genetic":[103],"engineering":[104],"express":[108,128],"their":[112,136],"tolerogenetic":[113],"activity.Aim:":[114],"The":[115,175,297],"aim":[116],"this":[118,261],"study":[119],"was":[120,186,236,304,336],"transdue":[122],"mouse":[123],"bone":[124,146],"marrow(BM)-derived":[125],"vIL-10,":[129],"assess":[132],"impact":[134],"on":[135],"allostimulatory":[137],"activity.":[138],"Methods":[139],"Results:":[141],"from":[144,167],"marrow":[147],"B10":[149],"(H-2b)":[150],"mice":[151],"GM-CSF":[153],"+":[154],"IL-4":[155],"were":[156],"transduced":[157,199,234],"centrifugal":[160],"enhancement":[161],"method":[162],"using":[163],"retroviral":[164,189],"supernatant":[165,231,265],"obtained":[166,219],"BOSC":[169],"23":[170],"ecotropic":[171],"producer":[172],"line.":[174],"cDNA":[176],"(provided":[179],"Dr.":[181],"Moore,":[182],"DNAX,":[183],"SanDiego,":[184],"CA)":[185],"subcloned":[187],"into":[188],"vector":[190],"termed":[191],"MFG.":[192],"To":[193,223],"transduction":[196,221,314],"efficiency,":[197],"we":[198],"DFG-human":[200],"CD80(hCD80)":[201],"-neo":[202],"as":[203],"a":[204],"control":[205],"marker":[207],"gene,":[208],"examined":[210,237],"expression":[212,284],"hCD80":[214],"flow":[216],"cytometry.":[217],"We":[218],"20%":[220],"efficiency.":[222],"protein,":[229],"cultured":[233],"for":[238,323],"protein":[240],"level":[241,250],"ELISA.":[243],"Transduced":[244],"expressed":[246],"at":[248],"28":[252],"ng":[253],"per":[254,257],"106":[255],"48":[258],"hr":[259],"accumulation":[262],"culture":[264],"increased":[266],"over":[267],"time.":[269],"In":[270],"comparison":[271],"with":[272],"hCD80-transduced":[273],"DC,":[274],"vIL-10-transduced":[275],"exhibited":[277],"decreased":[278],"surface":[280],"MHC":[281],"class":[282],"II":[283],"failed":[286],"stimulate":[288],"allogeneic(C3H;":[289],"H-2k)":[290],"mixed":[294],"leukocyte":[295],"reactions.":[296],"allospecific":[300],"cytotoxic":[301],"also":[305],"strongly":[306],"impaired.Conclusion:":[307],"These":[308],"results":[309],"suggest":[310],"gene":[313],"BM-derived":[317],"have":[320],"therapeutic":[321],"potential":[322],"modification":[324],"anti-donor":[326],"response":[328],"allogeneic":[330],"transplantation.This":[334],"research":[335],"supported":[337],"NIH":[339],"Grant":[340],"AI-41011.":[341]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}
