{"id":"https://openalex.org/W4232225994","doi":"https://doi.org/10.1177/117727190600100017","title":"C-reactive Protein in Patients with Metastatic Clear Cell Renal Carcinoma: An Important Biomarker for Tumor-associated Inflammation","display_name":"C-reactive Protein in Patients with Metastatic Clear Cell Renal Carcinoma: An Important Biomarker for Tumor-associated Inflammation","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W4232225994","doi":"https://doi.org/10.1177/117727190600100017","mag":"1550510855","pmid":"https://pubmed.ncbi.nlm.nih.gov/19690640","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2716790"},"language":"en","primary_location":{"id":"doi:10.1177/117727190600100017","doi":"https://doi.org/10.1177/117727190600100017","is_oa":true,"landing_page_url":"https://doi.org/10.1177/117727190600100017","pdf_url":null,"source":{"id":"https://openalex.org/S50152778","display_name":"Biomarker Insights","issn_l":"1177-2719","issn":["1177-2719"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarker Insights","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/117727190600100017","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041945240","display_name":"Albrecht Reichle","orcid":"https://orcid.org/0000-0002-1821-7887","observed_orcids":["https://orcid.org/0000-0002-1821-7887"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Albrecht Reichle","raw_affiliation_strings":["Department of Hematology and Oncology, University Hospital of Regensburg","Department of Urology, University Hospital of Regensburg, Germany","Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035657449","display_name":"Jochen Grassinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jochen Grassinger","raw_affiliation_strings":["Department of Hematology and Oncology, University Hospital of Regensburg","Department of Urology, University Hospital of Regensburg, Germany","Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032506729","display_name":"K. Bross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus Bross","raw_affiliation_strings":["Department of Hematology and Oncology, University Hospital of Regensburg","Department of Urology, University Hospital of Regensburg, Germany","Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111686136","display_name":"Jochen Wilke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jochen Wilke","raw_affiliation_strings":["Department of Hematology and Oncology, University Hospital of Regensburg","Department of Urology, University Hospital of Regensburg, Germany","Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059179292","display_name":"Thomas Suedhoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Suedhoff","raw_affiliation_strings":["Department of Hematology and Oncology, University Hospital of Regensburg","Department of Urology, University Hospital of Regensburg, Germany","Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062089074","display_name":"Bernhard Walter","orcid":"https://orcid.org/0000-0002-3284-4035","observed_orcids":["https://orcid.org/0000-0002-3284-4035"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernhard Walter","raw_affiliation_strings":["Department of Hematology and Oncology, University Hospital of Regensburg","Department of Urology, University Hospital of Regensburg, Germany","Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045651628","display_name":"Wolf Ferdinand Wieland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolf-Ferdinand Wieland","raw_affiliation_strings":["Department of Hematology and Oncology, University Hospital of Regensburg","Department of Urology, University Hospital of Regensburg, Germany","Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086833189","display_name":"Anna Berand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna Berand","raw_affiliation_strings":["Department of Hematology and Oncology, University Hospital of Regensburg","Department of Urology, University Hospital of Regensburg, Germany","Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431","https://openalex.org/I60668342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105833741","display_name":"Reinhard Andreesen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Reinhard Andreesen","raw_affiliation_strings":["Department of Hematology and Oncology, University Hospital of Regensburg","Department of Urology, University Hospital of Regensburg, Germany","Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital of Regensburg.Department of Urology, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431","https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":0.5611,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.71770442,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1","issue":null,"first_page":"117727190600100","last_page":"117727190600100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9909999966621399},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.8980000019073486},{"id":"https://openalex.org/keywords/metastatic-renal-cell-carcinoma","display_name":"metastatic renal cell carcinoma","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tumor-inflammation","display_name":"tumor inflammation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7049999833106995},{"id":"https://openalex.org/keywords/capecitabine","display_name":"capecitabine","score":0.8830000162124634},{"id":"https://openalex.org/keywords/rofecoxib","display_name":"rofecoxib","score":0.996999979019165},{"id":"https://openalex.org/keywords/etoricoxib","display_name":"etoricoxib","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.7440000176429749},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.531000018119812},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8679999709129333},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5730000138282776},{"id":"https://openalex.org/keywords/tumor-response","display_name":"tumor response","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9053506851196289},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5916538834571838},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.5814509391784668},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5300334095954895},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4909096360206604},{"id":"https://openalex.org/C2778582115","wikidata":"https://www.wikidata.org/wiki/Q411412","display_name":"Rofecoxib","level":4,"score":0.48223456740379333},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4722665548324585},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4704434275627136},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.46947821974754333},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.45362088084220886},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.423954039812088},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34043100476264954},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.10414665937423706},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1177/117727190600100017","doi":"https://doi.org/10.1177/117727190600100017","is_oa":true,"landing_page_url":"https://doi.org/10.1177/117727190600100017","pdf_url":null,"source":{"id":"https://openalex.org/S50152778","display_name":"Biomarker Insights","issn_l":"1177-2719","issn":["1177-2719"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarker Insights","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2716790","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2716790","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomark Insights","raw_type":"Text"},{"id":"pmid:19690640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19690640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarker insights","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6eb0686fcd2d4bdab8aa84b9630537ac","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6eb0686fcd2d4bdab8aa84b9630537ac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomarker Insights, Vol 1, Pp 87-98 (2006)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:eb30a8ae947545e48174ab550b4b407c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/eb30a8ae947545e48174ab550b4b407c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomarker Insights, Vol 1 (2006)","raw_type":"article"},{"id":"mag:1550510855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19690640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.1177/117727190600100017","doi":"https://doi.org/10.1177/117727190600100017","is_oa":true,"landing_page_url":"https://doi.org/10.1177/117727190600100017","pdf_url":null,"source":{"id":"https://openalex.org/S50152778","display_name":"Biomarker Insights","issn_l":"1177-2719","issn":["1177-2719"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarker Insights","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1619649505","https://openalex.org/W1774021084","https://openalex.org/W1928193662","https://openalex.org/W1969600215","https://openalex.org/W1972934671","https://openalex.org/W1981866612","https://openalex.org/W1984458529","https://openalex.org/W1986332851","https://openalex.org/W1987426056","https://openalex.org/W2000272522","https://openalex.org/W2005112720","https://openalex.org/W2006751258","https://openalex.org/W2009555565","https://openalex.org/W2011924809","https://openalex.org/W2012346602","https://openalex.org/W2021743788","https://openalex.org/W2033527945","https://openalex.org/W2039871782","https://openalex.org/W2047146496","https://openalex.org/W2047852384","https://openalex.org/W2058035682","https://openalex.org/W2061809006","https://openalex.org/W2063373049","https://openalex.org/W2068555261","https://openalex.org/W2073444913","https://openalex.org/W2076636076","https://openalex.org/W2078221442","https://openalex.org/W2078878717","https://openalex.org/W2091246533","https://openalex.org/W2104540972","https://openalex.org/W2105677187","https://openalex.org/W2106555100","https://openalex.org/W2113743444","https://openalex.org/W2117838810","https://openalex.org/W2121727262","https://openalex.org/W2125622371","https://openalex.org/W2138120427","https://openalex.org/W2142247109","https://openalex.org/W2145379648","https://openalex.org/W2149026055","https://openalex.org/W2150162153","https://openalex.org/W2160921084","https://openalex.org/W2166431178","https://openalex.org/W2230952198","https://openalex.org/W2279160356","https://openalex.org/W2318706214","https://openalex.org/W2418250679","https://openalex.org/W3010916979","https://openalex.org/W4285719527","https://openalex.org/W4298379398"],"related_works":["https://openalex.org/W7097133633","https://openalex.org/W2189382048","https://openalex.org/W2598374129","https://openalex.org/W2025488184","https://openalex.org/W2885876919","https://openalex.org/W2583296432","https://openalex.org/W2009555565","https://openalex.org/W2169718723","https://openalex.org/W2123096356","https://openalex.org/W2626302687"],"abstract_inverted_index":{"Two":[0],"consecutive":[1],"multi-center":[2],"phase":[3],"II":[4,69,108,173],"trials":[5,27],"were":[6,98],"designed":[7],"to":[8,154,156,160],"prove":[9],"the":[10],"hypothesis,":[11],"whether":[12],"therapeutic":[13],"modeling":[14],"of":[15,29,148,171,179,191],"tumor-associated":[16,180],"inflammatory":[17],"processes":[18],"could":[19,140],"result":[20,186],"in":[21,25,106,128,162,187],"improved":[22],"tumor":[23,192],"response.Therapy":[24],"both":[26],"consisted":[28],"low-dose":[30,70],"capecitabine":[31],"1g/m2":[32],"twice":[33],"daily":[34,48,57,63],"p.o.":[35],"for":[36],"14":[37],"days,":[38],"every":[39],"3":[40],"weeks,":[41],"day":[42,50,65],"1+,":[43,80],"and":[44,86,95,113,194],"rofecoxib":[45],"25":[46],"mg":[47,56,62],"p.o.,":[49,64],"1+":[51],"(from":[52],"11/04":[53],"etoricoxib":[54],"60":[55,61],"instead)":[58],"plus":[59],"pioglitazone":[60],"1+.":[66],"In":[67],"study":[68,107,163],"IFN-alpha":[71],"4.5":[72],"MU":[73],"sc.":[74],"three":[75],"times":[76],"a":[77,116,146,188],"week,":[78],"week":[79],"was":[81,103,174],"added":[82],"until":[83],"disease":[84,97],"progression.Eighteen,":[85],"33":[87],"patients,":[88],"respectively,":[89],"with":[90,133],"clear":[91],"cell":[92],"renal":[93],"carcinoma":[94],"progressive":[96],"enrolled.":[99],"Objective":[100],"response":[101,119,193],"(48%)":[102],"exclusively":[104],"observed":[105],"(PR":[109],"35%,":[110],"CR":[111],"13%),":[112],"paralleled":[114],"by":[115,182],"strong":[117],"CRP":[118,135],"after":[120],"4":[121],"weeks":[122],"on":[123],"treatment,":[124],"p":[125,165],"=":[126,166],"0.0005,":[127],"all":[129],"29":[130],"pts":[131],"(100%)":[132],"elevated":[134],"levels.":[136],"Median":[137,168],"progression-free":[138],"survival":[139,170],"be":[141],"more":[142],"than":[143],"doubled":[144],"from":[145],"median":[147],"4.7":[149],"months":[150,158],"(95%":[151],"CI,":[152],"1.0":[153],"10.4)":[155],"11.5":[157],"(6.8":[159],"16.2)":[161],"II,":[164],"0.00001.":[167],"overall":[169],"population":[172],"26":[175],"months.Efficacious":[176],"negative":[177],"regulation":[178],"inflammation":[181],"transcription":[183],"modulators":[184],"may":[185],"steep":[189],"increase":[190],"survival.":[195]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}
