{"id":"https://openalex.org/W4232190480","doi":"https://doi.org/10.1002/ange.201916534","title":"Nickel\u2010Catalyzed Asymmetric Hydrogenation of 2\u2010Amidoacrylates","display_name":"Nickel\u2010Catalyzed Asymmetric Hydrogenation of 2\u2010Amidoacrylates","publication_year":2020,"publication_date":"2020-01-20","ids":{"openalex":"https://openalex.org/W4232190480","doi":"https://doi.org/10.1002/ange.201916534"},"language":"en","primary_location":{"id":"doi:10.1002/ange.201916534","doi":"https://doi.org/10.1002/ange.201916534","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.201916534","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034008093","display_name":"Yawen Hu","orcid":"https://orcid.org/0000-0003-3284-8893","observed_orcids":["https://orcid.org/0000-0003-3284-8893"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yawen Hu","raw_affiliation_strings":["Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009267288","display_name":"Jianzhong Chen","orcid":"https://orcid.org/0000-0002-7117-269X","observed_orcids":["https://orcid.org/0000-0002-7117-269X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianzhong Chen","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-7117-269X","affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387290","display_name":"Bowen Li","orcid":"https://orcid.org/0000-0002-8595-0712","observed_orcids":["https://orcid.org/0000-0002-8595-0712"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bowen Li","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100731779","display_name":"Zhenfeng Zhang","orcid":"https://orcid.org/0000-0003-3295-6966","observed_orcids":["https://orcid.org/0000-0003-3295-6966"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenfeng Zhang","raw_affiliation_strings":["Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103220757","display_name":"Ilya D. Gridnev","orcid":"https://orcid.org/0000-0001-9306-7316","observed_orcids":["https://orcid.org/0000-0001-9306-7316","https://orcid.org/0000-0002-6711-9036"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ilya D. Gridnev","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, Tohoku University, Aramaki 3-6, Aoba-ku, Sendai, 980-8578 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, Tohoku University, Aramaki 3-6, Aoba-ku, Sendai, 980-8578 Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051565228","display_name":"Wanbin Zhang","orcid":"https://orcid.org/0000-0002-4788-4195","observed_orcids":["https://orcid.org/0000-0002-4788-4195"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wanbin Zhang","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China","Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-4788-4195","affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051565228"],"corresponding_institution_ids":["https://openalex.org/I183067930"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":3.5766,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.92400667,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"132","issue":"13","first_page":"5409","last_page":"5413"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11281","display_name":"Asymmetric Hydrogenation and Catalysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11281","display_name":"Asymmetric Hydrogenation and Catalysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12240","display_name":"Nanomaterials for catalytic reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nickel-catalysis","display_name":"nickel catalysis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/asymmetric-hydrogenation","display_name":"asymmetric hydrogenation","score":0.996999979019165},{"id":"https://openalex.org/keywords/chiral-bisphosphine-ligands","display_name":"chiral bisphosphine ligands","score":0.9700000286102295},{"id":"https://openalex.org/keywords/alpha-amino-acid-esters","display_name":"\u03b1-amino esters","score":0.8769999742507935},{"id":"https://openalex.org/keywords/enantioselectivity","display_name":"enantioselectivity","score":0.8460000157356262},{"id":"https://openalex.org/keywords/catalyst-loading","display_name":"catalyst loading","score":0.4749999940395355},{"id":"https://openalex.org/keywords/deuterium-labeling","display_name":"deuterium labeling","score":0.847000002861023},{"id":"https://openalex.org/keywords/catalytic-mechanism","display_name":"catalytic mechanism","score":0.9319999814033508},{"id":"https://openalex.org/keywords/beta-amino-alcohols","display_name":"\u03b2-amino alcohols","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.9115244746208191},{"id":"https://openalex.org/C197356162","wikidata":"https://www.wikidata.org/wiki/Q4812077","display_name":"Asymmetric hydrogenation","level":4,"score":0.8609491586685181},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7619158029556274},{"id":"https://openalex.org/C504270822","wikidata":"https://www.wikidata.org/wiki/Q744","display_name":"Nickel","level":2,"score":0.7530220746994019},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5298373699188232},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5139300227165222},{"id":"https://openalex.org/C58364064","wikidata":"https://www.wikidata.org/wiki/Q102296","display_name":"Deuterium","level":2,"score":0.49475592374801636},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.4787975251674652},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.46820858120918274},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.4632021486759186},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/ange.201916534","doi":"https://doi.org/10.1002/ange.201916534","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.201916534","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2624239250","display_name":null,"funder_award_id":"17ZR1415200","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G275662071","display_name":null,"funder_award_id":"21702134","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4703902075","display_name":null,"funder_award_id":"201701070002E00030","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G6283388288","display_name":null,"funder_award_id":"19JC1430100","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G7563999613","display_name":null,"funder_award_id":"21620102003, 21991112","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7870574544","display_name":null,"funder_award_id":"91856106","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1828409208","https://openalex.org/W1965704764","https://openalex.org/W2000821509","https://openalex.org/W2007683040","https://openalex.org/W2009884940","https://openalex.org/W2013434549","https://openalex.org/W2034475135","https://openalex.org/W2041804869","https://openalex.org/W2058318301","https://openalex.org/W2061630997","https://openalex.org/W2063736472","https://openalex.org/W2087684011","https://openalex.org/W2100328667","https://openalex.org/W2105946794","https://openalex.org/W2109560352","https://openalex.org/W2117487885","https://openalex.org/W2129111124","https://openalex.org/W2133585946","https://openalex.org/W2140577624","https://openalex.org/W2149912287","https://openalex.org/W2153697537","https://openalex.org/W2159327167","https://openalex.org/W2283287692","https://openalex.org/W2320501534","https://openalex.org/W2322146348","https://openalex.org/W2331049837","https://openalex.org/W2332799615","https://openalex.org/W2423902806","https://openalex.org/W2528722199","https://openalex.org/W2552085994","https://openalex.org/W2605414559","https://openalex.org/W2731779568","https://openalex.org/W2733274387","https://openalex.org/W2736550722","https://openalex.org/W2741152209","https://openalex.org/W2754178805","https://openalex.org/W2758331302","https://openalex.org/W2791761438","https://openalex.org/W2793388895","https://openalex.org/W2800005613","https://openalex.org/W2803721628","https://openalex.org/W2807750439","https://openalex.org/W2884973196","https://openalex.org/W2890469981","https://openalex.org/W2892918490","https://openalex.org/W2897287430","https://openalex.org/W2899384021","https://openalex.org/W2901892671","https://openalex.org/W2916030268","https://openalex.org/W2921634767","https://openalex.org/W2934515320","https://openalex.org/W2944232011","https://openalex.org/W2945327129","https://openalex.org/W2952428916","https://openalex.org/W2970820132","https://openalex.org/W2971571858","https://openalex.org/W2986370572","https://openalex.org/W2991545174","https://openalex.org/W3022651122","https://openalex.org/W4210951905","https://openalex.org/W4230130429","https://openalex.org/W4231116307","https://openalex.org/W4234599884","https://openalex.org/W4237649929","https://openalex.org/W4238123508","https://openalex.org/W4239305899","https://openalex.org/W4240649393","https://openalex.org/W4240903737","https://openalex.org/W4241633008","https://openalex.org/W4244358448","https://openalex.org/W4248201081","https://openalex.org/W4248844678","https://openalex.org/W4249129529","https://openalex.org/W4249856338","https://openalex.org/W4250916034","https://openalex.org/W4251913474","https://openalex.org/W4253068377","https://openalex.org/W4253976517","https://openalex.org/W4256754612","https://openalex.org/W4297405635"],"related_works":["https://openalex.org/W3044050250","https://openalex.org/W2773002248","https://openalex.org/W2754178805","https://openalex.org/W2140577624","https://openalex.org/W2755301035","https://openalex.org/W4387845018","https://openalex.org/W3136338484","https://openalex.org/W2058318301","https://openalex.org/W2733274387","https://openalex.org/W4405860114"],"abstract_inverted_index":{"Abstract":[0],"Earth\u2010abundant":[1],"nickel,":[2],"coordinated":[3],"with":[4,61],"a":[5,58,62],"suitable":[6],"chiral":[7,25,75],"bisphosphine":[8],"ligand,":[9],"was":[10,43,88],"found":[11],"to":[12,36,52],"be":[13,71],"an":[14],"efficient":[15],"catalyst":[16,41,64],"for":[17],"the":[18,24,85],"asymmetric":[19],"hydrogenation":[20],"of":[21],"2\u2010amidoacrylates,":[22],"affording":[23],"\u03b1\u2010amino":[26,76],"acid":[27],"esters":[28],"in":[29],"quantitative":[30],"yields":[31],"and":[32,47,80,93],"excellent":[33],"enantioselectivity":[34],"(up":[35],"96":[37],"%ee).":[38],"The":[39,67],"active":[40],"component":[42],"studied":[44],"by":[45],"NMR":[46],"HRMS,":[48],"which":[49],"helped":[50],"us":[51],"realize":[53],"high":[54],"catalytic":[55,86],"efficiency":[56],"on":[57],"gram":[59],"scale":[60],"low":[63],"loading":[65],"(S/C=2000).":[66],"hydrogenated":[68],"products":[69],"could":[70],"simply":[72],"converted":[73],"into":[74],"acids,":[77],"\u03b2\u2010amino":[78],"alcohols,":[79],"their":[81],"bioactive":[82],"derivatives.":[83],"Furthermore,":[84],"mechanism":[87],"investigated":[89],"using":[90],"deuterium\u2010labeling":[91],"experiments":[92],"computational":[94],"calculations.":[95]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}