{"id":"https://openalex.org/W4231995113","doi":"https://doi.org/10.1038/ajg.2014.275","title":"Use of Bayesian Analysis to Predict Pancreatic Fibrosis With the Secretin Endoscopic Pancreatic Function Test (ePFT): Comparisons to Histopathology Gold Standards","display_name":"Use of Bayesian Analysis to Predict Pancreatic Fibrosis With the Secretin Endoscopic Pancreatic Function Test (ePFT): Comparisons to Histopathology Gold Standards","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W4231995113","doi":"https://doi.org/10.1038/ajg.2014.275","pmid":"https://pubmed.ncbi.nlm.nih.gov/25289908"},"language":"en","primary_location":{"id":"doi:10.1038/ajg.2014.275","doi":"https://doi.org/10.1038/ajg.2014.275","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ajg.2014.275","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100749474","display_name":"Feng Li","orcid":"https://orcid.org/0000-0002-7063-9497","observed_orcids":["https://orcid.org/0000-0002-7063-9497"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng Li","raw_affiliation_strings":["Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061124226","display_name":"Wendy L. Frankel","orcid":"https://orcid.org/0000-0003-1658-1009","observed_orcids":["https://orcid.org/0000-0003-1658-1009"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Frankel","raw_affiliation_strings":["Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091084441","display_name":"Alice M. Hinton","orcid":"https://orcid.org/0000-0003-4505-4021","observed_orcids":["https://orcid.org/0000-0003-4505-4021"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice Hinton","raw_affiliation_strings":["Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Philip Hart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Hart","raw_affiliation_strings":["Section of Pancreatic Disorders, Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pancreatic Disorders, Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036774311","display_name":"Darwin L. Conwell","orcid":"https://orcid.org/0000-0003-0449-3730","observed_orcids":["https://orcid.org/0000-0003-0449-3730","https://orcid.org/0000-0002-4845-7769"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darwin Conwell","raw_affiliation_strings":["Section of Pancreatic Disorders, Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pancreatic Disorders, Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.6602,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.75500352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"109","issue":null,"first_page":"S59","last_page":"S59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-fibrosis","display_name":"pancreatic fibrosis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bayesian-analysis","display_name":"Bayesian analysis","score":0.4269999861717224},{"id":"https://openalex.org/keywords/likelihood-ratios","display_name":"likelihood ratios","score":0.8339999914169312},{"id":"https://openalex.org/keywords/pretest-probability","display_name":"pretest probability","score":0.8009999990463257},{"id":"https://openalex.org/keywords/post-test-probability","display_name":"post-test probability","score":0.7940000295639038},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.6549999713897705},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.6039999723434448},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.6740000247955322},{"id":"https://openalex.org/keywords/alcohol-abuse","display_name":"alcohol abuse","score":0.8420000076293945},{"id":"https://openalex.org/keywords/exocrine-insufficiency","display_name":"exocrine insufficiency","score":0.8830000162124634},{"id":"https://openalex.org/keywords/endoscopic-ultrasound","display_name":"endoscopic ultrasound","score":0.6940000057220459},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"magnetic resonance imaging","score":0.7889999747276306},{"id":"https://openalex.org/keywords/exocrine-pancreatic-function","display_name":"pancreatic exocrine function","score":0.5139999985694885},{"id":"https://openalex.org/keywords/pancreatic-endocrine-function","display_name":"pancreatic endocrine function","score":0.7039999961853027},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.3370000123977661},{"id":"https://openalex.org/keywords/abdominal-pain","display_name":"abdominal pain","score":0.9380000233650208},{"id":"https://openalex.org/keywords/recurrent-pancreatitis","display_name":"recurrent pancreatitis","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8176350593566895},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.6705353260040283},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.6498080492019653},{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.6000203490257263},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5029379725456238},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4964025616645813},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.49604496359825134},{"id":"https://openalex.org/C2776737053","wikidata":"https://www.wikidata.org/wiki/Q7130407","display_name":"Pancreatic disease","level":3,"score":0.4828925132751465},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42796817421913147},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3673243522644043}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/ajg.2014.275","doi":"https://doi.org/10.1038/ajg.2014.275","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ajg.2014.275","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:25289908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25289908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8700000047683716}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4281627852","https://openalex.org/W2977840537","https://openalex.org/W2059609571","https://openalex.org/W2067959898","https://openalex.org/W2979229996","https://openalex.org/W2572404281","https://openalex.org/W1983231000","https://openalex.org/W2000345891","https://openalex.org/W2027993109","https://openalex.org/W3155740355"],"abstract_inverted_index":{"Introduction:":[0],"Chronic":[1],"pancreatitis":[2],"(CP)":[3],"is":[4,36,263,282],"a":[5,27,37,63,71,223,264,283,294,321],"complex":[6],"syndrome":[7],"characterized":[8],"by":[9],"pancreatic":[10,53,83],"fibrosis":[11,84,343],"(PF),":[12],"chronic":[13,268,325,338],"inflammation,":[14],"and":[15,21,92,112,126,155,161,177,208,241,243,313],"progressive":[16],"loss":[17],"of":[18,26,34,42,67,82,106,118,123,144,170,201,211,216,232,251,267,277,324,337,342],"glandular":[19],"exocrine":[20],"endocrine":[22],"function.":[23],"The":[24],"lack":[25],"practical":[28],"\u201cgold":[29],"standard\u201d":[30],"in":[31,89,109,120,179,257,274,304,344,356],"the":[32,43,87,198,258,275,291,340,357],"diagnosis":[33,323,336],"CP":[35,279],"challenge,":[38],"as":[39,183],"direct":[40],"biopsy":[41],"pancreas":[44],"to":[45,60,140,196,228,286,346],"evaluate":[46],"histology":[47,111],"may":[48],"not":[49,328],"be":[50,58,302],"feasible.":[51],"Endoscopic":[52],"functional":[54],"tests":[55],"(ePFTs)":[56],"can":[57,255,297,354],"used":[59,139,195],"predict":[61,298],"PF,":[62,261,299],"key":[64,265],"histologic":[65,220],"component":[66,266],"CP.":[68,98],"To":[69],"construct":[70],"diagnostic":[72,358],"tool":[73,285],"based":[74,174,234],"on":[75,175,219,235],"Fagan\u2019s":[76,190,224],"nomogram":[77,191,225],"for":[78,97,104,150,166,260,320],"calculating":[79],"post-test":[80,199,230],"probability":[81,143,200,205,231],"(PF)":[85],"utilizing":[86],"ePFT":[88,168,244,254,272,296],"subjects":[90,124,151],"with":[91,125,152,306,331],"without":[93,127],"known":[94,278],"risk":[95,129,237,280],"factors":[96,130,238,348],"Methods:":[99],"Exhaustive":[100],"literature":[101,180],"was":[102,138,148,194,226],"conducted":[103],"review":[105],"PF":[107,119,171,202,233,332],"data":[108,147],"surgical":[110],"autopsy":[113],"studies.":[114],"Step":[115,158,188],"1:":[116,213],"Prevalence":[117],"histopathology":[121,182],"studies":[122],"major":[128],"(smoking,":[131],"alcohol":[132,156],"abuse,":[133],"neither":[134],"smoking":[135,154],"nor":[136],"alcohol)":[137],"determine":[141,197],"pre-test":[142,204,236],"PF.":[145,289],"No":[146],"available":[149],"both":[153],"use.":[157],"2:":[159,248],"Positive":[160],"negative":[162,271],"likelihood":[163],"ratios":[164],"(LR)":[165],"secretin":[167],"detection":[169],"were":[172],"calculated":[173],"sensitivity":[176],"specificity":[178],"using":[181],"gold":[184,221],"standard":[185],"(Table":[186,246],"1).":[187],"3:":[189],"(Bayesian":[192],"analysis)":[193],"incorporating":[203],"(risk":[206],"factors)":[207,281],"positive/negative":[209],"LR":[210],"ePFT.Table":[212],"Test":[214],"Characteristics":[215],"ePFTResults:":[217],"Based":[218],"standards,":[222],"constructed":[227],"estimate":[229],"(smokers,":[239],"alcoholics,":[240],"controls)":[242],"results":[245],"2).Table":[247],"Posttest":[249],"Pprobability":[250],"Pancreatic":[252],"FibrosisConclusion:":[253],"assist":[256,355],"assessment":[259],"which":[262],"pancreatitis.":[269,326],"A":[270],"(even":[273],"setting":[276],"useful":[284],"rule":[287],"out":[288],"On":[290],"other":[292,307,347],"hand,":[293],"positive":[295],"but":[300],"should":[301],"interpreted":[303],"combination":[305],"testing":[308],"modalities":[309],"(i.e.,":[310],"EUS,":[311],"MRI)":[312],"clinical":[314,335],"features":[315],"(abdominal":[316],"pain,":[317,352],"recurrent":[318],"pancreatitis)":[319],"definitive":[322],"While":[327],"all":[329],"patients":[330],"will":[333],"have":[334],"pancreatitis,":[339],"presence":[341],"addition":[345],"(exocrine":[349],"insufficiency,":[350],"abdominal":[351],"diabetes)":[353],"evaluation.":[359]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}