{"id":"https://openalex.org/W4231315539","doi":"https://doi.org/10.3109/9781420019858-22","title":"Molecular Imaging, Clinical Trial Design, and the Development of Emerging Therapies for Metastatic Prostate Cancer","display_name":"Molecular Imaging, Clinical Trial Design, and the Development of Emerging Therapies for Metastatic Prostate Cancer","publication_year":2016,"publication_date":"2016-04-19","ids":{"openalex":"https://openalex.org/W4231315539","doi":"https://doi.org/10.3109/9781420019858-22"},"language":"en","primary_location":{"id":"doi:10.3109/9781420019858-22","doi":"https://doi.org/10.3109/9781420019858-22","is_oa":false,"landing_page_url":"https://doi.org/10.3109/9781420019858-22","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostate Cancer","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2505569703","display_name":"Prostate Cancer"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017288060","display_name":"Michael J. Morris","orcid":"https://orcid.org/0000-0002-9454-0096","observed_orcids":["https://orcid.org/0000-0002-9454-0096"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael J. Morris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088338532","display_name":"Neeta Pandit-Taksar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neeta Pandit-Taksar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066901026","display_name":"Chaitanya R. Divgi","orcid":"https://orcid.org/0000-0002-0146-3678","observed_orcids":["https://orcid.org/0000-0002-0146-3678"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chaitanya Divgi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015396908","display_name":"Steven M. Larson","orcid":"https://orcid.org/0000-0002-6111-7507","observed_orcids":["https://orcid.org/0000-0002-6111-7507"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven Larson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072850546","display_name":"Howard I. Scher","orcid":"https://orcid.org/0000-0002-6791-9324","observed_orcids":["https://orcid.org/0000-0002-6791-9324"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Howard I. Scher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.47169811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"309","last_page":"332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.08089999854564667,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.03370000049471855,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-prostate-cancer","display_name":"metastatic prostate cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/molecular-imaging","display_name":"molecular imaging","score":0.9860000014305115},{"id":"https://openalex.org/keywords/clinical-trial-design","display_name":"clinical trial design","score":0.9810000061988831},{"id":"https://openalex.org/keywords/novel-therapies","display_name":"new drugs","score":0.6340000033378601},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9070000052452087},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.824999988079071},{"id":"https://openalex.org/keywords/immunosurveillance","display_name":"immune surveillance","score":0.7689999938011169},{"id":"https://openalex.org/keywords/bone-microenvironment","display_name":"bone microenvironment","score":0.949999988079071},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.3889999985694885},{"id":"https://openalex.org/keywords/drug-response-assessment","display_name":"drug response assessment","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7297571897506714},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5956071615219116},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5363539457321167},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5254096984863281},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4329957365989685},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4004736542701721}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3109/9781420019858-22","doi":"https://doi.org/10.3109/9781420019858-22","is_oa":false,"landing_page_url":"https://doi.org/10.3109/9781420019858-22","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostate Cancer","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W1595561754"],"related_works":["https://openalex.org/W2176988810","https://openalex.org/W2067015202","https://openalex.org/W2014363449","https://openalex.org/W2098173779","https://openalex.org/W2426467811","https://openalex.org/W1983086877","https://openalex.org/W2052410863","https://openalex.org/W3042822447","https://openalex.org/W1978957686","https://openalex.org/W2188606843"],"abstract_inverted_index":{"Patients":[0],"with":[1],"metastatic":[2,31,55],"prostate":[3,26,61],"cancer":[4,27,62],"and":[5,29,48,54,67,101,114],"their":[6],"physicians":[7],"can":[8,35,58,68],"choose":[9],"among":[10],"an":[11],"unprecedented":[12],"array":[13],"of":[14,25,51,94,117],"investigational":[15],"therapeutics":[16],"whose":[17],"aim":[18],"is":[19],"to":[20,84,108],"alter":[21],"the":[22,30,39,70,91,104,111,115,120],"basic":[23],"biology":[24],"growth":[28,53],"cascade.":[32],"These":[33],"drugs":[34,118],"target":[36,69],"intracellular":[37],"signaling,":[38],"androgen":[40],"receptor":[41],"(AR),":[42],"apoptosis":[43],"regulation,":[44],"angiogenesis,":[45],"immune":[46],"surveillance,":[47],"other":[49],"mechanisms":[50],"tumor":[52,81,112,121],"spread.":[56],"They":[57],"also":[59],"distinguish":[60],"cells":[63,82],"from":[64],"normal":[65,85],"tissues":[66],"bone":[71],"microenvironment.":[72],"Many":[73],"have":[74],"enhanced":[75],"antiproliferative":[76],"or":[77],"proapoptotic":[78],"effects":[79,116],"on":[80,119],"relative":[83],"tissues.":[86],"Despite":[87],"these":[88],"advances":[89],"in":[90],"clinical":[92],"availability":[93],"biologic":[95],"agents,":[96],"novel":[97],"cytotoxics,":[98],"immunologic":[99],"manipulations,":[100],"targeted":[102],"therapies,":[103],"standard":[105],"imaging":[106],"tools":[107],"assess":[109],"both":[110],"itself":[113],"are":[122],"relatively":[123],"primitive.":[124]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2022-05-12T00:00:00"}