{"id":"https://openalex.org/W4231290725","doi":"https://doi.org/10.1158/1538-7445.am2019-592","title":"Abstract 592: Associations of mammographic breast density with breast stem cell marker-defined breast cancer subtypes","display_name":"Abstract 592: Associations of mammographic breast density with breast stem cell marker-defined breast cancer subtypes","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4231290725","doi":"https://doi.org/10.1158/1538-7445.am2019-592"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2019-592","doi":"https://doi.org/10.1158/1538-7445.am2019-592","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-592","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042705991","display_name":"Lusine Yaghjyan","orcid":"https://orcid.org/0000-0002-1626-5340","observed_orcids":["https://orcid.org/0000-0002-1626-5340"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lusine Yaghjyan","raw_affiliation_strings":["1Univ. of Florida, Gainesville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Florida, Gainesville, FL;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025576841","display_name":"Ashwini Kumar Esnakula","orcid":"https://orcid.org/0000-0001-6029-0124","observed_orcids":["https://orcid.org/0000-0001-6029-0124"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashwini Esnakula","raw_affiliation_strings":["1Univ. of Florida, Gainesville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Florida, Gainesville, FL;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085699345","display_name":"Christopher G. Scott","orcid":"https://orcid.org/0000-0003-1340-0647","observed_orcids":["https://orcid.org/0000-0003-1340-0647"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Scott","raw_affiliation_strings":["2Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056035709","display_name":"Akemi T. Wijayabahu","orcid":"https://orcid.org/0000-0003-3659-3701","observed_orcids":["https://orcid.org/0000-0003-3659-3701"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akemi Wijayabahu","raw_affiliation_strings":["1Univ. of Florida, Gainesville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Florida, Gainesville, FL;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Matthew Jensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Jensen","raw_affiliation_strings":["2Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065185741","display_name":"Celine M. Vachon","orcid":"https://orcid.org/0000-0002-1962-9322","observed_orcids":["https://orcid.org/0000-0002-1962-9322"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celine Vachon","raw_affiliation_strings":["2Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"13_Supplement","first_page":"592","last_page":"592"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11361","display_name":"Digital Radiography and Breast Imaging","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11361","display_name":"Digital Radiography and Breast Imaging","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-density","display_name":"breast density","score":0.9919999837875366},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.7829999923706055},{"id":"https://openalex.org/keywords/breast-cancer-subtypes","display_name":"breast cancer subtypes","score":0.7760000228881836},{"id":"https://openalex.org/keywords/stem-cell-markers","display_name":"stem cell markers","score":0.734000027179718},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.996999979019165},{"id":"https://openalex.org/keywords/cd24","display_name":"CD24","score":1.0},{"id":"https://openalex.org/keywords/aldh1a1","display_name":"ALDH1A1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.7419999837875366},{"id":"https://openalex.org/keywords/hormone-receptor-negative-breast-cancer","display_name":"hormone receptor-negative breast cancer","score":0.6959999799728394},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.7229999899864197},{"id":"https://openalex.org/keywords/breast-carcinoma-in-situ","display_name":"breast cancer in situ","score":0.5009999871253967},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.8579999804496765},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.6370000243186951},{"id":"https://openalex.org/keywords/breast-cancer-risk-factors","display_name":"breast cancer risk factors","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8670486807823181},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6457643508911133},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.6051958203315735},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5966504812240601},{"id":"https://openalex.org/C2779492189","wikidata":"https://www.wikidata.org/wiki/Q1190762","display_name":"CD24","level":4,"score":0.5454410314559937},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5294197201728821},{"id":"https://openalex.org/C2780472235","wikidata":"https://www.wikidata.org/wiki/Q324634","display_name":"Mammography","level":4,"score":0.48267439007759094},{"id":"https://openalex.org/C136302470","wikidata":"https://www.wikidata.org/wiki/Q7607299","display_name":"Stem cell marker","level":3,"score":0.44321632385253906},{"id":"https://openalex.org/C111683008","wikidata":"https://www.wikidata.org/wiki/Q1657620","display_name":"CA 15-3","level":5,"score":0.4375495910644531},{"id":"https://openalex.org/C118646709","wikidata":"https://www.wikidata.org/wiki/Q1657620","display_name":"CA15-3","level":4,"score":0.4338819086551666},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4192712903022766},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39499858021736145},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3534497916698456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15498623251914978},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.10473725199699402},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2019-592","doi":"https://doi.org/10.1158/1538-7445.am2019-592","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-592","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Gender equality","score":0.5,"id":"https://metadata.un.org/sdg/5"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2966488731","https://openalex.org/W4399425394","https://openalex.org/W2751351669","https://openalex.org/W4390689842","https://openalex.org/W4220714676","https://openalex.org/W2757578817","https://openalex.org/W1219746990","https://openalex.org/W2523938415","https://openalex.org/W4309482264","https://openalex.org/W2170116249"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"High":[2],"mammographic":[3,382],"breast":[4,10,29,38,44,53,59,86,98,157,161,282,293,297,330,334,383,386,390],"density":[5,45,54,158,212,294,331,384],"is":[6,46],"a":[7,125,363],"strong,":[8],"well-established":[9],"cancer":[11,39,60,87,162,283,298,302,335,391],"risk":[12,40,57,163,284,336],"factor.":[13],"A":[14],"recent":[15],"study":[16,354],"found":[17,323],"increased":[18],"expression":[19,309],"of":[20,27,58,64,114,156,167,169,210,219,271,278,292,326,329,340,381,396],"stem":[21,33,65,341,387],"cell":[22,66,342,388],"markers":[23,67,116],"in":[24,72,180,191,352,362],"the":[25,50,56,62,73,115,154,165,170,178,188,192,220,338,397],"areas":[26],"high":[28,37,43],"density,":[30,99],"but,":[31],"whether":[32],"cells":[34],"may":[35],"explain":[36],"due":[41],"to":[42,124,152,176,358],"unknown.":[47],"We":[48,76,147,322],"investigated":[49],"association":[51],"between":[52],"and":[55,70,88,103,204,275,317,349],"by":[61,164,182,337],"status":[63,166,310,339],"CD44,":[68,199],"CD24,":[69],"ALDH1A1":[71],"tumor.":[74],"Methods:":[75],"included":[77],"223":[78,189],"postmenopausal":[79],"women":[80],"with":[81,128,132,160,281,296,333,385],"primary":[82],"invasive":[83],"or":[84,141,315],"in-situ":[85],"399":[89],"age-matched":[90],"controls":[91],"from":[92],"Mayo":[93],"Clinic":[94],"Mammography":[95],"Study.":[96],"Percent":[97],"absolute":[100,272],"dense":[101,273],"area":[102,105,274,280],"non-dense":[104,279],"were":[106,144,174,196,213,285,299,304],"assessed":[107],"using":[108,306],"computer-assisted":[109],"thresholding":[110],"technique.":[111],"Immunohistochemical":[112],"analysis":[113],"was":[117,347],"performed":[118],"on":[119,139],"tumor":[120,184],"tissue":[121],"microarrays":[122],"according":[123],"standard":[126],"protocol":[127],"commercial":[129],"antibodies.":[130],"Cases":[131],"positive":[133,197,313,319],"staining":[134],"(\u22651%":[135],"positively":[136],"stained":[137],"cells)":[138],"one":[140,312],"more":[142,318],"cores":[143],"considered":[145],"marker-positive.":[146],"used":[148],"polychotomous":[149],"logistic":[150],"regression":[151],"quantify":[153],"associations":[155,181,270,277,291,328,361],"measures":[159,295,332],"each":[168],"markers.":[171,343],"Heterogeneity":[172],"tests":[173],"conducted":[175],"compare":[177],"differences":[179],"marker-defined":[183,221,288,389],"subtypes.":[185,289],"Results:":[186],"Of":[187],"cancers":[190],"study,":[193],"182":[194],"(82%)":[195],"for":[198,202,207,231,238,245,252,259,266,400],"83":[200],"(37%)":[201],"CD24":[203],"52":[205],"(23%)":[206],"ALDH1A1.":[208],"Associations":[209,380],"percent":[211],"not":[214],"significantly":[215],"different":[216],"across":[217,287],"any":[218],"subtypes":[222,303,392],"(density":[223],"51%+":[224],"vs.":[225,233,247,261],"11-25%:":[226],"OR=2.83,":[227],"95%":[228,235,242,249,256,263],"CI":[229,236,243,250,257,264],"1.49-5.37":[230],"CD44+":[232],"OR=1.87,":[234],"0.47-7.51":[237],"CD44-,":[239],"p-heterogeneity=0.66;":[240],"OR=2.80,":[241],"1.27-6.18":[244],"CD24+":[246],"OR=2.44,":[248],"1.14-5.22":[251],"CD24-,":[253],"p-heterogeneity=0.61;":[254],"OR=3.04,":[255],"1.14-8.10":[258],"ALDH1A1+":[260],"OR=2.57.":[262],"1.30-5.08":[265],"ALDH1A1-,":[267],"p-heterogeneity=0.94).":[268],"Positive":[269],"inverse":[276],"similar":[286],"Similar":[290],"seen":[300],"when":[301],"defined":[305],"combined":[307],"marker":[308],"(none,":[311],"marker,":[314],"two":[316],"markers).":[320],"Conclusions:":[321],"no":[324],"evidence":[325],"differential":[327],"However,":[344],"our":[345],"power":[346],"limited":[348],"further":[350],"studies":[351],"larger":[353,364],"populations":[355],"are":[356],"warranted":[357],"confirm":[359],"these":[360],"sample.":[365],"Citation":[366],"Format:":[367],"Lusine":[368],"Yaghjyan,":[369],"Ashwini":[370],"Esnakula,":[371],"Christopher":[372],"Scott,":[373],"Akemi":[374],"Wijayabahu,":[375],"Matthew":[376],"Jensen,":[377],"Celine":[378],"Vachon.":[379],"[abstract].":[393],"In:":[394],"Proceedings":[395],"American":[398],"Association":[399],"Cancer":[401,415],"Research":[402],"Annual":[403],"Meeting":[404],"2019;":[405],"2019":[406],"Mar":[407],"29-Apr":[408],"3;":[409],"Atlanta,":[410],"GA.":[411],"Philadelphia":[412],"(PA):":[413],"AACR;":[414],"Res":[416],"2019;79(13":[417],"Suppl):Abstract":[418],"nr":[419],"592.":[420]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2022-05-12T00:00:00"}
