{"id":"https://openalex.org/W4231104271","doi":"https://doi.org/10.3171/foc.1999.7.5.1","title":"Intracranial hypertension and cerebral perfusion pressure: influence on neurological deterioration and outcome in severe head injury","display_name":"Intracranial hypertension and cerebral perfusion pressure: influence on neurological deterioration and outcome in severe head injury","publication_year":1999,"publication_date":"1999-11-01","ids":{"openalex":"https://openalex.org/W4231104271","doi":"https://doi.org/10.3171/foc.1999.7.5.1"},"language":"en","primary_location":{"id":"doi:10.3171/foc.1999.7.5.1","doi":"https://doi.org/10.3171/foc.1999.7.5.1","is_oa":true,"landing_page_url":"https://doi.org/10.3171/foc.1999.7.5.1","pdf_url":"https://thejns.org/downloadpdf/journals/neurosurg-focus/7/5/article-pE1.pdf","source":{"id":"https://openalex.org/S149215848","display_name":"Neurosurgical FOCUS","issn_l":"1092-0684","issn":["1092-0684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgical Focus","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://thejns.org/downloadpdf/journals/neurosurg-focus/7/5/article-pE1.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108507862","display_name":"Niels Juul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Niels Juul","raw_affiliation_strings":["Department of Neuroanesthesia and Neurointensive Care, Aalborg Hospital, Aalborg, Denmark","Division of Neurological Surgery , University of California , San Diego , California ; and","Committee of the International Selfotel Trial,","Division of Neurological Surgery, University of California, San Diego, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroanesthesia and Neurointensive Care, Aalborg Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]},{"raw_affiliation_string":"Division of Neurological Surgery , University of California , San Diego , California ; and","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Committee of the International Selfotel Trial,","institution_ids":[]},{"raw_affiliation_string":"Division of Neurological Surgery, University of California, San Diego, California;","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052565719","display_name":"Gabrielle F. Morris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Gabrielle F. Morris","raw_affiliation_strings":["Department of Neuroanesthesia and Neurointensive Care, Aalborg Hospital, Aalborg, Denmark","Division of Neurological Surgery , University of California , San Diego , California ; and","Committee of the International Selfotel Trial,","Division of Neurological Surgery, University of California, San Diego, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroanesthesia and Neurointensive Care, Aalborg Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]},{"raw_affiliation_string":"Division of Neurological Surgery , University of California , San Diego , California ; and","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Committee of the International Selfotel Trial,","institution_ids":[]},{"raw_affiliation_string":"Division of Neurological Surgery, University of California, San Diego, California;","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032307197","display_name":"Sharon Bowers Marshall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Sharon B. Marshall","raw_affiliation_strings":["Department of Neuroanesthesia and Neurointensive Care, Aalborg Hospital, Aalborg, Denmark","Division of Neurological Surgery , University of California , San Diego , California ; and","Committee of the International Selfotel Trial,","Division of Neurological Surgery, University of California, San Diego, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroanesthesia and Neurointensive Care, Aalborg Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]},{"raw_affiliation_string":"Division of Neurological Surgery , University of California , San Diego , California ; and","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Committee of the International Selfotel Trial,","institution_ids":[]},{"raw_affiliation_string":"Division of Neurological Surgery, University of California, San Diego, California;","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":null,"display_name":"_ _","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"_ _","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108822385","display_name":"Lawrence F. Marshall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Lawrence F. Marshall","raw_affiliation_strings":["Department of Neuroanesthesia and Neurointensive Care, Aalborg Hospital, Aalborg, Denmark","Division of Neurological Surgery , University of California , San Diego , California ; and","Committee of the International Selfotel Trial,","Division of Neurological Surgery, University of California, San Diego, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroanesthesia and Neurointensive Care, Aalborg Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]},{"raw_affiliation_string":"Division of Neurological Surgery , University of California , San Diego , California ; and","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Committee of the International Selfotel Trial,","institution_ids":[]},{"raw_affiliation_string":"Division of Neurological Surgery, University of California, San Diego, California;","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.42810554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"7","issue":"5","first_page":"E1","last_page":"E1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11467","display_name":"Trauma and Emergency Care Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracranial-hypertension","display_name":"intracranial hypertension","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cerebral-perfusion-pressure","display_name":"cerebral perfusion pressure","score":0.9869999885559082},{"id":"https://openalex.org/keywords/severe-traumatic-brain-injury","display_name":"severe traumatic brain injury","score":0.9139999747276306},{"id":"https://openalex.org/keywords/intracranial-pressure","display_name":"intracranial pressure","score":0.8040000200271606},{"id":"https://openalex.org/keywords/neurological-deterioration","display_name":"neurological deterioration","score":0.972000002861023},{"id":"https://openalex.org/keywords/prognosis-prediction","display_name":"outcome prediction","score":0.5809999704360962},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.9110000133514404},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.5540000200271606},{"id":"https://openalex.org/keywords/glasgow-outcome-scale","display_name":"Glasgow Outcome Scale","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8302696943283081},{"id":"https://openalex.org/C2780954326","wikidata":"https://www.wikidata.org/wiki/Q1416096","display_name":"Intracranial pressure","level":2,"score":0.7504807710647583},{"id":"https://openalex.org/C154281038","wikidata":"https://www.wikidata.org/wiki/Q629232","display_name":"Cerebral perfusion pressure","level":3,"score":0.7041124105453491},{"id":"https://openalex.org/C2777796830","wikidata":"https://www.wikidata.org/wiki/Q1529519","display_name":"Glasgow Outcome Scale","level":3,"score":0.6650257110595703},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5570239424705505},{"id":"https://openalex.org/C2777975874","wikidata":"https://www.wikidata.org/wiki/Q2920572","display_name":"Head injury","level":2,"score":0.5369069576263428},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.514714777469635},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.4974875748157501},{"id":"https://openalex.org/C17624336","wikidata":"https://www.wikidata.org/wiki/Q461644","display_name":"Glasgow Coma Scale","level":2,"score":0.34725862741470337},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34082984924316406},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.27776217460632324},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3171/foc.1999.7.5.1","doi":"https://doi.org/10.3171/foc.1999.7.5.1","is_oa":true,"landing_page_url":"https://doi.org/10.3171/foc.1999.7.5.1","pdf_url":"https://thejns.org/downloadpdf/journals/neurosurg-focus/7/5/article-pE1.pdf","source":{"id":"https://openalex.org/S149215848","display_name":"Neurosurgical FOCUS","issn_l":"1092-0684","issn":["1092-0684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgical Focus","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3171/foc.1999.7.5.1","doi":"https://doi.org/10.3171/foc.1999.7.5.1","is_oa":true,"landing_page_url":"https://doi.org/10.3171/foc.1999.7.5.1","pdf_url":"https://thejns.org/downloadpdf/journals/neurosurg-focus/7/5/article-pE1.pdf","source":{"id":"https://openalex.org/S149215848","display_name":"Neurosurgical FOCUS","issn_l":"1092-0684","issn":["1092-0684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgical Focus","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4231104271.pdf","grobid_xml":"https://content.openalex.org/works/W4231104271.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1575460937","https://openalex.org/W1974200878","https://openalex.org/W1982882231","https://openalex.org/W1987654866","https://openalex.org/W1999169806","https://openalex.org/W2023729026","https://openalex.org/W2084962044","https://openalex.org/W2139654564"],"related_works":["https://openalex.org/W2363576321","https://openalex.org/W2157675266","https://openalex.org/W2011335214","https://openalex.org/W116741996","https://openalex.org/W42852308","https://openalex.org/W2160183581","https://openalex.org/W1997730884","https://openalex.org/W2287405720","https://openalex.org/W2107739270","https://openalex.org/W208180107"],"abstract_inverted_index":{"Object":[0],"Recently,":[1],"a":[2,48,71],"renewed":[3],"emphasis":[4],"has":[5],"been":[6],"placed":[7],"on":[8,136,175,259],"managing":[9],"severe":[10,228,265],"head":[11,229,266],"injury":[12,230],"by":[13],"elevating":[14],"cerebral":[15],"perfusion":[16],"pressure":[17,26,30],"(CPP),":[18],"which":[19],"is":[20,38,45],"defined":[21,103,131],"as":[22,132,210,212],"the":[23,28,61,86,137,168,187,208,213,225,233,260],"mean":[24],"arterial":[25],"minus":[27],"intracranial":[29,46,190],"(ICP).":[31],"Some":[32],"authors":[33,59],"have":[34,256],"suggested":[35],"that":[36,50],"CPP":[37,174,209,214,248],"more":[39,117],"important":[40],"in":[41,70,78,96,110,147,154],"influencing":[42],"outcome":[43,69,176,261],"than":[44,217,241,250],"hypertension,":[47],"hypothesis":[49],"this":[51],"study":[52],"was":[53,177,186,204,215],"designed":[54],"to":[55,68,108,125,152,239,255],"investigate.":[56],"Methods":[57],"The":[58,179],"examined":[60],"relative":[62,169],"contribution":[63],"of":[64,73,85,105,118,165,171,183,189,227,236,262],"these":[65,119],"two":[66],"parameters":[67],"series":[72],"427":[74],"patients":[75,98,112,122,148,160,263],"prospectively":[76],"studied":[77],"an":[79],"international,":[80],"multicenter,":[81],"randomized,":[82],"double-blind":[83],"trial":[84],"N":[87],"-methyl-D-aspartate":[88],"antagonist":[89],"Selfotel.":[90],"Mortality":[91],"rates":[92],"rose":[93],"from":[94,145],"9.6%":[95],"292":[97],"who":[99,113,161],"had":[100,162],"no":[101,205],"clinically":[102],"episodes":[104],"neurological":[106,150,157,166,184,201],"deterioration":[107,151],"56.5%":[109],"117":[111],"suffered":[114],"one":[115],"or":[116,134,199],"episodes;":[120],"18":[121],"were":[123],"lost":[124],"follow":[126],"up.":[127],"Correspondingly,":[128],"favorable":[129],"outcome,":[130],"good":[133],"moderate":[135],"Glasgow":[138],"Outcome":[139],"Scale":[140],"at":[141],"6":[142],"months,":[143],"fell":[144],"67.8%":[146],"without":[149],"29.1%":[153],"those":[155],"with":[156,207,264],"deterioration.":[158,202],"In":[159],"clinical":[163],"evidence":[164],"deterioration,":[167],"influence":[170,258],"ICP":[172,238],"and":[173],"assessed.":[178],"most":[180],"powerful":[181],"predictor":[182],"worsening":[185],"presence":[188],"hypertension":[191],"(ICP":[192],">/=":[193],"20":[194,242],"mm":[195,219,243,252],"Hg)":[196],"either":[197],"initially":[198],"during":[200],"There":[203],"correlation":[206],"long":[211],"greater":[216,249],"60":[218,251],"Hg.":[220],"Conclusions":[221],"Treatment":[222],"protocols":[223],"for":[224],"management":[226],"should":[231],"emphasize":[232],"immediate":[234],"reduction":[235],"raised":[237],"less":[240],"Hg":[244,253],"if":[245],"possible.":[246],"A":[247],"appears":[254],"little":[257],"injury.":[267]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-11T00:00:00"}