{"id":"https://openalex.org/W4230889686","doi":"https://doi.org/10.3410/f.13026956.14344054","title":"Faculty Opinions recommendation of Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation.","display_name":"Faculty Opinions recommendation of Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation.","publication_year":2011,"publication_date":"2011-08-26","ids":{"openalex":"https://openalex.org/W4230889686","doi":"https://doi.org/10.3410/f.13026956.14344054"},"language":"en","primary_location":{"id":"doi:10.3410/f.13026956.14344054","doi":"https://doi.org/10.3410/f.13026956.14344054","is_oa":false,"landing_page_url":"https://doi.org/10.3410/f.13026956.14344054","pdf_url":null,"source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"volume":null,"type":"peer-review","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091345207","display_name":"Richard L. Klemke","orcid":"https://orcid.org/0000-0001-8230-2915","observed_orcids":["https://orcid.org/0000-0001-8230-2915"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Klemke","raw_affiliation_strings":["Department of Pathology, University of California, San Diego, USA"],"raw_orcid":"https://orcid.org/0000-0001-8230-2915","affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California, San Diego, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056918379","display_name":"Jonathan A. Kelber","orcid":"https://orcid.org/0000-0002-4606-1445","observed_orcids":["https://orcid.org/0000-0002-4606-1445"]},"institutions":[{"id":"https://openalex.org/I157638225","display_name":"California State University, Northridge","ror":"https://ror.org/005f5hv41","country_code":"US","type":"education","lineage":["https://openalex.org/I157638225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Kelber","raw_affiliation_strings":["Department of Biology, California State University, Northridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, California State University, Northridge, USA","institution_ids":["https://openalex.org/I157638225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.3747999966144562,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.3747999966144562,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.29440000653266907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.2888000011444092,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.777999997138977},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase","display_name":"pyruvate dehydrogenase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase-kinase-4","display_name":"PDK4","score":0.9789999723434448},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase-kinase","display_name":"pyruvate dehydrogenase kinase","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/metabolic-regulation","display_name":"metabolic regulation","score":0.6309999823570251},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.36399999260902405}],"concepts":[{"id":"https://openalex.org/C2778179274","wikidata":"https://www.wikidata.org/wiki/Q18030433","display_name":"PDK4","level":4,"score":0.8965926170349121},{"id":"https://openalex.org/C88099638","wikidata":"https://www.wikidata.org/wiki/Q412856","display_name":"Pyruvate dehydrogenase complex","level":3,"score":0.7680424451828003},{"id":"https://openalex.org/C9506865","wikidata":"https://www.wikidata.org/wiki/Q6321025","display_name":"Pyruvate dehydrogenase kinase","level":4,"score":0.6466896533966064},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5588847398757935},{"id":"https://openalex.org/C101972281","wikidata":"https://www.wikidata.org/wiki/Q899965","display_name":"Pyruvate decarboxylation","level":4,"score":0.53122478723526},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.49788451194763184},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.46816346049308777},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4307400584220886},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3328360319137573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21145150065422058},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1680799424648285},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.15855541825294495},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3410/f.13026956.14344054","doi":"https://doi.org/10.3410/f.13026956.14344054","is_oa":false,"landing_page_url":"https://doi.org/10.3410/f.13026956.14344054","pdf_url":null,"source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2091237315","https://openalex.org/W7203888569","https://openalex.org/W4250782400","https://openalex.org/W3216519615"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2022-05-11T00:00:00"}