{"id":"https://openalex.org/W4230769562","doi":"https://doi.org/10.1093/ibd/izy019.005","title":"P005 A MUCOSAL AND CHEMOKINE LIGAND FOR THE LYMPHOCYTE CHEMOATTRACTANT RECEPTOR GPR15","display_name":"P005 A MUCOSAL AND CHEMOKINE LIGAND FOR THE LYMPHOCYTE CHEMOATTRACTANT RECEPTOR GPR15","publication_year":2018,"publication_date":"2018-01-18","ids":{"openalex":"https://openalex.org/W4230769562","doi":"https://doi.org/10.1093/ibd/izy019.005"},"language":"en","primary_location":{"id":"doi:10.1093/ibd/izy019.005","doi":"https://doi.org/10.1093/ibd/izy019.005","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ibd/izy019.005","pdf_url":null,"source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078108210","display_name":"Borja Oc\u00f3n","orcid":"https://orcid.org/0000-0002-5136-7844","observed_orcids":["https://orcid.org/0000-0002-5136-7844"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Borja Oc\u00f3n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022283280","display_name":"Junliang Pan","orcid":"https://orcid.org/0000-0002-2373-0917","observed_orcids":["https://orcid.org/0000-0002-2373-0917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junliang Pan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056107240","display_name":"Thanh Theresa Dinh","orcid":"https://orcid.org/0000-0002-1307-7096","observed_orcids":["https://orcid.org/0000-0002-1307-7096"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theresa Dinh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100430113","display_name":"Wenjing Chen","orcid":"https://orcid.org/0009-0004-0167-125X","observed_orcids":["https://orcid.org/0009-0004-0167-125X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenjing Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008962705","display_name":"Romain Ballet","orcid":"https://orcid.org/0000-0002-5802-9346","observed_orcids":["https://orcid.org/0000-0002-5802-9346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Romain Ballet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066163473","display_name":"Michael Bscheider","orcid":"https://orcid.org/0000-0001-7808-3270","observed_orcids":["https://orcid.org/0000-0001-7808-3270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Bscheider","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019899805","display_name":"Aida Habtezion","orcid":"https://orcid.org/0000-0002-4473-006X","observed_orcids":["https://orcid.org/0000-0002-4473-006X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aida Habtezion","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065484457","display_name":"Hua Tu","orcid":"https://orcid.org/0000-0003-4361-4961","observed_orcids":["https://orcid.org/0000-0003-4361-4961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Tu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022371505","display_name":"Brian A. Zabel","orcid":"https://orcid.org/0000-0001-7293-6180","observed_orcids":["https://orcid.org/0000-0001-7293-6180"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian A Zabel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035047473","display_name":"Eugene C. Butcher","orcid":"https://orcid.org/0000-0001-8786-7907","observed_orcids":["https://orcid.org/0000-0001-8786-7907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugene C Butcher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3862,"currency":"USD","value_usd":3862},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"suppl_1","first_page":"S3","last_page":"S3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.10270000249147415,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gpr15","display_name":"GPR15","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemokine-receptors","display_name":"chemokine receptors","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C167454224","wikidata":"https://www.wikidata.org/wiki/Q2651746","display_name":"Lymphocyte homing receptor","level":4,"score":0.6135305762290955},{"id":"https://openalex.org/C135576274","wikidata":"https://www.wikidata.org/wiki/Q21112082","display_name":"CXCL16","level":5,"score":0.5794468522071838},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5424696803092957},{"id":"https://openalex.org/C94205230","wikidata":"https://www.wikidata.org/wiki/Q5005868","display_name":"C-C chemokine receptor type 6","level":5,"score":0.5343683362007141},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5115864872932434},{"id":"https://openalex.org/C2777310793","wikidata":"https://www.wikidata.org/wiki/Q1725675","display_name":"Lamina propria","level":3,"score":0.4945850074291229},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.42574208974838257},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4215025305747986},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.3844476044178009},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35117918252944946},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.3372681140899658},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3270165026187897},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.30127251148223877},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.17647579312324524},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.17475563287734985},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.14950227737426758},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.1136450469493866},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07892671227455139},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06893348693847656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ibd/izy019.005","doi":"https://doi.org/10.1093/ibd/izy019.005","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ibd/izy019.005","pdf_url":null,"source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2750710572","https://openalex.org/W1998935634","https://openalex.org/W2606016639","https://openalex.org/W4400014203","https://openalex.org/W4382788333","https://openalex.org/W2059302421","https://openalex.org/W4391055883","https://openalex.org/W4406705376","https://openalex.org/W2334263903","https://openalex.org/W4413149513"],"abstract_inverted_index":{"Lymphocytes":[0],"are":[1],"key":[2],"mediators":[3],"of":[4,29,36,42,69,84,107,117,130,132,195,205,239,245,249,272,279,288],"inflammation":[5],"and":[6,23,38,41,50,82,166,207,214,235,251,268],"IBD,":[7],"including":[8,228],"ulcerative":[9],"colitis":[10,87],"(UC).":[11],"GPR15":[12,85,96,190,196,206],"is":[13,24,32,56,75,97],"a":[14,100,121,143,222],"chemoattractant":[15],"receptor":[16,55,119],"for":[17,189,259,276],"lymphocyte":[18],"homing":[19],"to":[20,103,112,173,262,283],"the":[21,54,65,89,105,113,118,128,148,164,169,185,246,255,270,277,285],"colon":[22,231],"implicated":[25],"in":[26,47,64,88,137,142,163,168,221,230],"mouse":[27],"models":[28],"colitis.":[30],"It":[31],"expressed":[33,58,76],"by":[34,59,77,127,146,161,200],"subsets":[35],"CD4":[37,43],"CD8":[39],"effector":[40,109],"regulatory":[44],"T":[45,91,110,226,242],"cells":[46,63,111,227],"both":[48],"human":[49,165],"mouse.":[51],"In":[52,72,192],"humans":[53],"highly":[57],"presumed":[60],"pathogenic":[61,79,108],"Th2":[62],"colonic":[66],"lamina":[67],"propria":[68],"UC":[70],"patients.":[71],"mice":[73],"it":[74],"colon-homing":[78],"Th17":[80],"cells,":[81],"deficiency":[83],"suppresses":[86],"na\u00efve":[90],"cell":[92],"transfer":[93],"model.":[94],"Thus":[95],"considered":[98],"as":[99,120,184,217,219,254],"promising":[101],"target":[102,123],"control":[104],"recruitment":[106],"colon.":[114],"The":[115],"pursuit":[116],"drug":[122],"has":[124],"been":[125],"hampered":[126],"lack":[129],"understanding":[131],"its":[133,252,263],"physiological":[134],"ligand.":[135],"Recently,":[136],"an":[138],"exploratory":[139],"study":[140],"included":[141],"patent":[144],"filed":[145],"Novartis,":[147],"9":[149],"kDa":[150],"CC-motif":[151],"containing":[152],"cationic":[153],"polypeptide":[154],"AP57/colon-derived":[155],"SUSD2":[156],"binding":[157,204],"factor":[158],"(CSBF),":[159],"encoded":[160],"C10orf99":[162],"2610528A11Rik":[167],"mouse,":[170],"was":[171],"reported":[172,265],"trigger":[174],"Ca2+-mediated":[175],"signaling":[176],"upon":[177],"interaction":[178],"with":[179],"GPR15.":[180],"To":[181],"describe":[182],"AP57":[183],"colon-expressed":[186,256],"chemokine":[187],"ligand":[188,258],"(GPR15L).":[191],"vitro":[193],"assays":[194],"activation":[197],"(beta":[198],"arrestin)":[199],"GPR15L,":[201,250],"competitive":[202],"GPR15L":[203,212],"GPR15L-driven":[208],"chemotactic":[209,247,257],"migration":[210],"(Transwell).":[211],"binds":[213],"activates":[215],"GPR15,":[216,260],"well":[218],"attracts":[220],"GPR15-dependent":[223],"manner":[224],"GPR15-expressing":[225],"lymphocytes":[229],"draining":[232],"lymph":[233],"nodes":[234],"V\u03b33+":[236],"thymic":[237],"precursors":[238],"dermal":[240],"epithelial":[241],"cells.":[243],"Identification":[244],"activity":[248],"characterization":[253],"adds":[261],"already":[264],"anti-bacterial":[266],"activities,":[267],"suggests":[269],"potential":[271],"targeting":[273],"GPR15L-GPR15":[274],"interactions":[275],"development":[278],"new":[280],"drugs":[281],"intended":[282],"improve":[284],"clinical":[286],"management":[287],"UC.":[289]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-05-11T00:00:00"}
