{"id":"https://openalex.org/W4230396235","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.lb187","title":"Stimulation of GTP Cyclohydrolase I by Phosphorylation Upon T Cell Activation","display_name":"Stimulation of GTP Cyclohydrolase I by Phosphorylation Upon T Cell Activation","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W4230396235","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.lb187"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.24.1_supplement.lb187","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.lb187","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.lb187","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100344428","display_name":"Wei Chen","orcid":"https://orcid.org/0000-0002-3973-340X","observed_orcids":["https://orcid.org/0000-0002-3973-340X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Chen","raw_affiliation_strings":["Internal Medicine, Emory University, School of Medicine, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Emory University, School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103517506","display_name":"Li Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Li","raw_affiliation_strings":["Internal Medicine, Emory University, School of Medicine, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Emory University, School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027585865","display_name":"Torben Brod","orcid":"https://orcid.org/0000-0002-5088-9931","observed_orcids":["https://orcid.org/0000-0002-5088-9931"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Torben Brod","raw_affiliation_strings":["Internal Medicine, Emory University, School of Medicine, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Emory University, School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065189454","display_name":"Omar Saeed","orcid":"https://orcid.org/0000-0002-7290-2703","observed_orcids":["https://orcid.org/0000-0002-7290-2703"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omar Saeed","raw_affiliation_strings":["Internal Medicine, Emory University, School of Medicine, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Emory University, School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086468930","display_name":"Sergey Dikalov","orcid":"https://orcid.org/0000-0003-2976-6184","observed_orcids":["https://orcid.org/0000-0003-2976-6184"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serguei Dikalov","raw_affiliation_strings":["Internal Medicine, Emory University, School of Medicine, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Emory University, School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011627807","display_name":"David Glenn Harrison","orcid":"https://orcid.org/0000-0001-9363-6451","observed_orcids":["https://orcid.org/0000-0001-9363-6451"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G Harrison","raw_affiliation_strings":["Internal Medicine, Emory University, School of Medicine, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Emory University, School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.5009773,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.21780000627040863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gtp-cyclohydrolase-i","display_name":"GTP cyclohydrolase I","score":0.9879999756813049},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tetrahydrobiopterin","display_name":"tetrahydrobiopterin","score":0.906000018119812},{"id":"https://openalex.org/keywords/biopterin","display_name":"biopterin","score":0.6809999942779541},{"id":"https://openalex.org/keywords/bh4-biosynthesis","display_name":"BH4 biosynthesis","score":0.6460000276565552},{"id":"https://openalex.org/keywords/casein-kinase-2","display_name":"casein kinase 2","score":0.8140000104904175},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.8349999785423279},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.8830000162124634},{"id":"https://openalex.org/keywords/th2-polarization","display_name":"Th2 polarization","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.75},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C2776145790","wikidata":"https://www.wikidata.org/wiki/Q419808","display_name":"Tetrahydrobiopterin","level":4,"score":0.7686955332756042},{"id":"https://openalex.org/C2775956414","wikidata":"https://www.wikidata.org/wiki/Q1487359","display_name":"GTP cyclohydrolase I","level":5,"score":0.7641964554786682},{"id":"https://openalex.org/C2777451243","wikidata":"https://www.wikidata.org/wiki/Q408256","display_name":"Biopterin","level":5,"score":0.7304695844650269},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4912227988243103},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.4614284336566925},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4287322461605072},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41782140731811523},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4135550856590271},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3444356918334961},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.340842068195343},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33885592222213745},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30345821380615234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28105536103248596},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2085261046886444},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.18533068895339966},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14402875304222107},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.08951276540756226},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08177083730697632}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.24.1_supplement.lb187","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.lb187","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.lb187","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1754020608","display_name":"Immunity, Inflammation and Hypertension","funder_award_id":"R01HL039006","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6633342236","display_name":"Interactions Between Inflammation, Oxidant Stress and Cardiovascular Disease","funder_award_id":"P01HL058000","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1989089149","https://openalex.org/W2900171085","https://openalex.org/W1972816103","https://openalex.org/W123039622","https://openalex.org/W1986330406","https://openalex.org/W2095080894","https://openalex.org/W2147832891","https://openalex.org/W70806202","https://openalex.org/W2151166614","https://openalex.org/W2322501567"],"abstract_inverted_index":{"Recently,":[0],"we":[1,32],"found":[2],"that":[3,92],"phosphorylation":[4,98,109],"of":[5,49,54,103,119,142],"GTP":[6],"cyclohydrolase\u20101":[7],"(GTPCH\u20101),":[8],"the":[9,112],"rate\u2010limiting":[10],"enzyme":[11],"for":[12],"BH4":[13,19,50,129,189],"biosynthesis,":[14],"increases":[15,179],"its":[16],"activity":[17,181],"and":[18,39,51,67,69,86,110,131,145,182,208],"levels":[20,48,75],"in":[21,29,37,40,84,114,153,159,165],"endothelial":[22,56],"cells.":[23,88,156],"To":[24],"determine":[25],"if":[26],"this":[27,93,193],"occurs":[28],"non\u2010endothelial":[30],"cells,":[31],"stimulated":[33],"T":[34,43,64,115,127,133,166,170,196],"cells":[35,44],"both":[36,143],"vitro":[38],"vivo.":[41],"Na\u00efve":[42],"had":[45],"nearly":[46],"undetectable":[47,74],"minimal":[52],"expression":[53],"either":[55],"or":[57],"inducible":[58],"NOS.":[59],"Anti\u2010CD3":[60],"stimulation":[61],"robustly":[62],"induced":[63],"cell":[65,116,128,134,167,171,197],"eNOS":[66,144],"iNOS":[68],"increased":[70,132],"biopterin":[71,183],"from":[72],"near":[73],"to":[76],"5.4":[77],"pMol/mg":[78],"protein.":[79],"Biopterin":[80],"induction":[81],"was":[82,94,138,201],"similar":[83],"CD4":[85,155],"CD8":[87],"Western":[89],"blots":[90],"showed":[91],"associated":[95,174],"with":[96,121,175],"GTPCH\u20101":[97,108,120,147,176,180],"at":[99],"S72.":[100],"Pharmacological":[101],"inhibition":[102,148],"casein":[104],"kinase":[105],"II":[106],"prevented":[107,126],"blunted":[111],"increase":[113,164],"BH4.":[117,168],"Inhibition":[118],"diaminohdroxypyimidine":[122],"(DAHP,":[123],"500":[124],"\u03bcm)":[125],"accumulation":[130],"superoxide":[135],"production,":[136],"which":[137,178],"dependent":[139],"on":[140],"uncoupling":[141],"iNOS.":[146],"also":[149],"promoted":[150],"TH2":[151],"polarization":[152],"memory":[154],"OVA":[157],"immunization":[158],"vivo":[160],"confirmed":[161],"a":[162],"marked":[163],"Thus,":[169],"activation":[172],"is":[173,191],"phosphorylation,":[177],"production.":[184],"In":[185],"inflammatory":[186],"settings":[187],"where":[188],"oxidation":[190],"favored,":[192],"could":[194],"modulate":[195],"function.":[198],"This":[199],"study":[200],"supported":[202],"by":[203],"NIH":[204],"grants":[205],"PO1":[206],"HL58000":[207],"RO1":[209],"HL39006.":[210]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-05-11T00:00:00"}
