{"id":"https://openalex.org/W4230194856","doi":"https://doi.org/10.1172/jci200215175","title":"T cell homeostatic proliferation elicits effective antitumor autoimmunity","display_name":"T cell homeostatic proliferation elicits effective antitumor autoimmunity","publication_year":2002,"publication_date":"2002-07-15","ids":{"openalex":"https://openalex.org/W4230194856","doi":"https://doi.org/10.1172/jci200215175"},"language":"en","primary_location":{"id":"doi:10.1172/jci200215175","doi":"https://doi.org/10.1172/jci200215175","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci200215175","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090275347","display_name":"Wolfgang Dummer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wolfgang Dummer","raw_affiliation_strings":["Department of Immunology, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000135035","display_name":"Andreas G. Niethammer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andreas G. Niethammer","raw_affiliation_strings":["Department of Immunology, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088597500","display_name":"Roberto Baccal\u00e0","orcid":"https://orcid.org/0000-0002-3159-8469","observed_orcids":["https://orcid.org/0000-0002-3159-8469"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberto Baccala","raw_affiliation_strings":["Department of Immunology, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108215825","display_name":"Brian R. Lawson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian R. Lawson","raw_affiliation_strings":["Department of Immunology, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101678689","display_name":"Norbert Wagner","orcid":"https://orcid.org/0000-0003-2477-7255","observed_orcids":["https://orcid.org/0000-0003-2477-7255"]},"institutions":[{"id":"https://openalex.org/I4210127529","display_name":"Klinikum Dortmund","ror":"https://ror.org/037pq2a43","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210127529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Norbert Wagner","raw_affiliation_strings":["Department of Pediatrics, Klinikum Dortmund, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Klinikum Dortmund, Dortmund, Germany","institution_ids":["https://openalex.org/I4210127529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103782744","display_name":"Ralph A. Reisfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph A. Reisfeld","raw_affiliation_strings":["Department of Immunology, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108420436","display_name":"Argyrios N. Theofilopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Argyrios N. Theofilopoulos","raw_affiliation_strings":["Department of Immunology, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108420436"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":0.7666,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.70900538,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"110","issue":"2","first_page":"185","last_page":"192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5576000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5576000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.40939998626708984,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-homeostatic-proliferation","display_name":"T cell homeostatic proliferation","score":0.925000011920929},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6809999942779541},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.7609999775886536},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9039999842643738},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8550000190734863},{"id":"https://openalex.org/keywords/tumor-antigen-presentation","display_name":"tumor antigen presentation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/lymph-nodes","display_name":"lymph nodes","score":0.6100000143051147},{"id":"https://openalex.org/keywords/tumor-selective-cytotoxicity","display_name":"tumor-specific cytotoxicity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/t-cell-memory","display_name":"T cell memory","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.7965233325958252},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.6064160466194153},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5312661528587341},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.48587626218795776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40481072664260864},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37791526317596436},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.25751975178718567},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0879562497138977}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1172/jci200215175","doi":"https://doi.org/10.1172/jci200215175","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci200215175","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1493538138","https://openalex.org/W1501905334","https://openalex.org/W1537543309","https://openalex.org/W1577612079","https://openalex.org/W1623460711","https://openalex.org/W1763148533","https://openalex.org/W1803257539","https://openalex.org/W1964010927","https://openalex.org/W1974620735","https://openalex.org/W1987403252","https://openalex.org/W1993149812","https://openalex.org/W1999685520","https://openalex.org/W2003663896","https://openalex.org/W2013360299","https://openalex.org/W2031998530","https://openalex.org/W2036530328","https://openalex.org/W2036851895","https://openalex.org/W2040796340","https://openalex.org/W2041354260","https://openalex.org/W2051641513","https://openalex.org/W2055539643","https://openalex.org/W2057182724","https://openalex.org/W2083500661","https://openalex.org/W2085687864","https://openalex.org/W2099326339","https://openalex.org/W2107140931","https://openalex.org/W2107225522","https://openalex.org/W2107629538","https://openalex.org/W2143078668","https://openalex.org/W2145933283","https://openalex.org/W2148911309","https://openalex.org/W2151342537","https://openalex.org/W2155778479","https://openalex.org/W2158606911","https://openalex.org/W2160430737"],"related_works":["https://openalex.org/W2067704011","https://openalex.org/W2103401225","https://openalex.org/W2028512647","https://openalex.org/W2152467424","https://openalex.org/W7066249081","https://openalex.org/W2347871340","https://openalex.org/W2358169999","https://openalex.org/W2081100902","https://openalex.org/W2025177756","https://openalex.org/W1995109339"],"abstract_inverted_index":{"Development":[0],"of":[1,36,77,117,121],"tumor":[2,58,127],"immunotherapies":[3],"focuses":[4],"on":[5,74],"inducing":[6],"autoimmune":[7,137],"responses":[8,22],"against":[9],"tumor-associated":[10],"self-antigens":[11],"primarily":[12],"encoded":[13],"by":[14,26,96],"normal,":[15],"unmutated":[16],"genes.":[17],"We":[18],"hypothesized":[19],"that":[20,45,114],"such":[21],"could":[23],"be":[24],"elicited":[25],"T":[27,37,55,80,98,123],"cell":[28,81,124],"homeostatic":[29,75,122],"proliferation":[30,125],"in":[31,130],"the":[32,70,118],"periphery,":[33],"involving":[34],"expansion":[35,76],"cells":[38,56],"recognizing":[39],"self-MHC/peptide":[40],"ligands.":[41],"Herein,":[42],"we":[43],"demonstrate":[44],"sublethally":[46],"irradiated":[47],"lymphopenic":[48],"mice":[49],"transfused":[50],"with":[51,63,108],"autologous":[52],"or":[53,65],"syngeneic":[54],"showed":[57],"growth":[59],"inhibition":[60],"when":[61],"challenged":[62],"melanoma":[64],"colon":[66],"carcinoma":[67],"cells.":[68],"Importantly,":[69],"antitumor":[71,136],"response":[72,87],"depended":[73],"a":[78,134],"polyclonal":[79],"population":[82],"within":[83],"lymph":[84,131],"nodes.":[85],"This":[86],"was":[88,94,106],"effective":[89],"even":[90],"for":[91],"established":[92],"tumors,":[93],"characterized":[95],"CD8+":[97],"cell\u2013mediated":[99],"tumor-specific":[100],"cytotoxicity":[101],"and":[102,105,126],"IFN-\u03b3":[103],"production,":[104],"associated":[107],"long-term":[109],"memory.":[110],"The":[111],"results":[112],"indicate":[113],"concomitant":[115],"induction":[116],"physiologic":[119],"processes":[120],"antigen":[128],"presentation":[129],"nodes":[132],"triggers":[133],"beneficial":[135],"response.":[138]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-05-11T00:00:00"}
