{"id":"https://openalex.org/W4230141107","doi":"https://doi.org/10.3109/9780849375965-6","title":"Hydrolytic Pathways","display_name":"Hydrolytic Pathways","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W4230141107","doi":"https://doi.org/10.3109/9780849375965-6"},"language":"en","primary_location":{"id":"doi:10.3109/9780849375965-6","doi":"https://doi.org/10.3109/9780849375965-6","is_oa":false,"landing_page_url":"https://doi.org/10.3109/9780849375965-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4251941377","display_name":"Drug Metabolism"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039008828","display_name":"Jack Uetrecht","orcid":"https://orcid.org/0000-0003-1024-1302","observed_orcids":["https://orcid.org/0000-0003-1024-1302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jack P. Uetrecht","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111461042","display_name":"William F. Trager","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Trager","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.35816619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"120","last_page":"129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrolytic-enzymes","display_name":"hydrolytic enzymes","score":0.8360000252723694},{"id":"https://openalex.org/keywords/butyrylcholinesterase","display_name":"butyrylcholinesterase","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cholinesterase","display_name":"cholinesterase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/carboxylesterase","display_name":"carboxylesterase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/paraoxonase","display_name":"paraoxonase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/acetylation","display_name":"acetylation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/succinylcholine","display_name":"succinylcholine","score":0.8230000138282776},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/protein-digestion","display_name":"protein digestion","score":0.6399999856948853},{"id":"https://openalex.org/keywords/dihydrodiols","display_name":"dihydrodiols","score":0.7020000219345093},{"id":"https://openalex.org/keywords/epoxide-metabolites","display_name":"epoxide metabolites","score":0.7179999947547913},{"id":"https://openalex.org/keywords/glucuronide-conjugates","display_name":"glucuronide conjugates","score":0.953000009059906},{"id":"https://openalex.org/keywords/conjugate-hydrolysis","display_name":"conjugate hydrolysis","score":0.828000009059906},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.4790000021457672},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9340000152587891}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3276945650577545},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32562610507011414}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3109/9780849375965-6","doi":"https://doi.org/10.3109/9780849375965-6","is_oa":false,"landing_page_url":"https://doi.org/10.3109/9780849375965-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2429640894","https://openalex.org/W2041666513","https://openalex.org/W2076536739","https://openalex.org/W2415429189","https://openalex.org/W2149744136","https://openalex.org/W2257391775","https://openalex.org/W2139671669","https://openalex.org/W20701370","https://openalex.org/W2430156078","https://openalex.org/W2008739886"],"abstract_inverted_index":{"The":[0,52,116],"highest":[1],"hydrolytic":[2,21],"activity":[3],"is":[4,12,64,129],"in":[5,14],"the":[6,9,15,35,43,85,97,102,130,154],"liver,":[7],"but":[8],"enzyme":[10,48],"pseudocholinesterase":[11],"found":[13],"serum.":[16],"Gut":[17],"bacteria":[18],"also":[19,56,149],"contain":[20],"enzymes.":[22],"Esterases":[23],"that":[24,126],"contribute":[25],"to":[26,61,76,100,153],"human":[27],"drug":[28,62],"metabolism":[29,63],"fall":[30],"into":[31,96,111],"three":[32],"major":[33],"classes:":[34],"cholinesterases,":[36],"carboxylesterase,":[37],"and":[38,49,107,143],"paraoxonase.":[39],"Subsequent":[40],"hydrolysis":[41,103],"of":[42,54,91,104,118,140,145],"acetylated":[44],"species":[45],"regenerates":[46],"active":[47],"acetic":[50],"acid.":[51],"contribution":[53],"pseudocholinesterase,":[55],"known":[57],"simply":[58],"as":[59,67,124],"cholinesterase,":[60],"much":[65],"greater":[66],"it":[68,78],"possesses":[69],"considerably":[70],"broader":[71],"substrate":[72],"selectivity.":[73],"In":[74],"addition":[75],"acetylcholine,":[77],"will":[79],"hydrolyze":[80],"other":[81],"choline":[82],"esters":[83],"like":[84],"muscle":[86],"relaxant":[87],"succinylcholine.":[88],"A":[89],"number":[90],"proteolytic":[92],"enzymes":[93],"are":[94],"excreted":[95],"digestive":[98],"tract":[99],"affect":[101],"ingested":[105],"proteins":[106],"break":[108],"them":[109],"down":[110],"their":[112],"constitutive":[113],"amino":[114],"acids.":[115],"observation":[117],"a":[119,137],"dihydrodiol":[120],"has":[121],"been":[122],"taken":[123],"proof":[125],"an":[127],"epoxide":[128],"precursor":[131],"metabolite.":[132],"Glucuronide":[133],"conjugates":[134,147],"can":[135,148],"involve":[136],"wider":[138],"variety":[139],"functional":[141],"groups":[142],"many":[144],"these":[146],"be":[150],"hydrolyzed":[151],"back":[152],"parent":[155],"drugs.":[156]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-11T00:00:00"}