{"id":"https://openalex.org/W4230129623","doi":"https://doi.org/10.1111/j.1365-2133.1996.tb03607.x","title":"Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds","display_name":"Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W4230129623","doi":"https://doi.org/10.1111/j.1365-2133.1996.tb03607.x","mag":"2026244310","pmid":"https://pubmed.ncbi.nlm.nih.gov/8776359"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2133.1996.tb03607.x","doi":"https://doi.org/10.1111/j.1365-2133.1996.tb03607.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.1996.tb03607.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045261376","display_name":"Maarit Vaalamo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"M. VAALAMO","raw_affiliation_strings":["Department of Medical Genetics, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034763307","display_name":"Miina Weckroth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"M. WECKROTH","raw_affiliation_strings":["Department of Virology, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034799855","display_name":"Pauli Antero Puolakkainen","orcid":"https://orcid.org/0000-0003-2489-4371","observed_orcids":["https://orcid.org/0000-0003-2489-4371"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"P. PUOLAKKAINEN","raw_affiliation_strings":["Department of Surgery, Helsinki University Central Hospital. Meilahdentie 2, FIN\u201000250 Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Helsinki University Central Hospital. Meilahdentie 2, FIN\u201000250 Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100712980","display_name":"Juha Kere","orcid":"https://orcid.org/0000-0003-1974-0271","observed_orcids":["https://orcid.org/0000-0003-1974-0271"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"J. KERE","raw_affiliation_strings":["Department of Medical Genetics, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. SAARINEN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"P. SAARINEN","raw_affiliation_strings":["Department of Plastic Surgery, Helsinki University Central Hospital. Meilahdentie 2, FIN\u201000250 Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Helsinki University Central Hospital. Meilahdentie 2, FIN\u201000250 Helsinki","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043137538","display_name":"Jorma Lauharanta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"J. LAUHARANTA","raw_affiliation_strings":["Departments of Dermatology, Helsinki University Central Hospital. Meilahdentie 2, FIN\u201000250 Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, Helsinki University Central Hospital. Meilahdentie 2, FIN\u201000250 Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016790531","display_name":"Ulpu Saarialho\u2010Kere","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"U.K. SAARIALHO-KERE","raw_affiliation_strings":["Departments of Dermatology, Helsinki University Central Hospital. Meilahdentie 2, FIN\u201000250 Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, Helsinki University Central Hospital. Meilahdentie 2, FIN\u201000250 Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016790531"],"corresponding_institution_ids":["https://openalex.org/I2800394112"],"apc_list":{"value":3731,"currency":"GBP","value_usd":4920},"apc_paid":null,"fwci":19.2861,"has_fulltext":false,"cited_by_count":235,"citation_normalized_percentile":{"value":0.9964217,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"135","issue":"1","first_page":"52","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.07840000092983246,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9980000257492065},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.8840000033378601},{"id":"https://openalex.org/keywords/venous-ulcers","display_name":"venous ulcers","score":0.7549999952316284},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8379999995231628},{"id":"https://openalex.org/keywords/collagenase","display_name":"collagenase","score":0.8949999809265137},{"id":"https://openalex.org/keywords/stromelysin-1","display_name":"stromelysin-1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/stromelysin-2","display_name":"stromelysin-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/matrilysin","display_name":"matrilysin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.996999979019165},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9570000171661377}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.807749330997467},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6162289977073669},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6075349450111389},{"id":"https://openalex.org/C2991819120","wikidata":"https://www.wikidata.org/wiki/Q13033749","display_name":"Matrix metalloproteinase 9","level":3,"score":0.5014832019805908},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.46631062030792236},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23869693279266357},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21912187337875366}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014647","descriptor_name":"Varicose Ulcer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019714","descriptor_name":"Tissue Inhibitor of Metalloproteinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061965","descriptor_name":"Matrix Metalloproteinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1365-2133.1996.tb03607.x","doi":"https://doi.org/10.1111/j.1365-2133.1996.tb03607.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.1996.tb03607.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"doi:10.1046/j.1365-2133.1996.d01-932.x","doi":"https://doi.org/10.1046/j.1365-2133.1996.d01-932.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2133.1996.d01-932.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:8776359","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8776359","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of dermatology","raw_type":"Journal Article"},{"id":"mag:2026244310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8776359","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W68079187","https://openalex.org/W167520850","https://openalex.org/W643742543","https://openalex.org/W1583431816","https://openalex.org/W1886532383","https://openalex.org/W1967703995","https://openalex.org/W1980030028","https://openalex.org/W1980480613","https://openalex.org/W1983187343","https://openalex.org/W1991898537","https://openalex.org/W1992947181","https://openalex.org/W1995721306","https://openalex.org/W1999632736","https://openalex.org/W2003249540","https://openalex.org/W2007605838","https://openalex.org/W2009155717","https://openalex.org/W2013077332","https://openalex.org/W2022302688","https://openalex.org/W2024580059","https://openalex.org/W2024794839","https://openalex.org/W2025979487","https://openalex.org/W2027150670","https://openalex.org/W2041687576","https://openalex.org/W2057055923","https://openalex.org/W2066741376","https://openalex.org/W2069837802","https://openalex.org/W2076950376","https://openalex.org/W2082686603","https://openalex.org/W2085804760","https://openalex.org/W2088497174","https://openalex.org/W2097439538","https://openalex.org/W2109658199","https://openalex.org/W2121818137","https://openalex.org/W2131708693","https://openalex.org/W2183019695","https://openalex.org/W2253389883","https://openalex.org/W2618158098","https://openalex.org/W6685837867"],"related_works":["https://openalex.org/W1550844056","https://openalex.org/W2042396998","https://openalex.org/W2270677908","https://openalex.org/W7006342256","https://openalex.org/W7135491873","https://openalex.org/W2056105344","https://openalex.org/W6987583732","https://openalex.org/W4378375903","https://openalex.org/W2015031004","https://openalex.org/W2028147193"],"abstract_inverted_index":{"The":[0],"present":[1],"study":[2],"was":[3,31,98,109],"carried":[4],"out":[5],"to":[6,33],"characterize":[7],"the":[8,112,126],"patterns":[9],"of":[10,12,115],"expression":[11],"matrix":[13],"metalloproteinases":[14],"or":[15],"their":[16,131],"tissue":[17],"inhibitor":[18,132],"(TIMP-1)":[19],"in":[20,46,65,86,88,101,136],"normally":[21,53],"healing,":[22],"acute":[23,90,117],"vs.":[24],"chronic,":[25],"skin":[26],"wounds.":[27,121,139],"In":[28],"situ":[29],"hybridization":[30],"performed":[32],"localize":[34],"collagenase,":[35],"stromelysin-1,":[36],"stromelysin-2,":[37],"matrilysin,":[38],"urokinase":[39],"plasminogen":[40],"activator":[41],"(uPA)":[42],"and":[43,51,78,91,119,130],"TIMP-1":[44,96,108],"mRNAs":[45],"14":[47],"chronic":[48,92,103],"venous":[49],"ulcers":[50],"10":[52],"healing":[54,138],"wounds,":[55,63,93],"representing":[56],"different":[57],"time":[58,70],"points":[59],"after":[60],"wounding.":[61],"Surgical":[62],"made":[64],"piglets":[66],"harvested":[67],"at":[68,111],"several":[69],"points,":[71],"were":[72,84],"studied":[73],"as":[74,80,82],"controls.":[75],"Collagenase,":[76],"stromelysin-1":[77],"-2,":[79],"well":[81],"uPa,":[83],"expressed":[85,110],"keratinocytes":[87],"both":[89,116],"while":[94],"epithelial":[95,113],"mRNA":[97],"not":[99],"detected":[100],"any":[102],"wound":[104],"biopsies":[105],"studied.":[106],"However,":[107],"edges":[114],"human":[118],"pig":[120],"Our":[122],"results":[123],"suggest":[124],"that":[125],"balance":[127],"between":[128],"metalloenzymes":[129],"TIMP-1,":[133],"is":[134],"disturbed,":[135],"poorly":[137]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-11T00:00:00"}
