{"id":"https://openalex.org/W4230043615","doi":"https://doi.org/10.36721/pjps.2020.33.1.reg.021-026.1","title":"Yishenhuoxue formula regulates TGF-b/Smad signal transduction to protect rats against Diabetic kidney disease injury","display_name":"Yishenhuoxue formula regulates TGF-b/Smad signal transduction to protect rats against Diabetic kidney disease injury","publication_year":2019,"publication_date":"2019-12-23","ids":{"openalex":"https://openalex.org/W4230043615","doi":"https://doi.org/10.36721/pjps.2020.33.1.reg.021-026.1","mag":"3013553465","pmid":"https://pubmed.ncbi.nlm.nih.gov/32122826"},"language":"en","primary_location":{"id":"doi:10.36721/pjps.2020.33.1.reg.021-026.1","doi":"https://doi.org/10.36721/pjps.2020.33.1.reg.021-026.1","is_oa":true,"landing_page_url":"https://doi.org/10.36721/pjps.2020.33.1.reg.021-026.1","pdf_url":null,"source":{"id":"https://openalex.org/S24112332","display_name":"Pakistan Journal of Pharmaceutical Sciences","issn_l":"1011-601X","issn":["1011-601X","3105-9686"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319291","host_organization_name":"University of Karachi","host_organization_lineage":["https://openalex.org/P4310319291"],"host_organization_lineage_names":["University of Karachi"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.36721/pjps.2020.33.1.reg.021-026.1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101497129","display_name":"Na Du","orcid":"https://orcid.org/0000-0001-9540-5876","observed_orcids":["https://orcid.org/0000-0001-9540-5876"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Du","raw_affiliation_strings":["Department of Pharmacology, Jilin University, Jilin Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Jilin University, Jilin Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011014273","display_name":"Shunan Liu","orcid":"https://orcid.org/0000-0003-0765-4579","observed_orcids":["https://orcid.org/0000-0003-0765-4579"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shunan Liu","raw_affiliation_strings":["Department of Pharmacology, Jilin University, Jilin Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Jilin University, Jilin Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006601317","display_name":"Chongshuang Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chongshuang Cui","raw_affiliation_strings":["Department of Pharmacology, Jilin University, Jilin Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Jilin University, Jilin Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103078753","display_name":"Hao Fang","orcid":"https://orcid.org/0000-0001-8530-3999","observed_orcids":["https://orcid.org/0000-0001-8530-3999"]},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Hao","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102877062","display_name":"Mingyue Gao","orcid":"https://orcid.org/0009-0009-6283-8929","observed_orcids":["https://orcid.org/0009-0009-6283-8929","https://orcid.org/0000-0002-9701-5908"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingyue Gao","raw_affiliation_strings":["Department of Pharmacology, Jilin University, Jilin Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Jilin University, Jilin Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025816237","display_name":"Zhiping Xu","orcid":"https://orcid.org/0000-0002-7885-8926","observed_orcids":["https://orcid.org/0000-0002-7885-8926"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiping Xu","raw_affiliation_strings":["Department of Pharmacology, Jilin University, Jilin Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Jilin University, Jilin Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101712465","display_name":"Xia Cao","orcid":"https://orcid.org/0000-0002-2668-9374","observed_orcids":["https://orcid.org/0000-0002-2668-9374"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Cao","raw_affiliation_strings":["Department of Pharmacology, Jilin University, Jilin Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Jilin University, Jilin Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1924,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.52766042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"33","issue":"1","first_page":"21","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Traditional Chinese Medicine Clinical Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tgf-beta-smad-signaling-pathway","display_name":"TGF-\u03b2/Smad signaling","score":0.9750000238418579},{"id":"https://openalex.org/keywords/smad2-3-phosphorylation","display_name":"Smad2/3 phosphorylation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/smad7","display_name":"Smad7","score":0.9990000128746033},{"id":"https://openalex.org/keywords/connective-tissue-growth-factor","display_name":"connective tissue growth factor","score":0.8230000138282776},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9120000004768372},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.7070000171661377},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.6990000009536743},{"id":"https://openalex.org/keywords/glomerular-basement-membrane","display_name":"glomerular basement membrane","score":0.6970000267028809},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33411210775375366}],"mesh":[{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.36721/pjps.2020.33.1.reg.021-026.1","doi":"https://doi.org/10.36721/pjps.2020.33.1.reg.021-026.1","is_oa":true,"landing_page_url":"https://doi.org/10.36721/pjps.2020.33.1.reg.021-026.1","pdf_url":null,"source":{"id":"https://openalex.org/S24112332","display_name":"Pakistan Journal of Pharmaceutical Sciences","issn_l":"1011-601X","issn":["1011-601X","3105-9686"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319291","host_organization_name":"University of Karachi","host_organization_lineage":["https://openalex.org/P4310319291"],"host_organization_lineage_names":["University of Karachi"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:32122826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32122826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Journal Article"},{"id":"mag:3013553465","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pubmed/32122826","pdf_url":null,"source":{"id":"https://openalex.org/S24112332","display_name":"Pakistan Journal of Pharmaceutical Sciences","issn_l":"1011-601X","issn":["1011-601X","3105-9686"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319291","host_organization_name":"University of Karachi","host_organization_lineage":["https://openalex.org/P4310319291"],"host_organization_lineage_names":["University of Karachi"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences","raw_type":null}],"best_oa_location":{"id":"doi:10.36721/pjps.2020.33.1.reg.021-026.1","doi":"https://doi.org/10.36721/pjps.2020.33.1.reg.021-026.1","is_oa":true,"landing_page_url":"https://doi.org/10.36721/pjps.2020.33.1.reg.021-026.1","pdf_url":null,"source":{"id":"https://openalex.org/S24112332","display_name":"Pakistan Journal of Pharmaceutical Sciences","issn_l":"1011-601X","issn":["1011-601X","3105-9686"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319291","host_organization_name":"University of Karachi","host_organization_lineage":["https://openalex.org/P4310319291"],"host_organization_lineage_names":["University of Karachi"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3013553465","https://openalex.org/W4320498065","https://openalex.org/W1966155617","https://openalex.org/W1040388885","https://openalex.org/W3205985810","https://openalex.org/W7096176411","https://openalex.org/W394371989","https://openalex.org/W7221443779","https://openalex.org/W3143574205","https://openalex.org/W2267470350"],"abstract_inverted_index":{"TGF-\u03b2":[0],"signal":[1,22,229],"pathway":[2],"activation":[3],"is":[4,141],"vital":[5],"in":[6,24,150,163,192,205,231],"the":[7,15,79,112,180],"pathogenesis":[8],"of":[9,17,65,81,114,179,194,207,238,241,248],"DKD.":[10],"We":[11,128],"aim":[12],"to":[13,98,110],"investigate":[14],"role":[16],"Yishenhuoxue":[18,51,59,131,221],"formula":[19,52,60,132,222],"on":[20,227],"TGF-\u03b2/Smad":[21,228],"transduction":[23,230],"DKD":[25,138,232],"rats.":[26],"60":[27],"male":[28],"adult":[29],"Wistar":[30],"rats":[31],"were":[32,72,87,96,108],"enrolled":[33],"and":[34,55,85,105,122,157,173,199,210,245],"randomly":[35],"allocated":[36],"into":[37],"four":[38],"groups:":[39],"N":[40],"group,":[41],"M":[42,169,186,214],"group":[43,49,57,215],"(given":[44,50,58],"STZ":[45],"60mg/kg,":[46],"ip),":[47],"H":[48],"1.0g/kg/day,":[53],"ig)":[54],"L":[56],"0.5g/kg/day,":[61],"ig).":[62],"The":[63,92,217],"levels":[64,80,113,193,206],"BW,":[66,164],"24h":[67,153],"UV,":[68,154],"SCr,":[69,155],"UCr,":[70,165],"mALB":[71,156],"measured":[73],"after":[74],"8":[75],"weeks":[76],"treatment,":[77],"while":[78,159,201],"KW/BW":[82,151],"index,":[83,152],"CCr":[84,166],"UAER":[86],"calculated":[88],"by":[89,102,124,235],"relevant":[90],"formula.":[91],"rats'":[93,233],"left":[94],"kidneys":[95,107,136,234],"harvested":[97,109],"detect":[99,111],"histological":[100],"changes":[101,175],"PAS":[103],"staining":[104],"right":[106],"TGF-\u03b2,":[115],"Smad2/3,":[116],"phosphorylated":[117,196],"Smad":[118,120,197,208,242,249],"2/3,":[119],"7":[121],"CTGF":[123],"western":[125],"blot":[126],"analysis.":[127],"found":[129],"that":[130,220],"treatment":[133],"can":[134],"protect":[135],"from":[137],"injury,":[139],"which":[140],"illustrated":[142],"with":[143,185,213],"following":[144],"criteria:":[145],"1)":[146],"a":[147,160],"significant":[148,161],"decrement":[149],"UAER,":[158],"increment":[162],"(p<0.05":[167],"vs.":[168],"group);":[170],"2)":[171],"minor":[172],"segmental":[174],"as":[176],"slight":[177],"expansion":[178],"glomerular":[181],"basement":[182],"membrane":[183],"compared":[184,212],"group;":[187],"3)":[188],"an":[189,202],"apparent":[190,203],"decrease":[191],"TGF-\u03b21,":[195,239],"2/3":[198,209,243],"CTGF,":[200],"increase":[204],"Smad7":[211],"(p<0.05).":[216],"studies":[218],"confirm":[219],"has":[223],"strong":[224],"inhibitory":[225],"effect":[226],"decreasing":[236],"expression":[237,247],"weakening":[240],"phosphorylation":[244],"increasing":[246],"7.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-05-11T00:00:00"}