{"id":"https://openalex.org/W4230013634","doi":"https://doi.org/10.21203/rs.3.rs-826367/v1","title":"Purification and Characterization of Bioactive Compounds Extracted from Suaeda Maritima Leaf and its Impact on Pathogenicity of Pseudomonas Aeruginosa in Catla Catla Fingerlings","display_name":"Purification and Characterization of Bioactive Compounds Extracted from Suaeda Maritima Leaf and its Impact on Pathogenicity of Pseudomonas Aeruginosa in Catla Catla Fingerlings","publication_year":2021,"publication_date":"2021-08-31","ids":{"openalex":"https://openalex.org/W4230013634","doi":"https://doi.org/10.21203/rs.3.rs-826367/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-826367/v1","doi":"https://doi.org/10.21203/rs.3.rs-826367/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-826367/v1","pdf_url":"https://www.researchsquare.com/article/rs-826367/v1.pdf?c=1637263501000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-826367/v1.pdf?c=1637263501000","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075912949","display_name":"G. Beulah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177001074","display_name":"Acharya Nagarjuna University","ror":"https://ror.org/02mfapa96","country_code":"IN","type":"education","lineage":["https://openalex.org/I177001074"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Beulah G","raw_affiliation_strings":["Acharya Nagarjuna University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acharya Nagarjuna University","institution_ids":["https://openalex.org/I177001074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Divya D","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177001074","display_name":"Acharya Nagarjuna University","ror":"https://ror.org/02mfapa96","country_code":"IN","type":"education","lineage":["https://openalex.org/I177001074"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Divya D","raw_affiliation_strings":["Acharya Nagarjuna University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acharya Nagarjuna University","institution_ids":["https://openalex.org/I177001074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061282101","display_name":"N. S. Sampath Kumar","orcid":"https://orcid.org/0000-0002-8577-2143","observed_orcids":["https://orcid.org/0000-0002-8577-2143"]},"institutions":[{"id":"https://openalex.org/I149313025","display_name":"Vignan's Foundation for Science, Technology & Research","ror":"https://ror.org/03bzf1g85","country_code":"IN","type":"education","lineage":["https://openalex.org/I149313025"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sampath Kumar N.S.","raw_affiliation_strings":["Vignan's Foundation for Science Technology and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vignan's Foundation for Science Technology and Research","institution_ids":["https://openalex.org/I149313025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000392669","display_name":"M. V. N. Sravya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177001074","display_name":"Acharya Nagarjuna University","ror":"https://ror.org/02mfapa96","country_code":"IN","type":"education","lineage":["https://openalex.org/I177001074"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sravya M.V.N.","raw_affiliation_strings":["Acharya Nagarjuna University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acharya Nagarjuna University","institution_ids":["https://openalex.org/I177001074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023295636","display_name":"Govinda Rao K","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177001074","display_name":"Acharya Nagarjuna University","ror":"https://ror.org/02mfapa96","country_code":"IN","type":"education","lineage":["https://openalex.org/I177001074"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Govinda Rao K","raw_affiliation_strings":["Acharya Nagarjuna University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acharya Nagarjuna University","institution_ids":["https://openalex.org/I177001074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038612427","display_name":"Anjani Devi Chintagunta","orcid":"https://orcid.org/0000-0003-0807-8411","observed_orcids":["https://orcid.org/0000-0003-0807-8411"]},"institutions":[{"id":"https://openalex.org/I149313025","display_name":"Vignan's Foundation for Science, Technology & Research","ror":"https://ror.org/03bzf1g85","country_code":"IN","type":"education","lineage":["https://openalex.org/I149313025"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anjani Devi Chintagunta","raw_affiliation_strings":["Vignan's Foundation for Science Technology and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vignan's Foundation for Science Technology and Research","institution_ids":["https://openalex.org/I149313025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028160815","display_name":"Gubba Divya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149313025","display_name":"Vignan's Foundation for Science, Technology & Research","ror":"https://ror.org/03bzf1g85","country_code":"IN","type":"education","lineage":["https://openalex.org/I149313025"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Divya G","raw_affiliation_strings":["Vignan's Foundation for Science Technology and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vignan's Foundation for Science Technology and Research","institution_ids":["https://openalex.org/I149313025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080308519","display_name":"Hari Chandana S","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149313025","display_name":"Vignan's Foundation for Science, Technology & Research","ror":"https://ror.org/03bzf1g85","country_code":"IN","type":"education","lineage":["https://openalex.org/I149313025"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hari Chandana S","raw_affiliation_strings":["Vignan's Foundation for Science Technology and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vignan's Foundation for Science Technology and Research","institution_ids":["https://openalex.org/I149313025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004477565","display_name":"B. D. Blessy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149313025","display_name":"Vignan's Foundation for Science, Technology & Research","ror":"https://ror.org/03bzf1g85","country_code":"IN","type":"education","lineage":["https://openalex.org/I149313025"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Blessy Beulah Dantu","raw_affiliation_strings":["Vignan's Foundation for Science Technology and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vignan's Foundation for Science Technology and Research","institution_ids":["https://openalex.org/I149313025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109590863","display_name":"G. Simhachalam","orcid":"https://orcid.org/0000-0001-8952-2400","observed_orcids":["https://orcid.org/0000-0001-8952-2400"]},"institutions":[{"id":"https://openalex.org/I177001074","display_name":"Acharya Nagarjuna University","ror":"https://ror.org/02mfapa96","country_code":"IN","type":"education","lineage":["https://openalex.org/I177001074"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"SIMHACHALAM GULLI PALLI","raw_affiliation_strings":["Acharya Nagarjuna University"],"raw_orcid":"https://orcid.org/0000-0001-8952-2400","affiliations":[{"raw_affiliation_string":"Acharya Nagarjuna University","institution_ids":["https://openalex.org/I177001074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109590863"],"corresponding_institution_ids":["https://openalex.org/I177001074"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.2563000023365021,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/suaeda-maritima","display_name":"Suaeda maritima","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9200000166893005},{"id":"https://openalex.org/keywords/catla-catla","display_name":"Catla catla","score":0.921999990940094},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.8859999775886536},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ethanolic-leaf-extract","display_name":"ethanolic leaf extract","score":0.8330000042915344},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.5460000038146973},{"id":"https://openalex.org/keywords/saponins","display_name":"saponins","score":0.8939999938011169},{"id":"https://openalex.org/keywords/fish-bacterial-disease","display_name":"fish bacterial disease","score":0.6019999980926514},{"id":"https://openalex.org/keywords/aquaculture-disease-treatment","display_name":"aquaculture disease treatment","score":0.6970000267028809},{"id":"https://openalex.org/keywords/antibiotic-alternatives","display_name":"antibiotic alternatives","score":0.5989999771118164},{"id":"https://openalex.org/keywords/dpph-radical-scavenging-activity","display_name":"DPPH radical scavenging","score":0.8330000042915344},{"id":"https://openalex.org/keywords/reducing-power","display_name":"reducing power","score":0.7639999985694885},{"id":"https://openalex.org/keywords/survival-rate","display_name":"survival rate","score":0.4189999997615814},{"id":"https://openalex.org/keywords/fingerlings","display_name":"fingerlings","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2776463394","wikidata":"https://www.wikidata.org/wiki/Q1051224","display_name":"Catla","level":4,"score":0.9924339056015015},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.7945435047149658},{"id":"https://openalex.org/C64502627","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogenicity","level":2,"score":0.6697699427604675},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5472634434700012},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5427097082138062},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.13550719618797302},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.11876264214515686},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.061829715967178345},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2780996670","wikidata":"https://www.wikidata.org/wiki/Q133328","display_name":"Labeo","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-826367/v1","doi":"https://doi.org/10.21203/rs.3.rs-826367/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-826367/v1","pdf_url":"https://www.researchsquare.com/article/rs-826367/v1.pdf?c=1637263501000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-826367/v1","doi":"https://doi.org/10.21203/rs.3.rs-826367/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-826367/v1","pdf_url":"https://www.researchsquare.com/article/rs-826367/v1.pdf?c=1637263501000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4230013634.pdf","grobid_xml":"https://content.openalex.org/works/W4230013634.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1536371084","https://openalex.org/W2087644906","https://openalex.org/W2756770855","https://openalex.org/W2888266748","https://openalex.org/W2913376971","https://openalex.org/W2978197785","https://openalex.org/W2982672469","https://openalex.org/W2996384999","https://openalex.org/W2998069618","https://openalex.org/W3116548582","https://openalex.org/W3157807989"],"related_works":["https://openalex.org/W4210334320","https://openalex.org/W4312900395","https://openalex.org/W2787914312","https://openalex.org/W6903287090","https://openalex.org/W4406015829","https://openalex.org/W4388641341","https://openalex.org/W4404158096","https://openalex.org/W4285378301","https://openalex.org/W752181045","https://openalex.org/W2979598366"],"abstract_inverted_index":{"Abstract":[0],"Incidence":[1],"of":[2,10,34,42,72,162],"various":[3],"dreadful":[4],"microbial":[5],"infections":[6],"and":[7,36,57,64,68,93,116,131,146,158,172,202,208,220],"the":[8,18,32,46,74,160,212],"development":[9],"antibiotic":[11,235],"resistance":[12],"by":[13],"infection":[14],"causative":[15],"microbes":[16],"are":[17],"main":[19],"reasons":[20],"for":[21,31,39,61,103],"reducing":[22,117],"aquaculture":[23,251],"productivity.":[24],"Hence,":[25,237],"there":[26],"is":[27,226],"an":[28,135],"immense":[29],"need":[30],"discovery":[33],"alternative":[35,248],"efficient":[37,215],"treatment":[38],"quick":[40],"recovery":[41],"diseased":[43],"fishes.":[44],"In":[45],"present":[47],"study,":[48],"Suaeda":[49],"maritima":[50,239],"leaf":[51,240],"extracts":[52,213],"(hexane,":[53],"diethyl":[54],"ether,":[55],"ethanol,":[56],"water)":[58],"were":[59,178,193,204,214],"screened":[60],"in":[62,65,175,216,250],"vitro":[63],"vivo":[66,176],"antibacterial":[67,81,143],"antioxidant":[69,98,147],"activities.":[70],"Out":[71],"all":[73],"four":[75,163],"extracts,":[76],"ethanolic":[77,104,123],"extract":[78,105,124,241],"showed":[79],"highest":[80,142],"activity":[82,99],"against":[83],"S.aureus":[84],"(4.9\u00b11.3":[85],"mm),":[86,89,92],"B.subtilis":[87],"(1.6\u00b10.3":[88],"K.pneumonia":[90],"(4.2\u00b11.8":[91],"P.aeruginosa":[94],"(4.1\u00b11.2":[95],"mm).":[96],"Similarly,":[97],"was":[100,125,138,153],"also":[101],"higher":[102],"(500":[106],"\u00b5g/ml)":[107],"based":[108,140],"on":[109,141,180],"DPPH":[110],"radical":[111],"scavenging":[112],"ability":[113],"(71.6\u00b11.4":[114],"%)":[115],"potential":[118],"(149":[119],"\u03bcg/mL)":[120],"assays.":[121],"Further,":[122],"purified":[126,209],"consecutively":[127],"via":[128],"column":[129],"chromatography":[130],"preparative":[132],"TLC":[133],"where":[134],"active":[136,164],"fraction":[137,152],"selected":[139],"(10.1\u00b11.4":[144],"mm)":[145],"properties":[148],"(82.3\u00b12.8":[149],"%).":[150],"Active":[151],"loaded":[154],"onto":[155],"mass":[156],"spectroscopy":[157],"identified":[159],"presence":[161],"constituents":[165],"such":[166],"as":[167,245],"1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-3-yl)":[168],"methanol;":[169],"3',7-Dimethoxy-3-hydroxyflavone;":[170],"Saponin":[171],"(19R)9acetyl19hydroxy10,14dimethyl20oxopentacyclo[11.8.0.0<2,10>.0<4,9>.0<14,19>]henicos-17-yl-acetate.":[173],"Besides,":[174],"studies":[177],"conducted":[179],"Catla":[181],"catla":[182],"fingerlings":[183,192,219],"infected":[184,218],"with":[185,206,232],"P.":[186],"aeruginosa":[187],"under":[188],"laboratory":[189],"conditions.":[190],"The":[191],"segregated":[194],"into":[195],"5":[196,203],"groups,":[197],"among":[198],"which":[199,225],"group":[200],"4":[201],"treated":[205,231],"crude":[207],"extracts.":[210],"Both":[211],"treating":[217],"recorded":[221],"100%":[222],"survival":[223],"rate":[224],"even":[227],"better":[228],"than":[229],"group-3":[230],"a":[233,246],"synthetic":[234],"(77%).":[236],"S.":[238],"can":[242],"be":[243],"considered":[244],"possible":[247],"medicine":[249]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-05-11T00:00:00"}