{"id":"https://openalex.org/W4229920846","doi":"https://doi.org/10.1002/1097-0215(20000815)87:4<507::aid-ijc7>3.3.co;2-9","title":"A pilot study investigating the role of NAT1 and NAT2 polymorphisms in gastric adenocarcinoma","display_name":"A pilot study investigating the role of NAT1 and NAT2 polymorphisms in gastric adenocarcinoma","publication_year":2000,"publication_date":"2000-08-15","ids":{"openalex":"https://openalex.org/W4229920846","doi":"https://doi.org/10.1002/1097-0215(20000815)87:4<507::aid-ijc7>3.3.co;2-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/10918189"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0215(20000815)87:4<507::aid-ijc7>3.3.co;2-9","doi":"https://doi.org/10.1002/1097-0215(20000815)87:4<507::aid-ijc7>3.3.co;2-9","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0215(20000815)87:4<507::aid-ijc7>3.3.co;2-9","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0215%2820000815%2987%3A4%3C507%3A%3AAID-IJC7%3E3.0.CO%3B2-I","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0215%2820000815%2987%3A4%3C507%3A%3AAID-IJC7%3E3.0.CO%3B2-I","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084559916","display_name":"Robert Boissy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Boissy","raw_affiliation_strings":["Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mary A. Watson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary A. Watson","raw_affiliation_strings":["Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036278452","display_name":"David M. Umbach","orcid":"https://orcid.org/0000-0002-7142-2812","observed_orcids":["https://orcid.org/0000-0002-7142-2812"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Umbach","raw_affiliation_strings":["Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mark Deakin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56007636","display_name":"Keele University","ror":"https://ror.org/00340yn33","country_code":"GB","type":"education","lineage":["https://openalex.org/I56007636"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Deakin","raw_affiliation_strings":["University of Keele, North Staffordshire, Stoke-on-Trent, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Keele, North Staffordshire, Stoke-on-Trent, United Kingdom","institution_ids":["https://openalex.org/I56007636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015004042","display_name":"James T. Elder","orcid":"https://orcid.org/0000-0003-4215-3294","observed_orcids":["https://orcid.org/0000-0003-4215-3294"]},"institutions":[{"id":"https://openalex.org/I56007636","display_name":"Keele University","ror":"https://ror.org/00340yn33","country_code":"GB","type":"education","lineage":["https://openalex.org/I56007636"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Elder","raw_affiliation_strings":["University of Keele, North Staffordshire, Stoke-on-Trent, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Keele, North Staffordshire, Stoke-on-Trent, United Kingdom","institution_ids":["https://openalex.org/I56007636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000113898","display_name":"Richard C. Strange","orcid":"https://orcid.org/0000-0002-0980-6348","observed_orcids":["https://orcid.org/0000-0002-0980-6348"]},"institutions":[{"id":"https://openalex.org/I56007636","display_name":"Keele University","ror":"https://ror.org/00340yn33","country_code":"GB","type":"education","lineage":["https://openalex.org/I56007636"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard C. Strange","raw_affiliation_strings":["University of Keele, North Staffordshire, Stoke-on-Trent, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Keele, North Staffordshire, Stoke-on-Trent, United Kingdom","institution_ids":["https://openalex.org/I56007636"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032808829","display_name":"Douglas A. Bell","orcid":"https://orcid.org/0000-0001-7700-0840","observed_orcids":["https://orcid.org/0000-0001-7700-0840","https://orcid.org/0000-0002-8456-3024"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas A. Bell","raw_affiliation_strings":["Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5032808829"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":{"value":5030,"currency":"USD","value_usd":5030},"fwci":2.5769,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.89545387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"87","issue":"4","first_page":"507","last_page":"511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-adenocarcinoma","display_name":"gastric adenocarcinoma","score":0.8709999918937683},{"id":"https://openalex.org/keywords/n-acetyltransferase-1","display_name":"NAT1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/n-acetyltransferase-2","display_name":"N-acetyltransferase 2","score":0.9150000214576721},{"id":"https://openalex.org/keywords/nat2-polymorphism","display_name":"NAT2 polymorphism","score":0.9829999804496765},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.5920000076293945},{"id":"https://openalex.org/keywords/aromatic-amines","display_name":"aromatic amines","score":0.5839999914169312},{"id":"https://openalex.org/keywords/heterocyclic-amines","display_name":"heterocyclic amines","score":0.9760000109672546},{"id":"https://openalex.org/keywords/advanced-cancer","display_name":"advanced cancer","score":0.6800000071525574},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7266629934310913},{"id":"https://openalex.org/C2777278644","wikidata":"https://www.wikidata.org/wiki/Q2758348","display_name":"Heterocyclic amine","level":3,"score":0.7097786068916321},{"id":"https://openalex.org/C2778328694","wikidata":"https://www.wikidata.org/wiki/Q1117580","display_name":"Arylamine N-acetyltransferase","level":4,"score":0.6753137111663818},{"id":"https://openalex.org/C2778340702","wikidata":"https://www.wikidata.org/wiki/Q6951442","display_name":"N-acetyltransferase","level":4,"score":0.6446518898010254},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6027947664260864},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5692594647407532},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.5565210580825806},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.49787044525146484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48577311635017395},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.438726007938385},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34966155886650085},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23221302032470703},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.12589040398597717}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001191","descriptor_name":"Arylamine N-Acetyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001191","descriptor_name":"Arylamine N-Acetyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001191","descriptor_name":"Arylamine N-Acetyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001191","descriptor_name":"Arylamine N-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001191","descriptor_name":"Arylamine N-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001191","descriptor_name":"Arylamine N-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0215(20000815)87:4<507::aid-ijc7>3.3.co;2-9","doi":"https://doi.org/10.1002/1097-0215(20000815)87:4<507::aid-ijc7>3.3.co;2-9","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0215(20000815)87:4<507::aid-ijc7>3.3.co;2-9","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0215%2820000815%2987%3A4%3C507%3A%3AAID-IJC7%3E3.0.CO%3B2-I","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:10918189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10918189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1002/1097-0215(20000815)87:4<507::aid-ijc7>3.3.co;2-9","doi":"https://doi.org/10.1002/1097-0215(20000815)87:4<507::aid-ijc7>3.3.co;2-9","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0215(20000815)87:4<507::aid-ijc7>3.3.co;2-9","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0215%2820000815%2987%3A4%3C507%3A%3AAID-IJC7%3E3.0.CO%3B2-I","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5199999809265137,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4229920846.pdf","grobid_xml":"https://content.openalex.org/works/W4229920846.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W87254141","https://openalex.org/W1877917243","https://openalex.org/W1970241213","https://openalex.org/W1977702916","https://openalex.org/W2011006722","https://openalex.org/W2015901640","https://openalex.org/W2020818586","https://openalex.org/W2030988225","https://openalex.org/W2042503727","https://openalex.org/W2044692125","https://openalex.org/W2074093254","https://openalex.org/W2082763454","https://openalex.org/W2083841608","https://openalex.org/W2090846608","https://openalex.org/W2092128596","https://openalex.org/W2095038216","https://openalex.org/W2158140834","https://openalex.org/W2160496651","https://openalex.org/W2320937221"],"related_works":["https://openalex.org/W2084338678","https://openalex.org/W4213085369","https://openalex.org/W1971385173","https://openalex.org/W1970241213","https://openalex.org/W2042503727","https://openalex.org/W2276828254","https://openalex.org/W4229920846","https://openalex.org/W1987574388","https://openalex.org/W2048039062","https://openalex.org/W2025400403"],"abstract_inverted_index":{"In":[0],"humans,":[1],"aromatic":[2],"and":[3,61,80,91,108,120,122,139],"heterocyclic":[4],"amine":[5],"carcinogens":[6,35],"may":[7,50],"be":[8,192],"acetylated":[9],"by":[10],"the":[11,17,38,72,185],"expression":[12],"products":[13],"of":[14,16,33,66,74,86],"either":[15,29],"N-acetyltransferase":[18,76],"genes,":[19],"NAT1":[20,47,60,79,109,133,163],"or":[21,31,48],"NAT2.":[22],"This":[23,213],"conjugation":[24],"reaction":[25],"can":[26],"result":[27],"in":[28,46,59,82,208,218],"activation":[30],"detoxication":[32],"these":[34],"depending":[36],"on":[37],"tissue":[39],"involved.":[40],"Recent":[41],"studies":[42],"suggest":[43],"that":[44,158],"polymorphisms":[45],"NAT2":[49,62,107,149],"modulate":[51],"cancer":[52,173],"risk.":[53],"To":[54],"determine":[55],"if":[56],"genetic":[57],"differences":[58],"could":[63],"alter":[64],"risk":[65,145,170,186],"gastric":[67,88,172],"cancer,":[68],"we":[69,156],"tested":[70],"for":[71,106,131,148,171,188],"presence":[73],"polymorphic":[75],"alleles":[77,110,134],"(both":[78],"NAT2)":[81],"a":[83,161,167,205,219],"preliminary":[84,214],"study":[85],"94":[87],"adenocarcinoma":[89],"patients":[90],"112":[92],"control":[93],"subjects":[94],"from":[95],"North":[96],"Staffordshire,":[97],"England.":[98],"We":[99],"used":[100],"established":[101],"PCR":[102],"protocols":[103],"to":[104,129,191,210],"genotype":[105],"(NAT2*4,":[111],"NAT2*5,":[112],"NAT2*6,":[113],"NAT2*7,":[114],"NAT2*14;":[115],"NAT1*3,":[116],"NAT1*":[117],"4,":[118],"NAT1*10,":[119,165],"NAT1*11),":[121],"implemented":[123],"an":[124],"oligonucleotide":[125],"ligation":[126],"assay":[127],"(OLA)":[128],"test":[130],"low-activity":[132],"[NAT1*14":[135],"(G560A),":[136],"NAT1*15":[137],"(C559T),":[138],"NAT1*17":[140],"(C190T)].":[141],"No":[142],"significant":[143],"increased":[144],"was":[146],"observed":[147,187],"acetylation":[150],"genotypes.":[151],"However,":[152],"among":[153],"all":[154],"cases,":[155],"found":[157],"individuals":[159],"inheriting":[160],"variant":[162],"allele,":[164],"have":[166],"significantly":[168],"elevated":[169],"(OR":[174,198],"=":[175,199],"2.2,":[176],"95%":[177],"CI":[178],"1.":[179],"2-3.9,":[180],"P":[181,201],"<":[182,202],"0.01).":[183],"Interestingly,":[184],"NAT1*10":[189],"appears":[190],"solely":[193],"associated":[194],"with":[195],"advanced-stage":[196],"tumors":[197],"4.8,":[200],"0.001),":[203],"suggesting":[204],"possible":[206],"role":[207],"progression":[209],"advanced":[211],"disease.":[212],"finding":[215],"needs":[216],"confirmation":[217],"larger,":[220],"detailed":[221],"epidemiological":[222],"study.":[223]},"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}