{"id":"https://openalex.org/W4229503148","doi":"https://doi.org/10.1182/blood.v124.21.665.665","title":"Genetic Risk Factors for Sclerotic Graft-Versus-Host Disease","display_name":"Genetic Risk Factors for Sclerotic Graft-Versus-Host Disease","publication_year":2014,"publication_date":"2014-12-06","ids":{"openalex":"https://openalex.org/W4229503148","doi":"https://doi.org/10.1182/blood.v124.21.665.665"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v124.21.665.665","doi":"https://doi.org/10.1182/blood.v124.21.665.665","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v124.21.665.665","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026533672","display_name":"Yoshihiro Inamoto","orcid":"https://orcid.org/0000-0003-4881-0427","observed_orcids":["https://orcid.org/0000-0003-4881-0427"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoshihiro Inamoto","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059063645","display_name":"Paul J. Martin","orcid":"https://orcid.org/0000-0001-9051-1215","observed_orcids":["https://orcid.org/0000-0001-9051-1215"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J. Martin","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016644532","display_name":"Mary E.D. Flowers","orcid":"https://orcid.org/0000-0003-1631-0911","observed_orcids":["https://orcid.org/0000-0003-1631-0911"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary E. Flowers","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031390636","display_name":"Stephanie Joi Lee","orcid":"https://orcid.org/0000-0003-2600-6390","observed_orcids":["https://orcid.org/0000-0003-2600-6390"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie J. Lee","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017952176","display_name":"Paul A. Carpenter","orcid":"https://orcid.org/0000-0002-5021-0714","observed_orcids":["https://orcid.org/0000-0002-5021-0714","https://orcid.org/0000-0001-9810-1798"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Carpenter","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064080252","display_name":"Edus Houston Warren","orcid":"https://orcid.org/0000-0002-9570-2755","observed_orcids":["https://orcid.org/0000-0002-9570-2755"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edus Houston Warren","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038572943","display_name":"Michael Boeckh","orcid":"https://orcid.org/0000-0003-1538-7984","observed_orcids":["https://orcid.org/0000-0003-1538-7984"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Boeckh","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070467855","display_name":"Barry E. Storer","orcid":"https://orcid.org/0000-0003-1565-435X","observed_orcids":["https://orcid.org/0000-0003-1565-435X"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Barry E. Storer","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085922041","display_name":"David Levine","orcid":"https://orcid.org/0000-0002-9292-570X","observed_orcids":["https://orcid.org/0000-0002-9292-570X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Levine","raw_affiliation_strings":["University of Washington, School of Public Health, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, School of Public Health, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100518334","display_name":"Wenhong Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wenhong Fan","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005949750","display_name":"Lue Ping Zhao","orcid":"https://orcid.org/0000-0002-1387-7165","observed_orcids":["https://orcid.org/0000-0002-1387-7165","https://orcid.org/0000-0003-4817-4969"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lue Ping Zhao","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030733029","display_name":"John A. Hansen","orcid":"https://orcid.org/0000-0001-5984-9701","observed_orcids":["https://orcid.org/0000-0001-5984-9701"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Hansen","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005949750","https://openalex.org/A5070467855","https://openalex.org/A5085922041","https://openalex.org/A5100518334"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45730994,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"124","issue":"21","first_page":"665","last_page":"665"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-graft-versus-host-disease","display_name":"chronic graft-versus-host disease","score":0.9580000042915344},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.7429999709129333},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.890999972820282},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hla-dpa1","display_name":"HLA-DPA1","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hla-dp","display_name":"HLA-DP","score":0.6669999957084656},{"id":"https://openalex.org/keywords/bank1","display_name":"BANK1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cd247","display_name":"CD247","score":0.9929999709129333},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.902999997138977},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.5759999752044678},{"id":"https://openalex.org/keywords/candidate-gene-studies","display_name":"candidate gene association","score":0.5580000281333923},{"id":"https://openalex.org/keywords/hla-dra","display_name":"HLA-DRA","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.8171079158782959},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.7156999707221985},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.5777782797813416},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.477615088224411},{"id":"https://openalex.org/C163691529","wikidata":"https://www.wikidata.org/wiki/Q7391886","display_name":"SNP genotyping","level":5,"score":0.4605168104171753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44093188643455505},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.43946048617362976},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42026078701019287},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.41170620918273926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40495961904525757},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.3782650828361511},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3221208453178406},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.31918421387672424},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1813390851020813},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13531574606895447}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v124.21.665.665","doi":"https://doi.org/10.1182/blood.v124.21.665.665","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v124.21.665.665","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2572454237","https://openalex.org/W2093591139","https://openalex.org/W4245181688","https://openalex.org/W2571591034","https://openalex.org/W4412539982","https://openalex.org/W2055492080","https://openalex.org/W2587941972","https://openalex.org/W2463935317","https://openalex.org/W2285687880","https://openalex.org/W2101943718"],"abstract_inverted_index":{"Abstract":[0,422],"Background:":[1],"Sclerotic":[2,35],"graft-versus-host":[3],"disease":[4,47,415],"(GVHD)":[5],"is":[6,50],"a":[7,108,182,300,350,376],"distinctive":[8],"phenotype":[9,106,416,436],"of":[10,22,85,110,193,200,219,227,235,277,286,294,314,331,338,379,397,417,433,548],"chronic":[11,117,418,440],"GVHD":[12,36,87,118,237,340,370,400,419,441],"after":[13,420],"allogeneic":[14],"hematopoietic":[15],"cell":[16],"transplantation":[17],"(HCT),":[18],"characterized":[19],"by":[20,52,305,320],"fibrosis":[21],"the":[23,89,98,104,151,169,174,228,287,292,315,332,365,380,394,408,414,434],"skin":[24],"or":[25,122,308,324],"fascia,":[26],"and":[27,33,39,56,119,146,156,160,195,210,213,254,267,291,319,371,374,389,401,411],"often":[28],"associated":[29,232],"with":[30,42,69,83,103,116,198,233,244,275,349,431,439],"severe":[31],"disability":[32],"morbidity.":[34],"has":[37],"clinical":[38],"histopathological":[40],"similarities":[41,363],"systemic":[43,72,372,402],"sclerosis,":[44,373],"an":[45],"autoimmune":[46],"whose":[48],"risk":[49,84,199,234,276,293,337,432],"influenced":[51],"genetic":[53],"polymorphisms.":[54],"Patients":[55],"methods:":[57],"We":[58,74,96],"identified":[59],"15":[60],"candidate":[61,99,129,229,263],"single-nucleotide":[62],"polymorphisms":[63],"(SNPs)":[64],"that":[65,76,367],"have":[66,81,92,299],"well-documented":[67],"association":[68,102,288],"susceptibility":[70],"to":[71,190,260,550],"sclerosis.":[73,403],"hypothesized":[75],"these":[77],"SNPs":[78,100,130,165,180,197,230,264,426],"would":[79],"also":[80],"associations":[82,192,274,430],"sclerotic":[86,105,201,236,278,295,339,369,399,435],"if":[88],"two":[90],"diseases":[91],"similar":[93],"pathogenic":[94,395],"mechanisms.":[95],"evaluated":[97],"for":[101,126,207,281],"in":[107,133,265,343,364,393],"cohort":[109],"891":[111],"patients":[112,344,438],"who":[113,345],"were":[114,131,171,188,231],"diagnosed":[115],"had":[120,346],"recipient":[121,196],"donor":[123,194],"samples":[124],"available":[125],"genotyping.":[127],"The":[128,336],"located":[132],"BANK1,":[134],"BLK,":[135],"CD247,":[136],"HLA-DRA,":[137],"HLA-DQB1,":[138],"HLA-DPA1,":[139],"IL12RB2,":[140],"IRF8,":[141],"PTPN22,":[142],"STAT4,":[143],"TNFSF4,":[144],"TNIP1":[145],"TNPO3-IRF5.":[147],"Genotyping":[148],"assays":[149],"used":[150,189],"Affymetrix":[152],"5.0":[153],"Human":[154],"GeneChip":[155],"Illumina":[157,161],"1M":[158],"Quad":[159],"2.5M":[162],"BeadArrays.":[163],"Candidate":[164],"not":[166,270],"genotyped":[167],"on":[168],"array":[170],"imputed":[172],"using":[173],"1000":[175],"Genomes":[176],"Project":[177],"Phase":[178],"1":[179,425],"as":[181],"reference":[183],"panel.":[184],"Cox":[185],"regression":[186],"models":[187],"examine":[191],"GVHD.":[202,279,296],"Each":[203],"SNP":[204,444],"was":[205,221,341],"assessed":[206],"allelic":[208],"(additive)":[209],"genotypic":[211],"(dominant":[212],"recessive)":[214],"models.":[215],"A":[216],"two-sided":[217],"P-value":[218],"<0.05":[220],"considered":[222],"statistically":[223,272,428],"significant.":[224],"Results:":[225],"Three":[226],"(Table):":[238],"rs10516487":[239,455],"(BANK1:":[240],"B-cell":[241],"scaffold":[242],"protein":[243],"ankyrin":[245],"repeats":[246],"1),":[247],"rs2056626":[248,473,491],"(CD247:":[249],"T-cell":[250],"receptor":[251],"zeta":[252],"subunit)":[253],"rs987870":[255,509,527],"(HLA-DPA1).":[256],"Despite":[257],"adequate":[258],"power":[259],"detect":[261],"associations,":[262],"HLA-DRA":[266],"HLA-DQB1":[268],"did":[269],"show":[271],"significant":[273,429],"Results":[280],"r987870":[282],"motivated":[283],"further":[284],"exploration":[285],"between":[289],"HLA-DP":[290,297,347],"molecules":[298,348],"P1":[301],"peptide-presentation":[302],"pocket":[303,352],"defined":[304],"M":[306],"(methionine)":[307],"Q":[309],"(glutamine)":[310],"at":[311,328],"position":[312],"31":[313],"DP":[316,333],"alpha":[317],"chain":[318],"EAV":[321],"(glutamic":[322],"acid-alanine-valine)":[323],"GPM":[325],"(glycine-proline-methionine)":[326],"motifs":[327],"positions":[329],"85-87":[330],"beta":[334],"chain.":[335],"decreased":[342],"Q~GPM":[351],"(HR":[353],"0.55,":[354],"95%":[355],"CI":[356],"0.38-0.80,":[357],"P=0.002).":[358],"Conclusion:":[359],"These":[360],"results":[361],"suggest":[362],"mechanisms":[366,396],"cause":[368],"indicate":[375],"critical":[377],"role":[378],"adaptive":[381],"immune":[382,409],"system,":[383],"including":[384],"B":[385],"cells,":[386,388],"T":[387],"HLA-DP-mediated":[390],"antigen":[391],"presentation":[392],"both":[398],"Genetic":[404],"variation":[405],"can":[406],"modify":[407],"pathology":[410],"significantly":[412],"alter":[413],"HCT.":[421],"665.":[423],"Table":[424],"showing":[427],"among":[437],"Genome":[442],"Gene":[443],"Alleles*":[445],"MAF":[446],"N":[447],"Model":[448],"HR":[449],"(95%":[450],"CI)":[451],"P":[452],"Donor":[453,489,525],"BANK1":[454],"T/C":[456],"0.30":[457],"857":[458],"Allelic":[459,477,495,513,531],"0.87":[460,532],"(0.69-1.08)":[461],".21":[462],"Dominant":[463,481,499,517,535],"0.96":[464],"(0.73-1.27)":[465],".80":[466],"Recessive":[467,485,503,521,539],"0.43":[468],"(0.21-0.88)":[469],".02":[470,542],"Recipient":[471,507],"CD247":[472,490],"G/T":[474,492],"0.40":[475],"839":[476],"1.21":[478,496],"(1.00-1.48)":[479,497],".05":[480,498,524],"1.49":[482],"(1.09-2.03)":[483],".01":[484],"1.09":[486],"(0.75-1.57)":[487],".65":[488],"0.41":[493],"858":[494],"1.58":[500],"(1.15-2.18)":[501],".005":[502],"0.99":[504],"(0.68-1.44)":[505],".97":[506],"HLA-DPA1":[508,526],"C/T":[510,528],"0.16":[511],"829":[512],"0.80":[514],"(0.59-1.09)":[515],".15":[516],"0.68":[518],"(0.48-0.96)":[519],".03":[520],"2.04":[522],"(1.01-4.14)":[523],"0.15":[529],"843":[530],"(0.65-1.17)":[533],".35":[534],"0.75":[536],"(0.54-1.04)":[537],".09":[538],"2.28":[540],"(1.12-4.63)":[541],"*minor/major":[543],"Disclosures":[544],"No":[545],"relevant":[546],"conflicts":[547],"interest":[549],"declare.":[551]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2022-05-11T00:00:00"}