{"id":"https://openalex.org/W4229458897","doi":"https://doi.org/10.3390/ijms23095278","title":"AOM/DSS Induced Colitis-Associated Colorectal Cancer in 14-Month-Old Female Balb/C and C57/Bl6 Mice\u2014A Pilot Study","display_name":"AOM/DSS Induced Colitis-Associated Colorectal Cancer in 14-Month-Old Female Balb/C and C57/Bl6 Mice\u2014A Pilot Study","publication_year":2022,"publication_date":"2022-05-09","ids":{"openalex":"https://openalex.org/W4229458897","doi":"https://doi.org/10.3390/ijms23095278","pmid":"https://pubmed.ncbi.nlm.nih.gov/35563665","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9104960"},"language":"en","primary_location":{"id":"doi:10.3390/ijms23095278","doi":"https://doi.org/10.3390/ijms23095278","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23095278","pdf_url":"https://www.mdpi.com/1422-0067/23/9/5278/pdf?version=1652233225","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/9/5278/pdf?version=1652233225","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085349184","display_name":"Martin Schepelmann","orcid":"https://orcid.org/0000-0002-7017-5426","observed_orcids":["https://orcid.org/0000-0002-7017-5426"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Martin Schepelmann","raw_affiliation_strings":["Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0002-7017-5426","affiliations":[{"raw_affiliation_string":"Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040508860","display_name":"Nadja Kupper","orcid":"https://orcid.org/0000-0001-6497-024X","observed_orcids":["https://orcid.org/0000-0001-6497-024X","https://orcid.org/0000-0003-1586-1914"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Nadja Kupper","raw_affiliation_strings":["Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0001-6497-024X","affiliations":[{"raw_affiliation_string":"Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017718040","display_name":"Valeriya Gushchina","orcid":"https://orcid.org/0000-0002-9773-1808","observed_orcids":["https://orcid.org/0000-0002-9773-1808"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Valeriya Gushchina","raw_affiliation_strings":["Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0002-9773-1808","affiliations":[{"raw_affiliation_string":"Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080045343","display_name":"Ildik\u00f3 Mesteri","orcid":"https://orcid.org/0000-0002-2831-8147","observed_orcids":["https://orcid.org/0000-0002-2831-8147"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ildiko Mesteri","raw_affiliation_strings":["Pathologie \u00dcberlingen, 88662 \u00dcberlingen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2831-8147","affiliations":[{"raw_affiliation_string":"Pathologie \u00dcberlingen, 88662 \u00dcberlingen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110129665","display_name":"Teresa Manhardt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Teresa Manhardt","raw_affiliation_strings":["Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081134083","display_name":"Stefan Moritsch","orcid":"https://orcid.org/0000-0002-1849-1616","observed_orcids":["https://orcid.org/0000-0002-1849-1616"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Stefan Moritsch","raw_affiliation_strings":["Center for Cancer Research, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101869442","display_name":"Christian J. M\u00fcller","orcid":"https://orcid.org/0000-0002-5031-7255","observed_orcids":["https://orcid.org/0000-0002-5031-7255"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christian M\u00fcller","raw_affiliation_strings":["Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029494593","display_name":"Karina Piatek","orcid":"https://orcid.org/0000-0002-1834-4800","observed_orcids":["https://orcid.org/0000-0002-1834-4800"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Karina Piatek","raw_affiliation_strings":["Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0002-1834-4800","affiliations":[{"raw_affiliation_string":"Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063757088","display_name":"Martina Salzmann","orcid":"https://orcid.org/0000-0001-7400-5785","observed_orcids":["https://orcid.org/0000-0001-7400-5785"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Martina Salzmann","raw_affiliation_strings":["Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077389824","display_name":"Andrea Vlasaty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Andrea Vlasaty","raw_affiliation_strings":["Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047633052","display_name":"Robert Eferl","orcid":"https://orcid.org/0000-0002-6074-7144","observed_orcids":["https://orcid.org/0000-0002-6074-7144"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Robert Eferl","raw_affiliation_strings":["Center for Cancer Research, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077481159","display_name":"Enik\u00f6 K\u00e1llay","orcid":"https://orcid.org/0000-0002-4996-0104","observed_orcids":["https://orcid.org/0000-0002-4996-0104"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Enik\u00f6 Kallay","raw_affiliation_strings":["Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0002-4996-0104","affiliations":[{"raw_affiliation_string":"Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085349184"],"corresponding_institution_ids":["https://openalex.org/I76134821"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2170,"currency":"EUR","value_usd":2340},"fwci":4.8306,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.96066513,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"9","first_page":"5278","last_page":"5278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.053700000047683716,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colitis-associated-cancer","display_name":"colitis-associated colorectal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aom-dss-model","display_name":"AOM/DSS model","score":0.9179999828338623},{"id":"https://openalex.org/keywords/azoxymethane","display_name":"azoxymethane","score":0.9330000281333923},{"id":"https://openalex.org/keywords/dextran-sulfate","display_name":"dextran sulfate","score":0.9490000009536743},{"id":"https://openalex.org/keywords/aged-mice","display_name":"aged mice","score":0.6949999928474426},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.8930000066757202},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.9129999876022339},{"id":"https://openalex.org/keywords/mouse-strain-differences","display_name":"mouse strain differences","score":0.8180000185966492},{"id":"https://openalex.org/keywords/ki-67-proliferation-index","display_name":"Ki-67 proliferation index","score":0.7070000171661377},{"id":"https://openalex.org/keywords/colon-histology","display_name":"colon histology","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2778452354","wikidata":"https://www.wikidata.org/wiki/Q794084","display_name":"Azoxymethane","level":4,"score":0.9745044708251953},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7261903285980225},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.6750146150588989},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6686971187591553},{"id":"https://openalex.org/C2776529007","wikidata":"https://www.wikidata.org/wiki/Q9820","display_name":"BALB/c","level":3,"score":0.5263743996620178},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.4836222231388092},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46662792563438416},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4392692744731903},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43819326162338257},{"id":"https://openalex.org/C2777928079","wikidata":"https://www.wikidata.org/wiki/Q2677027","display_name":"Rat\u00f3n","level":2,"score":0.4227147698402405},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3710166811943054},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32148081064224243},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.20164459943771362}],"mesh":[{"descriptor_ui":"D000083023","descriptor_name":"Colitis-Associated Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001397","descriptor_name":"Azoxymethane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016264","descriptor_name":"Dextran Sulfate","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms23095278","doi":"https://doi.org/10.3390/ijms23095278","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23095278","pdf_url":"https://www.mdpi.com/1422-0067/23/9/5278/pdf?version=1652233225","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:35563665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35563665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9104960","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9104960/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8cfe9542bb1d48be85ea603cb7e25f2b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8cfe9542bb1d48be85ea603cb7e25f2b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 23, Iss 5278, p 5278 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms23095278","doi":"https://doi.org/10.3390/ijms23095278","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23095278","pdf_url":"https://www.mdpi.com/1422-0067/23/9/5278/pdf?version=1652233225","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1306661235","display_name":"CDHR5 in intestinal barrier function and inflammation","funder_award_id":"P35069","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G2093536466","display_name":null,"funder_award_id":"P35069-B and DOC 59-833","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G2303185496","display_name":null,"funder_award_id":"P-32840-B","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G3343706013","display_name":null,"funder_award_id":"P-29948-B28","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G3685198513","display_name":null,"funder_award_id":"P35069-B","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G4178063278","display_name":null,"funder_award_id":"DOC 59\u2010833","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G4257769065","display_name":"Effect of ageing on a chemically induced colon cancer model","funder_award_id":"P32840","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G6854347141","display_name":null,"funder_award_id":"P 32840-B","funder_id":"https://openalex.org/F4320321960","funder_display_name":"Herzfelder'sche Familienstiftung"},{"id":"https://openalex.org/G6941063286","display_name":"MUW International PhD Program in Translational Oncology (IPPTO)","funder_award_id":"DOC 59","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G8990616090","display_name":"Loss of the CaSR in colorectal tumourigenesis","funder_award_id":"P29948","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"}],"funders":[{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"},{"id":"https://openalex.org/F4320321960","display_name":"Herzfelder'sche Familienstiftung","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4229458897.pdf","grobid_xml":"https://content.openalex.org/works/W4229458897.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W189621701","https://openalex.org/W1986760556","https://openalex.org/W2002618689","https://openalex.org/W2041838266","https://openalex.org/W2128726450","https://openalex.org/W2144240857","https://openalex.org/W2152785381","https://openalex.org/W2153178471","https://openalex.org/W2754189939","https://openalex.org/W2789769227","https://openalex.org/W2911772760","https://openalex.org/W2995010663","https://openalex.org/W2995931981","https://openalex.org/W2998529369","https://openalex.org/W3095410100"],"related_works":["https://openalex.org/W3186897768","https://openalex.org/W2470809252","https://openalex.org/W2921185643","https://openalex.org/W2112696943","https://openalex.org/W2807141590","https://openalex.org/W4286853206","https://openalex.org/W2357974850","https://openalex.org/W3000495252","https://openalex.org/W7008110969","https://openalex.org/W3028738849"],"abstract_inverted_index":{"Colitis":[0],"is":[1,27],"a":[2,69,132,173],"major":[3],"risk":[4],"factor":[5],"for":[6,55,59,193,237],"the":[7,28,45,111,117,120,128,154,177,218,234,254],"development":[8,260],"of":[9,37,94,119,135,253,256],"colorectal":[10,15],"cancer,":[11],"leading":[12],"to":[13,24,149,176,203,225],"colitis-associated":[14],"cancer":[16],"(CAC).":[17],"The":[18,33,105,144],"most":[19],"commonly":[20],"used":[21,46],"animal":[22],"model":[23,39,249],"study":[25,73],"CAC":[26,75,178,194,241,259],"azoxymethane-dextran":[29],"sulphate-sodium":[30],"(AOM/DSS)":[31],"model.":[32],"ideal":[34],"experimental":[35,113],"conditions":[36,54,192],"this":[38],"depend":[40],"on":[41,51,258],"several":[42],"factors,":[43],"including":[44],"mouse":[47,129],"strain.":[48],"No":[49,180],"data":[50],"feasibility":[52],"and":[53,82,90,98,125,157,245,261],"older":[56],"mice,":[57,170],"e.g.,":[58],"aging":[60,257],"studies,":[61],"have":[62],"yet":[63],"been":[64],"reported.":[65],"Thus,":[66],"we":[67],"conducted":[68],"descriptive,":[70],"observational":[71],"pilot":[72],"where":[74],"was":[76,147,215],"induced":[77],"in":[78,100,163,168,182,196,242],"14-month-old":[79],"female":[80],"Balb/C":[81,169,221,244],"C57/Bl6":[83,164,246],"mice":[84,106,121,165,222],"using":[85],"12.5":[86],"mg/kg":[87],"AOM":[88],"i.p.":[89],"three":[91],"different":[92],"concentrations":[93],"DSS":[95,145,214,231],"(1,":[96],"2,":[97],"3%)":[99],"drinking":[101],"water":[102],"(ad.":[103],"lib.).":[104],"were":[107,122,138,189],"monitored":[108],"regularly":[109],"during":[110],"three-month":[112],"phase.":[114],"After":[115],"euthanasia,":[116],"colons":[118],"evaluated":[123],"macroscopically":[124],"microscopically.":[126],"Both":[127],"strains":[130],"showed":[131,172],"DSS-concentration-dependent":[133],"induction":[134,195],"CAC.":[136],"Carcinomas":[137],"only":[139,162],"observed":[140],"at":[141],"3%":[142,205,226],"DSS.":[143],"dose":[146],"found":[148],"be":[150,204,233],"significantly":[151],"correlated":[152],"with":[153],"histology":[155],"score":[156],"%":[158],"Ki67":[159],"positive":[160],"cells":[161],"but":[166],"not":[167,210],"which":[171],"variable":[174],"response":[175],"induction.":[179],"differences":[181],"colon":[183],"length,":[184],"weight,":[185],"or":[186],"mucin":[187],"content":[188],"observed.":[190],"Optimal":[191],"these":[197],"aged":[198,243],"animals":[199],"are":[200],"thus":[201],"considered":[202],"DSS,":[206,227],"as":[207],"carcinomas":[208],"did":[209],"develop":[211],"when":[212],"2%":[213],"used.":[216],"On":[217],"other":[219],"hand,":[220],"reacted":[223],"severely":[224],"indicating":[228],"that":[229],"2.5%":[230],"may":[232],"\"sweet":[235],"spot\"":[236],"future":[238],"experiments":[239],"comparing":[240],"mice.":[247],"This":[248],"will":[250],"allow":[251],"investigation":[252],"effect":[255],"therapy.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-05-11T00:00:00"}
