{"id":"https://openalex.org/W4229457828","doi":"https://doi.org/10.1183/23120541.lsc-2022.44","title":"Lung Cancer-Associated Fibroblasts in MHCII immunity: Understanding its Molecular Basis to Design Novel Immunotherapies","display_name":"Lung Cancer-Associated Fibroblasts in MHCII immunity: Understanding its Molecular Basis to Design Novel Immunotherapies","publication_year":2022,"publication_date":"2022-03-10","ids":{"openalex":"https://openalex.org/W4229457828","doi":"https://doi.org/10.1183/23120541.lsc-2022.44"},"language":"en","primary_location":{"id":"doi:10.1183/23120541.lsc-2022.44","doi":"https://doi.org/10.1183/23120541.lsc-2022.44","is_oa":false,"landing_page_url":"https://doi.org/10.1183/23120541.lsc-2022.44","pdf_url":null,"source":{"id":"https://openalex.org/S100767427","display_name":"Lung Cancer","issn_l":"0169-5002","issn":["0169-5002","1872-8332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung cancer","raw_type":"proceedings-article"},"parent_works":[],"lineage":["https://openalex.org/W4229457828"],"child_works_count":0,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020270904","display_name":"Ilias Angelidis","orcid":"https://orcid.org/0000-0002-0549-8878","observed_orcids":["https://orcid.org/0000-0002-0549-8878"]},"institutions":[{"id":"https://openalex.org/I6820528","display_name":"Alexander Fleming Biomedical Sciences Research Center","ror":"https://ror.org/013x0ky90","country_code":"GR","type":"facility","lineage":["https://openalex.org/I6820528"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ilias Angelidis","raw_affiliation_strings":["Biomedical Sciences Research Center \u201cAlexander Fleming\u201d, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Research Center \u201cAlexander Fleming\u201d, Athens, Greece","institution_ids":["https://openalex.org/I6820528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047002892","display_name":"Dimitrios Konstandopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6820528","display_name":"Alexander Fleming Biomedical Sciences Research Center","ror":"https://ror.org/013x0ky90","country_code":"GR","type":"facility","lineage":["https://openalex.org/I6820528"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios Konstandopoulos","raw_affiliation_strings":["Biomedical Sciences Research Center \u201cAlexander Fleming\u201d, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Research Center \u201cAlexander Fleming\u201d, Athens, Greece","institution_ids":["https://openalex.org/I6820528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072046104","display_name":"Dimitra Kerdidani","orcid":"https://orcid.org/0000-0001-8681-693X","observed_orcids":["https://orcid.org/0000-0001-8681-693X"]},"institutions":[{"id":"https://openalex.org/I6820528","display_name":"Alexander Fleming Biomedical Sciences Research Center","ror":"https://ror.org/013x0ky90","country_code":"GR","type":"facility","lineage":["https://openalex.org/I6820528"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitra Kerdidani","raw_affiliation_strings":["Biomedical Sciences Research Center \u201cAlexander Fleming\u201d, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Research Center \u201cAlexander Fleming\u201d, Athens, Greece","institution_ids":["https://openalex.org/I6820528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021871668","display_name":"Emmanouil Aerakis","orcid":"https://orcid.org/0000-0003-2410-3234","observed_orcids":["https://orcid.org/0000-0003-2410-3234"]},"institutions":[{"id":"https://openalex.org/I6820528","display_name":"Alexander Fleming Biomedical Sciences Research Center","ror":"https://ror.org/013x0ky90","country_code":"GR","type":"facility","lineage":["https://openalex.org/I6820528"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Emmanouil Aerakis","raw_affiliation_strings":["Biomedical Sciences Research Center \u201cAlexander Fleming\u201d, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Research Center \u201cAlexander Fleming\u201d, Athens, Greece","institution_ids":["https://openalex.org/I6820528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087312205","display_name":"Katerina Douka","orcid":"https://orcid.org/0000-0002-7126-5212","observed_orcids":["https://orcid.org/0000-0002-7126-5212"]},"institutions":[{"id":"https://openalex.org/I6820528","display_name":"Alexander Fleming Biomedical Sciences Research Center","ror":"https://ror.org/013x0ky90","country_code":"GR","type":"facility","lineage":["https://openalex.org/I6820528"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Katerina Douka","raw_affiliation_strings":["Biomedical Sciences Research Center \u201cAlexander Fleming\u201d, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Research Center \u201cAlexander Fleming\u201d, Athens, Greece","institution_ids":["https://openalex.org/I6820528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020600468","display_name":"\u0394\u03c9\u03c1\u03bf\u03b8\u03ad\u03b1 \u039c\u03b1\u03bd\u03ad\u03c4\u03b1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6820528","display_name":"Alexander Fleming Biomedical Sciences Research Center","ror":"https://ror.org/013x0ky90","country_code":"GR","type":"facility","lineage":["https://openalex.org/I6820528"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dorothea Maneta","raw_affiliation_strings":["Biomedical Sciences Research Center \u201cAlexander Fleming\u201d, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Research Center \u201cAlexander Fleming\u201d, Athens, Greece","institution_ids":["https://openalex.org/I6820528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080568812","display_name":"Ioannis N. Vamvakaris","orcid":"https://orcid.org/0000-0002-2917-7155","observed_orcids":["https://orcid.org/0000-0002-2917-7155"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ioannis Vamvakaris","raw_affiliation_strings":["Department of Pathology, Sotiria Chest Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sotiria Chest Hospital, Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041623899","display_name":"\u039aonstantinos Potaris","orcid":"https://orcid.org/0000-0001-6636-5078","observed_orcids":["https://orcid.org/0000-0001-6636-5078"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konstantinos Potaris","raw_affiliation_strings":["Department of Thoracic Surgery, Sotiria Chest Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Sotiria Chest Hospital, Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056114569","display_name":"\u039aonstantinos Vachlas","orcid":"https://orcid.org/0000-0001-8907-5786","observed_orcids":["https://orcid.org/0000-0001-8907-5786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konstantinos Vachlas","raw_affiliation_strings":["Department of Thoracic Surgery, Sotiria Chest Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Sotiria Chest Hospital, Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082060632","display_name":"Evangelos Sepsas","orcid":"https://orcid.org/0000-0001-6771-0750","observed_orcids":["https://orcid.org/0000-0001-6771-0750"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Evangelos Sepsas","raw_affiliation_strings":["Department of Thoracic Surgery, Sotiria Chest Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Sotiria Chest Hospital, Athens, Greece","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078676208","display_name":"Maria Tsoumakidou","orcid":"https://orcid.org/0000-0001-7959-4793","observed_orcids":["https://orcid.org/0000-0001-7959-4793"]},"institutions":[{"id":"https://openalex.org/I6820528","display_name":"Alexander Fleming Biomedical Sciences Research Center","ror":"https://ror.org/013x0ky90","country_code":"GR","type":"facility","lineage":["https://openalex.org/I6820528"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Maria Tsoumakidou","raw_affiliation_strings":["Biomedical Sciences Research Center \u201cAlexander Fleming\u201d, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Research Center \u201cAlexander Fleming\u201d, Athens, Greece","institution_ids":["https://openalex.org/I6820528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3020,"currency":"USD","value_usd":3020},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"44","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.39010000228881836,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.9200000166893005},{"id":"https://openalex.org/keywords/mhc-class-ii-antigen-presentation","display_name":"MHC class II antigen presentation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.753000020980835},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.6209999918937683},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.6460000276565552},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.9049999713897705},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/immunotherapy-targets","display_name":"immunotherapy targets","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6146104335784912},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5058205127716064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46092721819877625},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.45072224736213684},{"id":"https://openalex.org/C2909706936","wikidata":"https://www.wikidata.org/wiki/Q42417562","display_name":"Cancer-Associated Fibroblasts","level":4,"score":0.43216919898986816},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4147145748138428},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.3639844059944153},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3467862606048584},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3227262496948242},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1898464858531952},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1730893850326538},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08487218618392944}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/23120541.lsc-2022.44","doi":"https://doi.org/10.1183/23120541.lsc-2022.44","is_oa":false,"landing_page_url":"https://doi.org/10.1183/23120541.lsc-2022.44","pdf_url":null,"source":{"id":"https://openalex.org/S100767427","display_name":"Lung Cancer","issn_l":"0169-5002","issn":["0169-5002","1872-8332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung cancer","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4206489510","https://openalex.org/W7169565055","https://openalex.org/W4408152119","https://openalex.org/W4403519928","https://openalex.org/W4385686450","https://openalex.org/W7212161697","https://openalex.org/W4293370809","https://openalex.org/W4409946286","https://openalex.org/W4214603940"],"abstract_inverted_index":{"In":[0],"situ":[1],"antigen":[2,14,81],"presentation":[3],"is":[4],"essential":[5],"to":[6,35,74,153],"retain":[7],"T":[8,43,58,137,165],"cells":[9,16,44,189],"within":[10],"tumors":[11,107],"however":[12],"the":[13,76,86,100,141,175,192],"presenting":[15,82],"and":[17,39,61,108,134,163,190],"pathways":[18],"involved":[19],"are":[20,33,197],"incompletely":[21],"understood.":[22],"Recent":[23],"data":[24,173],"indicate":[25],"that":[26,130,178,195],"a":[27],"subset":[28],"of":[29,53,79,103,121,144],"cancer-associated":[30],"fibroblasts":[31],"(CAFs)":[32],"induced":[34],"present":[36],"MHCII":[37,54],"antigens":[38],"prime":[40],"intratumoral":[41],"CD4+":[42,57,136],"in":[45,68,105,113,128,147,159,169,181],"human":[46,106,160],"lung":[47,80],"carcinomas":[48],"(Fig.1).":[49],"Fibroblast-specific":[50],"targeted":[51],"ablation":[52],"impacts":[55],"tumor-infiltrating":[56],"cell":[59,149,166],"numbers":[60],"metabolic":[62],"profile,":[63],"accompanied":[64],"by":[65],"an":[66],"increase":[67],"tumor":[69,182],"burden.":[70],"Our":[71,171],"study":[72],"aims":[73],"uncover":[75],"molecular":[77,157],"signature":[78,112],"CAFs":[83,196],"(apCAFs),":[84],"providing":[85],"basis":[87],"for":[88],"their":[89],"future":[90],"targeting.":[91],"Using":[92],"scRNA":[93],"sequencing":[94],"we":[95,151],"have":[96,109],"so":[97],"far":[98],"identified":[99],"transcriptional":[101],"profile":[102],"apCAFs":[104,133],"overlayed":[110],"these":[111],"paired":[114],"spatial":[115],"transcriptomic":[116],"data.":[117],"The":[118],"expression":[119],"patterns":[120],"spatially":[122],"resolved":[123],"transcriptoms":[124],"highlight":[125],"up-regulated":[126],"genes":[127,146],"spots":[129],"contain":[131],"adjacent":[132],"activated":[135],"cells.":[138],"To":[139],"dissect":[140],"biological":[142],"role":[143],"candidate":[145],"apCAF-T":[148],"comunications":[150],"intend":[152],"knock":[154],"down":[155],"promising":[156],"targets":[158],"derived":[161],"apCAF":[162],"assess":[164],"activation":[167],"capacities":[168],"cocultures.":[170],"preliminary":[172],"challenge":[174],"immunological":[176],"dogma":[177],"physiological":[179],"significance":[180],"immunity":[183],"comes":[184],"only":[185],"through":[186],"professional":[187],"antigen-presenting":[188],"refute":[191],"general":[193],"concept":[194],"immunosuppressive.":[198]},"counts_by_year":[],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2022-05-11T00:00:00"}
