{"id":"https://openalex.org/W4229457533","doi":"https://doi.org/10.1186/s12989-022-00477-8","title":"Aluminium oxide nanoparticles compromise spatial memory performance and proBDNF-mediated neuronal function in the hippocampus of rats","display_name":"Aluminium oxide nanoparticles compromise spatial memory performance and proBDNF-mediated neuronal function in the hippocampus of rats","publication_year":2022,"publication_date":"2022-05-10","ids":{"openalex":"https://openalex.org/W4229457533","doi":"https://doi.org/10.1186/s12989-022-00477-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/35538555","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9087928"},"language":"en","primary_location":{"id":"doi:10.1186/s12989-022-00477-8","doi":"https://doi.org/10.1186/s12989-022-00477-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12989-022-00477-8","pdf_url":"https://particleandfibretoxicology.biomedcentral.com/track/pdf/10.1186/s12989-022-00477-8","source":{"id":"https://openalex.org/S189275214","display_name":"Particle and Fibre Toxicology","issn_l":"1743-8977","issn":["1743-8977"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://particleandfibretoxicology.biomedcentral.com/track/pdf/10.1186/s12989-022-00477-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wei Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Sun","raw_affiliation_strings":["Behavioral Neuroscience Laboratory, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China","Department of Pediatric, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioral Neuroscience Laboratory, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatric, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064554209","display_name":"Jia Li","orcid":"https://orcid.org/0000-0002-3606-3949","observed_orcids":["https://orcid.org/0000-0002-3606-3949"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia Li","raw_affiliation_strings":["College of Acupuncture and Orthopedics, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Acupuncture and Orthopedics, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, Guizhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100693571","display_name":"Xiaoliang Li","orcid":"https://orcid.org/0000-0002-2058-7764","observed_orcids":["https://orcid.org/0000-0002-2058-7764"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoliang Li","raw_affiliation_strings":["Department of Neurology, Jinan Geriatric/Rehabilitation Hospital, Jinan, 250013, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Jinan Geriatric/Rehabilitation Hospital, Jinan, 250013, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101840269","display_name":"Xiao Chen","orcid":"https://orcid.org/0000-0001-9432-015X","observed_orcids":["https://orcid.org/0000-0001-9432-015X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao Chen","raw_affiliation_strings":["Behavioral Neuroscience Laboratory, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China","Department of Neurology, Jinan Geriatric/Rehabilitation Hospital, Jinan, 250013, China","Department of Pediatric, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioral Neuroscience Laboratory, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, Jinan Geriatric/Rehabilitation Hospital, Jinan, 250013, China","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatric, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021280560","display_name":"Yazi Mei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yazi Mei","raw_affiliation_strings":["Graduate School of Guangzhou, University of Chinese Medicine, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Guangzhou, University of Chinese Medicine, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100397405","display_name":"Yang Yang","orcid":"https://orcid.org/0000-0001-6612-8865","observed_orcids":["https://orcid.org/0000-0001-6612-8865"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Yang","raw_affiliation_strings":["Department of Pediatric, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100340365","display_name":"Lei An","orcid":"https://orcid.org/0000-0002-1406-7471","observed_orcids":["https://orcid.org/0000-0002-1406-7471"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei An","raw_affiliation_strings":["Behavioral Neuroscience Laboratory, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China. al_totti@sina.com","Department of Neurology, Jinan Geriatric/Rehabilitation Hospital, Jinan, 250013, China. al_totti@sina.com","Department of Pediatric, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China. al_totti@sina.com","Graduate School of Guangzhou, University of Chinese Medicine, Guangzhou, 510006, China. al_totti@sina.com","Behavioral Neuroscience Laboratory, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China"],"raw_orcid":"https://orcid.org/0000-0002-1406-7471","affiliations":[{"raw_affiliation_string":"Behavioral Neuroscience Laboratory, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China. al_totti@sina.com","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, Jinan Geriatric/Rehabilitation Hospital, Jinan, 250013, China. al_totti@sina.com","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatric, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China. al_totti@sina.com","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Guangzhou, University of Chinese Medicine, Guangzhou, 510006, China. al_totti@sina.com","institution_ids":["https://openalex.org/I117532281"]},{"raw_affiliation_string":"Behavioral Neuroscience Laboratory, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, Guizhou, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100340365"],"corresponding_institution_ids":["https://openalex.org/I117532281"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":1.889,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.84890386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"19","issue":"1","first_page":"34","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.44530001282691956,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.44530001282691956,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.1485999971628189,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.10029999911785126,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/al2o3-nanoparticles","display_name":"Al2O3 nanoparticles","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nanoparticle-neurotoxicity","display_name":"nanoparticle neurotoxicity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/spatial-memory-impairment","display_name":"spatial memory impairment","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7889999747276306},{"id":"https://openalex.org/keywords/probdnf","display_name":"proBDNF","score":0.9300000071525574},{"id":"https://openalex.org/keywords/p75-neurotrophin-receptor","display_name":"p75 neurotrophin receptor","score":0.9150000214576721},{"id":"https://openalex.org/keywords/rhoa-signaling","display_name":"RhoA signaling","score":0.9419999718666077},{"id":"https://openalex.org/keywords/memory-consolidation","display_name":"memory consolidation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.7570000290870667},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8840000033378601},{"id":"https://openalex.org/keywords/synaptic-dysfunction","display_name":"synaptic dysfunction","score":0.48500001430511475},{"id":"https://openalex.org/keywords/blood-brain-barrier-penetration","display_name":"blood-brain barrier penetration","score":0.625}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7908025979995728},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6955899000167847},{"id":"https://openalex.org/C48455012","wikidata":"https://www.wikidata.org/wiki/Q2892593","display_name":"Memory consolidation","level":3,"score":0.6137984991073608},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6098759174346924},{"id":"https://openalex.org/C3018842126","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Memory impairment","level":3,"score":0.5885540843009949},{"id":"https://openalex.org/C2909666625","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Impaired memory","level":3,"score":0.4238319993019104},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.422350138425827},{"id":"https://openalex.org/C2779042817","wikidata":"https://www.wikidata.org/wiki/Q6815736","display_name":"Memory improvement","level":3,"score":0.4113399386405945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3484387993812561},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3162667751312256},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.13944166898727417}],"mesh":[{"descriptor_ui":"D000537","descriptor_name":"Aluminum Oxide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065852","descriptor_name":"Spatial Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12989-022-00477-8","doi":"https://doi.org/10.1186/s12989-022-00477-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12989-022-00477-8","pdf_url":"https://particleandfibretoxicology.biomedcentral.com/track/pdf/10.1186/s12989-022-00477-8","source":{"id":"https://openalex.org/S189275214","display_name":"Particle and Fibre Toxicology","issn_l":"1743-8977","issn":["1743-8977"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9087928","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9087928","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Part Fibre Toxicol","raw_type":"Text"},{"id":"pmid:35538555","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35538555","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and fibre toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:233f21ba38954035a26181acdf05ddc4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/233f21ba38954035a26181acdf05ddc4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-14 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12989-022-00477-8","doi":"https://doi.org/10.1186/s12989-022-00477-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12989-022-00477-8","pdf_url":"https://particleandfibretoxicology.biomedcentral.com/track/pdf/10.1186/s12989-022-00477-8","source":{"id":"https://openalex.org/S189275214","display_name":"Particle and Fibre Toxicology","issn_l":"1743-8977","issn":["1743-8977"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2066900581","display_name":null,"funder_award_id":"32160196","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5636782639","display_name":null,"funder_award_id":"31700929","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4229457533.pdf","grobid_xml":"https://content.openalex.org/works/W4229457533.grobid-xml"},"referenced_works_count":130,"referenced_works":["https://openalex.org/W126551111","https://openalex.org/W161347900","https://openalex.org/W1558107540","https://openalex.org/W1685481958","https://openalex.org/W1817467313","https://openalex.org/W1850032865","https://openalex.org/W1857269611","https://openalex.org/W1963870951","https://openalex.org/W1967431173","https://openalex.org/W1968893466","https://openalex.org/W1975368375","https://openalex.org/W1976137737","https://openalex.org/W1981114447","https://openalex.org/W1983628548","https://openalex.org/W1988783332","https://openalex.org/W1993258381","https://openalex.org/W1993397740","https://openalex.org/W1994899839","https://openalex.org/W1997111539","https://openalex.org/W1997410784","https://openalex.org/W1997747766","https://openalex.org/W2004342703","https://openalex.org/W2006856113","https://openalex.org/W2010778459","https://openalex.org/W2011290724","https://openalex.org/W2019756575","https://openalex.org/W2021198303","https://openalex.org/W2023709895","https://openalex.org/W2025772150","https://openalex.org/W2033568399","https://openalex.org/W2034048630","https://openalex.org/W2035352282","https://openalex.org/W2036597812","https://openalex.org/W2039025948","https://openalex.org/W2042656945","https://openalex.org/W2049511526","https://openalex.org/W2051247819","https://openalex.org/W2054752442","https://openalex.org/W2057575061","https://openalex.org/W2066605983","https://openalex.org/W2067302534","https://openalex.org/W2074051174","https://openalex.org/W2077673578","https://openalex.org/W2078195119","https://openalex.org/W2082725131","https://openalex.org/W2083826459","https://openalex.org/W2084416577","https://openalex.org/W2091428840","https://openalex.org/W2092877594","https://openalex.org/W2093220563","https://openalex.org/W2097367797","https://openalex.org/W2109290667","https://openalex.org/W2109309568","https://openalex.org/W2109727228","https://openalex.org/W2112354679","https://openalex.org/W2115253295","https://openalex.org/W2116384075","https://openalex.org/W2118995962","https://openalex.org/W2120605643","https://openalex.org/W2123067258","https://openalex.org/W2125153103","https://openalex.org/W2129146157","https://openalex.org/W2134527764","https://openalex.org/W2138182618","https://openalex.org/W2139475683","https://openalex.org/W2142925967","https://openalex.org/W2151776276","https://openalex.org/W2158332939","https://openalex.org/W2160418959","https://openalex.org/W2161760743","https://openalex.org/W2168333882","https://openalex.org/W2178783545","https://openalex.org/W2292155060","https://openalex.org/W2336608745","https://openalex.org/W2337208828","https://openalex.org/W2572596207","https://openalex.org/W2586441381","https://openalex.org/W2588841610","https://openalex.org/W2598896942","https://openalex.org/W2615012275","https://openalex.org/W2626315766","https://openalex.org/W2774227519","https://openalex.org/W2779389688","https://openalex.org/W2793994192","https://openalex.org/W2801471608","https://openalex.org/W2889333485","https://openalex.org/W2889437543","https://openalex.org/W2898899965","https://openalex.org/W2900684106","https://openalex.org/W2904552500","https://openalex.org/W2927113798","https://openalex.org/W2927712307","https://openalex.org/W2930592873","https://openalex.org/W2948506592","https://openalex.org/W2969020054","https://openalex.org/W2970543923","https://openalex.org/W2972894018","https://openalex.org/W2979183421","https://openalex.org/W2990904878","https://openalex.org/W2991825859","https://openalex.org/W2998554651","https://openalex.org/W2999437268","https://openalex.org/W3003672752","https://openalex.org/W3006464183","https://openalex.org/W3012682152","https://openalex.org/W3013181597","https://openalex.org/W3013591214","https://openalex.org/W3022391689","https://openalex.org/W3035961408","https://openalex.org/W3047714386","https://openalex.org/W3048237863","https://openalex.org/W3082129961","https://openalex.org/W3084997728","https://openalex.org/W3097307673","https://openalex.org/W3099873505","https://openalex.org/W3110106680","https://openalex.org/W3120126170","https://openalex.org/W3124244829","https://openalex.org/W3126385000","https://openalex.org/W3132108264","https://openalex.org/W3137741648","https://openalex.org/W3155192538","https://openalex.org/W3159948322","https://openalex.org/W3184636103","https://openalex.org/W3185863968","https://openalex.org/W3190900928","https://openalex.org/W3201902131","https://openalex.org/W3202349605","https://openalex.org/W3208999672","https://openalex.org/W3214449456"],"related_works":["https://openalex.org/W4310191644","https://openalex.org/W4380877270","https://openalex.org/W3201902131","https://openalex.org/W6902009182","https://openalex.org/W3029600857","https://openalex.org/W4280640929","https://openalex.org/W3202349605","https://openalex.org/W4409323883","https://openalex.org/W2930592873","https://openalex.org/W4399341559"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Alumina":[2],"nanoparticles":[3],"(aluminaNPs),":[4],"which":[5,251],"are":[6],"widely":[7],"used":[8],"in":[9,28,106,160,185,199,226,244],"a":[10,58],"range":[11],"of":[12,35,62,68,95,118,126,130,137,148,169,193,205,223,242],"daily":[13],"and":[14,24,26,40,45,75,79,207,255],"medical":[15],"fields,":[16],"have":[17,48],"been":[18,50],"shown":[19],"to":[20,115,253],"penetrate":[21],"blood-brain":[22],"barrier,":[23],"distribute":[25],"accumulate":[27],"different":[29],"brain":[30],"areas.":[31],"Although":[32],"oral":[33],"treatment":[34],"aluminaNPs":[36,63,96,149,243],"induces":[37],"hippocampus-dependent":[38],"learning":[39,101],"memory":[41,104,121,145,194,228,256],"impairments,":[42],"characteristic":[43],"effects":[44,117,156],"exact":[46],"mechanisms":[47],"not":[49,98],"fully":[51],"elucidated.":[52],"Here,":[53],"male":[54],"adult":[55],"rats":[56],"received":[57],"single":[59],"bilateral":[60],"infusion":[61],"(10":[64],"or":[65],"20":[66],"\u00b5g/kg":[67],"body":[69],"weight)":[70],"into":[71],"the":[72,89,107,116,131,144,167,186,190,200,221,236,240,245],"hippocampal":[73,135,161,187],"region,":[74],"their":[76],"behavioral":[77],"performance":[78],"neural":[80,254],"function":[81],"were":[82],"assessed.":[83],"Results":[84],"The":[85,203],"results":[86],"indicated":[87],"that":[88,239],"intra-hippocampus":[90],"infusions":[91,136],"at":[92],"both":[93],"doses":[94],"did":[97],"cause":[99],"spatial":[100],"inability":[102],"but":[103],"deficit":[105],"water":[108],"maze":[109],"task.":[110],"This":[111],"impairment":[112],"was":[113,178,196],"attributed":[114],"aluminaNP":[119],"on":[120,157],"consolidation":[122],"phase":[123],"through":[124],"activation":[125],"proBDNF/RhoA":[127],"pathway.":[128],"Inhibition":[129],"increased":[132,173],"proBDNF":[133,215,224,249],"by":[134,180,213],"p75":[138,217],"NTR":[139,183,218],"antagonist":[140],"could":[141,164,209],"effectively":[142],"rescue":[143],"impairment.":[146],"Incubation":[147],"exaggerated":[150],"GluN2B-dependent":[151],"LTD":[152,158],"induction":[153],"with":[154],"no":[155],"expression":[159],"slices.":[162],"AluminaNP":[163],"also":[165],"depress":[166],"amplitude":[168],"NMDA-GluN2B":[170],"EPSCs.":[171],"Meanwhile,":[172],"reactive":[174],"oxygen":[175],"specie":[176],"production":[177],"reduced":[179],"blocking":[181,214],"proBDNF-p75":[182],"pathway":[184],"homogenates.":[188],"Furthermore,":[189],"neuronal":[191,208],"correlate":[192],"behavior":[195],"drastically":[197],"weakened":[198],"aluminaNP-infused":[201],"groups.":[202],"dysfunction":[204],"synaptic":[206],"be":[210],"obviously":[211],"mitigated":[212],"receptor":[216],",":[219],"implying":[220],"involvement":[222],"signaling":[225],"aluminaNP-impaired":[227],"process.":[229],"Conclusions":[230],"Taken":[231],"together,":[232],"our":[233],"findings":[234],"provide":[235],"first":[237],"evidence":[238],"accumulation":[241],"hippocampus":[246],"exaggeratedly":[247],"activates":[248],"signaling,":[250],"leads":[252],"impairments.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-11T00:00:00"}