{"id":"https://openalex.org/W4229455637","doi":"https://doi.org/10.3855/jidc.15220","title":"Molecular analysis for the OprD gene among Pseudomonas aueroginosa clinical isolates obtained from hospitals in Jordan","display_name":"Molecular analysis for the OprD gene among Pseudomonas aueroginosa clinical isolates obtained from hospitals in Jordan","publication_year":2022,"publication_date":"2022-04-30","ids":{"openalex":"https://openalex.org/W4229455637","doi":"https://doi.org/10.3855/jidc.15220","pmid":"https://pubmed.ncbi.nlm.nih.gov/35544631"},"language":"en","primary_location":{"id":"doi:10.3855/jidc.15220","doi":"https://doi.org/10.3855/jidc.15220","is_oa":true,"landing_page_url":"https://doi.org/10.3855/jidc.15220","pdf_url":"https://www.jidc.org/index.php/journal/article/download/35544631/2805","source":{"id":"https://openalex.org/S175466255","display_name":"The Journal of Infection in Developing Countries","issn_l":"1972-2680","issn":["1972-2680","2036-6590"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320415","host_organization_name":"Open Learning on Enteric Pathogens","host_organization_lineage":["https://openalex.org/P4310320415"],"host_organization_lineage_names":["Open Learning on Enteric Pathogens"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infection in Developing Countries","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jidc.org/index.php/journal/article/download/35544631/2805","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043216025","display_name":"Khalid Mohammad. Abu Khadra","orcid":"https://orcid.org/0000-0001-5483-3831","observed_orcids":["https://orcid.org/0000-0001-5483-3831"]},"institutions":[{"id":"https://openalex.org/I85507684","display_name":"Yarmouk University","ror":"https://ror.org/004mbaj56","country_code":"JO","type":"education","lineage":["https://openalex.org/I85507684"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Khalid M Abu Khadra","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan. khalidmohd99@yahoo.com","Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan. khalidmohd99@yahoo.com","institution_ids":["https://openalex.org/I85507684"]},{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan","institution_ids":["https://openalex.org/I85507684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097220690","display_name":"Safa\u2019a Y Al-Rabaia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85507684","display_name":"Yarmouk University","ror":"https://ror.org/004mbaj56","country_code":"JO","type":"education","lineage":["https://openalex.org/I85507684"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Safa\u2019a Y Al-Rabaia","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan","institution_ids":["https://openalex.org/I85507684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039458149","display_name":"Ahmad Mohammad Khalil","orcid":"https://orcid.org/0000-0002-1081-7300","observed_orcids":["https://orcid.org/0000-0002-1081-7300"]},"institutions":[{"id":"https://openalex.org/I85507684","display_name":"Yarmouk University","ror":"https://ror.org/004mbaj56","country_code":"JO","type":"education","lineage":["https://openalex.org/I85507684"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Ahmad M Khalil","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan","institution_ids":["https://openalex.org/I85507684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006981350","display_name":"Luay Abu-Qatouseh","orcid":"https://orcid.org/0000-0003-1551-2343","observed_orcids":["https://orcid.org/0000-0003-1551-2343"]},"institutions":[{"id":"https://openalex.org/I36622005","display_name":"Petra University","ror":"https://ror.org/039d9es10","country_code":"JO","type":"education","lineage":["https://openalex.org/I36622005"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Luay F Abu-Qatouseh","raw_affiliation_strings":["Department of Pharmacology and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan","institution_ids":["https://openalex.org/I36622005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071632150","display_name":"Mahmoud J. Abussaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85507684","display_name":"Yarmouk University","ror":"https://ror.org/004mbaj56","country_code":"JO","type":"education","lineage":["https://openalex.org/I85507684"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Mahmoud J Abussaud","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan","institution_ids":["https://openalex.org/I85507684"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":366,"currency":"EUR","value_usd":394},"apc_paid":{"value":366,"currency":"EUR","value_usd":394},"fwci":0.119,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.27537837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"16","issue":"04","first_page":"683","last_page":"690"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":1.0},{"id":"https://openalex.org/keywords/carbapenem-resistance","display_name":"carbapenem resistance","score":0.8479999899864197},{"id":"https://openalex.org/keywords/meropenem-resistance","display_name":"meropenem resistance","score":0.953000009059906},{"id":"https://openalex.org/keywords/insertion-sequences","display_name":"insertion sequences","score":0.8149999976158142},{"id":"https://openalex.org/keywords/outer-membrane-porins","display_name":"outer membrane porins","score":0.8360000252723694},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.7599999904632568},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility","display_name":"antimicrobial susceptibility","score":0.7089999914169312},{"id":"https://openalex.org/keywords/jordan","display_name":"Jordan","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.873510479927063},{"id":"https://openalex.org/C2779375183","wikidata":"https://www.wikidata.org/wiki/Q421670","display_name":"Meropenem","level":4,"score":0.7592067718505859},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7443081736564636},{"id":"https://openalex.org/C2779631663","wikidata":"https://www.wikidata.org/wiki/Q425152","display_name":"Imipenem","level":4,"score":0.7259207963943481},{"id":"https://openalex.org/C168007829","wikidata":"https://www.wikidata.org/wiki/Q857299","display_name":"Restriction fragment length polymorphism","level":4,"score":0.6252180337905884},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6157006621360779},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5697773694992065},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5075063109397888},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.5028635859489441},{"id":"https://openalex.org/C128319531","wikidata":"https://www.wikidata.org/wiki/Q219715","display_name":"Restriction enzyme","level":3,"score":0.4759797155857086},{"id":"https://openalex.org/C2776685102","wikidata":"https://www.wikidata.org/wiki/Q410897","display_name":"Carbapenem","level":3,"score":0.4720664322376251},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.46580320596694946},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4253506660461426},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.35683703422546387},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2728126049041748}],"mesh":[{"descriptor_ui":"D000077731","descriptor_name":"Meropenem","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006761","descriptor_name":"Hospitals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007597","descriptor_name":"Jordan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011549","descriptor_name":"Pseudomonas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D018272","descriptor_name":"Porins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3855/jidc.15220","doi":"https://doi.org/10.3855/jidc.15220","is_oa":true,"landing_page_url":"https://doi.org/10.3855/jidc.15220","pdf_url":"https://www.jidc.org/index.php/journal/article/download/35544631/2805","source":{"id":"https://openalex.org/S175466255","display_name":"The Journal of Infection in Developing Countries","issn_l":"1972-2680","issn":["1972-2680","2036-6590"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320415","host_organization_name":"Open Learning on Enteric Pathogens","host_organization_lineage":["https://openalex.org/P4310320415"],"host_organization_lineage_names":["Open Learning on Enteric Pathogens"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infection in Developing Countries","raw_type":"journal-article"},{"id":"pmid:35544631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35544631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of infection in developing countries","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2249897fcc8a426b8c62b087c470f103","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2249897fcc8a426b8c62b087c470f103","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Infection in Developing Countries, Vol 16, Iss 04 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3855/jidc.15220","doi":"https://doi.org/10.3855/jidc.15220","is_oa":true,"landing_page_url":"https://doi.org/10.3855/jidc.15220","pdf_url":"https://www.jidc.org/index.php/journal/article/download/35544631/2805","source":{"id":"https://openalex.org/S175466255","display_name":"The Journal of Infection in Developing Countries","issn_l":"1972-2680","issn":["1972-2680","2036-6590"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320415","host_organization_name":"Open Learning on Enteric Pathogens","host_organization_lineage":["https://openalex.org/P4310320415"],"host_organization_lineage_names":["Open Learning on Enteric Pathogens"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infection in Developing Countries","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323855","display_name":"Yarmouk University","ror":"https://ror.org/004mbaj56"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4229455637.pdf","grobid_xml":"https://content.openalex.org/works/W4229455637.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1966877930","https://openalex.org/W1998021456","https://openalex.org/W1999194567","https://openalex.org/W2023693007","https://openalex.org/W2138337438","https://openalex.org/W2142855469","https://openalex.org/W2169457690","https://openalex.org/W2186893010","https://openalex.org/W2308848325","https://openalex.org/W2773154260","https://openalex.org/W2912369592","https://openalex.org/W2977386011","https://openalex.org/W3117729541","https://openalex.org/W3157447196","https://openalex.org/W4238849857"],"related_works":["https://openalex.org/W2123617308","https://openalex.org/W3123406660","https://openalex.org/W2214476620","https://openalex.org/W4292694662","https://openalex.org/W4411227013","https://openalex.org/W4360974166","https://openalex.org/W2595787507","https://openalex.org/W2146496628","https://openalex.org/W4381510255","https://openalex.org/W2620058843"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Pseudomonas":[1],"aeruginosa":[2,17,63,114,207,229],"has":[3],"increasingly":[4],"been":[5],"associated":[6,131,230],"with":[7,161,231,236],"the":[8,37,42,95,119,124,144,148,159,171,178,195,202,214,224,247],"emergence":[9],"of":[10,39,54,61,76,79,92,112,118,158,167,177,184,194,223,227,240],"antibiotic":[11],"resistance.":[12,233],"Antibiotic":[13],"resistance":[14,48],"among":[15,51,123,143],"P.":[16,55,62,113,206,228],"isolates":[18,53,60,115,146,160,209,242],"is":[19],"an":[20,162],"ambiguous":[21],"and":[22,28,85,106,132],"complicated":[23],"mechanism":[24],"utilizing":[25],"several":[26],"enzymes":[27],"structural":[29],"proteins.":[30],"This":[31,152],"study":[32],"was":[33,82,88,98,153,189,210],"conducted":[34],"to":[35,49,65,220,245],"investigate":[36],"prevalence":[38],"mutations":[40,93],"in":[41,72,94,155,191,201,205,213],"chromosomal":[43],"OprD":[44,96,203,215],"gene":[45,97,204,216],"that":[46],"show":[47],"carbapenems":[50],"clinical":[52,59,208],"aeruginosa.":[56],"METHODOLOGY:":[57],"Sixty-three":[58],"resistant":[64,145],"meropenem":[66,232],"were":[67,147],"collected":[68,125],"from":[69],"public":[70],"hospitals":[71],"Irbid":[73],"city,":[74],"north":[75],"Jordan.":[77],"Analysis":[78],"antimicrobial":[80],"susceptibility":[81,87],"carried":[83],"out":[84],"their":[86],"categorized.":[89],"Molecular":[90,110],"analysis":[91,111],"performed":[99],"using":[100],"restriction":[101,179],"fragment":[102],"length":[103],"polymorphism":[104],"(RFLP)":[105],"DNA":[107,174],"sequencing.":[108],"RESULTS:":[109],"showed":[116],"52%":[117],"common":[120],"molecular":[121,141],"modifications":[122],"isolates.":[126,196],"These":[127],"alterations":[128],"could":[129,217],"be":[130,218],"affect":[133],"meropenem-susceptibility":[134],"rather":[135],"than":[136],"imipenem.":[137],"The":[138,181],"most":[139],"frequent":[140],"changes":[142],"F170L":[149],"substitution":[150],"mutation.":[151],"detected":[154,190],"22":[156],"(35%)":[157],"unusual":[163],"insertion":[164],"sequence":[165,183],"(IS)":[166],"100":[168],"bp":[169,173],"within":[170],"590":[172],"segment":[175],"downstream":[176],"site.":[180],"divergent":[182],"10":[185],"amino":[186],"acids":[187],"372(VDSSSSYAGL)383":[188],"7":[192],"(11%)":[193],"CONCLUSIONS:":[197],"A":[198],"significant":[199],"alteration":[200],"found.":[211],"Alterations":[212],"linked":[219],"protein":[221],"permeability":[222],"outer":[225],"membrane":[226],"Further":[234],"investigations":[235],"a":[237],"larger":[238],"number":[239],"bacterial":[241],"are":[243],"needed":[244],"validate":[246],"proposed":[248],"association.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-11T00:00:00"}
