{"id":"https://openalex.org/W4229449702","doi":"https://doi.org/10.21203/rs.3.rs-1626193/v1","title":"Effect of diabetes mellitus on physical activity in patients with moderate-to-severe knee osteoarthritis scheduled for total knee arthroplasty: a cross-sectional study","display_name":"Effect of diabetes mellitus on physical activity in patients with moderate-to-severe knee osteoarthritis scheduled for total knee arthroplasty: a cross-sectional study","publication_year":2022,"publication_date":"2022-05-10","ids":{"openalex":"https://openalex.org/W4229449702","doi":"https://doi.org/10.21203/rs.3.rs-1626193/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-1626193/v1","doi":"https://doi.org/10.21203/rs.3.rs-1626193/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1626193/v1","pdf_url":"https://www.researchsquare.com/article/rs-1626193/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-1626193/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023214995","display_name":"Remi Fujita","orcid":"https://orcid.org/0000-0002-2904-0642","observed_orcids":["https://orcid.org/0000-0002-2904-0642"]},"institutions":[{"id":"https://openalex.org/I11317238","display_name":"Seijoh University","ror":"https://ror.org/0085wxm22","country_code":"JP","type":"education","lineage":["https://openalex.org/I11317238"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Remi Fujita","raw_affiliation_strings":["Seijoh University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seijoh University","institution_ids":["https://openalex.org/I11317238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025595837","display_name":"Susumu Ota","orcid":"https://orcid.org/0000-0003-3182-147X","observed_orcids":["https://orcid.org/0000-0003-3182-147X"]},"institutions":[{"id":"https://openalex.org/I11317238","display_name":"Seijoh University","ror":"https://ror.org/0085wxm22","country_code":"JP","type":"education","lineage":["https://openalex.org/I11317238"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Ota","raw_affiliation_strings":["Seijoh University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seijoh University","institution_ids":["https://openalex.org/I11317238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuri Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuri Yamamoto","raw_affiliation_strings":["Nagoya Orthopaedic and Joint Replacement Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya Orthopaedic and Joint Replacement Clinic","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049789133","display_name":"Akito Kataoka","orcid":"https://orcid.org/0000-0002-8381-459X","observed_orcids":["https://orcid.org/0000-0002-8381-459X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akito Kataoka","raw_affiliation_strings":["Nagoya Orthopaedic and Joint Replacement Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya Orthopaedic and Joint Replacement Clinic","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066963443","display_name":"Hideki Warashina","orcid":"https://orcid.org/0000-0003-1146-7338","observed_orcids":["https://orcid.org/0000-0003-1146-7338"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideki Warashina","raw_affiliation_strings":["Nagoya Orthopaedic and Joint Replacement Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya Orthopaedic and Joint Replacement Clinic","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114077211","display_name":"Tomoe Inoue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoe Inoue","raw_affiliation_strings":["Nagoya University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya University","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005275249","display_name":"Shinya Ozeki","orcid":"https://orcid.org/0000-0002-1616-2472","observed_orcids":["https://orcid.org/0000-0002-1616-2472"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shinya Ozeki","raw_affiliation_strings":["Mariana Home-Nursing Station"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mariana Home-Nursing Station","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070380363","display_name":"Hideshi Sugiura","orcid":"https://orcid.org/0000-0003-4703-9941","observed_orcids":["https://orcid.org/0000-0003-4703-9941"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideshi Sugiura","raw_affiliation_strings":["Nagoya University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya University","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10562","display_name":"Total Knee Arthroplasty Outcomes","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10562","display_name":"Total Knee Arthroplasty Outcomes","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.17630000412464142,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.09929999709129333,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9810000061988831},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":1.0},{"id":"https://openalex.org/keywords/total-knee-arthroplasty","display_name":"total knee arthroplasty","score":0.9279999732971191},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":1.0},{"id":"https://openalex.org/keywords/step-count","display_name":"step count","score":0.7990000247955322},{"id":"https://openalex.org/keywords/light-intensity-physical-activity","display_name":"light physical activity","score":0.9649999737739563},{"id":"https://openalex.org/keywords/moderate-to-vigorous-physical-activity","display_name":"moderate-to-vigorous physical activity","score":0.9539999961853027},{"id":"https://openalex.org/keywords/knee-function","display_name":"knee function","score":0.4959999918937683},{"id":"https://openalex.org/keywords/quadriceps-strength","display_name":"quadriceps strength","score":0.8259999752044678},{"id":"https://openalex.org/keywords/timed-up-and-go-test","display_name":"Timed Up and Go test","score":0.9269999861717224},{"id":"https://openalex.org/keywords/accelerometer-measured-physical-activity","display_name":"accelerometer-measured activity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/preoperative-physical-function","display_name":"preoperative physical function","score":0.6110000014305115},{"id":"https://openalex.org/keywords/knee-pain","display_name":"knee pain","score":0.47600001096725464},{"id":"https://openalex.org/keywords/range-of-motion","display_name":"range of motion","score":0.8740000128746033},{"id":"https://openalex.org/keywords/knee-flexion-and-extension","display_name":"knee flexion and extension","score":0.47699999809265137},{"id":"https://openalex.org/keywords/contralateral-knee","display_name":"contralateral knee","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8845531940460205},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.8670415878295898},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6186296939849854},{"id":"https://openalex.org/C2779279471","wikidata":"https://www.wikidata.org/wiki/Q6421876","display_name":"Knee pain","level":4,"score":0.6032885909080505},{"id":"https://openalex.org/C3017871827","wikidata":"https://www.wikidata.org/wiki/Q1693864","display_name":"Total knee arthroplasty","level":2,"score":0.5627815127372742},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.534168541431427},{"id":"https://openalex.org/C60465272","wikidata":"https://www.wikidata.org/wiki/Q494478","display_name":"Range of motion","level":2,"score":0.5325568914413452},{"id":"https://openalex.org/C2908736133","wikidata":"https://www.wikidata.org/wiki/Q37425","display_name":"Knee Joint","level":2,"score":0.5277643203735352},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5052312016487122},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.41776710748672485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36310330033302307},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1953355073928833},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-1626193/v1","doi":"https://doi.org/10.21203/rs.3.rs-1626193/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1626193/v1","pdf_url":"https://www.researchsquare.com/article/rs-1626193/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-1626193/v1","doi":"https://doi.org/10.21203/rs.3.rs-1626193/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1626193/v1","pdf_url":"https://www.researchsquare.com/article/rs-1626193/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5605028063","display_name":"Long-term outcomes of patients after total knee arthroplasty with comorbid diabetes mellitus and evaluation of the effectiveness of optimal intervention methods","funder_award_id":"19K19749","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4229449702.pdf","grobid_xml":"https://content.openalex.org/works/W4229449702.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1143568168","https://openalex.org/W1499170180","https://openalex.org/W1503544541","https://openalex.org/W1555992846","https://openalex.org/W1566914728","https://openalex.org/W1852484849","https://openalex.org/W1854000557","https://openalex.org/W1967057044","https://openalex.org/W1969453161","https://openalex.org/W1980950264","https://openalex.org/W1986552542","https://openalex.org/W1993568348","https://openalex.org/W1995890858","https://openalex.org/W2005781104","https://openalex.org/W2026123588","https://openalex.org/W2029822648","https://openalex.org/W2030299181","https://openalex.org/W2053410759","https://openalex.org/W2060995792","https://openalex.org/W2077374261","https://openalex.org/W2099883161","https://openalex.org/W2121804105","https://openalex.org/W2126243764","https://openalex.org/W2132579793","https://openalex.org/W2140513563","https://openalex.org/W2142856621","https://openalex.org/W2143696727","https://openalex.org/W2145609928","https://openalex.org/W2145739294","https://openalex.org/W2145821003","https://openalex.org/W2146763564","https://openalex.org/W2150722389","https://openalex.org/W2158708479","https://openalex.org/W2190378646","https://openalex.org/W2317654055","https://openalex.org/W2343399226","https://openalex.org/W2612117732","https://openalex.org/W2751884637","https://openalex.org/W2799787733","https://openalex.org/W2800892095","https://openalex.org/W2803710566","https://openalex.org/W2955666772","https://openalex.org/W4210254819","https://openalex.org/W6683447186","https://openalex.org/W7030239333"],"related_works":["https://openalex.org/W4386151454","https://openalex.org/W4205249006","https://openalex.org/W4406589055","https://openalex.org/W2903948056","https://openalex.org/W4411223265","https://openalex.org/W4394998362","https://openalex.org/W4392190694","https://openalex.org/W7118188568","https://openalex.org/W4409826436","https://openalex.org/W2461633455"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Studies":[2],"are":[3,67,74,114],"now":[4],"emphasizing":[5],"on":[6],"the":[7,97,103,330],"involvement":[8],"of":[9,78,105,307,332],"risk":[10],"factors":[11],"like":[12],"diabetes":[13],"mellitus":[14],"(DM)":[15],"in":[16,60,85,107,218,225,317],"knee":[17,22,36,50,64,71,111,124,133,136,141,167,184,219,300,321,345],"osteoarthritis":[18],"(OA).":[19],"Patients":[20],"with":[21,26,35,48,57,62,90,109,122,170,222,250,280,292,311,319,342],"OA":[23,37,51,65,112,125,168,220,290,301,322,346],"and":[24,38,52,91,94,102,143,152,172,181,186,201,208,234,243,260,314,347],"those":[25,173,226],"DM":[27,39,54,93,106,171,223,251,293,308],"have":[28,40],"lower":[29,281,295],"physical":[30,43,58,86,100,145,155,179,188,203,210,296,334],"activity.":[31],"However,":[32],"whether":[33,53],"patients":[34,47,61,89,108,121,169,221,291,302,318,341],"more":[41],"decreased":[42,333],"activity":[44,59,87,101,156,161,180,204,211,297,335],"than":[45,224,298],"do":[46],"only":[49],"is":[55],"associated":[56],"moderate-to-severe":[63,110,123,320,344],"who":[66,113,126],"scheduled":[68,115,128,323],"for":[69,116,129,231,324,340],"total":[70],"arthroplasty":[72],"(TKA)":[73],"unclear.":[75],"The":[76,176,192,305],"purpose":[77],"this":[79],"study":[80],"was":[81,164,190,197,277,309],"to":[82,95],"investigate":[83],"differences":[84],"between":[88,99,166,178],"without":[92,174,227,303],"determine":[96],"association":[98,177],"presence":[104,306],"TKA.Methods:":[117],"We":[118,131],"evaluated":[119,132],"183":[120],"were":[127,215,247],"TKA.":[130,325],"function":[134,146,185],"(i.e.,":[135],"flexion/extension":[137],"range-of-motion,":[138],"knee-extension":[139,283],"strength,":[140],"pain)":[142],"performance-based":[144,187],"(e.g.,":[147],"Timed":[148],"Up-and-Go":[149],"[TUG]":[150],"test),":[151],"objectively":[153],"measured":[154],"using":[157],"an":[158],"accelerometer.":[159],"Physical":[160],"by":[162],"intensity":[163],"compared":[165],"DM.":[175,228,304,348],"DM,":[182],"including":[183],"function,":[189],"evaluated.Results:":[191],"average":[193,239],"daily":[194,240],"step":[195,241,312],"count":[196,242,313],"significantly":[198,216,248,278],"fewer":[199,238],"(p<0.001),":[200],"light-intensity":[202],"(LPA)":[205],"time":[206,213,246,265,276,316],"(p<0.001)":[207],"moderate-to-vigorous-intensity":[209],"(MVPA)":[212],"(p=0.006)":[214],"shorter":[217,244],"After":[229],"adjusting":[230],"age,":[232],"sex,":[233],"body":[235],"mass":[236],"index,":[237],"LPA":[245,315],"correlated":[249,279,310],"(\u03b2":[252,266,285],"=":[253,257,267,271,286],"-0.200,":[254],"p=0.006;":[255],"\u03b2":[256,270],"-0.216,":[258],"p=0.004)":[259],"a":[261,338],"longer":[262],"TUG":[263],"test":[264],"-0.196,":[268],"p=0.014;":[269],"-0.208,":[272],"p=0.011).":[273],"Shorter":[274],"MVPA":[275],"contralateral":[282],"strength":[284],"0.187,":[287],"p=0.032).Conclusions:":[288],"Knee":[289],"had":[294],"did":[299],"Our":[326],"results":[327],"suggested":[328],"that":[329],"progression":[331],"should":[336],"be":[337],"concern":[339],"both":[343]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-05-11T00:00:00"}