{"id":"https://openalex.org/W4229449239","doi":"https://doi.org/10.1183/23120541.lsc-2022.149","title":"Development of novel alveolar and bronchial microphysiological systems for use in disease research and drug development.","display_name":"Development of novel alveolar and bronchial microphysiological systems for use in disease research and drug development.","publication_year":2022,"publication_date":"2022-03-10","ids":{"openalex":"https://openalex.org/W4229449239","doi":"https://doi.org/10.1183/23120541.lsc-2022.149"},"language":"en","primary_location":{"id":"doi:10.1183/23120541.lsc-2022.149","doi":"https://doi.org/10.1183/23120541.lsc-2022.149","is_oa":false,"landing_page_url":"https://doi.org/10.1183/23120541.lsc-2022.149","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway cell biology and immunopathology","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109545119","display_name":"Emily Richardson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128429","display_name":"CN Bio Innovations (United Kingdom)","ror":"https://ror.org/03gy09487","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210128429"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emily Richardson","raw_affiliation_strings":["CN Bio Innovations, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CN Bio Innovations, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I4210128429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085588982","display_name":"Hailey Sze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128429","display_name":"CN Bio Innovations (United Kingdom)","ror":"https://ror.org/03gy09487","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210128429"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hailey Sze","raw_affiliation_strings":["CN Bio Innovations, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CN Bio Innovations, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I4210128429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074477230","display_name":"Tomasz M. Kostrzewski","orcid":"https://orcid.org/0000-0001-6309-628X","observed_orcids":["https://orcid.org/0000-0001-6309-628X"]},"institutions":[{"id":"https://openalex.org/I4210128429","display_name":"CN Bio Innovations (United Kingdom)","ror":"https://ror.org/03gy09487","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210128429"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tomasz Kostrzewski","raw_affiliation_strings":["CN Bio Innovations, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CN Bio Innovations, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I4210128429"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101664027","display_name":"David J. Hughes","orcid":"https://orcid.org/0000-0002-7811-7263","observed_orcids":["https://orcid.org/0000-0002-7811-7263"]},"institutions":[{"id":"https://openalex.org/I4210128429","display_name":"CN Bio Innovations (United Kingdom)","ror":"https://ror.org/03gy09487","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210128429"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Hughes","raw_affiliation_strings":["CN Bio Innovations, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CN Bio Innovations, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I4210128429"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210128429"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"149","last_page":"149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/air-liquid-interface","display_name":"air-liquid interface","score":0.8489999771118164},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.8270000219345093},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.7639999985694885},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8349999785423279},{"id":"https://openalex.org/keywords/airway-epithelial-differentiation","display_name":"airway epithelial differentiation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/cytokine-response","display_name":"cytokine response","score":0.656000018119812},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.871999979019165},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6056571006774902},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4838053584098816},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4359683692455292},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40623176097869873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3614457845687866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3325093388557434},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09647500514984131}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/23120541.lsc-2022.149","doi":"https://doi.org/10.1183/23120541.lsc-2022.149","is_oa":false,"landing_page_url":"https://doi.org/10.1183/23120541.lsc-2022.149","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway cell biology and immunopathology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3173480750","https://openalex.org/W4213154644","https://openalex.org/W4298326006","https://openalex.org/W4402461306","https://openalex.org/W4412544619","https://openalex.org/W4415387743","https://openalex.org/W4392783429","https://openalex.org/W4412470434","https://openalex.org/W3183814188","https://openalex.org/W7214142688"],"abstract_inverted_index":{"There":[0],"is":[1],"an":[2],"immediate":[3],"need":[4],"for":[5,84,236],"better":[6,242],"preclinical":[7,232],"lung":[8,59,217],"models.":[9],"Respiratory":[10],"diseases":[11],"make":[12],"up":[13],"3":[14],"of":[15,19,21,27,40,49,56,104,228,239,244],"10":[16],"leading":[17],"causes":[18],"loss":[20],"life,":[22],"and":[23,70,107,146,163,188,241],"yet":[24],"only":[25],"3%":[26],"new":[28],"pulmonary":[29],"therapeutics":[30],"reach":[31],"the":[32,41,47,68,101,105,112,127,139,197,205,225],"market":[33],"to":[34,66,87,115,122,134,176,203,207,231],"alleviate":[35],"these":[36,229],"diseases.":[37],"The":[38,181],"advent":[39],"COVID-19":[42,212],"pandemic":[43],"has":[44],"further":[45],"realised":[46],"necessity":[48],"models":[50,141,182,206],"which":[51,222],"can":[52],"allow":[53,235],"rapid":[54,237],"identification":[55],"treatments.":[57],"Two":[58],"microphysiological":[60],"systems":[61],"(MPS)":[62],"have":[63,219],"been":[64,220],"developed":[65,221],"represent":[67,116],"alveoli":[69],"bronchi.":[71],"Primary":[72],"epithelial":[73],"cells":[74,99,119],"were":[75,154,183,201],"cultured":[76],"in":[77,111,126,172,178,211],"air-liquid-interphase":[78],"on":[79,100],"Transwells\u00ae":[80],"under":[81],"flow":[82],"conditions":[83],"14":[85],"days":[86],"produce":[88,142],"a":[89],"pseudostratified":[90],"epithelium.":[91],"Further":[92],"complexity":[93],"was":[94,131],"added":[95],"by":[96],"including":[97,156],"endothelial":[98],"basolateral":[102],"side":[103],"Transwell\u00ae":[106],"monocytes":[108],"either":[109],"basolaterally":[110],"bronchial":[113],"model":[114,224],"circulating":[117],"immune":[118],"or":[120],"apically":[121],"mimic":[123],"alveolar":[124,128],"macrophages":[125],"model.":[129],"It":[130],"found":[132],"compared":[133,175],"traditional":[135],"static":[136,179],"cultures":[137],"that":[138],"perfused":[140,173],"superior":[143],"cellular":[144],"phenotypes":[145],"tissue":[147,170],"structures.":[148],"Differentiation":[149],"into":[150],"key":[151],"cell":[152],"types":[153],"increased,":[155],"AT1":[157],"(3-fold),":[158],"AT2":[159],"(7-fold),":[160],"Club":[161],"(21-fold)":[162],"Goblet":[164],"(7-fold).":[165],"IHC":[166],"analysis":[167],"revealed":[168],"complex":[169],"formation":[171],"tissues":[174],"monolayers":[177],"cultures.":[180],"challenged":[184],"using":[185],"inflammatory":[186],"stimuli":[187],"cytokine":[189],"responses":[190],"mapped":[191],"over":[192],"time.":[193],"Pseudotyped":[194],"lentivirus":[195],"expressing":[196],"SARS-CoV-2":[198],"Spike":[199],"protein":[200],"used":[202],"infect":[204],"validate":[208],"their":[209],"use":[210],"research.":[213],"In":[214],"conclusion,":[215],"two":[216],"MPS":[218,230],"accurately":[223],"lung.":[226],"Addition":[227],"packages":[233],"will":[234],"diagnoses":[238],"targets":[240],"prediction":[243],"responses.":[245]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2022-05-11T00:00:00"}
