{"id":"https://openalex.org/W4229447752","doi":"https://doi.org/10.1021/acs.oprd.2c00036","title":"Synthesis Optimization, Scale-Up, and Catalyst Screening Efforts toward the MGAT2 Clinical Candidate, BMS-963272","display_name":"Synthesis Optimization, Scale-Up, and Catalyst Screening Efforts toward the MGAT2 Clinical Candidate, BMS-963272","publication_year":2022,"publication_date":"2022-03-24","ids":{"openalex":"https://openalex.org/W4229447752","doi":"https://doi.org/10.1021/acs.oprd.2c00036"},"language":"en","primary_location":{"id":"doi:10.1021/acs.oprd.2c00036","doi":"https://doi.org/10.1021/acs.oprd.2c00036","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.oprd.2c00036","pdf_url":null,"source":{"id":"https://openalex.org/S107255770","display_name":"Organic Process Research & Development","issn_l":"1083-6160","issn":["1083-6160","1520-586X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Process Research & Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070363563","display_name":"James Kempson","orcid":"https://orcid.org/0000-0002-9540-3886","observed_orcids":["https://orcid.org/0000-0002-9540-3886"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James Kempson","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":"https://orcid.org/0000-0002-9540-3886","affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082703411","display_name":"Xiaoping Hou","orcid":"https://orcid.org/0000-0001-6169-3443","observed_orcids":["https://orcid.org/0000-0001-6169-3443"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoping Hou","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":"https://orcid.org/0000-0001-6169-3443","affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111042377","display_name":"Jung\u2010Hui Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jung-Hui Sun","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103751419","display_name":"Michael Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Wong","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020195400","display_name":"Joseph M. Pawluczyk","orcid":"https://orcid.org/0009-0006-2856-6729","observed_orcids":["https://orcid.org/0009-0006-2856-6729"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Pawluczyk","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100641154","display_name":"Jianqing Li","orcid":"https://orcid.org/0000-0002-8445-9796","observed_orcids":["https://orcid.org/0000-0002-8445-9796"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianqing Li","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":"https://orcid.org/0000-0002-8445-9796","affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007234083","display_name":"Subramaniam Krishnananthan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subramaniam Krishnananthan","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028469979","display_name":"Eric M. Simmons","orcid":"https://orcid.org/0000-0002-3854-1561","observed_orcids":["https://orcid.org/0000-0002-3854-1561"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric M. Simmons","raw_affiliation_strings":["Chemical Development, Bristol-Myers Squibb, New Brunswick, New Jersey 08903, United States"],"raw_orcid":"https://orcid.org/0000-0002-3854-1561","affiliations":[{"raw_affiliation_string":"Chemical Development, Bristol-Myers Squibb, New Brunswick, New Jersey 08903, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110037621","display_name":"Yi Hsiao","orcid":"https://orcid.org/0009-0000-2528-0844","observed_orcids":["https://orcid.org/0009-0000-2528-0844"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Hsiao","raw_affiliation_strings":["Chemical Development, Bristol-Myers Squibb, New Brunswick, New Jersey 08903, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development, Bristol-Myers Squibb, New Brunswick, New Jersey 08903, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100459848","display_name":"Yixin Li","orcid":"https://orcid.org/0009-0000-9663-9324","observed_orcids":["https://orcid.org/0009-0000-9663-9324","https://orcid.org/0009-0005-0492-2234","https://orcid.org/0009-0005-7798-8322"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Xin Li","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051819016","display_name":"Dawn Sun","orcid":"https://orcid.org/0000-0002-2080-1484","observed_orcids":["https://orcid.org/0000-0002-2080-1484"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawn Sun","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036777383","display_name":"Dauh\u2013Rurng Wu","orcid":"https://orcid.org/0000-0002-2166-9753","observed_orcids":["https://orcid.org/0000-0002-2166-9753"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dauh-Rurng Wu","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057871676","display_name":"Wei Meng","orcid":"https://orcid.org/0000-0001-5186-419X","observed_orcids":["https://orcid.org/0000-0001-5186-419X"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Meng","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":"https://orcid.org/0000-0001-5186-419X","affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103246116","display_name":"Saleem Ahmad","orcid":"https://orcid.org/0000-0002-8812-2875","observed_orcids":["https://orcid.org/0000-0002-8812-2875","https://orcid.org/0009-0000-1148-0087"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saleem Ahmad","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lidet Negash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lidet Negash","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042165938","display_name":"Robert P. Brigance","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Brigance","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047585733","display_name":"Huji Turdi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huji Turdi","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040619462","display_name":"Jon J. Hangeland","orcid":"https://orcid.org/0000-0002-8234-8857","observed_orcids":["https://orcid.org/0000-0002-8234-8857"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon J. Hangeland","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":"https://orcid.org/0000-0002-8234-8857","affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023034647","display_name":"R. Michael Lawrence","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Michael Lawrence","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056896264","display_name":"Pratik V. Devasthale","orcid":"https://orcid.org/0000-0002-9332-7541","observed_orcids":["https://orcid.org/0000-0002-9332-7541"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratik Devasthale","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":"https://orcid.org/0000-0002-9332-7541","affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034859070","display_name":"Jeffrey A. Robl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Robl","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023575873","display_name":"Arvind Mathur","orcid":"https://orcid.org/0000-0003-3146-8485","observed_orcids":["https://orcid.org/0000-0003-3146-8485","https://orcid.org/0000-0002-7702-4006"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arvind Mathur","raw_affiliation_strings":["Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States","institution_ids":["https://openalex.org/I4210091812"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070363563"],"corresponding_institution_ids":["https://openalex.org/I4210091812"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.5716,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.52284021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"26","issue":"4","first_page":"1327","last_page":"1335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.3596000075340271,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.3596000075340271,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13180","display_name":"Chemistry and Chemical Engineering","score":0.2833999991416931,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.1680999994277954,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mgat2","display_name":"MGAT2","score":0.8420000076293945},{"id":"https://openalex.org/keywords/large-scale-synthesis","display_name":"large-scale synthesis","score":0.6919999718666077},{"id":"https://openalex.org/keywords/intramolecular-cyclization","display_name":"intramolecular cyclization","score":0.9950000047683716},{"id":"https://openalex.org/keywords/active-pharmaceutical-ingredients","display_name":"active pharmaceutical ingredients","score":0.8169999718666077},{"id":"https://openalex.org/keywords/catalyst-screening","display_name":"catalyst screening","score":0.8769999742507935},{"id":"https://openalex.org/keywords/convergent-synthesis","display_name":"convergent synthesis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/preclinical-toxicology","display_name":"preclinical toxicology","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.7057701349258423},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.6581454277038574},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.5893296003341675},{"id":"https://openalex.org/C164361826","wikidata":"https://www.wikidata.org/wiki/Q177604","display_name":"Alkylation","level":3,"score":0.5678860545158386},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.4921225905418396},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4408058822154999},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.329950213432312},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.27083301544189453},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.oprd.2c00036","doi":"https://doi.org/10.1021/acs.oprd.2c00036","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.oprd.2c00036","pdf_url":null,"source":{"id":"https://openalex.org/S107255770","display_name":"Organic Process Research & Development","issn_l":"1083-6160","issn":["1083-6160","1520-586X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Process Research & Development","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1915162911","https://openalex.org/W1967139760","https://openalex.org/W1988816975","https://openalex.org/W1996768696","https://openalex.org/W1999886247","https://openalex.org/W2026509206","https://openalex.org/W2062831929","https://openalex.org/W2074251819","https://openalex.org/W2075813623","https://openalex.org/W2082110646","https://openalex.org/W2168679251","https://openalex.org/W2853106163","https://openalex.org/W2884991008","https://openalex.org/W2944148756","https://openalex.org/W2950048387","https://openalex.org/W2981343807","https://openalex.org/W3201851991"],"related_works":["https://openalex.org/W2753103678","https://openalex.org/W7220370504","https://openalex.org/W4229667433","https://openalex.org/W3213210216","https://openalex.org/W2325867107","https://openalex.org/W4396773878","https://openalex.org/W3170071225","https://openalex.org/W3167995694","https://openalex.org/W3170140958","https://openalex.org/W2016769678"],"abstract_inverted_index":{"This":[0],"paper":[1],"describes":[2],"the":[3,35,88,91],"efficient":[4],"scale-up":[5],"synthesis":[6],"of":[7,52,69,81,90],"1":[8],"(BMS-963272)":[9],"which":[10,74],"relies":[11],"upon":[12],"a":[13,22,70,77],"highly":[14],"selective":[15],"Mannich-type":[16],"alkylation":[17],"strategy":[18],"to":[19,33,46],"stereospecifically":[20],"install":[21],"quaternary":[23],"carbon":[24],"center.":[25],"An":[26],"intramolecular":[27],"cyclization":[28],"reaction":[29],"is":[30,64],"also":[31,65],"used":[32],"form":[34],"aryl":[36,85],"dihydropyridone":[37],"(ADHP)":[38],"core.":[39,93],"The":[40],"optimized":[41],"route":[42],"has":[43],"been":[44],"demonstrated":[45],"provide":[47],"more":[48,78],"than":[49],"100":[50],"g":[51],"active":[53],"pharmaceutical":[54],"ingredient":[55],"for":[56],"preclinical":[57],"toxicology":[58],"evaluation.":[59],"A":[60],"catalyst":[61],"screening":[62],"effort":[63],"discussed":[66],"as":[67],"part":[68],"complimentary":[71],"convergent":[72],"approach":[73],"will":[75],"facilitate":[76],"expedient":[79],"assessment":[80],"back-up":[82],"molecules":[83],"bearing":[84],"diversity":[86],"at":[87],"C4-position":[89],"ADHP":[92]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2022-05-11T00:00:00"}