{"id":"https://openalex.org/W4229367352","doi":"https://doi.org/10.18063/cp.v4i1.240","title":"Application of Clustered Regularly Interspaced Short Palindromic Repeat\u2014Cas12a System in Cancer Research and its Structural Basis","display_name":"Application of Clustered Regularly Interspaced Short Palindromic Repeat\u2014Cas12a System in Cancer Research and its Structural Basis","publication_year":2022,"publication_date":"2022-01-25","ids":{"openalex":"https://openalex.org/W4229367352","doi":"https://doi.org/10.18063/cp.v4i1.240"},"language":"en","primary_location":{"id":"doi:10.18063/cp.v4i1.240","doi":"https://doi.org/10.18063/cp.v4i1.240","is_oa":true,"landing_page_url":"https://doi.org/10.18063/cp.v4i1.240","pdf_url":null,"source":{"id":"https://openalex.org/S4387280152","display_name":"Cancer Plus","issn_l":"2661-3832","issn":["2661-3832","2661-3840"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Plus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.18063/cp.v4i1.240","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100362736","display_name":"Yang Zhao","orcid":"https://orcid.org/0000-0002-1428-5145","observed_orcids":["https://orcid.org/0000-0002-1428-5145"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhao Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342359","display_name":"Kun Zhang","orcid":"https://orcid.org/0000-0002-7596-5224","observed_orcids":["https://orcid.org/0000-0002-7596-5224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kun Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003818254","display_name":"Tianying Xing","orcid":"https://orcid.org/0000-0003-1510-4956","observed_orcids":["https://orcid.org/0000-0003-1510-4956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tianying Xing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110700275","display_name":"Suhang Bai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suhang Bai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036140340","display_name":"Zongyi Shen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zongyi Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100385114","display_name":"Luyao Wang","orcid":"https://orcid.org/0000-0003-1595-6593","observed_orcids":["https://orcid.org/0000-0003-1595-6593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luyao Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100702884","display_name":"Lingzhi Wang","orcid":"https://orcid.org/0000-0001-5585-5426","observed_orcids":["https://orcid.org/0000-0001-5585-5426"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lingzhi Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100739118","display_name":"Zichen Zhang","orcid":"https://orcid.org/0000-0001-8376-0539","observed_orcids":["https://orcid.org/0000-0001-8376-0539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zichen Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100424935","display_name":"Chong Li","orcid":"https://orcid.org/0000-0002-3802-1507","observed_orcids":["https://orcid.org/0000-0002-3802-1507","https://orcid.org/0009-0009-7917-1569"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chong Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100441583","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0002-2077-3188","observed_orcids":["https://orcid.org/0000-0002-2077-3188"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0447613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"1","first_page":"30","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crispr-cas12a","display_name":"CRISPR/Cas12a","score":0.9869999885559082},{"id":"https://openalex.org/keywords/protospacer-adjacent-motif","display_name":"protospacer adjacent motif","score":0.8859999775886536},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.7960000038146973},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/ascas12a","display_name":"AsCas12a","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.6179999709129333},{"id":"https://openalex.org/keywords/immune-cells","display_name":"immune cells","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.968273937702179},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.7317295074462891},{"id":"https://openalex.org/C84356384","wikidata":"https://www.wikidata.org/wiki/Q7833575","display_name":"Trans-activating crRNA","level":5,"score":0.697351336479187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6417480111122131},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5994926691055298},{"id":"https://openalex.org/C97702854","wikidata":"https://www.wikidata.org/wiki/Q4039747","display_name":"Guide RNA","level":5,"score":0.5443761348724365},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.5382160544395447},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.49594101309776306},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4818885922431946},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42496001720428467},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18380039930343628}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18063/cp.v4i1.240","doi":"https://doi.org/10.18063/cp.v4i1.240","is_oa":true,"landing_page_url":"https://doi.org/10.18063/cp.v4i1.240","pdf_url":null,"source":{"id":"https://openalex.org/S4387280152","display_name":"Cancer Plus","issn_l":"2661-3832","issn":["2661-3832","2661-3840"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Plus","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18063/cp.v4i1.240","doi":"https://doi.org/10.18063/cp.v4i1.240","is_oa":true,"landing_page_url":"https://doi.org/10.18063/cp.v4i1.240","pdf_url":null,"source":{"id":"https://openalex.org/S4387280152","display_name":"Cancer Plus","issn_l":"2661-3832","issn":["2661-3832","2661-3840"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Plus","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.766700029373169}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3004706073","https://openalex.org/W4410605086","https://openalex.org/W6964388179","https://openalex.org/W3131971823","https://openalex.org/W7156284575","https://openalex.org/W3045235658","https://openalex.org/W3136862730","https://openalex.org/W4290647400","https://openalex.org/W4386480707","https://openalex.org/W3040362029"],"abstract_inverted_index":{"The":[0],"clustered":[1],"regularly":[2],"interspaced":[3],"short":[4],"palindromic":[5],"repeat-Cas12a":[6],"(CRISPR-Cas12a)":[7],"system":[8,53,128],"is":[9,61],"a":[10,17,62],"new":[11],"type":[12],"of":[13,33,45,57,126],"CRISPR-Cas":[14],"system.":[15,47],"As":[16],"unitary":[18],"effector":[19],"protein":[20],"in":[21,68,99,114,129],"this":[22],"system,":[23,51],"Cas12a":[24,80,85,89,94],"recognizes":[25],"5\u2019-TTTN-3\u2019":[26],"protospacer-adjacent":[27],"motif":[28],"and":[29,38,73,91,132],"exhibits":[30],"cleavage":[31],"activity":[32],"double-stranded":[34],"deoxyribonucleic":[35],"acid":[36,40],"(DNA)":[37],"ribonucleic":[39],"(RNA),":[41],"supplementing":[42],"the":[43,55,69,123],"toolbox":[44],"CRISPR":[46,106],"Compared":[48],"to":[49,109],"CRISPR-Cas9":[50],"CRISPR-Cas12a":[52,127],"has":[54],"advantage":[56],"high":[58],"specificity,":[59],"which":[60],"promising":[63],"tool":[64],"for":[65],"genetic":[66],"manipulation":[67],"basic":[70],"cancer":[71,75,115,130],"research":[72,131],"clinical":[74],"therapy.":[76],"To":[77],"date,":[78],"three":[79],"proteins":[81],"including":[82],"Acidaminococcus":[83],"sp.":[84],"(AsCas12a),":[86],"Francisella":[87],"novicida":[88],"(FnCas12a),":[90],"Lachnospiraceae":[92],"bacterium":[93],"(LpCas12a)":[95],"have":[96],"been":[97],"applied":[98],"transcriptional":[100],"regulation":[101],"or":[102,112,117],"genome":[103],"editing":[104],"through":[105],"RNAs":[107],"complementary":[108],"target":[110],"DNA":[111],"RNA":[113],"cells":[116],"immune":[118],"cells.":[119],"This":[120],"review":[121],"summarizes":[122],"latest":[124],"applications":[125],"its":[133],"structural":[134],"basis.":[135]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2022-05-10T00:00:00"}
