{"id":"https://openalex.org/W4229028563","doi":"https://doi.org/10.1371/journal.pcbi.1010039","title":"Spatial dynamics of feedback and feedforward regulation in cell lineages","display_name":"Spatial dynamics of feedback and feedforward regulation in cell lineages","publication_year":2022,"publication_date":"2022-05-06","ids":{"openalex":"https://openalex.org/W4229028563","doi":"https://doi.org/10.1371/journal.pcbi.1010039","pmid":"https://pubmed.ncbi.nlm.nih.gov/35522694","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9116666"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010039","doi":"https://doi.org/10.1371/journal.pcbi.1010039","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010039","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010039&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010039&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088451048","display_name":"Peter Uhl","orcid":"https://orcid.org/0000-0002-3299-9088","observed_orcids":["https://orcid.org/0000-0002-3299-9088"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Uhl","raw_affiliation_strings":["Department of Mathematics and Statistics, San Diego State University, San Diego, CA 92182, USA","Department of Population Health and Disease Prevention, Program in Public Health, University of California, Irvine CA 92697, USA","Department of Mathematics and Statistics, San Diego State University, San Diego, California, United States of America","Department of Population Health and Disease Prevention, Program in Public Health, University of California, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, San Diego State University, San Diego, CA 92182, USA","institution_ids":["https://openalex.org/I26538001"]},{"raw_affiliation_string":"Department of Population Health and Disease Prevention, Program in Public Health, University of California, Irvine CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Mathematics and Statistics, San Diego State University, San Diego, California, United States of America","institution_ids":["https://openalex.org/I26538001"]},{"raw_affiliation_string":"Department of Population Health and Disease Prevention, Program in Public Health, University of California, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010714351","display_name":"John S. Lowengrub","orcid":"https://orcid.org/0000-0003-1759-0900","observed_orcids":["https://orcid.org/0000-0003-1759-0900"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Lowengrub","raw_affiliation_strings":["Department of Mathematics, University of California, Irvine, CA 92697, USA","Department of Mathematics, University of California, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Mathematics, University of California, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053552440","display_name":"Natalia L. Komarova","orcid":"https://orcid.org/0000-0003-4876-0343","observed_orcids":["https://orcid.org/0000-0003-4876-0343","https://orcid.org/0000-0002-6148-0971"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia Komarova","raw_affiliation_strings":["Department of Mathematics, University of California, Irvine, CA 92697, USA","Department of Mathematics, University of California, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Mathematics, University of California, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089070170","display_name":"Dominik Wodarz","orcid":"https://orcid.org/0000-0002-8017-3707","observed_orcids":["https://orcid.org/0000-0002-8017-3707"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dominik Wodarz","raw_affiliation_strings":["Department of Mathematics, University of California, Irvine, CA 92697, USA","Department of Population Health and Disease Prevention, Program in Public Health, University of California, Irvine CA 92697, USA","Department of Mathematics, University of California, Irvine, California, United States of America","Department of Population Health and Disease Prevention, Program in Public Health, University of California, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Population Health and Disease Prevention, Program in Public Health, University of California, Irvine CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Mathematics, University of California, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Population Health and Disease Prevention, Program in Public Health, University of California, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089070170"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.7203,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.64735591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"18","issue":"5","first_page":"e1010039","last_page":"e1010039"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.43849998712539673,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.43849998712539673,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.2816999852657318,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.0949999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-homeostasis","display_name":"tissue homeostasis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/stem-cell-self-renewal","display_name":"stem cell self-renewal","score":0.9369999766349792},{"id":"https://openalex.org/keywords/negative-feedback-regulation","display_name":"negative feedback regulation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/feedforward-control","display_name":"feedforward control","score":0.9300000071525574},{"id":"https://openalex.org/keywords/spatial-structure","display_name":"spatial structure","score":0.7179999947547913},{"id":"https://openalex.org/keywords/stem-cell-differentiation","display_name":"stem cell differentiation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/transit-amplifying-cells","display_name":"transit amplifying cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cell-division","display_name":"cell division","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.6959999799728394},{"id":"https://openalex.org/keywords/spatially-explicit-model","display_name":"spatially explicit model","score":0.7300000190734863},{"id":"https://openalex.org/keywords/cell-density-regulation","display_name":"cell density regulation","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.7054476141929626},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.6542523503303528},{"id":"https://openalex.org/C38858127","wikidata":"https://www.wikidata.org/wiki/Q5441228","display_name":"Feed forward","level":2,"score":0.6070743799209595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5858873724937439},{"id":"https://openalex.org/C48207687","wikidata":"https://www.wikidata.org/wiki/Q918004","display_name":"Positive feedback","level":2,"score":0.5704827308654785},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.541795015335083},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5009880065917969},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.49599918723106384},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.49106860160827637},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4353224039077759},{"id":"https://openalex.org/C186886427","wikidata":"https://www.wikidata.org/wiki/Q5441213","display_name":"Feedback loop","level":2,"score":0.42547446489334106},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.42513924837112427},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.36435604095458984},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3318040370941162},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21057525277137756},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.20914679765701294},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.143951416015625},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1414845585823059},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.07224872708320618},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1010039","doi":"https://doi.org/10.1371/journal.pcbi.1010039","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010039","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010039&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"doi:10.1101/2021.06.15.448623","doi":"https://doi.org/10.1101/2021.06.15.448623","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.06.15.448623","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/06/16/2021.06.15.448623.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9116666","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9116666","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmid:35522694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35522694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:35617fe724d5424b9b22d677d13706e3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/35617fe724d5424b9b22d677d13706e3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 5, p e1010039 (2022)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8326g218","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8326g218","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology, vol 18, iss 5","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010039","doi":"https://doi.org/10.1371/journal.pcbi.1010039","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010039","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010039&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4166590128","display_name":"Hybrid Deterministic-Stochastic Methodology for Simulating Spatial Evolution in Large Populations","funder_award_id":"1815406","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6791967163","display_name":null,"funder_award_id":"DMS176\u20103272","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6840471226","display_name":"NSF-Simons Center for Multiscale Cell Fate Research","funder_award_id":"1763272","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7296013183","display_name":"Complexity, Cooperation and Community in Cancer","funder_award_id":"U54CA217378","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000005703","display_name":null,"funder_award_id":"NIH-NCI U54-CA217378","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000326434","display_name":null,"funder_award_id":"CA217378","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4229028563.pdf","grobid_xml":"https://content.openalex.org/works/W4229028563.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1782854590","https://openalex.org/W1970195787","https://openalex.org/W1977657840","https://openalex.org/W1977905227","https://openalex.org/W1980831371","https://openalex.org/W1982649435","https://openalex.org/W2000315116","https://openalex.org/W2004783314","https://openalex.org/W2018311787","https://openalex.org/W2022511877","https://openalex.org/W2023906737","https://openalex.org/W2034202604","https://openalex.org/W2040203149","https://openalex.org/W2041326103","https://openalex.org/W2041426549","https://openalex.org/W2042423362","https://openalex.org/W2045473729","https://openalex.org/W2061958868","https://openalex.org/W2066397696","https://openalex.org/W2092271761","https://openalex.org/W2114351911","https://openalex.org/W2118077148","https://openalex.org/W2127553277","https://openalex.org/W2131282078","https://openalex.org/W2131387288","https://openalex.org/W2135793203","https://openalex.org/W2141210417","https://openalex.org/W2161302946","https://openalex.org/W2163526661","https://openalex.org/W2168901267","https://openalex.org/W2300075358","https://openalex.org/W2343285928","https://openalex.org/W2589332930","https://openalex.org/W2615815819","https://openalex.org/W2730913510","https://openalex.org/W2805733506","https://openalex.org/W3096878615"],"related_works":["https://openalex.org/W2130617383","https://openalex.org/W7008620294","https://openalex.org/W2004783314","https://openalex.org/W2792665572","https://openalex.org/W2300075358","https://openalex.org/W4320737326","https://openalex.org/W2037570430","https://openalex.org/W4393115697","https://openalex.org/W3198408907","https://openalex.org/W2520392158"],"abstract_inverted_index":{"Feedback":[0],"mechanisms":[1,190],"within":[2],"cell":[3,19,36,73,92,120,175],"lineages":[4,176],"are":[5,51,177,191],"thought":[6],"to":[7,59,83,95],"be":[8,114,136],"important":[9],"for":[10],"maintaining":[11],"tissue":[12,174],"homeostasis.":[13,46],"Mathematical":[14],"models":[15],"that":[16,27,167,184],"assume":[17],"well-mixed":[18],"populations,":[20],"together":[21],"with":[22,147],"experimental":[23],"data,":[24],"have":[25],"suggested":[26],"negative":[28,87,141],"feedback":[29,88,117,142,171],"from":[30],"differentiated":[31],"cells":[32,157],"on":[33,90,143],"the":[34,86,100,124,130,159,168],"stem":[35,91,156],"self-renewal":[37,93,144],"probability":[38],"can":[39,57,118,135],"maintain":[40,96],"a":[41],"stable":[42],"equilibrium":[43],"and":[44,77,106,122,183],"hence":[45],"Cell":[47],"lineage":[48],"dynamics,":[49],"however,":[50,134],"characterized":[52],"by":[53],"spatial":[54,104,127,151],"structure,":[55],"which":[56,155],"lead":[58],"different":[60],"properties.":[61],"Here,":[62],"we":[63],"investigate":[64],"these":[65,84],"dynamics":[66,169],"using":[67],"spatially":[68,139,187],"explicit":[69,188],"computational":[70],"models,":[71,85],"including":[72],"division,":[74],"differentiation,":[75],"death,":[76],"migration":[78,108],"/":[79,109],"diffusion":[80],"processes.":[81],"According":[82],"loop":[89],"fails":[94],"homeostasis,":[97,133],"both":[98],"under":[99],"assumption":[101],"of":[102,126,161,170,186],"strong":[103],"restrictions":[105],"fast":[107],"diffusion.":[110],"Although":[111],"homeostasis":[112],"cannot":[113],"maintained,":[115],"this":[116],"regulate":[119,158],"density":[121],"promote":[123],"formation":[125],"structures":[128],"in":[129,154,173],"model.":[131],"Tissue":[132],"achieved":[137],"if":[138],"restricted":[140],"is":[145],"combined":[146],"an":[148],"experimentally":[149],"documented":[150],"feedforward":[152],"loop,":[153],"fate":[160],"transit":[162],"amplifying":[163],"cells.":[164],"This":[165],"indicates":[166],"regulation":[172],"more":[178],"complex":[179],"than":[180],"previously":[181],"thought,":[182],"combinations":[185],"control":[189],"likely":[192],"instrumental.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-05-08T00:00:00"}