{"id":"https://openalex.org/W4229019560","doi":"https://doi.org/10.1016/j.jdermsci.2022.05.002","title":"Nicotinamide mononucleotide reduces melanin production in aged melanocytes by inhibiting cAMP/Wnt signaling","display_name":"Nicotinamide mononucleotide reduces melanin production in aged melanocytes by inhibiting cAMP/Wnt signaling","publication_year":2022,"publication_date":"2022-05-07","ids":{"openalex":"https://openalex.org/W4229019560","doi":"https://doi.org/10.1016/j.jdermsci.2022.05.002","pmid":"https://pubmed.ncbi.nlm.nih.gov/35610161"},"language":"en","primary_location":{"id":"doi:10.1016/j.jdermsci.2022.05.002","doi":"https://doi.org/10.1016/j.jdermsci.2022.05.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jdermsci.2022.05.002","pdf_url":null,"source":{"id":"https://openalex.org/S186278352","display_name":"Journal of Dermatological Science","issn_l":"0923-1811","issn":["0923-1811","1873-569X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dermatological Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065839302","display_name":"Sofia Brito","orcid":"https://orcid.org/0000-0003-3530-1885","observed_orcids":["https://orcid.org/0000-0003-3530-1885"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sofia Brito","raw_affiliation_strings":["Department of Applied Biotechnology, Ajou University, Suwon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biotechnology, Ajou University, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022330754","display_name":"Jin-myoung Baek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin-Myoung Baek","raw_affiliation_strings":["Department of Applied Biotechnology, Ajou University, Suwon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biotechnology, Ajou University, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081925066","display_name":"Byungsun Cha","orcid":"https://orcid.org/0000-0001-7224-2058","observed_orcids":["https://orcid.org/0000-0001-7224-2058"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byungsun Cha","raw_affiliation_strings":["Department of Biological Sciences, Ajou University, Suwon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Ajou University, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083511399","display_name":"Hyojin Heo","orcid":"https://orcid.org/0000-0001-7862-3572","observed_orcids":["https://orcid.org/0000-0001-7862-3572"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyojin Heo","raw_affiliation_strings":["Department of Applied Biotechnology, Ajou University, Suwon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biotechnology, Ajou University, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100631912","display_name":"Su-Hyun Lee","orcid":"https://orcid.org/0000-0003-0526-7030","observed_orcids":["https://orcid.org/0000-0003-0526-7030"]},"institutions":[{"id":"https://openalex.org/I4210106637","display_name":"Biosolution (South Korea)","ror":"https://ror.org/01hbex578","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210106637"]},{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Su-Hyun Lee","raw_affiliation_strings":["Biosolution Co, Seoul, Republic of Korea","Department of Biological Sciences, Ajou University, Suwon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosolution Co, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210106637"]},{"raw_affiliation_string":"Department of Biological Sciences, Ajou University, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112321012","display_name":"Lei Lei","orcid":"https://orcid.org/0009-0004-4524-9616","observed_orcids":["https://orcid.org/0009-0004-4524-9616","https://orcid.org/0009-0000-3826-9169"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Lei Lei","raw_affiliation_strings":["Department of Biological Sciences, Ajou University, Suwon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Ajou University, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064554785","display_name":"So Young Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"So Young Jung","raw_affiliation_strings":["Department of Applied Biotechnology, Ajou University, Suwon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biotechnology, Ajou University, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047601551","display_name":"So Min Lee","orcid":"https://orcid.org/0000-0003-3833-6792","observed_orcids":["https://orcid.org/0000-0003-3833-6792"]},"institutions":[{"id":"https://openalex.org/I4210106637","display_name":"Biosolution (South Korea)","ror":"https://ror.org/01hbex578","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210106637"]},{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"So Min Lee","raw_affiliation_strings":["Biosolution Co, Seoul, Republic of Korea","Department of Biological Sciences, Ajou University, Suwon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosolution Co, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210106637"]},{"raw_affiliation_string":"Department of Biological Sciences, Ajou University, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100405635","display_name":"Sang Hun Lee","orcid":"https://orcid.org/0000-0002-6260-7911","observed_orcids":["https://orcid.org/0000-0002-6260-7911"]},"institutions":[{"id":"https://openalex.org/I4210106637","display_name":"Biosolution (South Korea)","ror":"https://ror.org/01hbex578","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210106637"]},{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Hun Lee","raw_affiliation_strings":["Biosolution Co, Seoul, Republic of Korea","Department of Biological Sciences, Ajou University, Suwon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosolution Co, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210106637"]},{"raw_affiliation_string":"Department of Biological Sciences, Ajou University, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005323979","display_name":"Byeong-Mun Kwak","orcid":"https://orcid.org/0000-0002-9375-9029","observed_orcids":["https://orcid.org/0000-0002-9375-9029"]},"institutions":[{"id":"https://openalex.org/I4210107562","display_name":"Semyung University","ror":"https://ror.org/01d100w34","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210107562"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byeong-Mun Kwak","raw_affiliation_strings":["Department of Meridian and Acupoint, College of Korean Medicine, Semyung University, Chungbuk, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Meridian and Acupoint, College of Korean Medicine, Semyung University, Chungbuk, Republic of Korea","institution_ids":["https://openalex.org/I4210107562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064378252","display_name":"Sehyun Chae","orcid":"https://orcid.org/0000-0001-6904-0623","observed_orcids":["https://orcid.org/0000-0001-6904-0623"]},"institutions":[{"id":"https://openalex.org/I4210155455","display_name":"Korea Brain Research Institute","ror":"https://ror.org/055zd7d59","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210155455"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sehyun Chae","raw_affiliation_strings":["Neurovascular Unit Research Group, Korea Brain Research Institute, Daegu, Republic of Korea. Electronic address: shchae@kbri.re.kr","Neurovascular Unit Research Group, Korea Brain Research Institute, Daegu, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurovascular Unit Research Group, Korea Brain Research Institute, Daegu, Republic of Korea. Electronic address: shchae@kbri.re.kr","institution_ids":["https://openalex.org/I4210155455"]},{"raw_affiliation_string":"Neurovascular Unit Research Group, Korea Brain Research Institute, Daegu, Republic of Korea","institution_ids":["https://openalex.org/I4210155455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046802032","display_name":"Mi\u2010Gi Lee","orcid":"https://orcid.org/0000-0003-4658-6732","observed_orcids":["https://orcid.org/0000-0003-4658-6732"]},"institutions":[{"id":"https://openalex.org/I4405260488","display_name":"Gyeonggido Business and Science Accelerator","ror":"https://ror.org/03tpec229","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405260488"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Mi-Gi Lee","raw_affiliation_strings":["Bio-Center, Gyeonggi-do Business and Science Accelerator, Suwon, Republic of Korea. Electronic address: migi1231@gmail.com","Bio-Center, Gyeonggi-do Business and Science Accelerator, Suwon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-Center, Gyeonggi-do Business and Science Accelerator, Suwon, Republic of Korea. Electronic address: migi1231@gmail.com","institution_ids":["https://openalex.org/I4405260488"]},{"raw_affiliation_string":"Bio-Center, Gyeonggi-do Business and Science Accelerator, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I4405260488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045615134","display_name":"Bum\u2010Ho Bin","orcid":"https://orcid.org/0000-0002-3314-4938","observed_orcids":["https://orcid.org/0000-0002-3314-4938"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Bum-Ho Bin","raw_affiliation_strings":["Department of Applied Biotechnology, Ajou University, Suwon, Republic of Korea; Department of Biological Sciences, Ajou University, Suwon, Republic of Korea. Electronic address: bhb@ajou.ac.kr","Department of Applied Biotechnology, Ajou University, Suwon, Republic of Korea","Department of Biological Sciences, Ajou University, Suwon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biotechnology, Ajou University, Suwon, Republic of Korea; Department of Biological Sciences, Ajou University, Suwon, Republic of Korea. Electronic address: bhb@ajou.ac.kr","institution_ids":["https://openalex.org/I57664883"]},{"raw_affiliation_string":"Department of Applied Biotechnology, Ajou University, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]},{"raw_affiliation_string":"Department of Biological Sciences, Ajou University, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5045615134","https://openalex.org/A5046802032","https://openalex.org/A5064378252"],"corresponding_institution_ids":["https://openalex.org/I4210155455","https://openalex.org/I4405260488","https://openalex.org/I57664883"],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":null,"fwci":3.1027,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.93362894,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"106","issue":"3","first_page":"159","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotinamide-mononucleotide","display_name":"nicotinamide mononucleotide","score":1.0},{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.7979999780654907},{"id":"https://openalex.org/keywords/melanocytes","display_name":"melanocytes","score":0.7210000157356262},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6050000190734863},{"id":"https://openalex.org/keywords/nicotinamide-adenine-dinucleotide","display_name":"NAD+","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tyrosinase","display_name":"tyrosinase","score":0.9290000200271606},{"id":"https://openalex.org/keywords/trp-1","display_name":"TRP-1","score":0.7820000052452087},{"id":"https://openalex.org/keywords/tyrosinase-related-protein-2","display_name":"tyrosinase-related protein 2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/skin-pigmentation","display_name":"skin pigmentation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/hyperpigmentation","display_name":"hyperpigmentation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/anti-aging-drugs","display_name":"anti-aging drugs","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2777088662","wikidata":"https://www.wikidata.org/wiki/Q21547155","display_name":"Nicotinamide mononucleotide","level":5,"score":0.933316707611084},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.7350980639457703},{"id":"https://openalex.org/C87554066","wikidata":"https://www.wikidata.org/wiki/Q85942926","display_name":"Tyrosinase","level":3,"score":0.7020115852355957},{"id":"https://openalex.org/C2780391879","wikidata":"https://www.wikidata.org/wiki/Q18035058","display_name":"Nicotinamide phosphoribosyltransferase","level":4,"score":0.6106890439987183},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5877455472946167},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5645160675048828},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5516022443771362},{"id":"https://openalex.org/C2776901170","wikidata":"https://www.wikidata.org/wiki/Q12499775","display_name":"Nicotinamide adenine dinucleotide","level":4,"score":0.543587863445282},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.5331748127937317},{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.5301510095596313},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.5230799317359924},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48345693945884705},{"id":"https://openalex.org/C2779769559","wikidata":"https://www.wikidata.org/wiki/Q247101","display_name":"Melanocyte","level":3,"score":0.46755659580230713},{"id":"https://openalex.org/C177504595","wikidata":"https://www.wikidata.org/wiki/Q336500","display_name":"Microphthalmia-associated transcription factor","level":4,"score":0.4246852993965149},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41002941131591797},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3918860852718353},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3596702814102173},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3572540879249573},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29530274868011475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2871242165565491},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2833240032196045},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.11493819952011108},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11270448565483093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11162814497947693},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08334118127822876},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009537","descriptor_name":"Nicotinamide Mononucleotide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009537","descriptor_name":"Nicotinamide Mononucleotide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014442","descriptor_name":"Monophenol Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jdermsci.2022.05.002","doi":"https://doi.org/10.1016/j.jdermsci.2022.05.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jdermsci.2022.05.002","pdf_url":null,"source":{"id":"https://openalex.org/S186278352","display_name":"Journal of Dermatological Science","issn_l":"0923-1811","issn":["0923-1811","1873-569X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dermatological Science","raw_type":"journal-article"},{"id":"pmid:35610161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35610161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of dermatological science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2130207842","display_name":null,"funder_award_id":"22-BR-01-02","funder_id":"https://openalex.org/F4320318413","funder_display_name":"Korea Brain Research Institute"},{"id":"https://openalex.org/G2828875410","display_name":null,"funder_award_id":"2019005607","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"}],"funders":[{"id":"https://openalex.org/F4320318413","display_name":"Korea Brain Research Institute","ror":"https://ror.org/055zd7d59"},{"id":"https://openalex.org/F4320321354","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73"},{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W47495918","https://openalex.org/W127919029","https://openalex.org/W1885354525","https://openalex.org/W1932983543","https://openalex.org/W1989374522","https://openalex.org/W1990492543","https://openalex.org/W1993184878","https://openalex.org/W1998767819","https://openalex.org/W2019240387","https://openalex.org/W2036897871","https://openalex.org/W2038011036","https://openalex.org/W2046385403","https://openalex.org/W2066290706","https://openalex.org/W2073720872","https://openalex.org/W2082763359","https://openalex.org/W2086698293","https://openalex.org/W2088591017","https://openalex.org/W2097065948","https://openalex.org/W2103667120","https://openalex.org/W2107018762","https://openalex.org/W2120670171","https://openalex.org/W2134526812","https://openalex.org/W2137531873","https://openalex.org/W2158217645","https://openalex.org/W2161678021","https://openalex.org/W2171748049","https://openalex.org/W2184415243","https://openalex.org/W2256451408","https://openalex.org/W2284984697","https://openalex.org/W2339121724","https://openalex.org/W2470982690","https://openalex.org/W2524832026","https://openalex.org/W2525968651","https://openalex.org/W2546015443","https://openalex.org/W2560740910","https://openalex.org/W2596179540","https://openalex.org/W2775008495","https://openalex.org/W2786518893","https://openalex.org/W2890809709","https://openalex.org/W2896826800","https://openalex.org/W2903854778","https://openalex.org/W2960905693","https://openalex.org/W2984194295","https://openalex.org/W3023781577","https://openalex.org/W3036489753","https://openalex.org/W3182612754","https://openalex.org/W3191357607","https://openalex.org/W4389883657"],"related_works":["https://openalex.org/W7207552678","https://openalex.org/W7166706297","https://openalex.org/W2546015443","https://openalex.org/W3150050051","https://openalex.org/W1866632434","https://openalex.org/W4416757399","https://openalex.org/W4414593272","https://openalex.org/W4404595686","https://openalex.org/W4410059746","https://openalex.org/W4289522776"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-08T00:00:00"}