{"id":"https://openalex.org/W4229014972","doi":"https://doi.org/10.3389/fbioe.2022.851904","title":"Cryogel Scaffold-Mediated Delivery of Adipose-Derived Stem Cells Promotes Healing in Murine Model of Atrophic Non-Union","display_name":"Cryogel Scaffold-Mediated Delivery of Adipose-Derived Stem Cells Promotes Healing in Murine Model of Atrophic Non-Union","publication_year":2022,"publication_date":"2022-05-05","ids":{"openalex":"https://openalex.org/W4229014972","doi":"https://doi.org/10.3389/fbioe.2022.851904","pmid":"https://pubmed.ncbi.nlm.nih.gov/35600896","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9117654"},"language":"en","primary_location":{"id":"doi:10.3389/fbioe.2022.851904","doi":"https://doi.org/10.3389/fbioe.2022.851904","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2022.851904","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbioe.2022.851904/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fbioe.2022.851904/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025419638","display_name":"Katherine R. Hixon","orcid":"https://orcid.org/0000-0002-3094-5537","observed_orcids":["https://orcid.org/0000-0002-3094-5537"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4405268834","display_name":"Musculoskeletal Research Center, Washington University in St. Louis","ror":"https://ror.org/02729ja77","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katherine R. Hixon","raw_affiliation_strings":["Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University, St. Louis, MO, United States","Thayer School of Engineering, Dartmouth College, Hanover, NH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4405268834"]},{"raw_affiliation_string":"Thayer School of Engineering, Dartmouth College, Hanover, NH, United States","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064774249","display_name":"Dakota B. Katz","orcid":"https://orcid.org/0000-0001-8400-0582","observed_orcids":["https://orcid.org/0000-0001-8400-0582"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210158667","display_name":"Shriners Hospitals for Children - St. Louis","ror":"https://ror.org/049mpkx27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210144267","https://openalex.org/I4210158667"]},{"id":"https://openalex.org/I4405268834","display_name":"Musculoskeletal Research Center, Washington University in St. Louis","ror":"https://ror.org/02729ja77","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dakota B. Katz","raw_affiliation_strings":["Center of Regenerative Medicine, Washington University, St. Louis, MO, United States","Department of Biomedical Engineering, Washington University, St. Louis, MO, United States","Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University, St. Louis, MO, United States","Shriners Hospitals for Children-St. Louis, St. Louis, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Regenerative Medicine, Washington University, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4405268834"]},{"raw_affiliation_string":"Shriners Hospitals for Children-St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I4210158667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003148432","display_name":"Jennifer A. McKenzie","orcid":"https://orcid.org/0000-0002-5723-4057","observed_orcids":["https://orcid.org/0000-0002-5723-4057"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4405268834","display_name":"Musculoskeletal Research Center, Washington University in St. Louis","ror":"https://ror.org/02729ja77","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer A. McKenzie","raw_affiliation_strings":["Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University, St. Louis, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4405268834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062791274","display_name":"Anna N. Miller","orcid":"https://orcid.org/0000-0002-7056-8502","observed_orcids":["https://orcid.org/0000-0002-7056-8502"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4405268834","display_name":"Musculoskeletal Research Center, Washington University in St. Louis","ror":"https://ror.org/02729ja77","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna N. Miller","raw_affiliation_strings":["Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University, St. Louis, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4405268834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090627153","display_name":"Farshid Guilak","orcid":"https://orcid.org/0000-0001-7380-0330","observed_orcids":["https://orcid.org/0000-0001-7380-0330"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210158667","display_name":"Shriners Hospitals for Children - St. Louis","ror":"https://ror.org/049mpkx27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210144267","https://openalex.org/I4210158667"]},{"id":"https://openalex.org/I4405268834","display_name":"Musculoskeletal Research Center, Washington University in St. Louis","ror":"https://ror.org/02729ja77","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farshid Guilak","raw_affiliation_strings":["Center of Regenerative Medicine, Washington University, St. Louis, MO, United States","Department of Biomedical Engineering, Washington University, St. Louis, MO, United States","Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University, St. Louis, MO, United States","Shriners Hospitals for Children-St. Louis, St. Louis, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Regenerative Medicine, Washington University, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4405268834"]},{"raw_affiliation_string":"Shriners Hospitals for Children-St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I4210158667"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056468741","display_name":"Matthew J. Silva","orcid":"https://orcid.org/0000-0001-7375-4522","observed_orcids":["https://orcid.org/0000-0001-7375-4522"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4405268834","display_name":"Musculoskeletal Research Center, Washington University in St. Louis","ror":"https://ror.org/02729ja77","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J. Silva","raw_affiliation_strings":["Center of Regenerative Medicine, Washington University, St. Louis, MO, United States","Department of Biomedical Engineering, Washington University, St. Louis, MO, United States","Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University, St. Louis, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Regenerative Medicine, Washington University, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4405268834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025419638"],"corresponding_institution_ids":["https://openalex.org/I107672454","https://openalex.org/I204465549","https://openalex.org/I4405268834"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.3629,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.44071446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"10","issue":null,"first_page":"851904","last_page":"851904"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.15549999475479126,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-nonunion","display_name":"bone nonunion","score":0.7870000004768372},{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.9309999942779541},{"id":"https://openalex.org/keywords/lentiviral-gene-delivery","display_name":"lentiviral gene delivery","score":0.7820000052452087},{"id":"https://openalex.org/keywords/doxycycline-inducible-transgene","display_name":"doxycycline-inducible transgene","score":0.8399999737739563},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.6309999823570251},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.6629999876022339},{"id":"https://openalex.org/keywords/endochondral-ossification","display_name":"endochondral ossification","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.6674129366874695},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5749872922897339},{"id":"https://openalex.org/C2777179404","wikidata":"https://www.wikidata.org/wiki/Q422442","display_name":"Doxycycline","level":3,"score":0.5425771474838257},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.5220772624015808},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5100336670875549},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5015053749084473},{"id":"https://openalex.org/C3018021831","wikidata":"https://www.wikidata.org/wiki/Q7049641","display_name":"Non union","level":2,"score":0.4742376208305359},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4320519268512726},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.41021233797073364},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34017303586006165},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28538089990615845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27842479944229126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13681471347808838},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fbioe.2022.851904","doi":"https://doi.org/10.3389/fbioe.2022.851904","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2022.851904","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbioe.2022.851904/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9117654","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9117654","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Bioeng Biotechnol","raw_type":"Text"},{"id":"pmid:35600896","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35600896","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioengineering and biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:oa_4-1715","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/oa_4/716","pdf_url":null,"source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2020-Current year OA Pubs","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:483f220f3d2943c89f50129305aa0a24","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/483f220f3d2943c89f50129305aa0a24","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fbioe.2022.851904","doi":"https://doi.org/10.3389/fbioe.2022.851904","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2022.851904","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbioe.2022.851904/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1201556103","display_name":null,"funder_award_id":"P30AR073752","funder_id":"https://openalex.org/F4320309650","funder_display_name":"Washington University in St. Louis"},{"id":"https://openalex.org/G2472603119","display_name":null,"funder_award_id":"AR074992","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2475445944","display_name":"New Murine Models for Study of Atrophic Fracture Nonunion","funder_award_id":"R21AR076636","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3810130841","display_name":null,"funder_award_id":"AG46927","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4296882399","display_name":null,"funder_award_id":"P30 AR074992","funder_id":"https://openalex.org/F4320334321","funder_display_name":"Musculoskeletal Research Center, Washington University in St. Louis"},{"id":"https://openalex.org/G4476993284","display_name":null,"funder_award_id":"S10 RR027552","funder_id":"https://openalex.org/F4320309650","funder_display_name":"Washington University in St. Louis"},{"id":"https://openalex.org/G4619719930","display_name":null,"funder_award_id":"AG15768","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5190218268","display_name":null,"funder_award_id":"R01 AR050211 R21 AR076636 T32 AR060719 F32 AR076191 P30 AR074992 P30 AR073752 R01 AG15768 R01 AG46927 R01 AR07299","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G75401140","display_name":null,"funder_award_id":"AR050211","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7638265760","display_name":"IN VIVO MICROCT SYSTEM","funder_award_id":"S10RR023660","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8154698928","display_name":"WHOLE SLIDE IMAGING SYSTEM FOR TRANSLATIONAL NEUROSCIENCE","funder_award_id":"S10RR027552","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8336665799","display_name":"The Development and Rescue of an Atrophic Nonunion Model","funder_award_id":"F32AR076191","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8343030177","display_name":"Osteogenic and Angiogenic Response to Skeletal Loading","funder_award_id":"R01AR050211","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8487592227","display_name":null,"funder_award_id":"AR073752","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000869552","display_name":"Washington University Rheumatic Diseases Research Resource-based Center","funder_award_id":"P30AR073752","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000880103","display_name":"RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINE","funder_award_id":"P30AR074992","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000913983","display_name":"Skeletal Disorders Training Program","funder_award_id":"T32AR060719","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320309650","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268"},{"id":"https://openalex.org/F4320310585","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71"},{"id":"https://openalex.org/F4320312021","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08"},{"id":"https://openalex.org/F4320334321","display_name":"Musculoskeletal Research Center, Washington University in St. Louis","ror":"https://ror.org/02729ja77"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4229014972.pdf","grobid_xml":"https://content.openalex.org/works/W4229014972.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W67293756","https://openalex.org/W1157656794","https://openalex.org/W1557190222","https://openalex.org/W1967971466","https://openalex.org/W1973086789","https://openalex.org/W1974163213","https://openalex.org/W1978750247","https://openalex.org/W1979242330","https://openalex.org/W1982965080","https://openalex.org/W1985575261","https://openalex.org/W1987155597","https://openalex.org/W1987504060","https://openalex.org/W1990847801","https://openalex.org/W1998727589","https://openalex.org/W2002417213","https://openalex.org/W2002425495","https://openalex.org/W2012886552","https://openalex.org/W2012954072","https://openalex.org/W2014386784","https://openalex.org/W2036557984","https://openalex.org/W2037219613","https://openalex.org/W2046270293","https://openalex.org/W2050754818","https://openalex.org/W2054603498","https://openalex.org/W2055942209","https://openalex.org/W2059873109","https://openalex.org/W2075113673","https://openalex.org/W2093784182","https://openalex.org/W2100221605","https://openalex.org/W2101357571","https://openalex.org/W2105255789","https://openalex.org/W2115496786","https://openalex.org/W2116581287","https://openalex.org/W2119500803","https://openalex.org/W2127064713","https://openalex.org/W2137491282","https://openalex.org/W2138305712","https://openalex.org/W2150086253","https://openalex.org/W2152347337","https://openalex.org/W2159310558","https://openalex.org/W2163179623","https://openalex.org/W2169757747","https://openalex.org/W2171768590","https://openalex.org/W2246647439","https://openalex.org/W2262174235","https://openalex.org/W2274322850","https://openalex.org/W2331589472","https://openalex.org/W2337958855","https://openalex.org/W2340110248","https://openalex.org/W2395858699","https://openalex.org/W2505322038","https://openalex.org/W2514979671","https://openalex.org/W2547867186","https://openalex.org/W2570007282","https://openalex.org/W2606254366","https://openalex.org/W2611203456","https://openalex.org/W2615201841","https://openalex.org/W2618267927","https://openalex.org/W2734031889","https://openalex.org/W2736526774","https://openalex.org/W2746574475","https://openalex.org/W2762565742","https://openalex.org/W2790664419","https://openalex.org/W2801438579","https://openalex.org/W2802981444","https://openalex.org/W2901558431","https://openalex.org/W2904072138","https://openalex.org/W2906898845","https://openalex.org/W2908011023","https://openalex.org/W2913382966","https://openalex.org/W2921763993","https://openalex.org/W2941025505","https://openalex.org/W2950275498","https://openalex.org/W3048029138","https://openalex.org/W3193578646","https://openalex.org/W4246651174"],"related_works":["https://openalex.org/W2618267927","https://openalex.org/W3193578646","https://openalex.org/W4398777275","https://openalex.org/W2125828283","https://openalex.org/W2308095233","https://openalex.org/W3210758860","https://openalex.org/W2183823299","https://openalex.org/W2802521991","https://openalex.org/W1981637888","https://openalex.org/W2159310558"],"abstract_inverted_index":{"Non-union":[0],"is":[1],"defined":[2],"as":[3,103],"the":[4,44,51,71,84,96,113,122,155,164,170,185,190,205,231,242,264,274,282,290,295,310,318],"permanent":[5],"failure":[6],"of":[7,17,40,88,115,124,166,172,187,229,254,273,292,320],"a":[8,36,65,104,125,135,144,301],"bone":[9,145,240,250,259],"to":[10,31,58,64,112,196,304,316],"heal":[11],"and":[12,29,67,108,189,210,218,223,238,260,266],"occurs":[13],"clinically":[14],"in":[15,43,134,169,278],"5%":[16],"fractures.":[18],"Atrophic":[19],"non-unions,":[20],"characterized":[21],"by":[22],"absent/minimal":[23],"callus":[24],"formation,":[25],"are":[26],"poorly":[27],"understood":[28],"difficult":[30],"treat.":[32],"We":[33],"recently":[34],"demonstrated":[35],"novel":[37],"murine":[38],"model":[39],"atrophic":[41,78,167],"non-union":[42,69,79,243],"3.6Col1A1-tk":[45],"(Col1-tk)":[46],"mouse,":[47],"wherein":[48],"dosing":[49],"with":[50,236,270],"nucleoside":[52],"analog":[53],"ganciclovir":[54],"(GCV)":[55],"was":[56],"used":[57,102],"deplete":[59],"proliferating":[60],"osteoprogenitor":[61],"cells,":[62],"leading":[63],"radiographic":[66],"biomechanical":[68],"after":[70],"mid-shaft":[72],"femur":[73],"fracture.":[74],"Using":[75],"this":[76],"Col1-tk":[77,173],"model,":[80],"we":[81],"hypothesized":[82],"that":[83,139],"scaffold-mediated":[85],"lentiviral":[86,161],"delivery":[87,111],"doxycycline-inducible":[89],"BMP-2":[90,198,293],"transgenes":[91],"would":[92],"induce":[93,197],"osteogenesis":[94],"at":[95,129,241],"fracture":[97,276],"site.":[98],"Cryogel":[99,117],"scaffolds":[100,118,180,233,247,269,315],"were":[101,119,152,181,192,216,234],"vehicle":[105],"for":[106,143,312],"GFP+":[107,202,246],"BMP-2+":[109,232,265],"cell":[110],"site":[114,186,277],"non-union.":[116],"biofabricated":[120],"through":[121],"cross-linking":[123],"chitosan-gelatin":[126],"polymer":[127],"solution":[128],"subzero":[130],"temperatures,":[131],"which":[132],"results":[133],"macroporous,":[136],"spongy":[137],"structure":[138],"may":[140,299],"be":[141],"advantageous":[142],"regeneration":[146],"application.":[147],"Murine":[148],"adipose-derived":[149],"stem":[150],"cells":[151,203],"seeded":[153,179],"onto":[154],"cryogel":[156,206,314],"scaffolds,":[157,207,209],"where":[158],"they":[159],"underwent":[160],"transduction.":[162],"Following":[163],"establishment":[165],"non-unions":[168],"femurs":[171],"mice":[174],"(4":[175],"weeks":[176,228,256],"post-fracture),":[177],"transduced,":[178],"surgically":[182],"placed":[183],"around":[184],"non-union,":[188],"animals":[191],"given":[193],"doxycycline":[194],"water":[195],"production.":[199],"Controls":[200],"included":[201,221],"on":[204],"acellular":[208],"sham":[211],"(no":[212],"scaffold).":[213],"Weekly":[214],"radiographs":[215],"taken,":[217],"endpoint":[219],"analysis":[220],"micro-CT":[222],"histological":[224],"staining.":[225],"After":[226],"2":[227],"implantation,":[230],"infiltrated":[235],"cartilage":[237],"woven":[239,249,258],"site,":[244],"while":[245,289],"had":[248,257],"formation.":[251],"Later,":[252],"timepoints":[253],"8":[255],"vessel":[261],"formation":[262],"within":[263],"GFP":[267],"+":[268],"cortical":[271],"bridging":[272],"original":[275],"both":[279],"groups.":[280],"Overall,":[281],"cell-seeded":[283],"cryogels":[284],"promoted":[285,294],"osseous":[286],"healing.":[287,305],"However,":[288],"addition":[291],"endochondral":[296],"ossification,":[297],"it":[298],"provide":[300],"slower":[302],"route":[303],"This":[306],"proof-of-concept":[307],"study":[308],"demonstrates":[309],"potential":[311],"cellularized":[313],"enhance":[317],"healing":[319],"non-unions.":[321]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-08T00:00:00"}
