{"id":"https://openalex.org/W4229011964","doi":"https://doi.org/10.1016/j.scr.2022.102807","title":"Generation of gene-corrected isogenic control cell lines from a DYT1 dystonia patient iPSC line carrying a heterozygous GAG mutation in TOR1A gene","display_name":"Generation of gene-corrected isogenic control cell lines from a DYT1 dystonia patient iPSC line carrying a heterozygous GAG mutation in TOR1A gene","publication_year":2022,"publication_date":"2022-05-05","ids":{"openalex":"https://openalex.org/W4229011964","doi":"https://doi.org/10.1016/j.scr.2022.102807","pmid":"https://pubmed.ncbi.nlm.nih.gov/35533513","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9366766"},"language":"en","primary_location":{"id":"doi:10.1016/j.scr.2022.102807","doi":"https://doi.org/10.1016/j.scr.2022.102807","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.scr.2022.102807","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1873506122001568/pdf","source":{"id":"https://openalex.org/S81007815","display_name":"Stem Cell Research","issn_l":"1873-5061","issn":["1873-5061","1876-7753"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1873506122001568/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086822553","display_name":"Masuma Akter","orcid":"https://orcid.org/0000-0002-7111-5222","observed_orcids":["https://orcid.org/0000-0002-7111-5222"]},"institutions":[{"id":"https://openalex.org/I79516672","display_name":"University of Louisiana at Lafayette","ror":"https://ror.org/01x8rc503","country_code":"US","type":"education","lineage":["https://openalex.org/I2799628689","https://openalex.org/I79516672"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masuma Akter","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA; Department of Biology, University of Louisiana at Lafayette, Lafayette LA 70503, USA","Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA","Department of Biology, University of Louisiana at Lafayette, Lafayette LA 70503, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA; Department of Biology, University of Louisiana at Lafayette, Lafayette LA 70503, USA","institution_ids":["https://openalex.org/I79516672","https://openalex.org/I81020160"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA","institution_ids":["https://openalex.org/I81020160"]},{"raw_affiliation_string":"Department of Biology, University of Louisiana at Lafayette, Lafayette LA 70503, USA","institution_ids":["https://openalex.org/I79516672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036614093","display_name":"Haochen Cui","orcid":"https://orcid.org/0000-0003-3590-2613","observed_orcids":["https://orcid.org/0000-0003-3590-2613"]},"institutions":[{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haochen Cui","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA","institution_ids":["https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016482769","display_name":"Yi\u2010Hsien Chen","orcid":"https://orcid.org/0000-0002-7019-2357","observed_orcids":["https://orcid.org/0000-0002-7019-2357"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Hsien Chen","raw_affiliation_strings":["Genome Engineering and iPSC Center (GEiC), Washington University in St Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Engineering and iPSC Center (GEiC), Washington University in St Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063467674","display_name":"Baojin Ding","orcid":"https://orcid.org/0000-0002-2149-2599","observed_orcids":["https://orcid.org/0000-0002-2149-2599"]},"institutions":[{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Baojin Ding","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA. Electronic address: baojin.ding@lsuhs.edu","Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA. Electronic address: baojin.ding@lsuhs.edu","institution_ids":["https://openalex.org/I81020160"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA","institution_ids":["https://openalex.org/I81020160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063467674"],"corresponding_institution_ids":["https://openalex.org/I81020160"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.6525,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.60353659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"62","issue":null,"first_page":"102807","last_page":"102807"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.08389999717473984,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gag-deletion","display_name":"GAG deletion","score":0.8270000219345093},{"id":"https://openalex.org/keywords/heterozygous-variants","display_name":"heterozygous mutation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/gene-correction","display_name":"gene correction","score":0.621999979019165},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8849999904632568},{"id":"https://openalex.org/keywords/patient-derived-ipscs","display_name":"patient-derived iPSCs","score":0.5929999947547913},{"id":"https://openalex.org/keywords/hereditary-movement-disorders","display_name":"hereditary movement disorders","score":0.7289999723434448},{"id":"https://openalex.org/keywords/stem-cell-markers","display_name":"stem cell markers","score":0.7770000100135803},{"id":"https://openalex.org/keywords/three-germ-layer-differentiation","display_name":"three germ layer differentiation","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9034919738769531},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.7201120853424072},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6714211106300354},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5771902799606323},{"id":"https://openalex.org/C2778559928","wikidata":"https://www.wikidata.org/wiki/Q906492","display_name":"Dystonia","level":2,"score":0.5424306392669678},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.5348044633865356},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5297756195068359},{"id":"https://openalex.org/C12125453","wikidata":"https://www.wikidata.org/wiki/Q5156837","display_name":"Compound heterozygosity","level":4,"score":0.5244924426078796},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.463900089263916},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.4450758397579193},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44033318758010864},{"id":"https://openalex.org/C18155467","wikidata":"https://www.wikidata.org/wiki/Q660498","display_name":"Germ layer","level":5,"score":0.4219192862510681},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34106576442718506},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.19428479671478271},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.17293286323547363},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004421","descriptor_name":"Dystonia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004422","descriptor_name":"Dystonia Musculorum Deformans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020821","descriptor_name":"Dystonic Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.scr.2022.102807","doi":"https://doi.org/10.1016/j.scr.2022.102807","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.scr.2022.102807","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1873506122001568/pdf","source":{"id":"https://openalex.org/S81007815","display_name":"Stem Cell Research","issn_l":"1873-5061","issn":["1873-5061","1876-7753"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research","raw_type":"journal-article"},{"id":"pmid:35533513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35533513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9366766","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9366766","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Stem Cell Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7c93d3b11b0b476a9431229f8757b4d5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7c93d3b11b0b476a9431229f8757b4d5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Research, Vol 62, Iss , Pp 102807- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.scr.2022.102807","doi":"https://doi.org/10.1016/j.scr.2022.102807","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.scr.2022.102807","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1873506122001568/pdf","source":{"id":"https://openalex.org/S81007815","display_name":"Stem Cell Research","issn_l":"1873-5061","issn":["1873-5061","1876-7753"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3480604629","display_name":null,"funder_award_id":"W81XWH2010186","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G413154657","display_name":null,"funder_award_id":"NS112910","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4188161251","display_name":null,"funder_award_id":"W81XWH2010186","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5326062177","display_name":"DETERMINING THE PATHOGENESIS OF DYSTONIA IN REPROGRAMMED HUMAN NEURONS","funder_award_id":"W81XWH2010186","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G6395581657","display_name":"Determining the pathogenesis of DYT1 dystonia in reprogrammed human neurons","funder_award_id":"R21NS112910","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G903426964","display_name":null,"funder_award_id":"NS112910","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320309650","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4229011964.pdf","grobid_xml":"https://content.openalex.org/works/W4229011964.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W1998724633","https://openalex.org/W3125504075","https://openalex.org/W3134838971","https://openalex.org/W3200346302","https://openalex.org/W4221132273"],"related_works":["https://openalex.org/W3200346302","https://openalex.org/W4403599940","https://openalex.org/W3134838971","https://openalex.org/W1555325451","https://openalex.org/W1651023999","https://openalex.org/W4416730817","https://openalex.org/W1896451807","https://openalex.org/W2006260024","https://openalex.org/W2043015901","https://openalex.org/W4280585505"],"abstract_inverted_index":{"Childhood-onset":[0],"torsin":[1,29],"dystonia":[2],"(DYT1)":[3],"is":[4],"a":[5,14,44,92],"rare":[6],"hereditary":[7],"movement":[8],"disorder":[9],"and":[10,31,60,80,85],"usually":[11],"caused":[12],"by":[13],"heterozygous":[15],"GAG":[16,58],"deletion":[17,59],"(c.907-909)":[18],"in":[19,95],"the":[20,32,70,75],"TOR1A":[21,72],"gene":[22],"(\u0394E,":[23],"p.Glu303del).":[24],"The":[25],"neuronal":[26],"functions":[27],"of":[28,34],"proteins":[30],"pathogenesis":[33],"\u0394E":[35],"mutation":[36],"are":[37],"not":[38],"clear.":[39],"Previously,":[40],"we":[41,55],"have":[42],"generated":[43],"hiPSC":[45,67],"line":[46],"from":[47],"DYT1":[48,96],"patient":[49],"fibroblast":[50],"cells.":[51],"In":[52],"this":[53],"study,":[54],"genetically":[56],"corrected":[57],"obtained":[61],"two":[62],"isogenic":[63],"control":[64],"lines.":[65],"These":[66],"lines":[68],"contain":[69],"wild-type":[71],"sequence,":[73],"showed":[74],"normal":[76],"stem":[77],"cell":[78],"morphology":[79],"karyotype,":[81],"expressed":[82],"pluripotency":[83],"markers,":[84],"differentiated":[86],"into":[87],"three":[88],"germ":[89],"layers,":[90],"providing":[91],"valuable":[93],"resource":[94],"research.":[97]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-08T00:00:00"}