{"id":"https://openalex.org/W4226497831","doi":null,"title":"MicroRNA-199a-3p promotes drug sensitivity in triple negative breast cancer by down-regulation of BRCA1.","display_name":"MicroRNA-199a-3p promotes drug sensitivity in triple negative breast cancer by down-regulation of BRCA1.","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4226497831","pmid":"https://pubmed.ncbi.nlm.nih.gov/35422914","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8991114"},"language":"en","primary_location":{"id":"pmid:35422914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35422914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8991114/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113723867","display_name":"John Chi-Wang Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141719","display_name":"University of Hong Kong - Shenzhen Hospital","ror":"https://ror.org/047w7d678","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141719"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"John Chi-Wang Ho","raw_affiliation_strings":["Department of Surgery, The University of Hong Kong and The University of Hong Kong-Shenzhen Hospital Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, The University of Hong Kong and The University of Hong Kong-Shenzhen Hospital Hong Kong, China","institution_ids":["https://openalex.org/I4210141719","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362810","display_name":"Jiawei Chen","orcid":"https://orcid.org/0000-0002-0895-9027","observed_orcids":["https://orcid.org/0000-0002-0895-9027"]},"institutions":[{"id":"https://openalex.org/I4210141719","display_name":"University of Hong Kong - Shenzhen Hospital","ror":"https://ror.org/047w7d678","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141719"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Jiawei Chen","raw_affiliation_strings":["Department of Surgery, The University of Hong Kong and The University of Hong Kong-Shenzhen Hospital Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, The University of Hong Kong and The University of Hong Kong-Shenzhen Hospital Hong Kong, China","institution_ids":["https://openalex.org/I4210141719","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071131613","display_name":"Isabella Cheuk","orcid":"https://orcid.org/0000-0002-9446-7239","observed_orcids":["https://orcid.org/0000-0002-9446-7239"]},"institutions":[{"id":"https://openalex.org/I4210141719","display_name":"University of Hong Kong - Shenzhen Hospital","ror":"https://ror.org/047w7d678","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141719"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Isabella Wai-Yin Cheuk","raw_affiliation_strings":["Department of Surgery, The University of Hong Kong and The University of Hong Kong-Shenzhen Hospital Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, The University of Hong Kong and The University of Hong Kong-Shenzhen Hospital Hong Kong, China","institution_ids":["https://openalex.org/I4210141719","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112362867","display_name":"Man-Ting Siu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141719","display_name":"University of Hong Kong - Shenzhen Hospital","ror":"https://ror.org/047w7d678","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141719"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Man-Ting Siu","raw_affiliation_strings":["Department of Surgery, The University of Hong Kong and The University of Hong Kong-Shenzhen Hospital Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, The University of Hong Kong and The University of Hong Kong-Shenzhen Hospital Hong Kong, China","institution_ids":["https://openalex.org/I4210141719","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100619956","display_name":"Vivian Yvonne Shin","orcid":"https://orcid.org/0000-0003-1282-7593","observed_orcids":["https://orcid.org/0000-0003-1282-7593"]},"institutions":[{"id":"https://openalex.org/I4210141719","display_name":"University of Hong Kong - Shenzhen Hospital","ror":"https://ror.org/047w7d678","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141719"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Vivian Yvonne Shin","raw_affiliation_strings":["Department of Surgery, The University of Hong Kong and The University of Hong Kong-Shenzhen Hospital Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, The University of Hong Kong and The University of Hong Kong-Shenzhen Hospital Hong Kong, China","institution_ids":["https://openalex.org/I4210141719","https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025137857","display_name":"Ava Kwong","orcid":"https://orcid.org/0000-0002-6968-9489","observed_orcids":["https://orcid.org/0000-0002-6968-9489"]},"institutions":[{"id":"https://openalex.org/I4210100061","display_name":"Hong Kong Sanatorium and Hospital","ror":"https://ror.org/010mjn423","country_code":"HK","type":"healthcare","lineage":["https://openalex.org/I4210100061"]},{"id":"https://openalex.org/I4210141719","display_name":"University of Hong Kong - Shenzhen Hospital","ror":"https://ror.org/047w7d678","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141719"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Ava Kwong","raw_affiliation_strings":["Department of Surgery, The University of Hong Kong and The University of Hong Kong-Shenzhen Hospital Hong Kong, China","Department of Surgery, Hong Kong Sanatorium & Hospital Hong Kong, China","Hong Kong Hereditary Breast Cancer Family Registry Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, The University of Hong Kong and The University of Hong Kong-Shenzhen Hospital Hong Kong, China","institution_ids":["https://openalex.org/I4210141719","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Department of Surgery, Hong Kong Sanatorium & Hospital Hong Kong, China","institution_ids":["https://openalex.org/I4210100061"]},{"raw_affiliation_string":"Hong Kong Hereditary Breast Cancer Family Registry Hong Kong, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6975,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.59902649,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"3","first_page":"2021","last_page":"2036"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.8830000162124634},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.7279999852180481},{"id":"https://openalex.org/keywords/microrna-downregulation","display_name":"microRNA downregulation","score":0.6460000276565552},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8889999985694885},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C2781312401","wikidata":"https://www.wikidata.org/wiki/Q7919041","display_name":"Veliparib","level":5,"score":0.7651864886283875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.764943540096283},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.7411201596260071},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6388594508171082},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5689360499382019},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.5313093662261963},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.5255704522132874},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.47797462344169617},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.43022286891937256},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41899335384368896},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4037966728210449},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3946424126625061},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39271843433380127},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37917542457580566},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3436727523803711},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.31576669216156006},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.24503135681152344},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.18042555451393127},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1706956923007965},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07777100801467896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:35422914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35422914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8991114","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8991114/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8991114","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8991114/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W299684343","https://openalex.org/W1555035643","https://openalex.org/W1829348795","https://openalex.org/W1901222597","https://openalex.org/W1928092242","https://openalex.org/W1973816122","https://openalex.org/W1989006164","https://openalex.org/W1993425229","https://openalex.org/W2004125597","https://openalex.org/W2012787384","https://openalex.org/W2015078920","https://openalex.org/W2030913322","https://openalex.org/W2033370338","https://openalex.org/W2033830808","https://openalex.org/W2040587605","https://openalex.org/W2045756380","https://openalex.org/W2060863314","https://openalex.org/W2064616338","https://openalex.org/W2068476548","https://openalex.org/W2086064725","https://openalex.org/W2103970959","https://openalex.org/W2105496345","https://openalex.org/W2113382133","https://openalex.org/W2118723994","https://openalex.org/W2131857902","https://openalex.org/W2138474420","https://openalex.org/W2140930673","https://openalex.org/W2142486051","https://openalex.org/W2145720555","https://openalex.org/W2149880040","https://openalex.org/W2150111967","https://openalex.org/W2158742893","https://openalex.org/W2170602872","https://openalex.org/W2199466904","https://openalex.org/W2281441010","https://openalex.org/W2345946157","https://openalex.org/W2463221577","https://openalex.org/W2493505337","https://openalex.org/W2507786826","https://openalex.org/W2552558017","https://openalex.org/W2555602737","https://openalex.org/W2559791049","https://openalex.org/W2586050845","https://openalex.org/W2606671506","https://openalex.org/W2621271973","https://openalex.org/W3140624803"],"related_works":["https://openalex.org/W2981677877","https://openalex.org/W2885398941","https://openalex.org/W2552558017","https://openalex.org/W2886206782","https://openalex.org/W7033594625","https://openalex.org/W2938526574","https://openalex.org/W2790566398","https://openalex.org/W2953473070","https://openalex.org/W2047395198","https://openalex.org/W4383710377"],"abstract_inverted_index":{"gene":[0],"dysfunction.":[1],"These":[2],"findings":[3],"may":[4],"provide":[5],"insights":[6],"into":[7],"the":[8],"potential":[9],"prognostic":[10],"and":[11],"therapeutic":[12],"values":[13],"of":[14],"miR-199a-3p":[15],"in":[16],"patients":[17],"with":[18],"TNBC.":[19]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-05-05T00:00:00"}