{"id":"https://openalex.org/W4226453057","doi":"https://doi.org/10.2139/ssrn.4089982","title":"Extracellular Vesicles From a Gut Symbiont Mediate Adenosinergic Responses to Promote Immune Tolerance","display_name":"Extracellular Vesicles From a Gut Symbiont Mediate Adenosinergic Responses to Promote Immune Tolerance","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4226453057","doi":"https://doi.org/10.2139/ssrn.4089982"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.4089982","doi":"https://doi.org/10.2139/ssrn.4089982","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4089982","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.4089982","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Tao Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tao Xu","raw_affiliation_strings":["Joslin Diabetes Center - Section on Pathophysiology and Molecular Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joslin Diabetes Center - Section on Pathophysiology and Molecular Pharmacology","institution_ids":["https://openalex.org/I1293231726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003950176","display_name":"Lidan Zhao","orcid":"https://orcid.org/0000-0001-6599-3339","observed_orcids":["https://orcid.org/0000-0001-6599-3339"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lidan Zhao","raw_affiliation_strings":["Chinese Academy of Medical Sciences and Peking Union Medical Colleg - Department of Rheumatology and Clinical Immunology"],"raw_orcid":"https://orcid.org/0000-0001-6599-3339","affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences and Peking Union Medical Colleg - Department of Rheumatology and Clinical Immunology","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019725382","display_name":"Md Zohorul Islam","orcid":"https://orcid.org/0000-0002-2015-5195","observed_orcids":["https://orcid.org/0000-0002-2015-5195"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Md  Zohorul Islam","raw_affiliation_strings":["Joslin Diabetes Center - Section on Pathophysiology and Molecular Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joslin Diabetes Center - Section on Pathophysiology and Molecular Pharmacology","institution_ids":["https://openalex.org/I1293231726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104082657","display_name":"Loc Pham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Loc  Duyen Pham","raw_affiliation_strings":["Joslin Diabetes Center - Section on Pathophysiology and Molecular Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joslin Diabetes Center - Section on Pathophysiology and Molecular Pharmacology","institution_ids":["https://openalex.org/I1293231726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002772047","display_name":"Martina Sassone\u2010Corsi","orcid":"https://orcid.org/0000-0002-4137-8371","observed_orcids":["https://orcid.org/0000-0002-4137-8371"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martina  Sassone Corsi","raw_affiliation_strings":["Harvard Medical School - Department of Microbiology and Immunobiology, 25 Shattuck St, Boston, MA 02115, United States","Harvard Medical School - Department of Microbiology and Immunobiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School - Department of Microbiology and Immunobiology, 25 Shattuck St, Boston, MA 02115, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School - Department of Microbiology and Immunobiology","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056408708","display_name":"Ramnik J. Xavier","orcid":"https://orcid.org/0000-0002-5630-5167","observed_orcids":["https://orcid.org/0000-0002-5630-5167"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramnik  J. Xavier","raw_affiliation_strings":["Harvard Medical School - Center for Computational and Integrative Biology and Gastrointestinal Unit, 25 Shattuck St, Boston, MA 02115, United States","Harvard Medical School - Center for Computational and Integrative Biology and Gastrointestinal Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School - Center for Computational and Integrative Biology and Gastrointestinal Unit, 25 Shattuck St, Boston, MA 02115, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School - Center for Computational and Integrative Biology and Gastrointestinal Unit","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040731525","display_name":"Christophe O. Benoist","orcid":"https://orcid.org/0000-0003-1172-6555","observed_orcids":["https://orcid.org/0000-0003-1172-6555"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christophe Benoist","raw_affiliation_strings":["Harvard Medical School - Department of Microbiology and Immunobiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School - Department of Microbiology and Immunobiology","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063494244","display_name":"Aleksandar David Kostic","orcid":"https://orcid.org/0000-0002-0837-4360","observed_orcids":["https://orcid.org/0000-0002-0837-4360","https://orcid.org/0000-0002-7596-7748"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aleksandar  David Kostic","raw_affiliation_strings":["Joslin Diabetes Center - Section on Pathophysiology and Molecular Pharmacology, One Joslin Place, Boston, MA 02115, United States","Joslin Diabetes Center - Section on Pathophysiology and Molecular Pharmacology"],"raw_orcid":"https://orcid.org/0000-0002-0837-4360","affiliations":[{"raw_affiliation_string":"Joslin Diabetes Center - Section on Pathophysiology and Molecular Pharmacology, One Joslin Place, Boston, MA 02115, United States","institution_ids":["https://openalex.org/I1293231726"]},{"raw_affiliation_string":"Joslin Diabetes Center - Section on Pathophysiology and Molecular Pharmacology","institution_ids":["https://openalex.org/I1293231726"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063494244"],"corresponding_institution_ids":["https://openalex.org/I1293231726"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.6518999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.6518999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.27219998836517334,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.02800000086426735,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9900000095367432},{"id":"https://openalex.org/keywords/parabacteroides-goldsteinii","display_name":"Parabacteroides goldsteinii","score":0.9649999737739563},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9769999980926514},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.9660000205039978},{"id":"https://openalex.org/keywords/adenosine-a2a-receptor","display_name":"adenosine A2A receptor","score":0.875},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9449999928474426},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9020000100135803},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pannexin-1","display_name":"pannexin 1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cd39","display_name":"CD39","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cd73","display_name":"CD73","score":0.9990000128746033},{"id":"https://openalex.org/keywords/extracellular-adenosine","display_name":"extracellular adenosine","score":0.8569999933242798},{"id":"https://openalex.org/keywords/arthritis","display_name":"arthritis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.8579999804496765},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2776992512","wikidata":"https://www.wikidata.org/wiki/Q28208900","display_name":"Adenosinergic","level":5,"score":0.7881530523300171},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6405247449874878},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.634926438331604},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.6002480983734131},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48151955008506775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4490814208984375},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.361357718706131},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1412171721458435},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.0},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.4089982","doi":"https://doi.org/10.2139/ssrn.4089982","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4089982","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.4089982","doi":"https://doi.org/10.2139/ssrn.4089982","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4089982","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1703384511","https://openalex.org/W1779530018","https://openalex.org/W1929503195","https://openalex.org/W1976582565","https://openalex.org/W2004774344","https://openalex.org/W2013147282","https://openalex.org/W2018505426","https://openalex.org/W2041292257","https://openalex.org/W2051349444","https://openalex.org/W2051373931","https://openalex.org/W2056506612","https://openalex.org/W2058258787","https://openalex.org/W2063017950","https://openalex.org/W2068089195","https://openalex.org/W2068767807","https://openalex.org/W2091707030","https://openalex.org/W2106829739","https://openalex.org/W2107277218","https://openalex.org/W2107285671","https://openalex.org/W2126147289","https://openalex.org/W2127788605","https://openalex.org/W2146607274","https://openalex.org/W2152245204","https://openalex.org/W2164386968","https://openalex.org/W2202439768","https://openalex.org/W2331942228","https://openalex.org/W2343758687","https://openalex.org/W2346233234","https://openalex.org/W2521901496","https://openalex.org/W2525306428","https://openalex.org/W2529902668","https://openalex.org/W2617586630","https://openalex.org/W2766025104","https://openalex.org/W2803664483","https://openalex.org/W2899391538","https://openalex.org/W2911391319","https://openalex.org/W2915010259","https://openalex.org/W2952200190","https://openalex.org/W2985013111","https://openalex.org/W3013222411","https://openalex.org/W3030972254","https://openalex.org/W3049052172","https://openalex.org/W3082173734","https://openalex.org/W3183749649","https://openalex.org/W3184663355","https://openalex.org/W4254509222","https://openalex.org/W4286856345"],"related_works":["https://openalex.org/W3194231011","https://openalex.org/W3034234484","https://openalex.org/W7100035194","https://openalex.org/W2086465908","https://openalex.org/W4388702438","https://openalex.org/W4379259603","https://openalex.org/W2944334002","https://openalex.org/W4388698051","https://openalex.org/W7147447180","https://openalex.org/W7166099479"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-05-05T00:00:00"}
