{"id":"https://openalex.org/W4226338598","doi":"https://doi.org/10.1093/oncolo/oyac102","title":"Topical Endoxifen for Mammographic Density Reduction\u2014A Randomized Controlled Trial","display_name":"Topical Endoxifen for Mammographic Density Reduction\u2014A Randomized Controlled Trial","publication_year":2022,"publication_date":"2022-04-27","ids":{"openalex":"https://openalex.org/W4226338598","doi":"https://doi.org/10.1093/oncolo/oyac102","pmid":"https://pubmed.ncbi.nlm.nih.gov/35604960","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9256025"},"language":"en","primary_location":{"id":"doi:10.1093/oncolo/oyac102","doi":"https://doi.org/10.1093/oncolo/oyac102","is_oa":true,"landing_page_url":"https://doi.org/10.1093/oncolo/oyac102","pdf_url":"https://academic.oup.com/oncolo/article-pdf/27/7/e597/44418316/oyac102.pdf","source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/oncolo/article-pdf/27/7/e597/44418316/oyac102.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025791635","display_name":"L. Magnus B\u00e4cklund","orcid":"https://orcid.org/0000-0003-0397-6538","observed_orcids":["https://orcid.org/0000-0003-0397-6538"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Magnus B\u00e4cklund","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden"],"raw_orcid":"https://orcid.org/0000-0003-0397-6538","affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037999437","display_name":"Mikael Eriksson","orcid":"https://orcid.org/0000-0001-8135-4270","observed_orcids":["https://orcid.org/0000-0001-8135-4270"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mikael Eriksson","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047591350","display_name":"Marike Gabrielson","orcid":"https://orcid.org/0000-0002-3171-1556","observed_orcids":["https://orcid.org/0000-0002-3171-1556"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Marike Gabrielson","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden"],"raw_orcid":"https://orcid.org/0000-0002-3171-1556","affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088964280","display_name":"Mattias Hammarstr\u00f6m","orcid":"https://orcid.org/0000-0001-6608-8867","observed_orcids":["https://orcid.org/0000-0001-6608-8867"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mattias Hammarstr\u00f6m","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Steve Quay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139967","display_name":"Atossa Therapeutics (United States)","ror":"https://ror.org/03yqekx34","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139967"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Quay","raw_affiliation_strings":["Atossa Therapeutics, Inc. , Seattle, WA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atossa Therapeutics, Inc. , Seattle, WA , USA","institution_ids":["https://openalex.org/I4210139967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074942134","display_name":"Jenny Bergqvist","orcid":"https://orcid.org/0000-0002-9875-7946","observed_orcids":["https://orcid.org/0000-0002-9875-7946"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210099778","display_name":"Saint G\u00f6ran Hospital","ror":"https://ror.org/00x6s3a91","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210099778"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jenny Bergqvist","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden","Department of Surgery, Breast Centre, Capio S:t G\u00f6rans Hospital , Stockholm , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Surgery, Breast Centre, Capio S:t G\u00f6rans Hospital , Stockholm , Sweden","institution_ids":["https://openalex.org/I4210099778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020456056","display_name":"Roxanna Hellgren","orcid":"https://orcid.org/0000-0003-4234-8323","observed_orcids":["https://orcid.org/0000-0003-4234-8323"]},"institutions":[{"id":"https://openalex.org/I4210094988","display_name":"Stockholm South General Hospital","ror":"https://ror.org/00ncfk576","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210094988"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Roxanna Hellgren","raw_affiliation_strings":["Department of Radiology, S\u00f6dersjukhuset , Stockholm , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, S\u00f6dersjukhuset , Stockholm , Sweden","institution_ids":["https://openalex.org/I4210094988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040540995","display_name":"Kamila Czene","orcid":"https://orcid.org/0000-0002-3233-5695","observed_orcids":["https://orcid.org/0000-0002-3233-5695"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kamila Czene","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden"],"raw_orcid":"https://orcid.org/0000-0002-3233-5695","affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053177403","display_name":"Per N Hall","orcid":"https://orcid.org/0000-0002-5640-9126","observed_orcids":["https://orcid.org/0000-0002-5640-9126"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210094988","display_name":"Stockholm South General Hospital","ror":"https://ror.org/00ncfk576","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210094988"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per Hall","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden","Department of Oncology, S\u00f6dersjukhuset , Stockholm , Sweden"],"raw_orcid":"https://orcid.org/0000-0002-5640-9126","affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Oncology, S\u00f6dersjukhuset , Stockholm , Sweden","institution_ids":["https://openalex.org/I4210094988"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025791635"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":3494,"currency":"USD","value_usd":3494},"apc_paid":{"value":1364,"currency":"EUR","value_usd":1471},"fwci":0.8455,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.64710596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"27","issue":"7","first_page":"e597","last_page":"e600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11361","display_name":"Digital Radiography and Breast Imaging","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11361","display_name":"Digital Radiography and Breast Imaging","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoxifen","display_name":"endoxifen","score":0.9490000009536743},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.6129999756813049},{"id":"https://openalex.org/keywords/breast-density","display_name":"breast density","score":0.9549999833106995},{"id":"https://openalex.org/keywords/breast-cancer-prevention","display_name":"breast cancer prevention","score":0.925000011920929},{"id":"https://openalex.org/keywords/tamoxifen-metabolites","display_name":"tamoxifen metabolites","score":0.9629999995231628},{"id":"https://openalex.org/keywords/z-endoxifen","display_name":"Z-endoxifen","score":0.7919999957084656},{"id":"https://openalex.org/keywords/primary-prevention","display_name":"primary prevention","score":0.6389999985694885},{"id":"https://openalex.org/keywords/skin-rash","display_name":"rash","score":0.6349999904632568},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.949018120765686},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.8858299255371094},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6902410984039307},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.6250103712081909},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5857962369918823},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5602188110351562},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.5225807428359985},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5192375779151917},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5086937546730042},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44035762548446655},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4126073718070984},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32058048248291016},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000071060","descriptor_name":"Breast Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/oncolo/oyac102","doi":"https://doi.org/10.1093/oncolo/oyac102","is_oa":true,"landing_page_url":"https://doi.org/10.1093/oncolo/oyac102","pdf_url":"https://academic.oup.com/oncolo/article-pdf/27/7/e597/44418316/oyac102.pdf","source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},{"id":"pmid:35604960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35604960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The oncologist","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9256025","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9256025/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncologist","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/oncolo/oyac102","doi":"https://doi.org/10.1093/oncolo/oyac102","is_oa":true,"landing_page_url":"https://doi.org/10.1093/oncolo/oyac102","pdf_url":"https://academic.oup.com/oncolo/article-pdf/27/7/e597/44418316/oyac102.pdf","source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4226338598.pdf","grobid_xml":"https://content.openalex.org/works/W4226338598.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1972100164","https://openalex.org/W1977853445","https://openalex.org/W2074335085","https://openalex.org/W2099535971","https://openalex.org/W2143486088","https://openalex.org/W2146845000","https://openalex.org/W2149275727","https://openalex.org/W2151340153","https://openalex.org/W2789572430","https://openalex.org/W2979073616"],"related_works":["https://openalex.org/W7160192563","https://openalex.org/W4390517471","https://openalex.org/W4411287200","https://openalex.org/W4404165513","https://openalex.org/W4396591959","https://openalex.org/W4409822050","https://openalex.org/W2099629052","https://openalex.org/W1979834599","https://openalex.org/W3133011507","https://openalex.org/W2183291585"],"abstract_inverted_index":{"Although":[0],"breast":[1,15,123,147],"cancer":[2,16,124,148],"incidence":[3,17,125],"is":[4,19,141],"increasing,":[5],"there":[6],"are":[7],"few":[8],"primary":[9,23],"preventive":[10],"initiatives.":[11],"Tamoxifen":[12],"can":[13],"reduce":[14,48],"but":[18,108],"rarely":[20],"used":[21,145],"for":[22,53,69,137,146],"prevention":[24],"due":[25],"to":[26,41,60,121,143],"adverse":[27],"events":[28],"and":[29,63,74,80,140],"tolerance":[30],"issues.":[31],"We":[32],"tested":[33],"if":[34],"endoxifen,":[35],"a":[36,51,84,94,99],"tamoxifen":[37,116],"metabolite,":[38],"applied":[39],"directly":[40],"the":[42,45,103,119],"skin":[43,90],"of":[44,66,105,115],"breast,":[46],"could":[47],"mammographic":[49,96],"density,":[50],"proxy":[52],"therapy":[54],"response.":[55],"Ninety":[56],"women":[57],"were":[58,76],"randomized":[59],"placebo,":[61],"10":[62],"20":[64],"mg":[65],"topical":[67,138],"Z-endoxifen":[68,107],"6":[70],"months.":[71],"Mammographic":[72],"density":[73,97],"symptoms":[75],"measured":[77],"at":[78],"baseline":[79],"study":[81],"exit.":[82],"Despite":[83],"high":[85],"discontinuation":[86],"rate,":[87],"driven":[88],"by":[89],"rashes,":[91],"we":[92],"found":[93],"significant":[95],"decrease,":[98],"dose-dependent":[100],"increase":[101],"in":[102],"concentration":[104],"plasma":[106],"no":[109],"systemic":[110,128],"side":[111,129],"effects.":[112,130],"Topical":[113],"application":[114],"metabolites":[117],"has":[118],"potential":[120],"decrease":[122],"without":[126],"major":[127],"However,":[131],"endoxifen":[132],"may":[133],"not":[134],"be":[135,144],"suitable":[136],"administration":[139],"unlikely":[142],"prevention.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-05-05T00:00:00"}