{"id":"https://openalex.org/W4226288317","doi":"https://doi.org/10.1161/circ.145.suppl_1.p125","title":"Abstract P125: Change In Low-density Lipoprotein Cholesterol And Risk Of Subsequent Cardiovascular Events Among Patients With Myocardial Infarction","display_name":"Abstract P125: Change In Low-density Lipoprotein Cholesterol And Risk Of Subsequent Cardiovascular Events Among Patients With Myocardial Infarction","publication_year":2022,"publication_date":"2022-03-01","ids":{"openalex":"https://openalex.org/W4226288317","doi":"https://doi.org/10.1161/circ.145.suppl_1.p125"},"language":"en","primary_location":{"id":"doi:10.1161/circ.145.suppl_1.p125","doi":"https://doi.org/10.1161/circ.145.suppl_1.p125","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.145.suppl_1.p125","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047526584","display_name":"Sheila M. Manemann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheila M Manemann","raw_affiliation_strings":["MAYO CLINIC, Rochester, MN","Sheila M Manemann MAYO CLINIC, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MAYO CLINIC, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Sheila M Manemann MAYO CLINIC, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010530964","display_name":"Sarah S. Cohen","orcid":"https://orcid.org/0000-0003-0421-1983","observed_orcids":["https://orcid.org/0000-0003-0421-1983"]},"institutions":[{"id":"https://openalex.org/I4403928214","display_name":"ToxStrategies LLC (United States)","ror":"https://ror.org/02cfpj844","country_code":"US","type":"company","lineage":["https://openalex.org/I4403928214"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Cohen","raw_affiliation_strings":["ToxStrategies, Cary, NC","Sarah Cohen ToxStrategies, Cary, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ToxStrategies, Cary, NC","institution_ids":["https://openalex.org/I4403928214"]},{"raw_affiliation_string":"Sarah Cohen ToxStrategies, Cary, NC","institution_ids":["https://openalex.org/I4403928214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028302182","display_name":"Stephanie R. Reading","orcid":"https://orcid.org/0000-0003-0494-7448","observed_orcids":["https://orcid.org/0000-0003-0494-7448"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie R Reading","raw_affiliation_strings":["Amgen, Newbury Park, CA","Stephanie R Reading Amgen, Newbury Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen, Newbury Park, CA","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"Stephanie R Reading Amgen, Newbury Park, CA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088992746","display_name":"Sina Noshad","orcid":"https://orcid.org/0000-0003-4681-351X","observed_orcids":["https://orcid.org/0000-0003-4681-351X"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sina Noshad","raw_affiliation_strings":["Amgen, Woodland Hills, CA","Sina Noshad Amgen, Woodland Hills, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen, Woodland Hills, CA","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"Sina Noshad Amgen, Woodland Hills, CA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055082239","display_name":"Naimisha Movva","orcid":"https://orcid.org/0000-0001-9300-5473","observed_orcids":["https://orcid.org/0000-0001-9300-5473"]},"institutions":[{"id":"https://openalex.org/I4403928214","display_name":"ToxStrategies LLC (United States)","ror":"https://ror.org/02cfpj844","country_code":"US","type":"company","lineage":["https://openalex.org/I4403928214"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naimisha Movva","raw_affiliation_strings":["ToxStrategies, Rockville, MD","Naimisha Movva ToxStrategies, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ToxStrategies, Rockville, MD","institution_ids":["https://openalex.org/I4403928214"]},{"raw_affiliation_string":"Naimisha Movva ToxStrategies, Rockville, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105422086","display_name":"Susan A. Weston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Weston","raw_affiliation_strings":["Mayo Clinic, Rochester, MN","Susan Weston Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Susan Weston Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025883880","display_name":"Jill M. Killian","orcid":"https://orcid.org/0000-0003-3906-4020","observed_orcids":["https://orcid.org/0000-0003-3906-4020"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill Killian","raw_affiliation_strings":["Mayo Clinic, Rochester, MN","Jill Killian Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Jill Killian Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044494735","display_name":"Alanna M. Chamberlain","orcid":"https://orcid.org/0000-0003-1888-9584","observed_orcids":["https://orcid.org/0000-0003-1888-9584"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alanna Chamberlain","raw_affiliation_strings":["MAYO CLINIC, Rochester, MN","Alanna Chamberlain MAYO CLINIC, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MAYO CLINIC, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Alanna Chamberlain MAYO CLINIC, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"145","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.03480000048875809,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9340000152587891},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.8209999799728394},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9079999923706055},{"id":"https://openalex.org/keywords/coronary-artery-bypass-grafting","display_name":"coronary artery bypass grafting","score":0.871999979019165},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":1.0},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.7670000195503235},{"id":"https://openalex.org/keywords/post-discharge-follow-up","display_name":"post-discharge follow-up","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9424669742584229},{"id":"https://openalex.org/C45393284","wikidata":"https://www.wikidata.org/wiki/Q191012","display_name":"Conventional PCI","level":3,"score":0.7971529364585876},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7913647890090942},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7534965872764587},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.7152734994888306},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7103654146194458},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5068395733833313},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4816988408565521},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4544014632701874},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.43471696972846985},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.43187570571899414},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4114357829093933},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.11902588605880737},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.145.suppl_1.p125","doi":"https://doi.org/10.1161/circ.145.suppl_1.p125","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.145.suppl_1.p125","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7799999713897705}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404363940","https://openalex.org/W2981688322","https://openalex.org/W4415799808","https://openalex.org/W3115254109","https://openalex.org/W7164163031","https://openalex.org/W4293171174","https://openalex.org/W2097038701","https://openalex.org/W7170044367","https://openalex.org/W2904887449","https://openalex.org/W2998313698"],"abstract_inverted_index":{"Background:":[0],"Among":[1,167],"patients":[2,170,199,270],"who":[3,313],"experience":[4],"a":[5,15,21,40,52,74,180,190,211,214,241,253,260,272,280,296],"myocardial":[6],"infarction":[7],"(MI),":[8],"elevated":[9],"low-density":[10],"lipoprotein":[11],"cholesterol":[12],"(LDL-C)":[13],"is":[14,29,267],"major":[16],"risk":[17,216,282,306],"factor":[18],"for":[19,83,113,307],"experiencing":[20],"subsequent":[22,46,114,284],"cardiovascular":[23],"(CV)":[24],"event;":[25],"however,":[26],"real-world":[27],"evidence":[28,268],"lacking":[30],"in":[31,36,234,250,274],"regard":[32],"to":[33,45,66,146,226,301],"how":[34],"changes":[35],"LDL-C":[37,59,61,87,95,107,152,161,182,222,242,254,275,294,318],"levels":[38],"after":[39,98,276,295],"MI":[41,54,169,264,277,297],"hospitalization":[42],"are":[43],"related":[44],"CV":[47,115,140,156,218,285,309],"events.":[48,286],"Methods:":[49],"Adults":[50],"with":[51,92,220,228,240,252,271],"hospitalized":[53],"and":[55,71,79,100,155,176,185,197,205,244,298,311],"an":[56,232],"available":[57],"baseline":[58,99,106,160,181],"(closest":[60],"within":[62,73],"2":[63],"years":[64],"prior":[65],"hospital":[67],"discharge)":[68],"between":[69,150],"2012":[70],"2018":[72],"27-county":[75],"region":[76],"across":[77],"MN":[78],"WI":[80],"were":[81,111,144],"included":[82],"study.":[84],"For":[85],"each":[86],"measurement":[88],"during":[89],"follow-up":[90,192],"(starting":[91],"the":[93,148,201,290],"first":[94],">30":[96],"days":[97],"\u22641-year":[101],"post-discharge),":[102],"percent":[103,153],"change":[104,154,230],"from":[105,223,316],"was":[108,236],"calculated.":[109],"Patients":[110],"followed":[112],"events":[116,219,310],"(composite":[117],"endpoint":[118,134,203],"1:":[119],"MI,":[120,136],"ischemic":[121],"stroke":[122],"[IS],":[123],"coronary":[124,130],"artery":[125],"bypass":[126],"grafting":[127],"[CABG],":[128],"percutaneous":[129],"intervention":[131],"[PCI];":[132],"composite":[133,202],"2:":[135],"IS,":[137],"CABG,":[138],"PCI,":[139],"death).":[141],"Cox":[142],"models":[143],"used":[145],"evaluate":[147],"association":[149],"time-dependent":[151],"events,":[157],"stratified":[158],"by":[159],"(<70,":[162],"70-99,":[163],"\u2265100":[164,186],"mg/dL).":[165],"Results:":[166],"3,034":[168],"identified,":[171],"740":[172],"(24%),":[173],"940":[174],"(31%)":[175],"1354":[177],"(45%)":[178],"had":[179],"<70,":[183],"70-99":[184,255],"mg/dL,":[187],"respectively.":[188,207],"After":[189,208],"mean":[191],"of":[193,217,263,283,292],"3.4":[194],"years,":[195],"471":[196],"667":[198],"experienced":[200],"1":[204],"2,":[206],"covariate":[209],"adjustment,":[210],"trend":[212],"towards":[213],"lower":[215],"decreasing":[221],"baseline,":[224],"compared":[225],"those":[227,239,251,312],"no":[229],"or":[231],"increase":[233],"LDL-C,":[235],"observed":[237],"among":[238],"<70":[243],">":[245],"100":[246],"mg/dl":[247],"but":[248],"not":[249],"mg/dL":[256],"(Table).":[257],"Conclusions:":[258],"In":[259],"population-based":[261],"cohort":[262],"patients,":[265],"there":[266],"that":[269],"decrease":[273],"may":[278,299,314],"have":[279],"reduced":[281],"These":[287],"results":[288],"underscore":[289],"importance":[291],"lowering":[293],"help":[300],"identify":[302],"subgroups":[303],"at":[304],"highest":[305],"additional":[308],"benefit":[315],"targeted":[317],"treatment":[319],"recommendations.":[320]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-05-05T00:00:00"}